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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Case Report Open Access

Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report

  • Authors:
    • Elena Stingu
    • Jerome-Maurice Dobrowolski
    • Paula Bombach
    • Dominik Nann
    • Stephan Singer
    • Marius Horger
    • Ulrich M. Lauer
    • Lars Zender
    • Clemens Hinterleitner
    • Martina Hinterleitner
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, D‑72076 Tuebingen, Germany, Department of Neurology and Interdisciplinary Neuro‑Oncology, University Hospital Tuebingen, D‑72076 Tuebingen, Germany, Department of Pathology, University Hospital Tuebingen, D‑72076 Tuebingen, Germany, Department of Radiology, University Hospital Tuebingen, D‑72076 Tuebingen, Germany
    Copyright: © Stingu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 523
    |
    Published online on: September 25, 2023
       https://doi.org/10.3892/etm.2023.12222
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Abstract

Myasthenia gravis (MG) is a heterogeneous autoimmune disease, which is characterized by a postsynaptic neuromuscular transmission defect, with antibodies directly targeting the acetylcholine receptor (AChR) or other structural proteins of the neuromuscular junction. The majority of MG cases are associated with thymic pathologies, including thymoma, thyroiditis, autoimmune diseases or malignant hematologic neoplasia. The present study reported a rare case of AChR‑positive and late‑onset ocular MG, which rapidly progressed to a generalized myasthenic syndrome as an initial presentation of a pancreatic neuroendocrine neoplasia (pNEN). Following complete surgical resection of the pNEN, the myasthenic syndrome was improved and the anti‑AChR antibody titers were reduced. It has been reported that MG is a paraneoplastic syndrome in thymic neoplasms and less common in hematologic malignancies. However, currently, only few cases of MG as initial presentation of a solid tumor, and more particular of a neuroendocrine neoplasm, have been reported in the literature. In conclusion, surveillance for extrathymic solid malignancies in newly diagnosed patients with MG could promote the early diagnosis of associated tumor diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Stingu E, Dobrowolski J, Bombach P, Nann D, Singer S, Horger M, Lauer UM, Zender L, Hinterleitner C, Hinterleitner M, Hinterleitner M, et al: Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report. Exp Ther Med 26: 523, 2023.
APA
Stingu, E., Dobrowolski, J., Bombach, P., Nann, D., Singer, S., Horger, M. ... Hinterleitner, M. (2023). Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report. Experimental and Therapeutic Medicine, 26, 523. https://doi.org/10.3892/etm.2023.12222
MLA
Stingu, E., Dobrowolski, J., Bombach, P., Nann, D., Singer, S., Horger, M., Lauer, U. M., Zender, L., Hinterleitner, C., Hinterleitner, M."Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report". Experimental and Therapeutic Medicine 26.5 (2023): 523.
Chicago
Stingu, E., Dobrowolski, J., Bombach, P., Nann, D., Singer, S., Horger, M., Lauer, U. M., Zender, L., Hinterleitner, C., Hinterleitner, M."Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report". Experimental and Therapeutic Medicine 26, no. 5 (2023): 523. https://doi.org/10.3892/etm.2023.12222
Copy and paste a formatted citation
x
Spandidos Publications style
Stingu E, Dobrowolski J, Bombach P, Nann D, Singer S, Horger M, Lauer UM, Zender L, Hinterleitner C, Hinterleitner M, Hinterleitner M, et al: Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report. Exp Ther Med 26: 523, 2023.
APA
Stingu, E., Dobrowolski, J., Bombach, P., Nann, D., Singer, S., Horger, M. ... Hinterleitner, M. (2023). Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report. Experimental and Therapeutic Medicine, 26, 523. https://doi.org/10.3892/etm.2023.12222
MLA
Stingu, E., Dobrowolski, J., Bombach, P., Nann, D., Singer, S., Horger, M., Lauer, U. M., Zender, L., Hinterleitner, C., Hinterleitner, M."Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report". Experimental and Therapeutic Medicine 26.5 (2023): 523.
Chicago
Stingu, E., Dobrowolski, J., Bombach, P., Nann, D., Singer, S., Horger, M., Lauer, U. M., Zender, L., Hinterleitner, C., Hinterleitner, M."Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report". Experimental and Therapeutic Medicine 26, no. 5 (2023): 523. https://doi.org/10.3892/etm.2023.12222
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