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Article

Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation

  • Authors:
    • Noriyuki Watanabe
    • Riyoko Tamai
    • Yusuke Kiyoura
  • View Affiliations / Copyright

    Affiliations: Department of Oral Infectious Diseases, Ohu University Graduate School of Dentistry, Koriyama, Fukushima 963‑8611, Japan
  • Article Number: 577
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    Published online on: October 26, 2023
       https://doi.org/10.3892/etm.2023.12276
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Abstract

Alendronate (ALN) is an anti‑bone‑resorptive drug with inflammatory side effects. ALN upregulates lipid A‑induced interleukin (IL)‑1α and IL‑1β release by J774.1 cells via apoptosis‑associated speck‑like protein containing a caspase recruitment domain (ASC) activation. The present study examined whether ALN augmented lipid A‑induced proinflammatory cytokine production using ASC‑deficient mouse macrophage‑like RAW264 cells. Pretreatment of RAW264 cells with ALN significantly augmented lipid A‑induced IL‑1β release, although ALN did not upregulate the expression of Toll‑like receptor 4, myeloid differentiation factor 88 (MyD88) and caspase‑11. Moreover, pretreatment of caspase‑11‑deficient RAW264.7 cells with ALN significantly augmented lipid A‑induced IL‑1β release. Notably, ALN upregulated the activation of FosB, c‑Jun or JunD, but not c‑Fos or NF‑κB in RAW264 cells. Furthermore, pretreatment with the activator protein 1 (AP‑1) inhibitor SR11302, but not the c‑Fos inhibitor T‑5224, before addition of ALN inhibited ALN‑augmented IL‑1β release by lipid A‑treated RAW264 cells. SR11302 also reduced ALN‑augmented lactate dehydrogenase release by the cells. These findings collectively suggested that ALN augmented lipid A‑induced IL‑1β release and cell membrane damage in ASC‑deficient RAW264 cells via activation of AP‑1, but not NF‑κB.
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1 

Malwal SR, O'Dowd B, Feng X, Turhanen P, Shin C, Yao J, Kim BK, Baig N, Zhou T, Bansal S, et al: Bisphosphonate-generated ATP-analogs inhibit cell signaling pathways. J Am Chem Soc. 140:7568–7578. 2018.PubMed/NCBI View Article : Google Scholar

2 

Tamai R, Sugiyama A and Kiyoura Y: Effects of nitrogen-containing bisphosphonates on the response of human peripheral blood mononuclear cells and gingival fibroblasts to bacterial components. J Oral Biosci. 52:268–274. 2010.

3 

Frith JC and Rogers MJ: Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro. J Bone Miner Res. 18:204–212. 2003.PubMed/NCBI View Article : Google Scholar

4 

Tamai R, Mashima I and Kiyoura Y: Alendronate augments lipid A-induced IL-1α release via activation of ASC but not caspase-11. Inflammation. 44:2132–2141. 2021.PubMed/NCBI View Article : Google Scholar

5 

Gendaszewska-Darmach E, Garstka MA and Blazewska KM: Targeting small GTPases and their prenylation in diabetes mellitus. J Med Chem. 64:9677–9710. 2021.PubMed/NCBI View Article : Google Scholar

6 

Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB and Kademani D: American association of oral and maxillofacial surgeons' position paper on medication-related osteonecrosis of the Jaws-2022 update. J Oral Maxillofac Surg. 80:920–943. 2022.PubMed/NCBI View Article : Google Scholar

7 

Pontillo A, Paoluzzi E and Crovella S: The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. Eur J Hum Genet. 18:844–847. 2010.PubMed/NCBI View Article : Google Scholar

8 

Yang J, Zhu HH, Chen GP, Ye Y, Zhao CZ, Mou Y and Hu SJ: Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo. Int J Biochem Cell Biol. 45:657–666. 2013.PubMed/NCBI View Article : Google Scholar

9 

Zhang Q, Yu W, Lee S, Xu Q, Naji A and Le AD: Bisphosphonate induces osteonecrosis of the jaw in diabetic mice via NLRP3/caspase-1-dependent IL-1β mechanism. J Bone Miner Res. 30:2300–2312. 2015.PubMed/NCBI View Article : Google Scholar

10 

Tamai R and Kiyoura Y: Alendronate augments lipid A-induced IL-1β release and Smad3/NLRP3/ASC-dependent cell death. Life Sci. 198:8–17. 2018.PubMed/NCBI View Article : Google Scholar

11 

Sing CW, Kiel DP, Hubbard RB, Lau WC, Li GH, Kung AW, Wong IC and Cheung CL: Nitrogen-containing bisphosphonates are associated with reduced risk of pneumonia in patients with hip fracture. J Bone Miner Res. 35:1676–1684. 2020.PubMed/NCBI View Article : Google Scholar

12 

Tamai R, Suzuki K, Mashima I and Kiyoura Y: MPMBP down-regulates toll-like receptor (TLR) 2 ligand-induced proinflammatory cytokine production by inhibiting NF-κB but not AP-1 activation. Int Immunopharmacol. 79(106085)2020.PubMed/NCBI View Article : Google Scholar

13 

Tamai R, Sakuta T, Matsushita K, Trii M, Takeuchi O, Akira S, Akashi S, Espevik T, Sugawara S and Takada H: Human gingival CD14+ fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression. Infect Immun. 70:1272–1278. 2002.PubMed/NCBI View Article : Google Scholar

14 

Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, et al: Non-canonical inflammasome activation targets caspase-11. Nature. 479:117–121. 2011.PubMed/NCBI View Article : Google Scholar

15 

Baroja-Mazo A, Martin-Sanchez F, Gomez AI, Martinez CM, Amores-Iniesta J, Compan V, Barbera-Cremades M, Yague J, Ruiz-Ortiz E, Anton J, et al: The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol. 15:738–748. 2014.PubMed/NCBI View Article : Google Scholar

16 

Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, et al: Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 593:607–611. 2021.PubMed/NCBI View Article : Google Scholar

17 

Chan JNE, Humphry M, Kitt L, Krzyzanska D, Filbey KJ, Bennett MR and Clarke MCH: Cell surface IL-1α trafficking is specifically inhibited by interferon-γ, and associates with the membrane via IL-1R2 and GPI anchors. Eur J Immunol. 50:1663–1675. 2020.PubMed/NCBI View Article : Google Scholar

18 

Weinstein RS, Roberson PK and Manolagas SC: Giant osteoclast formation and long-term oral bisphosphonate therapy. N Engl J Med. 360:53–62. 2009.PubMed/NCBI View Article : Google Scholar

19 

Rogers MJ, Gordon S, Benford HL, Coxon FP, Luckman SP, Monkkonen J and Frith JC: Cellular and molecular mechanisms of action of bisphosphonates. Cancer. 88:2961–2978. 2000.PubMed/NCBI View Article : Google Scholar

20 

Brennan A, Leech JT, Kad NM and Mason JM: Selective antagonism of cJun for cancer therapy. J Exp Clin Cancer Res. 39(184)2020.PubMed/NCBI View Article : Google Scholar

21 

Hasegawa M, Imamura R, Motani K, Nishiuchi T, Matsumoto N, Kinoshita T and Suda T: Mechanism and repertoire of ASC-mediated gene expression. J Immunol. 182:7655–7662. 2009.PubMed/NCBI View Article : Google Scholar

22 

Shi H, Sun L, Wang Y, Liu A, Zhan X, Li X, Tang M, Anderton P, Hildebrand S, Quan J, et al: N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization. Nat Commun. 12(1379)2021.PubMed/NCBI View Article : Google Scholar

23 

Gitlin AD, Heger K, Schubert AF, Reja R, Yan D, Pham VC, Suto E, Zhang J, Kwon YC, Freund EC, et al: Integration of innate immune signaling by caspase-8 cleavage of N4BP1. Nature. 587:275–280. 2020.PubMed/NCBI View Article : Google Scholar

24 

Gou C, Ni W, Ma P, Zhao F, Wang Z, Sun R, Wu Y, Wu Y, Chen M, Chen H, et al: The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration. Cell Death Dis. 12(488)2021.PubMed/NCBI View Article : Google Scholar

25 

Pelegrin P, Barroso-Gutierrez C and Surprenant A: P2X7 receptor differentially couples to distinct release pathways for IL-1β in mouse macrophage. J Immunol. 180:7147–7157. 2008.PubMed/NCBI View Article : Google Scholar

26 

Porras AG, Holland SD and Gertz BJ: Pharmacokinetics of alendronate. Clin Pharmacokinet. 36:315–328. 1999.PubMed/NCBI View Article : Google Scholar

27 

Vasudevan SO, Russo AJ, Kumari P, Vanaja SK and Rathinam VA: A TLR4-independent critical role for CD14 in intracellular LPS sensing. Cell Rep. 39(110755)2022.PubMed/NCBI View Article : Google Scholar

28 

Enosi Tuipulotu D, Feng S, Pandey A, Zhao A, Ngo C, Mathur A, Lee J, Shen C, Fox D, Xue Y, et al: Immunity against Moraxella catarrhalis requires guanylate-binding proteins and caspase-11-NLRP3 inflammasomes. EMBO J. 42(e112558)2023.PubMed/NCBI View Article : Google Scholar

29 

Zhao W, Beers DR, Bell S, Wang J, Wen S, Baloh RH and Appel SH: TDP-43 activates microglia through NF-κB and NLRP3 inflammasome. Exp Neurol. 273:24–35. 2015.PubMed/NCBI View Article : Google Scholar

30 

Yang H, Xiao L, Yuan Y, Luo X, Jiang M, Ni J and Wang N: Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells. Biochem Pharmacol. 92:599–606. 2014.PubMed/NCBI View Article : Google Scholar

31 

Zhou X, Hong T, Yu Q, Nie S, Gong D, Xiong T and Xie M: Exopolysaccharides from Lactobacillus plantarum NCU116 induce c-Jun dependent Fas/Fasl-mediated apoptosis via TLR2 in mouse intestinal epithelial cancer cells. Sci Rep. 7(14247)2017.PubMed/NCBI View Article : Google Scholar

32 

Matsumoto N, Imamura R and Suda T: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production. FEBS J. 274:2376–2384. 2007.PubMed/NCBI View Article : Google Scholar

33 

Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC and Bellido T: Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest. 104:1363–1374. 1999.PubMed/NCBI View Article : Google Scholar

34 

Wu Y, Qiu G, Zhang H, Zhu L, Cheng G, Wang Y, Li Y and Wu W: Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K/AKT/Nrf2-NLRP3 pathway. J Cell Mol Med. 25:9983–9994. 2021.PubMed/NCBI View Article : Google Scholar

35 

Han X, Li B, Bao J, Wu Z, Chen C, Ni J, Shen J, Song P, Peng Q, Wan R, et al: Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation. Front Immunol. 13(968639)2022.PubMed/NCBI View Article : Google Scholar

36 

Oh CC, Lee J, D'Souza K, Zhang W, Migrino RQ, Thornburg K and Reaven P: Activator protein-1 and caspase 8 mediate p38α MAPK-dependent cardiomyocyte apoptosis induced by palmitic acid. Apoptosis. 24:395–403. 2019.PubMed/NCBI View Article : Google Scholar

37 

Liao M, Liao J, Qu J, Shi P, Cheng Y, Pan Q, Zhao N, Zhang X, Zhang L, Tan Y, et al: Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/caspase-1/GSDMD signaling in cholestasis. Cell Death Discov. 9(26)2023.PubMed/NCBI View Article : Google Scholar

38 

Purbasari B, Madhyastha R, Madhyastha H, Nurrahmah QI, Maruyama M, Nakajima Y, Kataoka H and Watanabe N: Retinoic acid attenuates nuclear factor κB mediated induction of NLRP3 inflammasome. Pharmacol Rep. 74:189–203. 2022.PubMed/NCBI View Article : Google Scholar

39 

Fanjul A, Dawson MI, Hobbs PD, Jong L, Cameron JF, Harlev E, Graupner G, Lu XP and Pfahl M: A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature. 372:107–111. 1994.PubMed/NCBI View Article : Google Scholar

40 

Tsuchida K, Chaki H, Takakura T, Yokotani J, Aikawa Y, Shiozawa S, Gouda H and Hirono S: Design, synthesis, and biological evaluation of new cyclic disulfide decapeptides that inhibit the binding of AP-1 to DNA. J Med Chem. 47:4239–4246. 2004.PubMed/NCBI View Article : Google Scholar

41 

Liu X, Wang Y, Lu H, Li J, Yan X, Xiao M, Hao J, Alekseev A, Khong H, Chen T, et al: Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature. 567:525–529. 2019.PubMed/NCBI View Article : Google Scholar

42 

Shirato K and Kizaki T: SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via Toll-like receptor 4 signaling in murine and human macrophages. Heliyon. 7(e06187)2021.PubMed/NCBI View Article : Google Scholar

43 

Tamai R and Kiyoura Y: Heat-killed Candida albicans augments synthetic bacterial component-induced proinflammatory cytokine production. Folia Microbiol (Praha). 64:555–566. 2019.PubMed/NCBI View Article : Google Scholar

44 

Karga H, Giagourta I, Papaioannou G, Katsichti P, Pardalakis A, Kassi G, Zagoreou A, Triantaphyllopoulou M and Zerva C: Transient changes in thyroid functions tests after zoledronic acid infusion. Endocr J. 58:969–977. 2011.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Watanabe N, Tamai R and Kiyoura Y: Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation. Exp Ther Med 26: 577, 2023.
APA
Watanabe, N., Tamai, R., & Kiyoura, Y. (2023). Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation. Experimental and Therapeutic Medicine, 26, 577. https://doi.org/10.3892/etm.2023.12276
MLA
Watanabe, N., Tamai, R., Kiyoura, Y."Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation". Experimental and Therapeutic Medicine 26.6 (2023): 577.
Chicago
Watanabe, N., Tamai, R., Kiyoura, Y."Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation". Experimental and Therapeutic Medicine 26, no. 6 (2023): 577. https://doi.org/10.3892/etm.2023.12276
Copy and paste a formatted citation
x
Spandidos Publications style
Watanabe N, Tamai R and Kiyoura Y: Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation. Exp Ther Med 26: 577, 2023.
APA
Watanabe, N., Tamai, R., & Kiyoura, Y. (2023). Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation. Experimental and Therapeutic Medicine, 26, 577. https://doi.org/10.3892/etm.2023.12276
MLA
Watanabe, N., Tamai, R., Kiyoura, Y."Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation". Experimental and Therapeutic Medicine 26.6 (2023): 577.
Chicago
Watanabe, N., Tamai, R., Kiyoura, Y."Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation". Experimental and Therapeutic Medicine 26, no. 6 (2023): 577. https://doi.org/10.3892/etm.2023.12276
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