Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2023 Volume 26 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2023 Volume 26 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

FRZB affects Staphylococcus aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway

  • Authors:
    • Xin Li
    • Wenyong Pang
    • Hongsong Fan
    • Hao Wang
    • Leibing Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Surgery, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550023, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 531
    |
    Published online on: September 28, 2023
       https://doi.org/10.3892/etm.2023.12230
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteomyelitis is an infectious disease of bone tissue caused by bacterial infection, which can infect through hematogenous, traumatic or secondary ways and then lead to acute or chronic bone injury and relative clinical symptoms, bringing physical injury and economic burden to patients. Frizzled related protein (FRZB) participates in the regulation of various diseases (osteoarthritis, cardiovascular diseases and types of cancer) by regulating cell proliferation, motility, differentiation and inflammation, while its function in osteomyelitis remains to be elucidated. The present study aimed to uncover the role and underlying mechanism of FRZB mediation in Staphylococcus aureus (S. aureus)‑induced osteomyelitis. Human bone marrow derived stem cells (hBMSCs) were treated with S. aureus to imitate an inflammatory osteomyelitis micro‑environment in vitro, then mRNA and protein expression were severally assessed by RT‑PCR and western blotting. The activity, apoptosis and differentiation of the cells were characterized via CCK‑8, caspase‑3 activity and Alizarin red sulfate/alkaline phosphatase staining, respectively. Expression levels of FRZB were upregulated in S. aureus‑infected hBMSCs. Over‑expression of FRZB significantly reduced hBMSC cell viability and differentiation while promoting cell apoptosis with or without S. aureus infection. However, FRZB knockdown reversed these effects. Once Wnt was impeded, the effect of FRZB downregulation was impeded to a great extent. Taken together, FRZB participated to regulate the osteomyelitis by activating the Wnt/β‑catenin signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Cui Y, Lu S, Tan H, Li J, Zhu M and Xu Y: Silencing of long non-coding RNA NONHSAT009968 ameliorates the staphylococcal protein A-Inhibited osteogenic differentiation in human bone mesenchymal stem cells. Cell Physiol Biochem. 39:1347–1359. 2016.PubMed/NCBI View Article : Google Scholar

2 

Josse J, Velard F and Gangloff SC: Staphylococcus aureus vs. Osteoblast: Relationship and consequences in osteomyelitis. Front Cell Infect Microbiol. 5(85)2015.PubMed/NCBI View Article : Google Scholar

3 

Fantoni M, Taccari F and Giovannenze F: Systemic antibiotic treatment of chronic osteomyelitis in adults. Eur Rev Med Pharmacol Sci. 23 (2 Suppl):S258–S270. 2019.PubMed/NCBI View Article : Google Scholar

4 

Sanchez CJ Jr, Ward CL, Romano DR, Hurtgen BJ, Hardy SK, Woodbury RL, Trevino AV, Rathbone CR and Wenke JC: Staphylococcus aureus biofilms decrease osteoblast viability, inhibits osteogenic differentiation, and increases bone resorption in vitro. BMC Musculoskelet Disord. 14(187)2013.PubMed/NCBI View Article : Google Scholar

5 

Liu W, Konermann A, Guo T, Jäger A, Zhang L and Jin Y: Canonical Wnt signaling differently modulates osteogenic differentiation of mesenchymal stem cells derived from bone marrow and from periodontal ligament under inflammatory conditions. Biochim Biophys Acta. 1840:1125–1134. 2014.PubMed/NCBI View Article : Google Scholar

6 

Wang Y, Li YP, Paulson C, Shao JZ, Zhang X, Wu M and Chen W: Wnt and the Wnt signaling pathway in bone development and disease. Front Biosci (Landmark Ed). 19:379–407. 2014.PubMed/NCBI View Article : Google Scholar

7 

Qin X, Jiang Q, Komori H, Sakane C, Fukuyama R, Matsuo Y, Ito K, Miyazaki T and Komori T: Runt-related transcription factor-2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice. J Bone Miner Res. 36:2081–2095. 2021.PubMed/NCBI View Article : Google Scholar

8 

Kawaguchi H: Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process. J Bone Miner Res. 24:8–11. 2009.PubMed/NCBI View Article : Google Scholar

9 

Wang H, Sun W, Ma J, Pan Y, Wang L and Zhang WB: Biglycan mediates suture expansion osteogenesis via potentiation of Wnt/β-catenin signaling. J Biomech. 48:432–440. 2015.PubMed/NCBI View Article : Google Scholar

10 

Kwan T, Kazamel M, Thoenes K, Si Y, Jiang N and King PH: Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis. Sci Rep. 10(16679)2020.PubMed/NCBI View Article : Google Scholar

11 

Qin S, Zhang Z, Li J and Zang L: FRZB knockdown upregulates β-catenin activity and enhances cell aggressiveness in gastric cancer. Oncol Rep. 31:2351–2357. 2014.PubMed/NCBI View Article : Google Scholar

12 

Fernández-Torres J, Zamudio-Cuevas Y, López-Reyes A, Garrido-Rodríguez D, Martínez-Flores K, Lozada CA, Muñóz-Valle JF, Oregon-Romero E and Martínez-Nava GA: Gene-gene interactions of the Wnt/β-catenin signaling pathway in knee osteoarthritis. Mol Biol Rep. 45:1089–1098. 2018.PubMed/NCBI View Article : Google Scholar

13 

Ma Z, Wang X, Lv Q, Gong Y, Xia M, Zhuang L, Lu X, Yang Y, Zhang W, Fu G, et al: Identification of underlying hub genes associated with hypertrophic cardiomyopathy by integrated bioinformatics analysis. Pharmgenomics Pers Med. 14:823–837. 2021.PubMed/NCBI View Article : Google Scholar

14 

Huang J, Hu W, Lin X, Wang X and Jin K: FRZB up-regulated in hepatocellular carcinoma bone metastasis. Int J Clin Exp Pathol. 8:13353–13359, eCollection 2015. 2015.PubMed/NCBI

15 

Killock D: Osteoarthritis: Frzb knockout reveals the complexity of Wnt signaling in joint homeostasis. Nat Rev Rheumatol. 8(123)2012.PubMed/NCBI View Article : Google Scholar

16 

Corallini F, Secchiero P, Castellino G, Montecucco M, Trotta F and Zauli G: Circulating levels of frizzled-related protein (FRZB) are increased in patients with early rheumatoid arthritis and decrease in response to disease-modifying antirheumatic drugs. Ann Rheum Dis. 69:1733–1734. 2010.PubMed/NCBI View Article : Google Scholar

17 

Li H, Zhang S, Nie B, Long T, Qu X and Yue B: KR-12-a5 reverses adverse effects of lipopolysaccharides on HBMSC osteogenic differentiation by influencing BMP/Smad and P38 MAPK signaling pathways. Front Pharmacol. 10(639)2019.PubMed/NCBI View Article : Google Scholar

18 

Wang Y, Zhang X, Shao J, Liu H, Liu X and Luo E: Adiponectin regulates BMSC osteogenic differentiation and osteogenesis through the Wnt/β-catenin pathway. Sci Rep. 7(3652)2017.PubMed/NCBI View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

20 

Guo C, Wang SL, Xu ST, Wang JG and Song GH: SP600125 reduces lipopolysaccharide-induced apoptosis and restores the early-stage differentiation of osteoblasts inhibited by LPS through the MAPK pathway in MC3T3-E1 cells. Int J Mol Med. 35:1427–1434. 2015.PubMed/NCBI View Article : Google Scholar

21 

Jin Q, Yuan K, Lin W, Niu C, Ma R and Huang Z: Comparative characterization of mesenchymal stem cells from human dental pulp and adipose tissue for bone regeneration potential. Artif Cells Nanomed Biotechnol. 47:1577–1584. 2019.PubMed/NCBI View Article : Google Scholar

22 

Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J, Thomas JT and Luyten FP: Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum. 56:4095–4103. 2007.PubMed/NCBI View Article : Google Scholar

23 

Xiao H, Zeng Y, Wang Q, Wei S and Zhu X: A novel positive feedback loop between NTSR1 and Wnt/β-Catenin contributes to tumor growth of glioblastoma. Cell Physiol Biochem. 43:2133–2142. 2017.PubMed/NCBI View Article : Google Scholar

24 

Li F, Wang X and Niyibizi C: Bone marrow stromal cells contribute to bone formation following infusion into femoral cavities of a mouse model of osteogenesis imperfecta. Bone. 47:546–555. 2010.PubMed/NCBI View Article : Google Scholar

25 

Jin T, Zhu YL, Li J, Shi J, He XQ, Ding J and Xu YQ: Staphylococcal protein A, Panton-Valentine leukocidin and coagulase aggravate the bone loss and bone destruction in osteomyelitis. Cell Physiol Biochem. 32:322–333. 2013.PubMed/NCBI View Article : Google Scholar

26 

Beck-Broichsitter BE, Smeets R and Heiland M: Current concepts in pathogenesis of acute and chronic osteomyelitis. Curr Opin Infect Dis. 28:240–245. 2015.PubMed/NCBI View Article : Google Scholar

27 

Nasser A, Azimi T and Ostadmohammadi S and Ostadmohammadi S: A comprehensive review of bacterial osteomyelitis with emphasis on Staphylococcus aureus. Microb Pathog. 148(104431)2020.PubMed/NCBI View Article : Google Scholar

28 

Dubus M, Varin J, Papa S, Chevrier J, Quilès F, Francius G, Audonnet S, Mauprivez C, Gangloff SC, Siboni R, et al: Bone marrow mesenchymal stem cells offer an immune-privileged niche to Cutibacterium acnes in case of implant-associated osteomyelitis. Acta Biomater. 137:305–315. 2022.PubMed/NCBI View Article : Google Scholar

29 

Ding R, Wei S and Huang M: Long non-coding RNA KCNQ1OT1 overexpression promotes osteogenic differentiation of staphylococcus aureus-infected human bone mesenchymal stem cells by sponging microRNA miR-29b-3p. Bioengineered. 13:5855–5867. 2022.PubMed/NCBI View Article : Google Scholar

30 

Oh CK, Ko Y, Park JJ, Heo HJ, Kang J, Kwon EJ, Kang JW, Lee Y, Myung K, Kang JM, et al: FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity. Biosci Rep. 41(BSR20203204)2021.PubMed/NCBI View Article : Google Scholar

31 

Thysen S, Luyten FP and Lories RJ: Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis. Osteoarthritis Cartilage. 23:275–279. 2015.PubMed/NCBI View Article : Google Scholar

32 

Person AD, Garriock RJ, Krieg PA, Runyan RB and Klewer SE: Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development. Dev Biol. 278:35–48. 2005.PubMed/NCBI View Article : Google Scholar

33 

Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X and Hoang BH: Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 68:3350–3360. 2008.PubMed/NCBI View Article : Google Scholar

34 

Shi Q, Zhou C, Xie R, Li M, Shen P, Lu Y and Ma S: CircCNIH4 inhibits gastric cancer progression via regulating DKK2 and FRZB expression and Wnt/β-catenin pathway. J Biol Res (Thessalon). 28(19)2021.PubMed/NCBI View Article : Google Scholar

35 

Kim HY, Choi S, Yoon JH, Lim HJ, Lee H, Choi J, Ro EJ, Heo JN, Lee W, No KT and Choi KY: Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Mol Med. 8:375–387. 2016.PubMed/NCBI View Article : Google Scholar

36 

Zuo GL, Zhang LF, Qi J, Kang H, Jia P, Chen H, Shen X, Guo L, Zhou HB, Wang JS, et al: Activation of HIFa pathway in mature osteoblasts disrupts the integrity of the osteocyte/canalicular network. PLoS One. 10(e0121266)2015.PubMed/NCBI View Article : Google Scholar

37 

Tang CY, Chen W, Luo Y, Wu J, Zhang Y, McVicar A, McConnell M, Liu Y, Zhou HD and Li YP: Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis. Biochem J. 477:2421–2438. 2020.PubMed/NCBI View Article : Google Scholar

38 

Goldring SR: The osteocyte: Key player in regulating bone turnover. RMD Open. 1(Suppl 1)(e000049)2015.PubMed/NCBI View Article : Google Scholar

39 

Matsumoto Y, La Rose J, Lim M, Adissu HA, Law N, Mao X, Cong F, Mera P, Karsenty G, Goltzman D, et al: Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. J Clin Invest. 127:2612–2625. 2017.PubMed/NCBI View Article : Google Scholar

40 

Bovolenta P, Esteve P, Ruiz JM, Cisneros E and Lopez-Rios J: Beyond Wnt inhibition: New functions of secreted Frizzled-related proteins in development and disease. J Cell Sci. 121(Pt 6):737–746. 2008.PubMed/NCBI View Article : Google Scholar

41 

Lories RJ, Corr M and Lane NE: To Wnt or not to Wnt: The bone and joint health dilemma. Nat Rev Rheumatol. 9:328–339. 2013.PubMed/NCBI View Article : Google Scholar

42 

Sáenz A, Azpitarte M, Armañanzas R, Leturcq F, Alzualde A, Inza I, García-Bragado F, De la Herran G, Corcuera J, Cabello A, et al: Gene expression profiling in limb-girdle muscular dystrophy 2A. PLoS One. 3(e3750)2008.PubMed/NCBI View Article : Google Scholar

43 

Ren LR, Wang H, He XQ, Song MG, Chen XQ and Xu YQ: Staphylococcus aureus Protein A induces osteoclastogenesis via the NF-κB signaling pathway. Mol Med Rep. 16:6020–6028. 2017.PubMed/NCBI View Article : Google Scholar

44 

Song B, Estrada KD and Lyons KM: Smad signaling in skeletal development and regeneration. Cytokine Growth Factor Rev. 20:379–388. 2009.PubMed/NCBI View Article : Google Scholar

45 

Putnam NE, Fulbright LE, Curry JM, Ford CA, Petronglo JR, Hendrix AS and Cassat JE: MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis. PLoS Pathog. 15(e1007744)2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li X, Pang W, Fan H, Wang H and Zhang L: FRZB affects <em>Staphylococcus</em> aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway. Exp Ther Med 26: 531, 2023.
APA
Li, X., Pang, W., Fan, H., Wang, H., & Zhang, L. (2023). FRZB affects <em>Staphylococcus</em> aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway. Experimental and Therapeutic Medicine, 26, 531. https://doi.org/10.3892/etm.2023.12230
MLA
Li, X., Pang, W., Fan, H., Wang, H., Zhang, L."FRZB affects <em>Staphylococcus</em> aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 26.5 (2023): 531.
Chicago
Li, X., Pang, W., Fan, H., Wang, H., Zhang, L."FRZB affects <em>Staphylococcus</em> aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 26, no. 5 (2023): 531. https://doi.org/10.3892/etm.2023.12230
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Pang W, Fan H, Wang H and Zhang L: FRZB affects <em>Staphylococcus</em> aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway. Exp Ther Med 26: 531, 2023.
APA
Li, X., Pang, W., Fan, H., Wang, H., & Zhang, L. (2023). FRZB affects <em>Staphylococcus</em> aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway. Experimental and Therapeutic Medicine, 26, 531. https://doi.org/10.3892/etm.2023.12230
MLA
Li, X., Pang, W., Fan, H., Wang, H., Zhang, L."FRZB affects <em>Staphylococcus</em> aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 26.5 (2023): 531.
Chicago
Li, X., Pang, W., Fan, H., Wang, H., Zhang, L."FRZB affects <em>Staphylococcus</em> aureus‑induced osteomyelitis in human bone marrow derived stem cells by regulating the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 26, no. 5 (2023): 531. https://doi.org/10.3892/etm.2023.12230
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team