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Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty

  • Authors:
    • Yu Zhang
    • Yongxiang Zhang
    • Chang Liao
    • Xiaoxu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Infectious Disease, Heilongjiang Provincial People's Hospital, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 18
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    Published online on: November 17, 2023
       https://doi.org/10.3892/etm.2023.12306
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Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) plays a key role in the deterioration of lung hemodynamics and contributes to secondary dysfunction of the right heart, which is consistently accompanied by systemic malperfusion and a reduced glomerular filtration rate (GFR). The prognosis of CTEPH is markedly influenced by renal function. The aim of the present study was to evaluate the prognostic value of GFR in patients with CTEPH who have undergone balloon pulmonary angioplasty (BPA). From December 2012 to September 2020, a total of 47 patients diagnosed with CTEPH who received BPA were retrospectively studied. Patients were categorized according to their renal function on admission into two groups: GFR >53 and ≤53. Biological, clinical and demographic data of the patients were collected. Data for the two groups in hospital and during follow‑up were systematically analyzed and compared. All‑cause mortality, death from right heart failure (RHF) and rehospitalization associated with RHF were considered major adverse events (MAEs). The results revealed that the 6‑min walk distance, N‑terminal pro‑B type natriuretic peptide (NT‑proBNP), Troponin I and right ventricle diameter were significantly lower, and tricuspid annular plane systolic excursion was significantly higher in the GFR >53 group compared with the GFR ≤53 group at final follow‑up. In addition, GFR levels were significantly correlated with NT‑proBNP at baseline and final follow‑up. Furthermore, based on a multivariate analysis, it was determined that the decreased GFR was an independent predictor of MAEs during follow‑up. Therefore, it may be concluded that in addition to being associated with right ventricular function, decreased GFR is also a prognostic marker in CTEPH treated with BPA.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Zhang Y, Liao C and Wang X: Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty. Exp Ther Med 27: 18, 2024.
APA
Zhang, Y., Zhang, Y., Liao, C., & Wang, X. (2024). Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty. Experimental and Therapeutic Medicine, 27, 18. https://doi.org/10.3892/etm.2023.12306
MLA
Zhang, Y., Zhang, Y., Liao, C., Wang, X."Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty". Experimental and Therapeutic Medicine 27.1 (2024): 18.
Chicago
Zhang, Y., Zhang, Y., Liao, C., Wang, X."Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty". Experimental and Therapeutic Medicine 27, no. 1 (2024): 18. https://doi.org/10.3892/etm.2023.12306
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Zhang Y, Liao C and Wang X: Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty. Exp Ther Med 27: 18, 2024.
APA
Zhang, Y., Zhang, Y., Liao, C., & Wang, X. (2024). Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty. Experimental and Therapeutic Medicine, 27, 18. https://doi.org/10.3892/etm.2023.12306
MLA
Zhang, Y., Zhang, Y., Liao, C., Wang, X."Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty". Experimental and Therapeutic Medicine 27.1 (2024): 18.
Chicago
Zhang, Y., Zhang, Y., Liao, C., Wang, X."Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty". Experimental and Therapeutic Medicine 27, no. 1 (2024): 18. https://doi.org/10.3892/etm.2023.12306
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