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Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus

  • Authors:
    • Song Xue
    • Ying-Xuan Li
    • Xiao-Xiao Lu
    • Wei Tang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Shanghai Changzheng Hospital, Shanghai 200003, P.R. China, Department of Endocrinology, Shanghai Gongli Hospital, Shanghai 200135, P.R. China, Department of Endocrinology, Shanghai Zhoupu Hospital, Shanghai 201318, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 572
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    Published online on: October 24, 2023
       https://doi.org/10.3892/etm.2023.12271
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Abstract

The aim of the present study was to explore the effects of Dapagliflozin on renal fibrosis in streptozotocin (STZ)‑induced type 2 diabetes mellitus (T2DM) rats, and to determine the underlying mechanism of action. A total of 24 SPF male SD rats were randomly divided into 4 groups: A normal (Control) group, model group (STZ‑induced T2DM rats), Dapagliflozin group (STZ‑induced T2DM rats treated with 1 mg/kg Dapagliflozin), and a metformin group (STZ‑induced T2DM rats treated with 200 mg/kg metformin), with 6 rats per a group. Peripheral blood and renal tissues were collected from these rats, and the renal indices of each group were examined. The fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), blood urea nitrogen (BUN), and serum creatinine (SCr) of rats were detected. After 24 h, the urine was collected and the urine protein levels were measured. Hematoxylin and eosin staining was used to detect histological changes in the rat kidney; Masson staining was used to observe the degree of fibrosis in rat renal tissues; and western blot was performed to determine the expression levels of α‑smooth muscle actin (SMA), vimentin, E‑cadherin, TGF‑β1, Smad7, and p‑Smad3 in rat renal tissues. Dapagliflozin effectively inhibited the increase in FBG and HbA1c levels in diabetic mice, reduced renal tissue damage, reduced the renal index values, reduced collagen deposition in the glomerulus and interstitial area, and reduced the proliferation of glomerular mesangial cells. In addition, Dapagliflozin significantly lowered the levels of BUN, SCr, and 24‑h urine protein, decreased the protein expression of α‑SMA, vimentin, TGF‑β1, and p‑Smad3, and increased the protein expression levels of E‑cadherin and Smad7. Together, these results showed that Dapagliflozin alleviated renal fibrosis in STZ‑induced T2DM rats, and its mechanism of action may be related to the inhibition of the TGF‑β1/Smad pathway.
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1 

Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, et al: Prevalence and control of diabetes in Chinese adults. JAMA. 310:948–959. 2013.PubMed/NCBI View Article : Google Scholar

2 

Carracher AM, Marathe PH and Close KL: International diabetes federation 2017. J Diabetes. 10:353–356. 2018.PubMed/NCBI View Article : Google Scholar

3 

Ji L, Hu D, Pan C, Weng J, Huo Y, Ma C, Mu Y, Hao C, Ji Q, Ran X, et al: Primacy of the 3B approach to control risk factors for cardiovascular disease in type 2 diabetes patients. Am J Med. 126:925 e11–22. 2013.PubMed/NCBI View Article : Google Scholar

4 

Sutariya B and Saraf M: Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway. J Ethnopharmacol. 198:432–443. 2017.PubMed/NCBI View Article : Google Scholar

5 

Zhu PJ: Renal Fibrosis and Anti-fibrosis Treatment Research. Chinese Journal of Integrated Traditional and Western Nephrology 114-117, 2004.

6 

Zhang X, Guo K, Xia F, Zhao X, Huang Z and Niu J: FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation. BMC Biotechnol. 18(33)2018.PubMed/NCBI View Article : Google Scholar

7 

Forbes JM and Cooper ME: Mechanisms of diabetic complications. Physiol Rev. 93:137–188. 2013.PubMed/NCBI View Article : Google Scholar

8 

Tuttle KR, Bakris GL, Bilous RW, Chiang JL, de Boer IH, Goldstein-Fuchs J, Hirsch IB, Kalantar-Zadeh K, Narva AS, Navaneethan SD, et al: Diabetic kidney disease: A report from an ADA consensus conference. Am J Kidney Dis. 64:510–533. 2014.PubMed/NCBI View Article : Google Scholar

9 

Dekkers CCJ, Gansevoort RT and Heerspink HJL: New diabetes therapies and diabetic kidney disease progression: The role of SGLT-2 inhibitors. Curr Diab Rep. 18(27)2018.PubMed/NCBI View Article : Google Scholar

10 

Messerli FH, Bangalore S, Bavishi C and Rimoldi SF: Angiotensin-Converting enzyme inhibitors in hypertension: To use or not to use? J Am Coll Cardiol. 71:1474–1482. 2018.PubMed/NCBI View Article : Google Scholar

11 

Bhandari S, Mehta S, Khwaja A, Cleland JGF, Ives N, Brettell E, Chadburn M and Cockwell P: STOP ACEi Trial Investigators. Renin-Angiotensin system inhibition in advanced chronic kidney disease. N Engl J Med. 387:2021–2032. 2022.PubMed/NCBI View Article : Google Scholar

12 

Li J, Liu H, Takagi S, Nitta K, Kitada M, Srivastava SP, Takagaki Y, Kanasaki K and Koya D: Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules. JCI Insight. 5(e129034)2020.PubMed/NCBI View Article : Google Scholar

13 

Komers R, Oyama TT, Beard DR, Tikellis C, Xu B, Lotspeich DF and Anderson S: Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure. Kidney Int. 79:432–442. 2011.PubMed/NCBI View Article : Google Scholar

14 

Poursharif S, Hamza S and Braam B: Changes in Proximal tubular reabsorption modulate microvascular regulation via the TGF system. Int J Mol Sci. 23(11203)2022.PubMed/NCBI View Article : Google Scholar

15 

Xue J, Wang L, Sun Z and Xing C: Basic research in diabetic nephropathy health care: A study of the renoprotective mechanism of metformin. J Med Syst. 43(266)2019.PubMed/NCBI View Article : Google Scholar

16 

Shen Y, Miao N, Xu J, Gan X, Xu D, Zhou L, Xue H, Zhang W and Lu L: Metformin prevents renal fibrosis in mice with unilateral ureteral obstruction and inhibits Ang II-Induced ECM production in renal fibroblasts. Int J Mol Sci. 17(146)2016.PubMed/NCBI View Article : Google Scholar

17 

Rajasekeran H, Lytvyn Y and Cherney DZ: Sodium-glucose cotransporter 2 inhibition and cardiovascular risk reduction in patients with type 2 diabetes: The emerging role of natriuresis. Kidney Int. 89:524–526. 2016.PubMed/NCBI View Article : Google Scholar

18 

Schechter M, Jongs N, Chertow GM, Mosenzon O, McMurray JJV, Correa-Rotter R, Rossing P, Langkilde AM, Sjostrom CD, Toto RD, et al: Effects of dapagliflozin on hospitalizations in patients with chronic kidney disease: A post Hoc analysis of DAPA-CKD. Ann Intern Med. 176:59–66. 2023.PubMed/NCBI View Article : Google Scholar

19 

McEwan P, Darlington O, Miller R, McMurray JJV, Wheeler DC, Heerspink HJL, Briggs A, Bergenheim K and Garcia Sanchez JJ: Cost-Effectiveness of dapagliflozin as a treatment for chronic kidney disease: A health-economic analysis of DAPA-CKD. Clin J Am Soc Nephrol. 17:1730–1741. 2022.PubMed/NCBI View Article : Google Scholar

20 

Reifsnider OS, Kansal AR, Gandhi PK, Cragin L, Brand SB, Pfarr E, Fahrbach K and Ustyugova A: Cost-effectiveness of empagliflozin versus canagliflozin, dapagliflozin, or standard of care in patients with type 2 diabetes and established cardiovascular disease. BMJ Open Diabetes Res Care. 9(e001313)2021.PubMed/NCBI View Article : Google Scholar

21 

Hutter S, van Haaften WT, Hunerwadel A, Baebler K, Herfarth N, Raselli T, Mamie C, Misselwitz B, Rogler G, Weder B, et al: Intestinal activation of pH-Sensing Receptor OGR1 [GPR68] contributes to fibrogenesis. J Crohns Colitis. 12:1348–1358. 2018.PubMed/NCBI View Article : Google Scholar

22 

Lindquist JA and Mertens PR: Myofibroblasts, regeneration or renal fibrosis-is there a decisive hint? Nephrol Dial Transplant. 28:2678–2681. 2013.PubMed/NCBI View Article : Google Scholar

23 

Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M and Kalluri R: Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol. 19:2282–2287. 2008.PubMed/NCBI View Article : Google Scholar

24 

Cho JG, Lee A, Chang W, Lee MS and Kim J: Endothelial to mesenchymal transition represents a key link in the interaction between inflammation and endothelial dysfunction. Front Immunol. 9(294)2018.PubMed/NCBI View Article : Google Scholar

25 

Passerini AG, Milsted A and Rittgers SE: Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells. J Vasc Surg. 37:182–190. 2003.PubMed/NCBI View Article : Google Scholar

26 

Lu Y, Liu S, Zhang S, Cai G, Jiang H, Su H, Li X, Hong Q, Zhang X and Chen X: Tissue inhibitor of metalloproteinase-1 promotes NIH3T3 fibroblast proliferation by activating p-Akt and cell cycle progression. Mol Cells. 31:225–230. 2011.PubMed/NCBI View Article : Google Scholar

27 

Chen Y, Zou H, Lu H, Xiang H and Chen S: Research progress of endothelial-mesenchymal transition in diabetic kidney disease. J Cell Mol Med. 26:3313–3322. 2022.PubMed/NCBI View Article : Google Scholar

28 

Wahab NAA, Giribabu N, Kilari EK and Salleh N: Abietic acid ameliorates nephropathy progression via mitigating renal oxidative stress, inflammation, fibrosis and apoptosis in high fat diet and low dose streptozotocin-induced diabetic rats. Phytomedicine. 107(154464)2022.PubMed/NCBI View Article : Google Scholar

29 

Ilzecka J, Stelmasiak Z and Dobosz B: Transforming growth factor-Beta 1 (tgf-Beta 1) in patients with amyotrophic lateral sclerosis. Cytokine. 20:239–243. 2002.PubMed/NCBI View Article : Google Scholar

30 

Liu CL, Yan L, Cai KR, Sun K, Qi Y, Han YL, Zhang XD and Sun XD: Effects of soybean isoflavones on Wnt/β-catenin and the TGF-β1 signaling pathway in renal tissue of type 2 diabetic rats. J Biol Regul Homeost Agents. 32:455–464. 2018.PubMed/NCBI

31 

Sun M, Zhou W, Yao F, Song J, Xu Y, Deng Z, Diao H and Li S: MicroRNA-302b mitigates renal fibrosis via inhibiting TGF-β/Smad pathway activation. Braz J Med Biol Res. 54(e9206)2021.PubMed/NCBI View Article : Google Scholar

32 

Sun SF, Zhao TT, Zhang HJ, Huang XR, Zhang WK, Zhang L, Yan MH, Dong X, Wang H, Wen YM, et al: Renoprotective effect of berberine on type 2 diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 42:662–670. 2015.PubMed/NCBI View Article : Google Scholar

33 

Li Q, Ye F, Shi Y, Zhang L, Wang W, Tu Z, Qiu J, Wang J, Li S, Bu H and Li Y: Nuclear translocation of SMAD3 may enhance the TGF-beta/SMADS pathway in high glucose circumstances. Transplant Proc. 38:2158–2160. 2006.PubMed/NCBI View Article : Google Scholar

34 

Liu L, Wang Y, Yan R, Li S, Shi M, Xiao Y and Guo B: Oxymatrine inhibits renal tubular EMT induced by high glucose via upregulation of SnoN and inhibition of TGF-β1/smad signaling pathway. PLoS One. 11(e0151986)2016.PubMed/NCBI View Article : Google Scholar

35 

Zhang Q, Liu X, Sullivan MA, Shi C and Deng B: Protective Effect of Yi Shen Pai Du formula against diabetic kidney injury via inhibition of oxidative stress, inflammation, and epithelial-to-mesenchymal transition in db/db mice. Oxid Med Cell Longev. 2021(7958021)2021.PubMed/NCBI View Article : Google Scholar

36 

Mou X, Zhou DY, Zhou D, Liu K, Chen LJ and Liu WH: A bioinformatics and network pharmacology approach to the mechanisms of action of Shenxiao decoction for the treatment of diabetic nephropathy. Phytomedicine. 69(153192)2020.PubMed/NCBI View Article : Google Scholar

37 

Gan C, Zhang Q, Liu H, Wang G, Wang L, Li Y, Tan Z, Yin W, Yao Y, Xie Y, et al: Nifuroxazide ameliorates pulmonary fibrosis by blocking myofibroblast genesis: A drug repurposing study. Respir Res. 23(32)2022.PubMed/NCBI View Article : Google Scholar

38 

Jaikumkao K, Pongchaidecha A, Chueakula N, Thongnak LO, Wanchai K, Chatsudthipong V, Chattipakorn N and Lungkaphin A: Dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, slows the progression of renal complications through the suppression of renal inflammation, endoplasmic reticulum stress and apoptosis in prediabetic rats. Diabetes Obes Metab. 20:2617–2626. 2018.PubMed/NCBI View Article : Google Scholar

39 

Oraby MA, El-Yamany MF, Safar MM, Assaf N and Ghoneim HA: Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats. Biomed Pharmacother. 109:910–920. 2019.PubMed/NCBI View Article : Google Scholar

40 

Jihua C, Cai C, Xubin B and Yue Y: Effects of Dexmedetomidine on the RhoA/ROCK/Nox4 signaling pathway in renal fibrosis of diabetic rats. Open Med (Wars). 14:890–898. 2019.PubMed/NCBI View Article : Google Scholar

41 

Liu WH, Liu SM, Lin SF and Huang HQ: Role of berberine in fibronectin expression via S1P2-MAPK signaling pathway in diabetic nephropathy. Chinese Pharmacological Bulletin. 29:723–728. 2013.

42 

Tripathi BK and Srivastava AK: Diabetes mellitus: Complications and therapeutics. Med Sci Monit. 12:RA130–RA147. 2006.PubMed/NCBI

43 

Zhang PH, Chen ZW, Lv D, Xu YY, Gu WL, Zhang XH, Le YL, Zhu HH and Zhu YM: Increased risk of cancer in patients with type 2 diabetes mellitus: A retrospective cohort study in China. BMC Public Health. 12(567)2012.PubMed/NCBI View Article : Google Scholar

44 

Ou YL, Lee MY, Lin IT, Wen WL, Hsu WH and Chen SC: Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus. Ren Fail. 43:1250–1258. 2021.PubMed/NCBI View Article : Google Scholar

45 

Tokunaga T, Fujiwara Y, Matsushita M, Suzaki T and Suzaki E: Glomerular hypertrophy and hyperfiltration in obesity-related diabetic (ob/ob) mouse. Analytical and quantitative cytology and histology. 39:223–230. 2017.

46 

Yuan XL and Wang SJ: Clinical efficacy of dapagliflozin in patients with type 2 diabetic kidney disease. Henan Medical Research. 29:1969–1971. 2020.

47 

Zhang XR, Fu XJ, Zhu DS, Zhang CZ, Hou S, Li M and Yang XH: Salidroside-regulated lipid metabolism with down-regulation of miR-370 in type 2 diabetic mice. Eur J Pharmacol. 779:46–52. 2016.PubMed/NCBI View Article : Google Scholar

48 

Wang CH, Punde TH, Huang CD, Chou PC, Huang TT, Wu WH, Liu CH, Chung KF and Kuo HP: Fibrocyte trafficking in patients with chronic obstructive asthma and during an acute asthma exacerbation. J Allergy Clin Immunol. 135:1154–1162.e1-5. 2015.PubMed/NCBI View Article : Google Scholar

49 

Tian C, Wang Y, Chang H, Li J and La X: Spleen-Kidney supplementing formula alleviates renal fibrosis in diabetic rats via TGF-β1-miR-21-PTEN signaling pathway. Evid Based Complement Alternat Med. 2018(3824357)2018.PubMed/NCBI View Article : Google Scholar

50 

Huang H, You Y, Lin X, Tang C, Gu X, Huang M, Qin Y, Tan J and Huang F: Inhibition of TRPC6 signal pathway alleviates podocyte injury induced by TGF-β1. Cell Physiol Biochem. 41:163–172. 2017.PubMed/NCBI View Article : Google Scholar

51 

Loeffler I, Hopfer U, Koczan D and Wolf G: Type VIII collagen modulates TGF-β1-induced proliferation of mesangial cells. J Am Soc Nephrol. 22:649–663. 2011.PubMed/NCBI View Article : Google Scholar

52 

Overstreet JM, Samarakoon R, Meldrum KK and Higgins PJ: Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity. Cell Signal. 26:1427–1436. 2014.PubMed/NCBI View Article : Google Scholar

53 

Kim D, Lee AS, Jung YJ, Yang KH, Lee S, Park SK, Kim W and Kang KP: Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor α-mediated transforming growth factor-β1/Smad signaling pathway. Nephrol Dial Transplant. 29:2043–2053. 2014.PubMed/NCBI View Article : Google Scholar

54 

Samarakoon R, Overstreet JM and Higgins PJ: TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities. Cell Signal. 25:264–268. 2013.PubMed/NCBI View Article : Google Scholar

55 

Liu S, Yu N, Zhang XL, Chen XQ and Tang LQ: The regulation of berberine on the imbalance of TGF-β1/SnoN expression in renal tissues of rats with early diabetic nephropathy and the regulation of Smad signaling pathway. China Journal of Chinese Material Madica. 37:3604–3610. 2012.

56 

Ka SM, Yeh YC, Huang XR, Chao TK, Hung YJ, Yu CP, Lin TJ, Wu CC, Lan HY and Chen A: Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor kappaB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice. Diabetologia. 55:509–519. 2012.PubMed/NCBI View Article : Google Scholar

57 

Chatziantoniou C and Dussaule JC: Insights into the mechanisms of renal fibrosis: Is it possible to achieve regression? Am J Physiol Renal Physiol. 289:F227–F234. 2005.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Xue S, Li Y, Lu X and Tang W: Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus. Exp Ther Med 26: 572, 2023.
APA
Xue, S., Li, Y., Lu, X., & Tang, W. (2023). Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 26, 572. https://doi.org/10.3892/etm.2023.12271
MLA
Xue, S., Li, Y., Lu, X., Tang, W."Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus". Experimental and Therapeutic Medicine 26.6 (2023): 572.
Chicago
Xue, S., Li, Y., Lu, X., Tang, W."Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus". Experimental and Therapeutic Medicine 26, no. 6 (2023): 572. https://doi.org/10.3892/etm.2023.12271
Copy and paste a formatted citation
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Spandidos Publications style
Xue S, Li Y, Lu X and Tang W: Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus. Exp Ther Med 26: 572, 2023.
APA
Xue, S., Li, Y., Lu, X., & Tang, W. (2023). Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 26, 572. https://doi.org/10.3892/etm.2023.12271
MLA
Xue, S., Li, Y., Lu, X., Tang, W."Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus". Experimental and Therapeutic Medicine 26.6 (2023): 572.
Chicago
Xue, S., Li, Y., Lu, X., Tang, W."Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus". Experimental and Therapeutic Medicine 26, no. 6 (2023): 572. https://doi.org/10.3892/etm.2023.12271
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