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Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis

  • Authors:
    • Takashi Himoto
    • Koji Fujita
    • Shima Mimura
    • Joji Tani
    • Asashiro Morishita
    • Satoru Kubota
    • Tsutomu Masaki
  • View Affiliations / Copyright

    Affiliations: Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Takamatsu, Kagawa 761‑0123, Japan, Department of Gastroenterology and Neurology, Kagawa University, Faculty of Medicine, Miki-cho, Kagawa 761‑0793, Japan, Medico Consl Co, Ltd., Suita, Osaka 565‑0824, Japan
    Copyright: © Himoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 19
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    Published online on: November 17, 2023
       https://doi.org/10.3892/etm.2023.12307
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Abstract

Essential trace elements are involved in the pathogenesis of chronic liver disease (CLD), which causes hepatic inflammation, steatosis and fibrosis. The present study investigated the roles of essential trace elements in the pathogenesis of hepatitis C virus‑related CLD (CLD‑C) and nonalcoholic steatohepatitis (NASH), and compared the levels of these trace elements between the two groups. Serum zinc (Zn), selenium (Se), copper (Cu) and ferritin levels were measured in patients with CLD‑C (n=66) and NASH (n=26). Subsequently, the correlations between the levels of these essential trace elements in patient sera and the biochemical or pathological parameters of patients with CLD‑C and NASH were determined. The results demonstrated that the serum ferritin levels were significantly correlated with serum alanine aminotransferase levels in both the CLD‑C and NASH groups. In both groups, the serum Zn and Se levels were significantly associated with serum albumin levels, and inversely associated with the stages of hepatic fibrosis. Furthermore, serum ferritin levels were positively associated, and serum Zn levels were inversely correlated with the grades of hepatic steatosis in patients with CLD‑C, whereas serum Se levels were closely associated with the grades of hepatic steatosis only in patients with NASH. In both groups, serum ferritin levels were positively correlated, and serum Zn levels were inversely correlated with homeostasis model for the assessment of insulin resistance (HOMA‑IR) values, and serum Se was negatively correlated with the HOMA‑IR values in patients with CLD‑C only. In conclusion, these results indicated that the involvement of essential trace elements in insulin resistance and hepatic steatosis may differ slightly between patients with CLD‑C and those with NASH.
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Copy and paste a formatted citation
Spandidos Publications style
Himoto T, Fujita K, Mimura S, Tani J, Morishita A, Kubota S and Masaki T: Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis. Exp Ther Med 27: 19, 2024.
APA
Himoto, T., Fujita, K., Mimura, S., Tani, J., Morishita, A., Kubota, S., & Masaki, T. (2024). Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis. Experimental and Therapeutic Medicine, 27, 19. https://doi.org/10.3892/etm.2023.12307
MLA
Himoto, T., Fujita, K., Mimura, S., Tani, J., Morishita, A., Kubota, S., Masaki, T."Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis". Experimental and Therapeutic Medicine 27.1 (2024): 19.
Chicago
Himoto, T., Fujita, K., Mimura, S., Tani, J., Morishita, A., Kubota, S., Masaki, T."Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis". Experimental and Therapeutic Medicine 27, no. 1 (2024): 19. https://doi.org/10.3892/etm.2023.12307
Copy and paste a formatted citation
x
Spandidos Publications style
Himoto T, Fujita K, Mimura S, Tani J, Morishita A, Kubota S and Masaki T: Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis. Exp Ther Med 27: 19, 2024.
APA
Himoto, T., Fujita, K., Mimura, S., Tani, J., Morishita, A., Kubota, S., & Masaki, T. (2024). Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis. Experimental and Therapeutic Medicine, 27, 19. https://doi.org/10.3892/etm.2023.12307
MLA
Himoto, T., Fujita, K., Mimura, S., Tani, J., Morishita, A., Kubota, S., Masaki, T."Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis". Experimental and Therapeutic Medicine 27.1 (2024): 19.
Chicago
Himoto, T., Fujita, K., Mimura, S., Tani, J., Morishita, A., Kubota, S., Masaki, T."Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis". Experimental and Therapeutic Medicine 27, no. 1 (2024): 19. https://doi.org/10.3892/etm.2023.12307
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