Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2023 Volume 26 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2023 Volume 26 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.xlsx
    • Supplementary_Data3.xlsx
    • Supplementary_Data4.xlsx
    • Supplementary_Data5.xlsx
    • Supplementary_Data6.xlsx
Article Open Access

Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas

  • Authors:
    • Yujie Gao
    • Qifu Long
    • Hui Yang
    • Ying Hu
    • Yuzhen Xu
    • Chaoqun Tang
    • Cunlin Gu
    • Sheng Yong
  • View Affiliations / Copyright

    Affiliations: Department of Basic Medicine, School of Medicine, Qinghai University, Xining, Qinghai 810016, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 533
    |
    Published online on: September 28, 2023
       https://doi.org/10.3892/etm.2023.12232
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Exposure to hypoxia disrupts energy metabolism and induces inflammation. However, the pathways and mechanisms underlying energy metabolism disorders caused by hypoxic conditions remain unclear. In the present study, a hypoxic animal model was created and transcriptomic and non‑targeted metabolomics techniques were applied to further investigate the pathways and mechanisms of hypoxia exposure that disrupt energy metabolism. Transcriptome results showed that 3,007 genes were significantly differentially expressed under hypoxic exposure, and Gene Ontology annotation analysis and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analysis showed that the differentially expressed genes (DEGs) were mainly involved in energy metabolism and were significantly enriched in the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) pathway. The DEGs IDH3A, SUCLA2, and MDH2 in the TCA cycle and the DEGs NDUFA3, NDUFS7, UQCRC1, CYC1 and UQCRFS1 in the OXPHOS pathway were validated using mRNA and protein expression, and the results showed downregulation. The results of non‑targeted metabolomics showed that 365 significant differential metabolites were identified under plateau hypoxia stress. KEGG enrichment analysis showed that the differential metabolites were mainly enriched in metabolic processes, such as energy, nucleotide and amino acid metabolism. Hypoxia exposure disrupted the TCA cycle and reduced the synthesis of amino acids and nucleotides by decreasing the concentration of cis‑aconitate, α‑ketoglutarate, NADH, NADPH and that of most amino acids, purines, and pyrimidines. Bioinformatics analysis was used to identify inflammatory genes related to hypoxia exposure and some of them were selected for verification. It was shown that the mRNA and protein expression levels of IL1B, IL12B, S100A8 and S100A9 in kidney tissues were upregulated under hypoxic exposure. The results suggest that hypoxia exposure inhibits the TCA cycle and the OXPHOS signalling pathway by inhibiting IDH3A, SUCLA2, MDH2, NDUFFA3, NDUFS7, UQCRC1, CYC1 and UQCRFS1, thereby suppressing energy metabolism, inducing amino acid and nucleotide deficiency and promoting inflammation, ultimately leading to kidney damage.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Li Y and Zhang Y and Zhang Y: Research advances in pathogenesis and prophylactic measures of acute high altitude illness. Respir Med. 145:145–152. 2018.PubMed/NCBI View Article : Google Scholar

2 

Gaur P, Prasad S, Kumar B, Sharma SK and Vats P: High-altitude hypoxia induced reactive oxygen species generation, signaling, and mitigation approaches. Int J Biometeorol. 65:601–615. 2021.PubMed/NCBI View Article : Google Scholar

3 

Yang S and Lian G: ROS and diseases: Role in metabolism and energy supply. Mol Cell Biochem. 467:1–12. 2020.PubMed/NCBI View Article : Google Scholar

4 

Wilkins MR, Ghofrani HA, Weissmann N, Aldashev A and Zhao L: Pathophysiology and treatment of high-altitude pulmonary vascular disease. Circulation. 131:582–590. 2015.PubMed/NCBI View Article : Google Scholar

5 

Clark AJ and Parikh SM: Mitochondrial metabolism in acute kidney injury. Semin Nephrol. 40:101–113. 2020.PubMed/NCBI View Article : Google Scholar

6 

Infantino V, Santarsiero A, Convertini P, Todisco S and Iacobazzi V: Cancer cell metabolism in hypoxia: Role of HIF-1 as key regulator and therapeutic target. Int J Mol Sci. 22(5703)2021.PubMed/NCBI View Article : Google Scholar

7 

Fuhrmann DC and Brüne B: Mitochondrial composition and function under the control of hypoxia. Redox Biol. 12:208–215. 2017.PubMed/NCBI View Article : Google Scholar

8 

Liu X, Du H, Sun Y and Shao L: Role of abnormal energy metabolism in the progression of chronic kidney disease and drug intervention. Ren Fail. 44:790–805. 2022.PubMed/NCBI View Article : Google Scholar

9 

Cadenas S: Mitochondrial uncoupling, ROS generation and cardioprotection. Biochim Biophys Acta Bioenerg. 1859:940–950. 2018.PubMed/NCBI View Article : Google Scholar

10 

Han Y, Xu X, Tang C, Gao P, Chen X, Xiong X, Yang M, Yang S, Zhu X, Yuan S, et al: Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis. Redox Biol. 16:32–46. 2018.PubMed/NCBI View Article : Google Scholar

11 

Palomba H, Castro I, Yu L and Burdmann EA: The duration of acute kidney injury after cardiac surgery increases the risk of long-term chronic kidney disease. J Nephrol. 30:567–572. 2017.PubMed/NCBI View Article : Google Scholar

12 

Wei J, Zhang J, Wang L, Jiang S, Fu L, Buggs J and Liu R: New mouse model of chronic kidney disease transitioned from ischemic acute kidney injury. Am J Physiol Renal Physiol. 317:F286–F295. 2019.PubMed/NCBI View Article : Google Scholar

13 

Zhang X, Agborbesong E and Li X: The role of mitochondria in acute kidney injury and chronic kidney disease and its therapeutic potential. Int J Mol Sci. 22(11253)2021.PubMed/NCBI View Article : Google Scholar

14 

Jiang M, Bai M, Lei J, Xie Y, Xu S, Jia Z and Zhang A: Mitochondrial dysfunction and the AKI-to-CKD transition. Am J Physiol Renal Physiol. 319:F1105–F1116. 2020.PubMed/NCBI View Article : Google Scholar

15 

Kang W, Suzuki M, Saito T and Miyado K: Emerging role of TCA cycle-related enzymes in human diseases. Int J Mol Sci. 22(13057)2021.PubMed/NCBI View Article : Google Scholar

16 

Jourdain AA, Begg BE, Mick E, Shah H, Calvo SE, Skinner OS, Sharma R, Blue SM, Yeo GW, Burge CB and Mootha VK: Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS. Mol Cell. 81:1905–1919.e12. 2021.PubMed/NCBI View Article : Google Scholar

17 

Fuller GG and Kim JK: Compartmentalization and metabolic regulation of glycolysis. J Cell Sci. 134(jcs258469)2021.PubMed/NCBI View Article : Google Scholar

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

19 

Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15(550)2014.PubMed/NCBI View Article : Google Scholar

20 

Huss JM and Kelly DP: Nuclear receptor signaling and cardiac energetics. Circ Res. 95:568–578. 2004.PubMed/NCBI View Article : Google Scholar

21 

Zhang Q, Luo P, Chen J, Yang C, Xia F, Zhang J, Tang H, Liu D, Gu L, Shi Q, et al: Dissection of targeting molecular mechanisms of aristolochic acid-induced nephrotoxicity via a combined deconvolution strategy of chemoproteomics and metabolomics. Int J Biol Sci. 18:2003–2017. 2022.PubMed/NCBI View Article : Google Scholar

22 

Kanehisa M: Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28:1947–1951. 2019.PubMed/NCBI View Article : Google Scholar

23 

Kanehisa M, Furumichi M, Sato Y, Kawashima M and Ishiguro-Watanabe M: KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51:D587–D592. 2023.PubMed/NCBI View Article : Google Scholar

24 

Nissanka N and Moraes CT: Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease. FEBS Lett. 592:728–742. 2018.PubMed/NCBI View Article : Google Scholar

25 

Kan C, Ungelenk L, Lupp A, Dirsch O and Dahmen U: Ischemia-reperfusion injury in aged livers-the energy metabolism, inflammatory response, and autophagy. Transplantation. 102:368–377. 2018.PubMed/NCBI View Article : Google Scholar

26 

Vallée A, Guillevin R and Vallée JN: Vasculogenesis and angiogenesis initiation under normoxic conditions through Wnt/β-catenin pathway in gliomas. Rev Neurosci. 29:71–91. 2018.PubMed/NCBI View Article : Google Scholar

27 

May JL, Kouri FM, Hurley LA, Liu J, Tommasini-Ghelfi S, Ji Y, Gao P, Calvert AE, Lee A, Chandel NS, et al: IDH3α regulates one-carbon metabolism in glioblastoma. Sci Adv. 5(eaat0456)2019.PubMed/NCBI View Article : Google Scholar

28 

Findlay AS, Carter RN, Starbuck B, McKie L, Nováková K, Budd PS, Keighren MA, Marsh JA, Cross SH, Simon MM, et al: Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function. Dis Model Mech. 11(dmm036426)2018.PubMed/NCBI View Article : Google Scholar

29 

Lambeth DO, Tews KN, Adkins S, Frohlich D and Milavetz BI: Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues. J Biol Chem. 279:36621–36624. 2004.PubMed/NCBI View Article : Google Scholar

30 

Donti TR, Stromberger C, Ge M, Eldin KW, Craigen WJ and Graham BH: Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Dis Model Mech. 7:271–280. 2014.PubMed/NCBI View Article : Google Scholar

31 

Kohno S, Linn P, Nagatani N, Watanabe Y, Kumar S, Soga T and Takahashi C: Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. Oncogene. 39:5690–5707. 2020.PubMed/NCBI View Article : Google Scholar

32 

Shimozawa Y, Himiyama T, Nakamura T and Nishiya Y: Structural analysis and reaction mechanism of malate dehydrogenase from Geobacillus stearothermophilus. J Biochem. 170:97–105. 2021.PubMed/NCBI View Article : Google Scholar

33 

Gray LR, Tompkins SC and Taylor EB: Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci. 71:2577–2604. 2014.PubMed/NCBI View Article : Google Scholar

34 

Laemmle A, Steck AL, Schaller A, Kurth S, Perret Hoigné E, Felser AD, Slavova N, Salvisberg C, Atencio M, Mochel F, et al: Triheptanoin-novel therapeutic approach for the ultra-rare disease mitochondrial malate dehydrogenase deficiency. Mol Genet Metab Rep. 29(100814)2021.PubMed/NCBI View Article : Google Scholar

35 

Bergman O and Ben-Shachar D: Mitochondrial oxidative phosphorylation system (OXPHOS) deficits in schizophrenia: Possible interactions with cellular processes. Can J Psychiatry. 61:457–469. 2016.PubMed/NCBI View Article : Google Scholar

36 

Haapanen O, Reidelbach M and Sharma V: Coupling of quinone dynamics to proton pumping in respiratory complex I. Biochim Biophys Acta Bioenerg. 1861(148287)2020.PubMed/NCBI View Article : Google Scholar

37 

Grivennikova VG, Gladyshev GV and Vinogradov AD: Deactivation of mitochondrial NADH:ubiquinone oxidoreductase (respiratory complex I): Extrinsically affecting factors. Biochim Biophys Acta Bioenerg. 1861(148207)2020.PubMed/NCBI View Article : Google Scholar

38 

Zhu J, Vinothkumar KR and Hirst J: Structure of mammalian respiratory complex I. Nature. 536:354–358. 2016.PubMed/NCBI View Article : Google Scholar

39 

Rak M and Rustin P: Supernumerary subunits NDUFA3, NDUFA5 and NDUFA12 are required for the formation of the extramembrane arm of human mitochondrial complex I. FEBS Lett. 588:1832–1838. 2014.PubMed/NCBI View Article : Google Scholar

40 

Mimaki M, Wang X, McKenzie M, Thorburn DR and Ryan MT: Understanding mitochondrial complex I assembly in health and disease. Biochim Biophys Acta. 1817:851–862. 2012.PubMed/NCBI View Article : Google Scholar

41 

Chen Q, Thompson J, Hu Y, Dean J and Lesnefsky EJ: Inhibition of the ubiquitous calpains protects complex I activity and enables improved mitophagy in the heart following ischemia-reperfusion. Am J Physiol Cell Physiol. 317:C910–C921. 2019.PubMed/NCBI View Article : Google Scholar

42 

Heidari E, Rasoulinezhad M, Pak N, Reza Ashrafi M, Heidari M, Banwell B, Garshasbi M and Reza Tavasoli A: Defective complex III mitochondrial respiratory chain due to a novel variant in CYC1 gene masquerades acute demyelinating syndrome or leber hereditary optic neuropathy. Mitochondrion. 60:12–20. 2021.PubMed/NCBI View Article : Google Scholar

43 

Sánchez E, Lobo T, Fox JL, Zeviani M, Winge DR and Fernández-Vizarra E: LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial complex III assembly in human cells. Biochim Biophys Acta. 1827:285–293. 2013.PubMed/NCBI View Article : Google Scholar

44 

Gusic M, Schottmann G, Feichtinger RG, Du C, Scholz C, Wagner M, Mayr JA, Lee CY, Yépez VA, Lorenz N, et al: Bi-allelic UQCRFS1 variants are associated with mitochondrial complex III deficiency, cardiomyopathy, and alopecia totalis. Am J Hum Genet. 106:102–111. 2020.PubMed/NCBI View Article : Google Scholar

45 

Wang Q, Li M, Gan Y, Jiang S, Qiao J, Zhang W, Fan Y, Shen Y, Song Y, Meng Z, et al: Mitochondrial protein UQCRC1 is oncogenic and a potential therapeutic target for pancreatic cancer. Theranostics. 10:2141–2157. 2020.PubMed/NCBI View Article : Google Scholar

46 

Zeng J, Tao J, Xi L, Wang Z and Liu L: PCSK9 mediates the oxidative low-density lipoprotein-induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway. Int J Mol Med. 47(53)2021.PubMed/NCBI View Article : Google Scholar

47 

Giannos P, Prokopidis K, Raleigh SM, Kelaiditi E and Hill M: Altered mitochondrial microenvironment at the spotlight of musculoskeletal aging and Alzheimer's disease. Sci Rep. 12(11290)2022.PubMed/NCBI View Article : Google Scholar

48 

Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q and Wu P: CYC1 predicts poor prognosis in patients with breast cancer. Dis Markers. 2016(3528064)2016.PubMed/NCBI View Article : Google Scholar

49 

Oka SI, Hsu CP and Sadoshima J: Regulation of cell survival and death by pyridine nucleotides. Circ Res. 111:611–627. 2012.PubMed/NCBI View Article : Google Scholar

50 

Yang Y and Sauve AA: NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy. Biochim Biophys Acta. 1864:1787–1800. 2016.PubMed/NCBI View Article : Google Scholar

51 

Ying W: NAD+/NADH and NADP+/NADPH in cellular functions and cell death: Regulation and biological consequences. Antioxid Redox Signal. 10:179–206. 2008.PubMed/NCBI View Article : Google Scholar

52 

Shi F, Zhang Z, Wang J, Wang Y, Deng J, Zeng Y, Zou P, Ling X, Han F, Liu J, et al: Analysis by metabolomics and transcriptomics for the energy metabolism disorder and the Aryl hydrocarbon receptor activation in male reproduction of mice and GC-2spd cells exposed to PM2.5. Front Endocrinol (Lausanne). 12(807374)2022.PubMed/NCBI View Article : Google Scholar

53 

Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T and Murphy MP: A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury. Cell Metab. 23:254–263. 2016.PubMed/NCBI View Article : Google Scholar

54 

Baldissera MD, Souza CF, Grings M, Parmeggiani BS, Leipnitz G, Moreira KLS, da Rocha MIUM, da Veiga ML, Santos RCV, Stefani LM and Baldisserotto B: Inhibition of the mitochondrial respiratory chain in gills of Rhamdia quelen experimentally infected by Pseudomonas aeruginosa: Interplay with reactive oxygen species. Microb Pathog. 107:349–353. 2017.PubMed/NCBI View Article : Google Scholar

55 

Zhao M, Wang Y, Li L, Liu S, Wang C, Yuan Y, Yang G, Chen Y, Cheng J, Lu Y and Liu J: Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance. Theranostics. 11:1845–1863. 2021.PubMed/NCBI View Article : Google Scholar

56 

Hessam S, Gambichler T, Skrygan M, Sand M, Rüddel I, Scholl L and Bechara FG: Reduced ten-eleven translocation and isocitrate dehydrogenase expression in inflammatory hidradenitis suppurativa lesions. Eur J Dermatol. 28:449–456. 2018.PubMed/NCBI View Article : Google Scholar

57 

Alkhater RA, Ahonen S and Minassian BA: SUCLA2 Arg407Trp mutation can cause a nonprogressive movement disorder-deafness syndrome. Ann Clin Transl Neurol. 8:252–258. 2021.PubMed/NCBI View Article : Google Scholar

58 

Pei X, Li KY, Shen Y, Li JT, Lei MZ, Fang CY, Lu HJ, Yang HJ, Wen W, Yin M, et al: Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth. Sci China Life Sci. 65:2017–2030. 2022.PubMed/NCBI View Article : Google Scholar

59 

Chen J, Jin J, Zhang X, Yu H, Zhu X, Yu L, Chen Y, Liu P, Dong X, Cao X, et al: Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis. Mol Ther. 29:2873–2885. 2021.PubMed/NCBI View Article : Google Scholar

60 

Ma Q, Wang C, Wang M, Li Y, Li P, Wang J, Cheng L, An Y, Dai H, Duan Y, et al: Investigation of brain damage mechanism in middle cerebral artery occlusion/reperfusion rats based on i-TRAQ quantitative proteomics. Exp Brain Res. 239:1247–1260. 2021.PubMed/NCBI View Article : Google Scholar

61 

Wang B, Li ZL, Zhang YL, Wen Y, Gao YM and Liu BC: Hypoxia and chronic kidney disease. EBioMedicine. 77(103942)2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C and Yong S: Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas. Exp Ther Med 26: 533, 2023.
APA
Gao, Y., Long, Q., Yang, H., Hu, Y., Xu, Y., Tang, C. ... Yong, S. (2023). Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas. Experimental and Therapeutic Medicine, 26, 533. https://doi.org/10.3892/etm.2023.12232
MLA
Gao, Y., Long, Q., Yang, H., Hu, Y., Xu, Y., Tang, C., Gu, C., Yong, S."Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas". Experimental and Therapeutic Medicine 26.5 (2023): 533.
Chicago
Gao, Y., Long, Q., Yang, H., Hu, Y., Xu, Y., Tang, C., Gu, C., Yong, S."Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas". Experimental and Therapeutic Medicine 26, no. 5 (2023): 533. https://doi.org/10.3892/etm.2023.12232
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C and Yong S: Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas. Exp Ther Med 26: 533, 2023.
APA
Gao, Y., Long, Q., Yang, H., Hu, Y., Xu, Y., Tang, C. ... Yong, S. (2023). Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas. Experimental and Therapeutic Medicine, 26, 533. https://doi.org/10.3892/etm.2023.12232
MLA
Gao, Y., Long, Q., Yang, H., Hu, Y., Xu, Y., Tang, C., Gu, C., Yong, S."Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas". Experimental and Therapeutic Medicine 26.5 (2023): 533.
Chicago
Gao, Y., Long, Q., Yang, H., Hu, Y., Xu, Y., Tang, C., Gu, C., Yong, S."Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas". Experimental and Therapeutic Medicine 26, no. 5 (2023): 533. https://doi.org/10.3892/etm.2023.12232
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team