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Article

Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI

  • Authors:
    • Huihui Song
    • Yingjie Chu
    • Shujuan Dong
    • Haijia Yu
    • Shihua Cui
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, P.R. China, Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, P.R. China, Department of Cardiology, Dalian Medical University, Dalian, Liaoning 116000, P.R. China
  • Article Number: 561
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    Published online on: October 18, 2023
       https://doi.org/10.3892/etm.2023.12260
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Abstract

The present study aimed to investigate the relationship between morphological characteristics of culprit coronary plaques and thrombolysis in myocardial infarction (TIMI) blood flow grade in patients with ST‑segment elevation myocardial infarction (STEMI). According to the TIMI blood flow of the culprit vessel before percutaneous coronary intervention (PCI), 222 patients with STEMI were divided into two groups: TIMI 0/1 group (n=164) and TIMI 2/3 group (n=58). The baseline characteristics, coronary angiographic findings and optical coherence tomography images were collected. Multivariate logistic regression analysis was used to identify factors independently associated with poor initial TIMI blood flow. Compared with TIMI 2/3 group, TIMI 0/1 group had a significantly smaller minimum lumen diameter, greater diameter stenosis and longer lesion length, a higher incidence of lipid plaque, larger lipid length, maximum lipid arc, lipid index and maximum cross‑sectional area (CSA) of plaque rupture, as well as a higher prevalence of thin‑cap fibroatheroma (TCFA) and healed plaque (P<0.05). Multivariate logistic analysis demonstrated that lipid plaque, lipid length, maximum lipid arc, lipid index, TCFA, maximum CSA of plaque rupture and healed plaque were significantly associated with poor initial TIMI blood flow (P<0.05). In conclusion, the present study revealed that the morphological characteristics of culprit coronary plaques (lipid plaque, lipid length, maximum lipid arc, lipid index, TCFA, maximum CSA of plaque rupture and healed plaque) are significantly associated with poor initial TIMI blood flow before PCI in patients with STEMI.
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Copy and paste a formatted citation
Spandidos Publications style
Song H, Chu Y, Dong S, Yu H and Cui S: Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI. Exp Ther Med 26: 561, 2023.
APA
Song, H., Chu, Y., Dong, S., Yu, H., & Cui, S. (2023). Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI. Experimental and Therapeutic Medicine, 26, 561. https://doi.org/10.3892/etm.2023.12260
MLA
Song, H., Chu, Y., Dong, S., Yu, H., Cui, S."Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI". Experimental and Therapeutic Medicine 26.6 (2023): 561.
Chicago
Song, H., Chu, Y., Dong, S., Yu, H., Cui, S."Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI". Experimental and Therapeutic Medicine 26, no. 6 (2023): 561. https://doi.org/10.3892/etm.2023.12260
Copy and paste a formatted citation
x
Spandidos Publications style
Song H, Chu Y, Dong S, Yu H and Cui S: Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI. Exp Ther Med 26: 561, 2023.
APA
Song, H., Chu, Y., Dong, S., Yu, H., & Cui, S. (2023). Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI. Experimental and Therapeutic Medicine, 26, 561. https://doi.org/10.3892/etm.2023.12260
MLA
Song, H., Chu, Y., Dong, S., Yu, H., Cui, S."Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI". Experimental and Therapeutic Medicine 26.6 (2023): 561.
Chicago
Song, H., Chu, Y., Dong, S., Yu, H., Cui, S."Relationship between thrombolysis in myocardial infarction blood flow before percutaneous coronary intervention and the morphological characteristics of culprit vessel plaques in patients with STEMI". Experimental and Therapeutic Medicine 26, no. 6 (2023): 561. https://doi.org/10.3892/etm.2023.12260
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