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Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy

  • Authors:
    • Yuanyuan Li
    • Youfu Fang
    • Jing Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Weifang Yidu Central Hospital, Weifang, Shandong 262550, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 576
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    Published online on: October 26, 2023
       https://doi.org/10.3892/etm.2023.12275
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Abstract

Idiopathic membranous nephropathy (IMN) is a common glomerular disease, in which 50‑60% of patients can progress to end‑stage renal disease within 10‑20 years, seriously endangering human health. Podocyte injury is the direct cause of IMN. Sublytic C5b‑9 complement complex induces damage in podocytes' structure and function. In sublytic C5b‑9 treated podocytes, the expression of canonical transient receptor potential 6 (TRPC6) is increased. However, the specific mechanism of TRPC6 in sublytic C5b‑9 treated podocytes is unclear. The present study aimed to reveal the effect and mechanism of TRPC6 on sublytic C5b‑9‑induced podocytes. Normal human serum was stimulated using zymosan to form C5b‑9. A lactate dehydrogenase release assay was used to examine C5b‑9 cytotoxicity in podocytes. The RNA and protein expression levels were analyzed using reverse transcription‑quantitative PCR, western blotting and immunofluorescent assay, respectively. Cell Counting Kit‑8 assay and flow cytometry were carried out to test the viability and apoptosis of podocytes, respectively. Transmission electron microscopy was used to observe autophagic vacuole. F‑actin was tested through phalloidin staining. Sublytic C5b‑9 was deposited and TRPC6 expression was boosted in podocytes stimulated through zymosan activation serum. Knockdown of TRPC6 raised the viability and reduced the apoptosis rate of sublytic C5b‑9‑induced podocytes. Meanwhile, transfection of small‑interfering (si)TRPC6 facilitated autophagy progression and enhanced the activation of cathepsin B/L in sublytic C5b‑9‑induced podocytes. The phosphorylation level of ERK1/2 was receded in siTRPC6 and sublytic C5b‑9 co‑treated podocytes. Moreover, the addition of the ERK1/2 activator partially reversed the effect of TRPC6 inhibition on sublytic C5b‑9‑induced podocytes. TRPC6 knockdown reduced the damage of sublytic C5b‑9 to podocytes by weakening the ERK1/2 phosphorylation level to activate autophagy. These results indicated that targeting TRPC6 reduced the injury of sublytic C5b‑9 on podocytes.
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1 

Keri KC, Blumenthal S, Kulkarni V, Beck L and Chongkrairatanakul T: Primary membranous nephropathy: Comprehensive review and historical perspective. Postgrad Med J. 95:23–31. 2019.PubMed/NCBI View Article : Google Scholar

2 

Safar-Boueri L, Piya A, Beck LH Jr and Ayalon R: Membranous nephropathy: Diagnosis, treatment, and monitoring in the post-PLA2R era. Pediatr Nephrol. 36:19–30. 2021.PubMed/NCBI View Article : Google Scholar

3 

Liu W, Gao C, Liu Z, Dai H, Feng Z, Dong Z, Zheng Y, Gao Y, Tian X and Liu B: Idiopathic membranous nephropathy: Glomerular pathological pattern caused by extrarenal immunity activity. Front Immunol. 11(1846)2020.PubMed/NCBI View Article : Google Scholar

4 

Ma H, Sandor DG and Beck LH Jr: The role of complement in membranous nephropathy. Semin Nephrol. 33:531–542. 2013.PubMed/NCBI View Article : Google Scholar

5 

Nagata M: Podocyte injury and its consequences. Kidney Int. 89:1221–1230. 2016.PubMed/NCBI View Article : Google Scholar

6 

Galindo-Izquierdo M and Pablos Alvarez JL: Complement as a therapeutic target in systemic autoimmune diseases. Cells. 10(148)2021.PubMed/NCBI View Article : Google Scholar

7 

Yang P, Skiba NP, Tewkesbury GM, Treboschi VM, Baciu P and Jaffe GJ: Complement-mediated regulation of apolipoprotein E in cultured human RPE cells. Invest Ophthalmol Vis Sci. 58:3073–3085. 2017.PubMed/NCBI View Article : Google Scholar

8 

Fishelson Z and Kirschfink M: Complement C5b-9 and Cancer: Mechanisms of cell damage, cancer counteractions, and approaches for intervention. Front Immunol. 10(752)2019.PubMed/NCBI View Article : Google Scholar

9 

Takano T, Elimam H and Cybulsky AV: Complement-mediated cellular injury. Semin Nephrol. 33:586–601. 2013.PubMed/NCBI View Article : Google Scholar

10 

Bateman RM, Sharpe MD, Jagger JE, Ellis CG, Solé-Violán J, López-Rodríguez M, Herrera-Ramos E, Ruíz-Hernández J, Borderías L, Horcajada J, et al: 36th International symposium on intensive care and emergency medicine: Brussels, Belgium. 15-18 March 2016. Crit Care. 20 (Suppl 2)(S94)2016.PubMed/NCBI View Article : Google Scholar

11 

Tan Y and Zhao MH: Complement in glomerular diseases. Nephrology (Carlton). 23 (Suppl 4):S11–S15. 2018.PubMed/NCBI View Article : Google Scholar

12 

Xie H, Yang L, Yang Y, Jiang W, Wang X, Huang M, Zhang J and Zhu Q: C5b-9 membrane attack complex activated NLRP3 inflammasome mediates renal tubular immune injury in trichloroethylene sensitized mice. Ecotoxicol Environ Saf. 208(111439)2021.PubMed/NCBI View Article : Google Scholar

13 

Wang X, Liu J, Tian R, Zheng B, Li C, Huang L, Lu Z, Zhang J, Mao W, Liu B, et al: Sanqi oral solution mitigates proteinuria in rat passive heymann nephritis and blocks podocyte apoptosis via Nrf2/HO-1 Pathway. Front Pharmacol. 12(727874)2021.PubMed/NCBI View Article : Google Scholar

14 

Zhou XJ, Klionsky DJ and Zhang H: Podocytes and autophagy: A potential therapeutic target in lupus nephritis. Autophagy. 15:908–912. 2019.PubMed/NCBI View Article : Google Scholar

15 

Yoshibayashi M, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Osawa N, Chin-Kanasaki M, Nakae Y, Yokoi H, Mukoyama M, et al: Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes. Biochem Biophys Res Commun. 525:319–325. 2020.PubMed/NCBI View Article : Google Scholar

16 

Liu WJ, Li ZH, Chen XC, Zhao XL, Zhong Z, Yang C, Wu HL, An N, Li WY and Liu HF: Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy. Sci Rep. 7(8643)2017.PubMed/NCBI View Article : Google Scholar

17 

Liu X, Yao X and Tsang SY: Post-Translational modification and natural mutation of TRPC Channels. Cells. 9(135)2020.PubMed/NCBI View Article : Google Scholar

18 

Hou X, Huang M, Zeng X, Zhang Y, Sun A, Wu Q, Zhu L, Zhao H and Liao Y: The Role of TRPC6 in renal ischemia/reperfusion and cellular hypoxia/reoxygenation injuries. Front Mol Biosci. 8(698975)2021.PubMed/NCBI View Article : Google Scholar

19 

Dryer SE, Roshanravan H and Kim EY: TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease. Biochim Biophys Acta Mol Basis Dis. 1865:1041–1066. 2019.PubMed/NCBI View Article : Google Scholar

20 

Moller CC, Wei C, Altintas MM, Li J, Greka A, Ohse T, Pippin JW, Rastaldi MP, Wawersik S, Schiavi S, et al: Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol. 18:29–36. 2007.PubMed/NCBI View Article : Google Scholar

21 

Yu S and Yu L: Dexamethasone resisted podocyte injury via stabilizing TRPC6 expression and distribution. Evid Based Complement Alternat Med. 2012(652059)2012.PubMed/NCBI View Article : Google Scholar

22 

Shengyou Y and Li Y: The effects of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII. J Renin Angiotensin Aldosterone Syst. 16:1266–1273. 2015.PubMed/NCBI View Article : Google Scholar

23 

Zhang MH, Fan JM, Xie XS, Deng YY, Chen YP, Zhen R, Li J, Cheng Y and Wen J: Ginsenoside-Rg1 protects podocytes from complement mediated injury. J Ethnopharmacol. 137:99–107. 2011.PubMed/NCBI View Article : Google Scholar

24 

Liu Y, Zhang J, Wang Y and Zeng X: Apelin involved in progression of diabetic nephropathy by inhibiting autophagy in podocytes. Cell Death Dis. 8(e3006)2017.PubMed/NCBI View Article : Google Scholar

25 

Ishikawa S, Tsukada H and Bhattacharya J: Soluble complex of complement increases hydraulic conductivity in single microvessels of rat lung. J Clin Invest. 91:103–109. 1993.PubMed/NCBI View Article : Google Scholar

26 

Schmittgen TD and Livak KJ: Analyzing Real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008.PubMed/NCBI View Article : Google Scholar

27 

Pasquier B: Autophagy inhibitors. Cell Mol Life Sci. 73:985–1001. 2016.PubMed/NCBI View Article : Google Scholar

28 

Jefferson JA, Pippin JW and Shankland SJ: Experimental models of membranous nephropathy. Drug Discov Today Dis Models. 7:27–33. 2010.PubMed/NCBI View Article : Google Scholar

29 

Papagianni AA, Alexopoulos E, Leontsini M and Papadimitriou M: C5b-9 and adhesion molecules in human idiopathic membranous nephropathy. Nephrol Dial Transplant. 17:57–63. 2002.PubMed/NCBI View Article : Google Scholar

30 

Zheng R, Deng Y, Chen Y, Fan J, Zhang M, Zhong Y, Zhu R and Wang L: Astragaloside IV attenuates complement membranous attack complex induced podocyte injury through the MAPK pathway. Phytother Res. 26:892–898. 2012.PubMed/NCBI View Article : Google Scholar

31 

Wang L, Liang H, Sun B, Mi J, Tong X, Wang Y, Chen M, Yu L, Pan J, Liu S, et al: Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress. Stem Cell Res Ther. 13(401)2022.PubMed/NCBI View Article : Google Scholar

32 

Zhou LF, Chen QZ, Yang CT, Fu ZD, Zhao ST, Chen Y, Li SN, Liao L, Zhou YB, Huang JR and Li JH: TRPC6 contributes to LPS-induced inflammation through ERK1/2 and p38 pathways in bronchial epithelial cells. Am J Physiol Cell Physiol. 314:C278–C288. 2018.PubMed/NCBI View Article : Google Scholar

33 

Putta P, Smith AH, Chaudhuri P, Guardia-Wolff R, Rosenbaum MA and Graham LM: Activation of the cytosolic calcium-independent phospholipase A2 β isoform contributes to TRPC6 externalization via release of arachidonic acid. J Biol Chem. 297(101180)2021.PubMed/NCBI View Article : Google Scholar

34 

Hartleben B, Godel M, Meyer-Schwesinger C, Liu S, Ulrich T, Kobler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, et al: Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest. 120:1084–1096. 2010.PubMed/NCBI View Article : Google Scholar

35 

Fang L, Zhou Y, Cao H, Wen P, Jiang L, He W, Dai C and Yang J: Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One. 8(e60546)2013.PubMed/NCBI View Article : Google Scholar

36 

Qi YY, Zhou XJ, Cheng FJ, Hou P, Ren YL, Wang SX, Zhao MH, Yang L, Martinez J and Zhang H: Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-α in lupus nephritis. Ann Rheum Dis. 77:1799–1809. 2018.PubMed/NCBI View Article : Google Scholar

37 

Lenoir O, Jasiek M, Henique C, Guyonnet L, Hartleben B, Bork T, Chipont A, Flosseau K, Bensaada I, Schmitt A, et al: Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy. 11:1130–1145. 2015.PubMed/NCBI View Article : Google Scholar

38 

Hou X, Xiao H, Zhang Y, Zeng X, Huang M, Chen X, Birnbaumer L and Liao Y: Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis. 9(1015)2018.PubMed/NCBI View Article : Google Scholar

39 

Farmer LK, Rollason R, Whitcomb DJ, Ni L, Goodliff A, Lay AC, Birnbaumer L, Heesom KJ, Xu SZ, Saleem MA and Welsh GI: TRPC6 binds to and activates calpain, independent of its channel activity, and regulates podocyte cytoskeleton, cell adhesion, and motility. J Am Soc Nephrol. 30:1910–1924. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Fang Y and Liu J: Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy. Exp Ther Med 26: 576, 2023.
APA
Li, Y., Fang, Y., & Liu, J. (2023). Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy. Experimental and Therapeutic Medicine, 26, 576. https://doi.org/10.3892/etm.2023.12275
MLA
Li, Y., Fang, Y., Liu, J."Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy". Experimental and Therapeutic Medicine 26.6 (2023): 576.
Chicago
Li, Y., Fang, Y., Liu, J."Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy". Experimental and Therapeutic Medicine 26, no. 6 (2023): 576. https://doi.org/10.3892/etm.2023.12275
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Fang Y and Liu J: Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy. Exp Ther Med 26: 576, 2023.
APA
Li, Y., Fang, Y., & Liu, J. (2023). Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy. Experimental and Therapeutic Medicine, 26, 576. https://doi.org/10.3892/etm.2023.12275
MLA
Li, Y., Fang, Y., Liu, J."Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy". Experimental and Therapeutic Medicine 26.6 (2023): 576.
Chicago
Li, Y., Fang, Y., Liu, J."Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b‑9 complement complex‑induced podocyte injury through activating autophagy". Experimental and Therapeutic Medicine 26, no. 6 (2023): 576. https://doi.org/10.3892/etm.2023.12275
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