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Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis

  • Authors:
    • Qianqian Xu
    • Xinjuan Fu
    • Zhigang Xiu
    • Hongli Yang
    • Xiaoxiao Men
    • Mingyue Liu
    • Changqin Xu
    • Bin Li
    • Shulei Zhao
    • Hongwei Xu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 578
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    Published online on: October 26, 2023
       https://doi.org/10.3892/etm.2023.12277
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Abstract

Acute pancreatitis (AP) is a severe inflammatory condition characterized by the activation of pancreatic enzymes within acinar cells, leading to tissue damage and inflammation. Interleukin (IL)‑22 is a potential therapeutic agent for AP owing to its anti‑inflammatory properties and ability to promote tissue repair. The present study evaluated the differentially expressed proteins in arginine‑induced pancreatic acinar cell injury following treatment with IL‑22, and the possible mechanisms involved in IL‑22‑mediated alleviation of AP. AR42J cells were stimulated using L‑arginine to establish an acinar cell injury model in vitro and the damaged cells were subsequently treated with IL‑22. The characteristics of the model and the potential therapeutic effects of IL‑22 were examined by CCK‑8 assay, flow cytometry, TUNEL assay, transmission electron microscopy and ELISA. Differentially expressed proteins in cells induced by arginine and treated with IL‑22 were assessed using liquid chromatography‑mass spectrometry. The identified proteins were further subjected to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis to elucidate their functional roles. The present study demonstrated that arginine‑stimulated cells showed significant pathological changes resembling those in AP, which were alleviated after IL‑22 treatment. Proteomic analysis then demonstrated that in IL‑22‑treated cells, proteins related to the formation and fusion of autophagosomes with lysosomes were significantly downregulated, whereas endocytosis related proteins were enriched in the upregulated proteins. After IL‑22 treatment, western blotting demonstrated reduced expression of autophagy‑associated proteins. In conclusion, by inhibiting the formation and fusion of autophagosomes with lysosomes, IL‑22 may have mitigated premature trypsinogen activation, subsequently minimizing acinar cell injury induced by L‑arginine. This was accompanied by concurrent upregulation of endocytosis, which serves a pivotal role in sustaining regular cellular material transport and signal propagation. This research underscored the potential of IL‑22 in mitigating arginine‑induced AR42J injury, which could be valuable in refining treatment strategies for AP.
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1 

Lankisch PG, Apte M and Banks PA: Acute pancreatitis. Lancet. 386:85–96. 2015.PubMed/NCBI View Article : Google Scholar

2 

Zhan X, Wan J, Zhang G, Song L, Gui F, Zhang Y, Li Y, Guo J, Dawra RK, Saluja AK, et al: Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 316:G816–G825. 2019.PubMed/NCBI View Article : Google Scholar

3 

Dambrauskas Z, Giese N, Gulbinas A, Giese T, Berberat PO, Pundzius J, Barauskas G and Friess H: Different profiles of cytokine expression during mild and severe acute pancreatitis. World J Gastroenterol. 16:1845–1853. 2010.PubMed/NCBI View Article : Google Scholar

4 

Saluja A, Dudeja V, Dawra R and Sah RP: Early intra-acinar events in pathogenesis of pancreatitis. Gastroenterology. 156:1979–1993. 2019.PubMed/NCBI View Article : Google Scholar

5 

Gukovsky I, Pandol SJ, Mareninova OA, Shalbueva N, Jia W and Gukovskaya AS: Impaired autophagy and organellar dysfunction in pancreatitis. J Gastroenterol Hepatol. 27 (Suppl 2):S27–S32. 2012.PubMed/NCBI View Article : Google Scholar

6 

Keir M, Yi Y, Lu T and Ghilardi N: The role of IL-22 in intestinal health and disease. J Exp Med. 217(e20192195)2020.PubMed/NCBI View Article : Google Scholar

7 

Ouyang W and O'Garra A: IL-10 family cytokines IL-10 and IL-22: From basic science to clinical translation. Immunity. 50:871–891. 2019.PubMed/NCBI View Article : Google Scholar

8 

Yao Y, Yang G, Lu G, Ye J, Cui L, Zeng Z, Chen J and Zhou J: Th22 Cells/IL-22 serves as a protumor regulator to drive poor prognosis through the JAK-STAT3/MAPK/AKT signaling pathway in non-small-cell lung cancer. J Immunol Res. 2022(8071234)2022.PubMed/NCBI View Article : Google Scholar

9 

Costa MM, Saraceni PR, Forn-Cuní G, Dios S, Romero A, Figueras A and Novoa B: IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling. Dev Comp Immunol. 41:746–755. 2013.PubMed/NCBI View Article : Google Scholar

10 

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, et al: Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 528:560–564. 2015.PubMed/NCBI View Article : Google Scholar

11 

Geng H, Bu HF, Liu F, Wu L, Pfeifer K, Chou PM, Wang X, Sun J, Lu L, Pandey A, et al: In inflamed intestinal tissues and epithelial cells, interleukin 22 signaling increases expression of H19 long noncoding RNA, which promotes mucosal regeneration. Gastroenterology. 155:144–155. 2018.PubMed/NCBI View Article : Google Scholar

12 

Zindl CL, Lai JF, Lee YK, Maynard CL, Harbour SN, Ouyang W, Chaplin DD and Weaver CT: IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc Natl Acad Sci USA. 110:12768–12773. 2013.PubMed/NCBI View Article : Google Scholar

13 

Vasseur P, Devaure I, Sellier J, Delwail A, Chagneau-Derrode C, Charier F, Tougeron D, Tasu JP, Rabeony H, Lecron JC and Silvain C: High plasma levels of the pro-inflammatory cytokine IL-22 and the anti-inflammatory cytokines IL-10 and IL-1ra in acute pancreatitis. Pancreatology. 14:465–469. 2014.PubMed/NCBI View Article : Google Scholar

14 

Huan C, Kim D, Ou P, Alfonso A and Stanek A: Mechanisms of interleukin-22's beneficial effects in acute pancreatitis. World J Gastrointest Pathophysiol. 7:108–116. 2016.PubMed/NCBI View Article : Google Scholar

15 

Bai J, Bai J and Yang M: Interleukin-22 attenuates acute pancreatitis-associated intestinal mucosa injury in mice via STAT3 activation. Gut Liver. 15:771–781. 2021.PubMed/NCBI View Article : Google Scholar

16 

Qiao YY, Liu XQ, Xu CQ, Zhang Z and Xu HW: Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice. World J Gastroenterol. 22:5023–5032. 2016.PubMed/NCBI View Article : Google Scholar

17 

Jin M, Zhang H, Wu M, Wang Z, Chen X, Guo M, Zhou R, Yang H and Qian J: Colonic interleukin-22 protects intestinal mucosal barrier and microbiota abundance in severe acute pancreatitis. FASEB J. 36(e22174)2022.PubMed/NCBI View Article : Google Scholar

18 

Hu G, Shen J, Cheng L, Guo C, Xu X, Wang F, Huang L, Yang L, He M, Xiang D, et al: Reg4 protects against acinar cell necrosis in experimental pancreatitis. Gut. 60:820–828. 2011.PubMed/NCBI View Article : Google Scholar

19 

Berner A, Bachmann M, Bender C, Pfeilschifter J, Christen U and Mühl H: Though active on RINm5F insulinoma cells and cultured pancreatic islets, recombinant IL-22 fails to modulate cytotoxicity and disease in a protocol of streptozotocin-induced experimental diabetes. Front Pharmacol. 6(317)2015.PubMed/NCBI View Article : Google Scholar

20 

Rost-Roszkowska MM, Vilimová J, Tajovský K, Chachulska-Żymełka A, Sosinka A, Kszuk-Jendrysik M, Ostróżka A and Kaszuba F: Autophagy and apoptosis in the midgut epithelium of millipedes. Microsc Microanal. 25:1004–1016. 2019.PubMed/NCBI View Article : Google Scholar

21 

Furey C, Buxbaum J and Chambliss AB: A review of biomarker utilization in the diagnosis and management of acute pancreatitis reveals amylase ordering is favored in patients requiring laparoscopic cholecystectomy. Clin Biochem. 77:54–56. 2020.PubMed/NCBI View Article : Google Scholar

22 

De Faveri F, Chvanov M, Voronina S, Moore D, Pollock L, Haynes L, Awais M, Beckett AJ, Mayer U, Sutton R, et al: LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells. Autophagy. 16:1314–1331. 2020.PubMed/NCBI View Article : Google Scholar

23 

Garber A, Frakes C, Arora Z and Chahal P: Mechanisms and management of acute pancreatitis. Gastroenterol Res Pract. 2018(6218798)2018.PubMed/NCBI View Article : Google Scholar

24 

Eşrefoğlu M, Gül M, Ateş B and Selimoğlu MA: Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. J Pineal Res. 40:92–97. 2006.PubMed/NCBI View Article : Google Scholar

25 

Sherwood MW, Prior IA, Voronina SG, Barrow SL, Woodsmith JD, Gerasimenko OV, Petersen OH and Tepikin AV: Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc Natl Acad Sci USA. 104:5674–5679. 2007.PubMed/NCBI View Article : Google Scholar

26 

Sendler M, Maertin S, John D, Persike M, Weiss FU, Krüger B, Wartmann T, Wagh P, Halangk W, Schaschke N, et al: Cathepsin B activity initiates apoptosis via digestive protease activation in pancreatic acinar cells and experimental pancreatitis. J Biol Chem. 291:14717–14731. 2016.PubMed/NCBI View Article : Google Scholar

27 

Liu X, Qiao Y, Xu C, Zhu S and Xu H: Protective effects of interleukin-22 on severe acute pancreatitis-associated kidney injury in mice. Austin Intern Med. 2(1016)2017.

28 

Tashiro M, Schäfer C, Yao H, Ernst SA and Williams JA: Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression in rat pancreatic acinar cells. Gut. 49:241–250. 2001.PubMed/NCBI View Article : Google Scholar

29 

Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A and Pasterkamp RJ: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol. 31:3603–3615. 2011.PubMed/NCBI View Article : Google Scholar

30 

Gukovskaya AS, Gukovsky I, Algül H and Habtezion A: Autophagy, inflammation, and immune dysfunction in the pathogenesis of pancreatitis. Gastroenterology. 153:1212–1226. 2017.PubMed/NCBI View Article : Google Scholar

31 

Yang Y and Klionsky DJ: Autophagy and disease: Unanswered questions. Cell Death Differ. 27:858–871. 2020.PubMed/NCBI View Article : Google Scholar

32 

Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, et al: Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models. Gastroenterology. 154:689–703. 2018.PubMed/NCBI View Article : Google Scholar

33 

Iwahashi K, Hikita H, Makino Y, Shigekawa M, Ikezawa K, Yoshioka T, Kodama T, Sakamori R, Tatsumi T and Takehara T: Autophagy impairment in pancreatic acinar cells causes zymogen granule accumulation and pancreatitis. Biochem Biophys Res Commun. 503:2576–2582. 2018.PubMed/NCBI View Article : Google Scholar

34 

Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C and Jung JU: Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 10:776–787. 2008.PubMed/NCBI View Article : Google Scholar

35 

Kang R, Zeh HJ, Lotze MT and Tang D: The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18:571–580. 2011.PubMed/NCBI View Article : Google Scholar

36 

Schaaf MB, Keulers TG, Vooijs MA and Rouschop KM: LC3/GABARAP family proteins: Autophagy-(un)related functions. FASEB J. 30:3961–3978. 2016.PubMed/NCBI View Article : Google Scholar

37 

Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y and Shimizu S: Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature. 461:654–658. 2009.PubMed/NCBI View Article : Google Scholar

38 

Green DR and Levine B: To be or not to be? How selective autophagy and cell death govern cell fate. Cell. 157:65–75. 2014.PubMed/NCBI View Article : Google Scholar

39 

Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, Brunner T and Simon HU: Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 8:1124–1132. 2006.PubMed/NCBI View Article : Google Scholar

40 

Panda PK, Mukhopadhyay S, Das DN, Sinha N, Naik PP and Bhutia SK: Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics. Semin Cell Dev Biol. 39:43–55. 2015.PubMed/NCBI View Article : Google Scholar

41 

Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS and Groblewski GE: Early to late endosome trafficking controls secretion and zymogen activation in rodent and human pancreatic acinar cells. Cell Mol Gastroenterol Hepatol. 1:695–709. 2015.PubMed/NCBI View Article : Google Scholar

42 

Messenger SW, Jones EK, Holthaus CL, Thomas DDH, Cooley MM, Byrne JA, Mareninova OA, Gukovskaya AS and Groblewski GE: Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation. J Biol Chem. 292:7828–7839. 2017.PubMed/NCBI View Article : Google Scholar

43 

Mahapatra KK, Panigrahi DP, Praharaj PP, Bhol CS, Patra S, Mishra SR, Behera BP and Bhutia SK: Molecular interplay of autophagy and endocytosis in human health and diseases. Biol Rev Camb Philos Soc. 94:1576–1590. 2019.PubMed/NCBI View Article : Google Scholar

44 

Trofimenko E, Homma Y, Fukuda M and Widmann C: The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7. Cell Rep. 37(109945)2021.PubMed/NCBI View Article : Google Scholar

45 

Ao X, Zou L and Wu Y: Regulation of autophagy by the Rab GTPase network. Cell Death Differ. 21:348–358. 2014.PubMed/NCBI View Article : Google Scholar

46 

Chu J, Ji H, Lu M, Li Z, Qiao X, Sun B, Zhang W and Xue D: Proteomic analysis of apoptotic and oncotic pancreatic acinar AR42J cells treated with caerulein. Mol Cell Biochem. 382:1–17. 2013.PubMed/NCBI View Article : Google Scholar

47 

Li Z, Lu M, Chu J, Qiao X, Meng X, Sun B, Zhang W and Xue D: Early proteome analysis of rat pancreatic acinar AR42J cells treated with taurolithocholic acid 3-sulfate. Pancreatology. 12:248–256. 2012.PubMed/NCBI View Article : Google Scholar

48 

Yu JH, Yun SY, Lim JW, Kim H and Kim KH: Proteome analysis of rat pancreatic acinar cells: Implication for cerulein-induced acute pancreatitis. Proteomics. 3:2446–2453. 2003.PubMed/NCBI View Article : Google Scholar

49 

Wu LG, Hamid E, Shin W and Chiang HC: Exocytosis and endocytosis: Modes, functions, and coupling mechanisms. Annu Rev Physiol. 76:301–331. 2014.PubMed/NCBI View Article : Google Scholar

50 

Sun S, Han Y, Zhang C, Liu H, Wang B, Cao S, Yuan Q, Wei S and Chen Y: adenosine kinase inhibition prevents severe acute pancreatitis via suppressing inflammation and acinar cell necroptosis. Front Cell Dev Biol. 10(827714)2022.PubMed/NCBI View Article : Google Scholar

51 

Huang H, Wang M, Guo Z, Wu D, Wang H, Jia Y, Liu H, Ding J and Peng J: Rutaecarpine alleviates acute pancreatitis in mice and AR42J cells by suppressing the MAPK and NF-κB signaling pathways via calcitonin gene-related peptide. Phytother Res. 35:6472–6485. 2021.PubMed/NCBI View Article : Google Scholar

52 

Zhang Z, Liu Q, Zang H, Shao Q and Sun T: Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signalling. Pharm Biol. 57:595–603. 2019.PubMed/NCBI View Article : Google Scholar

53 

Xiao J, Feng X, Huang XY, Huang Z, Huang Y, Li C, Li G, Nong S, Wu R, Huang Y and Long XD: Spautin-1 ameliorates acute pancreatitis via inhibiting impaired autophagy and alleviating calcium overload. Mol Med. 22:643–652. 2016.PubMed/NCBI View Article : Google Scholar

54 

Mukherjee S, Ghosh RN and Maxfield FR: Endocytosis. Physiol Rev. 77:759–803. 1997.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Xu Q, Fu X, Xiu Z, Yang H, Men X, Liu M, Xu C, Li B, Zhao S, Xu H, Xu H, et al: Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis. Exp Ther Med 26: 578, 2023.
APA
Xu, Q., Fu, X., Xiu, Z., Yang, H., Men, X., Liu, M. ... Xu, H. (2023). Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis. Experimental and Therapeutic Medicine, 26, 578. https://doi.org/10.3892/etm.2023.12277
MLA
Xu, Q., Fu, X., Xiu, Z., Yang, H., Men, X., Liu, M., Xu, C., Li, B., Zhao, S., Xu, H."Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis". Experimental and Therapeutic Medicine 26.6 (2023): 578.
Chicago
Xu, Q., Fu, X., Xiu, Z., Yang, H., Men, X., Liu, M., Xu, C., Li, B., Zhao, S., Xu, H."Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis". Experimental and Therapeutic Medicine 26, no. 6 (2023): 578. https://doi.org/10.3892/etm.2023.12277
Copy and paste a formatted citation
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Spandidos Publications style
Xu Q, Fu X, Xiu Z, Yang H, Men X, Liu M, Xu C, Li B, Zhao S, Xu H, Xu H, et al: Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis. Exp Ther Med 26: 578, 2023.
APA
Xu, Q., Fu, X., Xiu, Z., Yang, H., Men, X., Liu, M. ... Xu, H. (2023). Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis. Experimental and Therapeutic Medicine, 26, 578. https://doi.org/10.3892/etm.2023.12277
MLA
Xu, Q., Fu, X., Xiu, Z., Yang, H., Men, X., Liu, M., Xu, C., Li, B., Zhao, S., Xu, H."Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis". Experimental and Therapeutic Medicine 26.6 (2023): 578.
Chicago
Xu, Q., Fu, X., Xiu, Z., Yang, H., Men, X., Liu, M., Xu, C., Li, B., Zhao, S., Xu, H."Interleukin‑22 alleviates arginine‑induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis". Experimental and Therapeutic Medicine 26, no. 6 (2023): 578. https://doi.org/10.3892/etm.2023.12277
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