Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2023 Volume 26 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2023 Volume 26 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Case Report Open Access

Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report

  • Authors:
    • Lijiang Chen
    • Meijuan Di
    • Lijun Sun
    • Qiong Fu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 555
    |
    Published online on: October 17, 2023
       https://doi.org/10.3892/etm.2023.12254
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mucinous cystic tumors of low malignant potential (MCTLMP) are rare urachal neoplasms. The morphological characteristics and clinical prognosis of MCTLMP is similar to that of mucinous cystic tumors occurring in the ovary and appendix. After complete resection, almost no cases of recurrence or metastasis have been reported. Because MCTLMP is rare, it may be missed in the clinic. MCTLMP can lead to the formation of pseudomyxoma peritonei (PMP), which manifests as the widespread production of mucus in the abdominal cavity and makes the disease complex or difficult to diagnose. At present, only 3 cases of MCTLMP with PMP have been reported in the literature. In the present study a fourth case of urachal MCTLMP in a 74‑year‑old male that resulted in widespread PMP is presented. Initially, a multilocular cystic lesion was revealed in the urachal duct area at the anterior upper margin of the bladder after a patient, experiencing lower abdominal pain, was imaged. As revealed using light microscopy, the cyst was lined with a mucous columnar epithelium, and part of the epithelium indicated pseudolamellar hyperplasia and papillary structures. The cells indicated mild atypia and low mitotic activity. There was no stromal infiltration of tumor cells, and a large amount of mucous exudate was observed. As preoperative computed tomography examination suggested the presence of a large amount of ascites and there were increased levels of blood tumor markers, carcinoembryonic antigen and carbohydrate antigen 125, clinicians considered that the diagnosis maybe a malignant tumor of the urachal gland with peripheral dissemination. However, the diagnosis of MCTLMP with PMP was confirmed by histopathological examination. The mass was completely removed, along with part of the peritoneum and bladder wall as these were within the tumor margin. The appendix appeared normal during surgery. A one off dose of intraperitoneal infusion chemotherapy with 1,000 mg 5‑fluorouracil was performed after surgery. No recurrence was observed during the 8‑month follow‑up period.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Nguyen M, Addicott B, Chu J, Parham D and Kim E: Congenital cyst of the umbilical cord. Fetal Pediatr Pathol. 35:344–347. 2016.PubMed/NCBI View Article : Google Scholar

2 

Netto GJ, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, et al: The 2022 world health organization classification of tumors of the urinary system and male genital organs-part B: Prostate and urinary tract tumors. Eur Urol. 82:469–482. 2022.PubMed/NCBI View Article : Google Scholar

3 

Humphrey PA, Moch H, Cubilla AL, Ulbright TM and Reuter VE: The 2016 WHO classification of tumours of the urinary system and male genital organs-part B: Prostate and bladder tumours. Eur Urol. 70:106–119. 2016.PubMed/NCBI View Article : Google Scholar

4 

Amin MB, Smith SC, Eble JN, Rao P, Choi WW, Tamboli P and Young RH: Glandular neoplasms of the urachus: A report of 55 cases emphasizing mucinous cystic tumors with proposed classification. Am J Surg Pathol. 38:1033–1045. 2014.PubMed/NCBI View Article : Google Scholar

5 

Wang D and Sule N: Mucinous cystadenoma of the urachus and review of current classification of urachal mucinous cystic neoplasms. Arch Pathol Lab Med. 143:258–263. 2019.PubMed/NCBI View Article : Google Scholar

6 

Wu J, Liu A, Chen A and Zhang P: Urachal borderline mucinous cystadenoma: A rare case report and literature review. Medicine (Baltimore). 96(e8740)2017.PubMed/NCBI View Article : Google Scholar

7 

Chen L, Wei N, Zhou G, Hou Y, Cheng J and Lu C: Low malignant potential mucinous cystic tumor of urachus:Case report. Chin J Med Imaging Technol. 37(1254)2021.(In Chinese).

8 

Miao J, Shang P, Huang Y and Zhao X: Low malignant potential mucinous cystic tumor of urachus-Case report. Chin J Diffic and Compl Cas. 20:1263–1265. 2021.(In Chinese).

9 

Brennan K, Johnson P, Curtis H and Arnason T: Urachal mucinous cystic tumor of low malignant potential with concurrent sigmoid colon adenocarcinoma. Case Rep Gastrointest Med. 2019(1434838)2019.PubMed/NCBI View Article : Google Scholar

10 

Schmeusser B, Wiedemer J, Obery D, Buckley K and Yu M: Urachal mucinous cystic tumor of low malignant potential in a polymorbid female: A case report and review of the literature. Int Cancer Conf J. 11:104–108. 2022.PubMed/NCBI View Article : Google Scholar

11 

de Bree E, Witkamp A, Van De Vijver M and Zoetmulde F: Unusual origins of Pseudomyxoma peritonei. J Surg Oncol. 75:270–274. 2000.PubMed/NCBI View Article : Google Scholar

12 

Mukherjee A, Parvaiz A, Cecil TD and Moran BJ: Pseudomyxoma peritonei usually originates from the appendix: A review of the evidence. Eur J Gynaecol Oncol. 25:411–414. 2004.PubMed/NCBI

13 

Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T and Moran B: Pathology and prognosis in pseudomyxoma peritonei: A review of 274 cases. J Clin Pathol. 65:919–923. 2012.PubMed/NCBI View Article : Google Scholar

14 

Yan TD, Sugarbaker PH and Brun EA: Pseudomyxoma peritonei from mucinous adenocarcinoma of the urachus. J Clin Oncol. 24:4944–4946. 2006.PubMed/NCBI View Article : Google Scholar

15 

Agrawal AK, Bobiński P, Grzebieniak Z, Rudnicki J, Marek G, Kobielak P, Kazanowski M, Agrawal S and Hałoń A: Pseudomyxoma peritonei originating from urachus-case report and review of the literature. Curr Oncol. 21:e155–e165. 2014.PubMed/NCBI View Article : Google Scholar

16 

Stenhouse G, McRae D and Pollock AM: Urachal adenocarcinoma in situ with pseudomyxoma peritonei: A case report. J Clin Pathol. 56:152–153. 2003.PubMed/NCBI View Article : Google Scholar

17 

Shinohara T, Misawa K, Sano H, Okawa Y and Takada A: Pseudomyxoma peritonei due to mucinous cystadenocarcinoma in situ of the urachus presenting as an inguinal hernia. Int J Clin Oncol. 11:416–419. 2006.PubMed/NCBI View Article : Google Scholar

18 

Paner GP, Lopez-Beltran A, Sirohi D and Amin MB: Updates in the pathologic diagnosis and classification of epithelial neoplasms of urachal origin. Adv Anat Pathol. 23:71–83. 2016.PubMed/NCBI View Article : Google Scholar

19 

Sugarbaker PH, Verghese M, Yan TD and Brun E: Management of mucinous urachal neoplasm presenting as pseudomyxoma peritonei. Tumori. 94:732–736. 2008.PubMed/NCBI View Article : Google Scholar

20 

Gupta S, Singh G, Gupta A, Singh H, Arya AK, Shrotriya D and Kumar A: Pseudomyxoma peritonei: An uncommon tumor. Indian J Med Paediatr Oncol. 31:58–61. 2010.PubMed/NCBI View Article : Google Scholar

21 

Adams E, Sepich-Poore GD, Miller-Montgomery S and Knight R: Using all our genomes: Blood-based liquid biopsies for the early detection of cancer. View (Beijing). 3(20200118)2022.PubMed/NCBI View Article : Google Scholar

22 

Cao J, Wang Y, Zhang Y and Qian K: Emerging applications of mass spectrometry-based metabolic fingerprinting in clinics. Adv Int Syst. 4(2100191)2022.

23 

Li Y, Bao Q, Yang S, Yang M and Mao C: Bionanoparticles in cancer imaging, diagnosis, and treatment. View. 3(20200027)2022.

24 

Wang L, Zhang M, Pan X, Zhao M, Huang L, Hu X, Wang X, Qiao L, Guo Q, Xu W, et al: Integrative serum metabolic fingerprints based multi-modal platforms for lung adenocarcinoma early detection and pulmonary nodule classification. Adv Sci (Weinh). 9(e2203786)2022.PubMed/NCBI View Article : Google Scholar

25 

Martínez A, Ferron G, Mery E, Gladieff L, Delord JP and Querleu D: Peritoneal pseudomyxoma arising from the urachus. Surg Oncol. 21:1–5. 2012.PubMed/NCBI View Article : Google Scholar

26 

Bartoška P, Antoš F, Vítek P, Marx J, Kopic J and Holečková P: Pseudomyxoma Peritonei. Klin Onkol. 32:329–332. 2019.PubMed/NCBI View Article : Google Scholar

27 

Mohamed F, Cecil T, Moran B and Sugarbaker P: A new standard of care for the management of peritoneal surface malignancy. Curr Oncol. 18:e84–e96. 2011.PubMed/NCBI View Article : Google Scholar

28 

Nozaki T, Yasuda K, Watanabe A and Fuse H: Laparoscopic management of urachal mucinous borderline tumor associated with pseudomyxoma peritonei. Surg Laparosc Endosc Percutan Tech. 21:e152–e155. 2011.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen L, Di M, Sun L and Fu Q: Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report. Exp Ther Med 26: 555, 2023.
APA
Chen, L., Di, M., Sun, L., & Fu, Q. (2023). Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report. Experimental and Therapeutic Medicine, 26, 555. https://doi.org/10.3892/etm.2023.12254
MLA
Chen, L., Di, M., Sun, L., Fu, Q."Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report". Experimental and Therapeutic Medicine 26.6 (2023): 555.
Chicago
Chen, L., Di, M., Sun, L., Fu, Q."Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report". Experimental and Therapeutic Medicine 26, no. 6 (2023): 555. https://doi.org/10.3892/etm.2023.12254
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Di M, Sun L and Fu Q: Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report. Exp Ther Med 26: 555, 2023.
APA
Chen, L., Di, M., Sun, L., & Fu, Q. (2023). Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report. Experimental and Therapeutic Medicine, 26, 555. https://doi.org/10.3892/etm.2023.12254
MLA
Chen, L., Di, M., Sun, L., Fu, Q."Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report". Experimental and Therapeutic Medicine 26.6 (2023): 555.
Chicago
Chen, L., Di, M., Sun, L., Fu, Q."Rare urachal mucinous cystic tumor of low malignant potential with peritoneal pseudomyxoma: A case report". Experimental and Therapeutic Medicine 26, no. 6 (2023): 555. https://doi.org/10.3892/etm.2023.12254
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team