SARS‑CoV‑2 infection and associated risk factors for clinical cases of cerebral venous thrombosis: A case series

Axelerad,Any; Muja,Lavinia Florenta; Mihai,Cristina Maria; Stuparu,Alina Zorina; Gogu,Anca Elena; Jianu,Dragos Catalin; Frecus,Corina Elena; Axelerad,Silviu Docu; Petrov,Silvia Georgeta; Sirbu,Carmen Adella; Cambrea,Simona Claudia; Baz,Radu Andrei; Ionita‑radu,Florentina

doi:10.3892/etm.2023.12300

January-2024 Volume 27 Issue 1

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January-2024 Volume 27 Issue 1

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Article Open Access

SARS‑CoV‑2 infection and associated risk factors for clinical cases of cerebral venous thrombosis: A case series

Authors:
- Any Axelerad
- Lavinia Florenta Muja
- Cristina Maria Mihai
- Alina Zorina Stuparu
- Anca Elena Gogu
- Dragos Catalin Jianu
- Corina Elena Frecus
- Silviu Docu Axelerad
- Silvia Georgeta Petrov
- Carmen Adella Sirbu
- Simona Claudia Cambrea
- Radu Andrei Baz
- Florentina Ionita‑radu
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Affiliations: Department of Neurology, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania, Department of Pediatrics, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania, Department of Neurology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania, Vasile Goldis' University, Faculty of General Medicine, 317046 Arad, Romania, Doctoral School of The Faculty of Psychology and Educational Sciences within The University of Bucharest, 050663 Bucharest, Romania, Neurology Department, Titu Maiorescu University, 040441 Bucharest, Romania, Infectious Diseases Clinic, Clinical Infectious Diseases Hospital, 900708 Constanta, Romania, Department of Radiology, Faculty of Medicine, Ovidius University, 900470 Constanta, Romania, Faculty of Medicine, Titu Maiorescu University, 004051 Bucharest, Romania

Copyright: © Axelerad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 13
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Published online on: November 14, 2023

https://doi.org/10.3892/etm.2023.12300
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Abstract

The present study focused on examining the association between the SARS‑CoV‑2 virus, responsible for the COVID‑19 pandemic, and cerebral venous thrombosis (CVT), a specific form of stroke that affects the brain's vessels and sinuses. While COVID‑19 is primarily recognized for its respiratory impact, it may also affect other organs, including the brain. One notable aspect of COVID‑19 is its association with coagulopathy, an abnormal condition of blood clotting. Coagulopathy may result in various complications, including neurological ones such as stroke. The study analyzed data obtained from patients admitted to a neurology department who had confirmed neurological pathologies along with COVID‑19. It specifically examined the cases of three patients with neurological conditions and COVID‑19, discussing their risk factors and how their conditions progressed clinically. The study concluded that COVID‑19 infection increases the likelihood of stroke, particularly within the initial 10 days after infection. CVT in particular is strongly linked to COVID‑19 and its underlying mechanisms involve immune systemic processes, cytokine storms, increased blood thickness, thrombogenesis, hypercoagulability and inflammation. The presence of SARS‑CoV‑2 infection may worsen the procoagulant cascade, thereby affecting the clinical condition of patients with CVT. The study underscores the importance of recognizing this uncommon but treatable consequence of COVID‑19 infection. Furthermore, it highlights the uniqueness of the study in evaluating COVID‑19 infection in patients with CVT from Romania and South‑East Europe. The findings support the existence of neurological disorders, including clotting complications in the brain's sinuses and vessels, in individuals infected with SARS‑CoV‑2. Several risk factors contribute to the development of CVT, such as infections, oral contraceptives, pregnancy, hematological disorders, trauma, autoimmune disorders and malignancies.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

SARS‑CoV‑2 infection and associated risk factors for clinical cases of cerebral venous thrombosis: A case series

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