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Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population

  • Authors:
    • Lixing Ma
    • Kang Song
    • Jinfeng Zang
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    Affiliations: Department of Surgery, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Hepatobiliary Surgery, Taixing People's Hospital, The Affiliated Taixing People's Hospital of Yangzhou University, Taixing, Jiangsu 225400, P.R. China, Department of Hepatobiliary Surgery, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu 225300, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 532
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    Published online on: September 28, 2023
       https://doi.org/10.3892/etm.2023.12231
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Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor and a major cause of cancer mortality worldwide. Integrin β5 (ITGB5) is considered to be involved in the intercellular signal transduction and regulation of tumorigenesis and development. The present study investigated the association between ITGB5 expression levels and the prognosis of ICC, as well as the effects of ITGB5 on the proliferation and invasion of ICC cells. RNA‑sequencing transcriptomic profiling data of ICC samples were retrieved from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Tissue specimens from patients with ICC treated at Taizhou People's Hospital were collected and the ITGB5 expression levels were evaluated using immunohistochemical staining. The biological function of ITGB5 in ICC was investigated using Gene Ontology (GO), Gene Set Enrichment Analysis (GSEA) and in vitro experiments using HuCCT1 cells. After knocking down ITGB5 expression, cell proliferation was detected using Cell Counting Kit‑8 assay, while cell invasion was assessed using Transwell assays. According to TCGA dataset, ITGB5 was highly expressed in ICC; however, there was no significant difference in prognosis between patients with high and low ITGB5 expression levels. High expression of ITGB5 was present in the tissues of patients with ICC from the GEO database, which was associated with poor prognosis. Survival analyses of the clinical data obtained in the present study revealed that high expression levels of ITGB5 in patients with ICC were associated with a reduced overall survival. GO and GSEA indicated that genes associated with ITGB5 were enriched in the extracellular matrix‑receptor interaction and focal adhesion signaling pathways. Silencing ITGB5 inhibited the proliferation and invasion of ICC cells. In conclusion, ITGB5 may act as an essential regulator of ICC development and progression by influencing the proliferation and invasion of ICC cells. However, future studies with larger sample sizes are required to validate the role of ITGB5 in the prognosis of patients with ICC.
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1 

Muñoz-Martínez S and Forner A: The tireless search to improve the prognostic assessment of intrahepatic cholangiocarcinoma: An urgent need. Liver Int. 41:252–254. 2021.PubMed/NCBI View Article : Google Scholar

2 

Saha SK, Zhu AX, Fuchs CS and Brooks GA: Forty-year trends in cholangiocarcinoma incidence in the U.S.: Intrahepatic disease on the rise. Oncologist. 21:594–599. 2016.PubMed/NCBI View Article : Google Scholar

3 

Rizvi S, Khan SA, Hallemeier CL, Kelley RK and Gores GJ: Cholangiocarcinoma-evolving concepts and therapeutic strategies. Nat Rev Clin Oncol. 15:95–111. 2018.PubMed/NCBI View Article : Google Scholar

4 

Brunt E, Aishima S, Clavien PA, Fowler K, Goodman Z, Gores G, Gouw A, Kagen A, Klimstra D, Komuta M, et al: cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. Hepatology. 68:113–126. 2018.PubMed/NCBI View Article : Google Scholar

5 

Wu L, Tsilimigras DI, Paredes AZ, Mehta R, Hyer JM, Merath K, Sahara K, Bagante F, Beal EW, Shen F and Pawlik TM: Trends in the incidence, treatment and outcomes of patients with intrahepatic cholangiocarcinoma in the USA: Facility type is associated with margin status, use of lymphadenectomy and overall survival. World J Surg. 43:1777–1787. 2019.PubMed/NCBI View Article : Google Scholar

6 

Van Dyke AL, Shiels MS, Jones GS, Pfeiffer RM, Petrick JL, Beebe-Dimmer JL and Koshiol J: Biliary tract cancer incidence and trends in the United States by demographic group, 1999-2013. Cancer. 125:1489–1498. 2019.PubMed/NCBI View Article : Google Scholar

7 

Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, et al: Cholangiocarcinoma 2020: The next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol. 17:557–588. 2020.PubMed/NCBI View Article : Google Scholar

8 

Rahnemai-Azar AA, Weisbrod A, Dillhoff M, Schmidt C and Pawlik TM: Intrahepatic cholangiocarcinoma: Molecular markers for diagnosis and prognosis. Surg Oncol. 26:125–137. 2017.PubMed/NCBI View Article : Google Scholar

9 

Massarweh NN and El-Serag HB: Epidemiology of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Cancer Control. 24(1073274817729245)2017.PubMed/NCBI View Article : Google Scholar

10 

Fujita T: Liver transplantation for intrahepatic cholangiocarcinoma. Lancet. 384(1182)2014.PubMed/NCBI View Article : Google Scholar

11 

Khan SA, Davidson BR, Goldin RD, Heaton N, Karani J, Pereira SP, Rosenberg WM, Tait P, Taylor-Robinson SD, Thillainayagam AV, et al: Guidelines for the diagnosis and treatment of cholangiocarcinoma: An update. Gut. 61:1657–1669. 2012.PubMed/NCBI View Article : Google Scholar

12 

Lamarca A, Ross P, Wasan HS, Hubner RA, McNamara MG, Lopes A, Manoharan P, Palmer D, Bridgewater J and Valle JW: Advanced intrahepatic cholangiocarcinoma: Post hoc analysis of the ABC-01, -02, and -03 clinical trials. J Natl Cancer Inst. 112:200–210. 2020.PubMed/NCBI View Article : Google Scholar

13 

Ryerson AB, Eheman CR, Altekruse SF, Ward JW, Jemal A, Sherman RL, Henley SJ, Holtzman D, Lake A, Noone AM, et al: Annual report to the nation on the status of cancer, 1975-2012, featuring the increasing incidence of liver cancer. Cancer. 122:1312–1337. 2016.PubMed/NCBI View Article : Google Scholar

14 

Hamidi H and Ivaska J: Every step of the way: Integrins in cancer progression and metastasis. Nat Rev Cancer. 18:533–548. 2018.PubMed/NCBI View Article : Google Scholar

15 

Humphries JD, Byron A and Humphries MJ: Integrin ligands at a glance. J Cell Sci. 119:3901–3903. 2006.PubMed/NCBI View Article : Google Scholar

16 

Arruda Macêdo JK, Fox JW and de Souza Castro M: Disintegrins from snake venoms and their applications in cancer research and therapy. Curr Protein Pept Sci. 16:532–548. 2015.PubMed/NCBI View Article : Google Scholar

17 

Hussein HA, Walker LR, Abdel-Raouf UM, Desouky SA, Montasser AK and Akula SM: Beyond RGD: Virus interactions with integrins. Arch Virol. 160:2669–2681. 2015.PubMed/NCBI View Article : Google Scholar

18 

Zhao ZS, Wang YY, Chu YQ, Ye ZY and Tao HQ: SPARC is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res. 16:260–268. 2010.PubMed/NCBI View Article : Google Scholar

19 

Petricevic B, Vrbanec D, Jakic-Razumovic J, Brcic I, Rabic D, Badovinac T, Ozimec E and Bali V: Expression of Toll-like receptor 4 and beta 1 integrin in breast cancer. Med Oncol. 29:486–494. 2012.PubMed/NCBI View Article : Google Scholar

20 

Zhou G, Chiu D, Qin D, Niu L, Cai J, He L, Tan D and Xu K: Expression of CD44v6 and integrin-β1 for the prognosis evaluation of pancreatic cancer patients after cryosurgery. Diagn Pathol. 8(146)2013.PubMed/NCBI View Article : Google Scholar

21 

Liu QZ, Gao XH, Chang WJ, Gong HF, Fu CG, Zhang W and Cao GW: Expression of ITGB1 predicts prognosis in colorectal cancer: A large prospective study based on tissue microarray. Int J Clin Exp Pathol. 8:12802–12810. 2015.PubMed/NCBI

22 

Takada Y, Ye X and Simon S: The integrins. Genome Biol. 8(215)2007.PubMed/NCBI View Article : Google Scholar

23 

Shi W, He J, Huang Y, Zeng Z, Feng Z, Xu H and Nie Y: Integrin β5 enhances the malignancy of human colorectal cancer by increasing the TGF-β signaling. Anticancer Drugs. 32:717–726. 2021.PubMed/NCBI View Article : Google Scholar

24 

Lin Z, He R, Luo H, Lu C, Ning Z, Wu Y, Han C, Tan G and Wang Z: Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability. J Exp Clin Cancer Res. 37(17)2018.PubMed/NCBI View Article : Google Scholar

25 

Wortzel I, Dror S, Kenific CM and Lyden D: Exosome-mediated metastasis: Communication from a distance. Dev Cell. 49:347–360. 2019.PubMed/NCBI View Article : Google Scholar

26 

Shang L, Ye X, Zhu G, Su H, Su Z, Chen B, Xiao K, Li L, Peng M and Peng T: Prognostic value of integrin variants and expression in post-operative patients with HBV-related hepatocellular carcinoma. Oncotarget. 8:76816–76831. 2017.PubMed/NCBI View Article : Google Scholar

27 

Andersen JB, Spee B, Blechacz BR, Avital I, Komuta M, Barbour A, Conner EA, Gillen MC, Roskams T, Roberts LR, et al: Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. Gastroenterology. 142:1021–1031.e15. 2012.PubMed/NCBI View Article : Google Scholar

28 

Ahn KS, O'Brien D, Kang YN, Mounajjed T, Kim YH, Kim TS, Kocher JA, Allotey LK, Borad MJ, Roberts LR and Kang KJ: Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular-clinical analysis and potential targeted approach. Hepatol Int. 13:490–500. 2019.PubMed/NCBI View Article : Google Scholar

29 

Davis S and Meltzer PS: GEOquery: A bridge between the gene expression omnibus (GEO) and Bioconductor. Bioinformatics. 23:1846–1847. 2007.PubMed/NCBI View Article : Google Scholar

30 

Colaprico A, Silva TC, Olsen C, Garofano L, Cava C, Garolini D, Sabedot TS, Malta TM, Pagnotta SM, Castiglioni I, et al: TCGAbiolinks: An R/Bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res. 44(e71)2016.PubMed/NCBI View Article : Google Scholar

31 

Chen C, Chen H, Zhang Y, Thomas HR, Frank MH, He Y and Xia R: TBtools: An integrative toolkit developed for interactive analyses of big biological data. Mol Plant. 13:1194–1202. 2020.PubMed/NCBI View Article : Google Scholar

32 

Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington KM, Carneiro F and Cree IA: WHO Classification of Tumours Editorial Board. The 2019 WHO classification of tumours of the digestive system. Histopathology. 76:182–188. 2020.PubMed/NCBI View Article : Google Scholar

33 

Chun YS, Pawlik TM and Vauthey JN: 8th Edition of the AJCC cancer staging manual: Pancreas and hepatobiliary cancers. Ann Surg Oncol. 25:845–847. 2018.PubMed/NCBI View Article : Google Scholar

34 

The Gene Ontology Consortium. The gene ontology resource: 20 Years and still GOing strong. Nucleic Acids Res. 47 (D1):D330–D338. 2019.PubMed/NCBI View Article : Google Scholar

35 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000.PubMed/NCBI View Article : Google Scholar

36 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10(1523)2019.PubMed/NCBI View Article : Google Scholar

37 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003.PubMed/NCBI View Article : Google Scholar

38 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45 (W1):W98–W102. 2017.PubMed/NCBI View Article : Google Scholar

39 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005.PubMed/NCBI View Article : Google Scholar

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

41 

Gao C, Li J, Zeng F, Wang L, Chen K, Chen D, Hong J and Qu C: MCM6 promotes intrahepatic cholangiocarcinoma progression by upregulating E2F1 and enhancing epithelial-mesenchymal transition. Carcinogenesis. 44:279–290. 2023.PubMed/NCBI View Article : Google Scholar

42 

Zhang JN, Ding DY, Yang SY, Tao QF, Yang Y and Zhou WP: The role of tripartite motif containing 59 (TRIM59) in the proliferation and prognosis of intrahepatic cholangiocarcinoma. Pathol Res Pract. 236(153989)2022.PubMed/NCBI View Article : Google Scholar

43 

Nakamura H, Arai Y, Totoki Y, Shirota T, Elzawahry A, Kato M, Hama N, Hosoda F, Urushidate T, Ohashi S, et al: Genomic spectra of biliary tract cancer. Nat Genet. 47:1003–1010. 2015.PubMed/NCBI View Article : Google Scholar

44 

Sia D, Hoshida Y, Villanueva A, Roayaie S, Ferrer J, Tabak B, Peix J, Sole M, Tovar V, Alsinet C, et al: Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. Gastroenterology. 144:829–840. 2013.PubMed/NCBI View Article : Google Scholar

45 

Liu J, Ren G, Li K, Liu Z, Wang Y, Chen T, Mu W, Yang X, Li X, Shi A, et al: The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma. Cell Death Differ. 29:818–831. 2022.PubMed/NCBI View Article : Google Scholar

46 

Hozaka Y, Seki N, Tanaka T, Asai S, Moriya S, Idichi T, Wada M, Tanoue K, Kawasaki Y, Mataki Y, et al: Molecular pathogenesis and regulation of the miR-29-3p-family: Involvement of ITGA6 and ITGB1 in intra-hepatic cholangiocarcinoma. Cancers (Basel). 13(2804)2021.PubMed/NCBI View Article : Google Scholar

47 

Ricono JM, Huang M, Barnes LA, Lau SK, Weis SM, Schlaepfer DD, Hanks SK and Cheresh DA: Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res. 69:1383–1391. 2009.PubMed/NCBI View Article : Google Scholar

48 

Bianchi-Smiraglia A, Paesante S and Bakin AV: Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways. Oncogene. 32:3049–3058. 2013.PubMed/NCBI View Article : Google Scholar

49 

Hung WY, Huang KH, Wu CW, Chi CW, Kao HL, Li AF, Yin PH and Lee HC: Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells. Biochim Biophys Acta. 1820:1102–1110. 2012.PubMed/NCBI View Article : Google Scholar

50 

Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, Lawson C, Miller NL, Jean C, Chen XL, Ward KK and Schlaepfer DD: FAK inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth. Mol Cancer Ther. 13:2050–2061. 2014.PubMed/NCBI View Article : Google Scholar

51 

Zhang LY, Guo Q, Guan GF, Cheng W, Cheng P and Wu AH: Integrin beta 5 is a prognostic biomarker and potential therapeutic target in glioblastoma. Front Oncol. 9(904)2019.PubMed/NCBI View Article : Google Scholar

52 

An XZ, Zhao ZG, Luo YX, Zhang R, Tang XQ, Hao D, Zhao X, Lv X and Liu D: Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 7:24719–24733. 2016.PubMed/NCBI View Article : Google Scholar

53 

Yang GY, Guo S, Dong CY, Wang XQ, Hu BY, Liu YF, Chen YW, Niu J and Dong JH: Integrin αvβ6 sustains and promotes tumor invasive growth in colon cancer progression. World J Gastroenterol. 21:7457–7467. 2015.PubMed/NCBI View Article : Google Scholar

54 

Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, et al: The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. J Pathol. 249:332–342. 2019.PubMed/NCBI View Article : Google Scholar

55 

Hurtado de Mendoza T, Mose ES, Botta GP, Braun GB, Kotamraju VR, French RP, Suzuki K, Miyamura N, Teesalu T, Ruoslahti E, et al: Tumor-penetrating therapy for β5 integrin-rich pancreas cancer. Nat Commun. 12(1541)2021.PubMed/NCBI View Article : Google Scholar

56 

Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, et al: Tumour exosome integrins determine organotropic metastasis. Nature. 527:329–335. 2015.PubMed/NCBI View Article : Google Scholar

57 

Li H, Long J, Xie F, Kang K, Shi Y, Xu W, Wu X, Lin J, Xu H, Du S, et al: Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma. Oncol Rep. 42:1833–1842. 2019.PubMed/NCBI View Article : Google Scholar

58 

Wu D, Sun J, Wang H and Ma C: LncRNA SOCS2-AS1 promotes the progression of glioma via regulating ITGB1 expression. Neurosci Lett. 765(136248)2021.PubMed/NCBI View Article : Google Scholar

59 

Que ZJ, Yang Y, Liu HT, Shang-Guan WJ, Yu P, Zhu LH, Li HG, Liu HM and Tian JH: Jinfukang regulates integrin/Src pathway and anoikis mediating circulating lung cancer cells migration. J Ethnopharmacol. 267(113473)2021.PubMed/NCBI View Article : Google Scholar

60 

Bergamaschi A, Tagliabue E, Sørlie T, Naume B, Triulzi T, Orlandi R, Russnes HG, Nesland JM, Tammi R, Auvinen P, et al: Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome. J Pathol. 214:357–367. 2008.PubMed/NCBI View Article : Google Scholar

61 

Yang J, Hou Y, Zhou M, Wen S, Zhou J, Xu L, Tang X, Du YE, Hu P and Liu M: Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network. Int J Biochem Cell Biol. 71:62–71. 2016.PubMed/NCBI View Article : Google Scholar

62 

Eke I and Cordes N: Focal adhesion signaling and therapy resistance in cancer. Semin Cancer Biol. 31:65–75. 2015.PubMed/NCBI View Article : Google Scholar

63 

Murphy JM, Rodriguez YAR, Jeong K, Ahn EE and Lim SS: Targeting focal adhesion kinase in cancer cells and the tumor microenvironment. Exp Mol Med. 52:877–886. 2020.PubMed/NCBI View Article : Google Scholar

64 

Liu D, Liu S, Fang Y, Liu L and Hu K: Comprehensive analysis of the expression and prognosis for ITGBs: Identification of ITGB5 as a biomarker of poor prognosis and correlated with immune infiltrates in gastric cancer. Front Cell Dev Biol. 9(816230)2022.PubMed/NCBI View Article : Google Scholar

65 

Yang X, Chen L, Mao Y, Hu Z and He M: Progressive and prognostic performance of an extracellular matrix-receptor interaction signature in gastric cancer. Dis Markers. 2020(8816070)2020.PubMed/NCBI View Article : Google Scholar

66 

Shimizu S, Okumura T, Oshiro Y, Fukumitsu N, Fukuda K, Ishige K, Hasegawa N, Numajiri H, Murofushi K, Ohnishi K, et al: Clinical outcomes of previously untreated patients with unresectable intrahepatic cholangiocarcinoma following proton beam therapy. Radiat Oncol. 14(241)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ma L, Song K and Zang J: Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population. Exp Ther Med 26: 532, 2023.
APA
Ma, L., Song, K., & Zang, J. (2023). Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population. Experimental and Therapeutic Medicine, 26, 532. https://doi.org/10.3892/etm.2023.12231
MLA
Ma, L., Song, K., Zang, J."Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population". Experimental and Therapeutic Medicine 26.5 (2023): 532.
Chicago
Ma, L., Song, K., Zang, J."Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population". Experimental and Therapeutic Medicine 26, no. 5 (2023): 532. https://doi.org/10.3892/etm.2023.12231
Copy and paste a formatted citation
x
Spandidos Publications style
Ma L, Song K and Zang J: Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population. Exp Ther Med 26: 532, 2023.
APA
Ma, L., Song, K., & Zang, J. (2023). Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population. Experimental and Therapeutic Medicine, 26, 532. https://doi.org/10.3892/etm.2023.12231
MLA
Ma, L., Song, K., Zang, J."Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population". Experimental and Therapeutic Medicine 26.5 (2023): 532.
Chicago
Ma, L., Song, K., Zang, J."Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population". Experimental and Therapeutic Medicine 26, no. 5 (2023): 532. https://doi.org/10.3892/etm.2023.12231
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