Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2024 Volume 27 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2024 Volume 27 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report

  • Authors:
    • Liangchao Hao
    • Wei Cai
    • Zhaomu Zeng
    • Xiuchao Geng
    • Qiang Li
    • Hong Chen
    • Yuhao Zhang
    • Juan Ding
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Shaoxing People's Hospital, Shaoxing, Zhejiang 312000, P.R. China, Department of Neurosurgery, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi 330000, P.R. China, School of Medicine, Taizhou University, Taizhou, Zhejiang 318000, P.R. China, Department of Neurosurgery, Cancer Centre, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 20
    |
    Published online on: November 20, 2023
       https://doi.org/10.3892/etm.2023.12309
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chronic liver disease can cause an increase in portal sinus pressure, which may lead to rupture and bleeding of esophageal and gastric varices. Oesophageal variceal ligation, with use of sclerosing agent and tissue glue injection is commonly used in clinical practice to address oesophageal bleeding. A 58‑year‑old male patient with chronic liver disease was treated with oesophageal variceal ligation, sclerosing agent and tissue glue injection due to oesophageal and gastric variceal bleeding. After 2 days, the skin of the patient exhibited erythema to different degrees. After 10 days of dexamethasone treatment, the whole‑body rash worsened, and a severe skin reaction appeared that was suggestive of toxic epidermal necrolysis (TEN). Strict mucosal care was provided, and corticosteroids, γ globulin and adalimumab were concurrently used for treatment. After 20 days, the patient recovered from the skin problems. To the best of our knowledge, TEN after endoscopic surgery has rarely been reported in the relevant literature. Furthermore, when patients being treated with multiple drugs have erythema multiforme, physicians should be alert to the possibility of its development into TEN. The present case report summarizes the treatment methods for patients with TEN, providing a practical clinical basis and direction for the future diagnosis and treatment of the condition.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Kinoshita Y and Saeki H: A review of toxic epidermal necrolysis management in Japan. Allergol Int. 66:36–41. 2017.PubMed/NCBI View Article : Google Scholar

2 

Ordoñez L, Salgueiro E, Jimeno FJ and Manso G: Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs. Eur Rev Med Pharmacol. 19:2732–2737. 2015.PubMed/NCBI

3 

Gaghan LJ, Coates MM, Crouse LN, Miedema J, Mervak JE and Ziemer CM: Photodistributed toxic epidermal necrolysis: Case report and review of current literature. JAMA Dermatol. 158:787–790. 2022.PubMed/NCBI View Article : Google Scholar

4 

Maity S, Banerjee I, Sinha R, Jha H, Ghosh P and Mustafi S: Nikolsky's sign: A pathognomic boon. J Family Med Prim Care. 9:526–530. 2020.PubMed/NCBI View Article : Google Scholar

5 

Lerch M, Mainetti C, Terziroli Beretta-Piccoli B and Harr T: Current perspectives on stevens-johnson syndrome and toxic epidermal necrolysis. Clin Rev Allergy Immunol. 54:147–176. 2018.PubMed/NCBI View Article : Google Scholar

6 

Chen CB, Abe R, Pan RY, Wang CW, Hung SI, Tsai YG and Chung WH: An updated review of the molecular mechanisms in drug hypersensitivity. J Immunol Res. 2018(6431694)2018.PubMed/NCBI View Article : Google Scholar

7 

Torrelo A: Methylprednisolone aceponate for atopic dermatitis. Int J Dermatol. 56:691–697. 2017.PubMed/NCBI View Article : Google Scholar

8 

Chinese Medical Association, Chinese Medical Journals Publishing House, Chinese Society of Dermatology, Chinese Society of General Practice, Editorial Board of Chinese Journal of General Practitioners of Chinese Medical Association, Expert Group of Guidelines for Primary Care of Skin and Venereal Disease. Guideline for primary care of drug eruption (2022). Chin J Gen Pract. 21:804–813. 2022.(In Chinese).

9 

Wilkerson RG: Drug hypersensitivity reactions. Emerg Med Clin North Am. 40:39–55. 2022.PubMed/NCBI View Article : Google Scholar

10 

Ueta M: Susceptibility genes and HLA for cold medicine-related SJS/TEN with SOC. Front Genet. 13(912478)2022.PubMed/NCBI View Article : Google Scholar

11 

Tassaneeyakul W, Prabmeechai N, Sukasem C, Kongpan T, Konyoung P, Chumworathayi P, Tiamkao S, Khunarkornsiri U, Kulkantrakorn K, Saksit N, et al: Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population. Pharmacogenet Genomics. 26:225–234. 2016.PubMed/NCBI View Article : Google Scholar

12 

Grünwald P, Mockenhaupt M, Panzer R and Emmert S: Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis-diagnosis and treatment. J Dtsch Dermatol Ges. 18:547–553. 2020.PubMed/NCBI View Article : Google Scholar

13 

Schneider JA and Cohen PR: Stevens-Johnson Syndrome and toxic epidermal necrolysis: A concise review with a comprehensive summary of therapeutic interventions emphasizing supportive measures. Adv Ther. 34:1235–1244. 2017.PubMed/NCBI View Article : Google Scholar

14 

Garcia-Doval I, LeCleach L, Bocquet H, Otero XL and Roujeau JC: Toxic epidermal necrolysis and Stevens-Johnson syndrome: Does early withdrawal of causative drugs decrease the risk of death? Arch Dermatol. 136:323–327. 2000.PubMed/NCBI View Article : Google Scholar

15 

Rizzo JA, Johnson R and Cartie RJ: Pediatric toxic epidermal necrolysis: Experience of a Tertiary Burn Center. Pediatr Dermatol. 32:704–709. 2015.PubMed/NCBI View Article : Google Scholar

16 

Noe MH and Micheletti RG: Diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis. Clin Dermatol. 38:607–612. 2020.PubMed/NCBI View Article : Google Scholar

17 

Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, et al: Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome. Cochrane Database Syst Rev. 3(CD013130)2022.PubMed/NCBI View Article : Google Scholar

18 

Zimmermann S, Sekula P, Venhoff M, Motschall E, Knaus J, Schumacher M and Mockenhaupt M: Systemic immunomodulating therapies for stevens-johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis. JAMA Dermatol. 153:514–522. 2017.PubMed/NCBI View Article : Google Scholar

19 

Chafranska L, Saunte DM, Behrendt N, Nygaard U, Christensen RJ, Sand C and Jemec GB: Pediatric toxic epidermal necrolysis treated successfully with infliximab. Pediatr Dermatol. 36:342–345. 2019.PubMed/NCBI View Article : Google Scholar

20 

Da W, Zhu J, Wang L and Lu Y: Adalimumab for Crohn's disease after infliximab treatment failure: A systematic review. Eur J Gastroenterol Hepatol. 25:885–891. 2013.PubMed/NCBI View Article : Google Scholar

21 

Zeng C, Liao Q, Hu Y, Shen Y, Geng F and Chen L: The role of periplaneta americana (Blattodea: Blattidae) in modern versus traditional Chinese medicine. J Med Entomol. 56:1522–1526. 2019.PubMed/NCBI View Article : Google Scholar

22 

Fu S, Chen J, Zhang C, Shi J, Nie X, Hu Y, Fu C, Li X and Zhang J: Gastroprotective effects of periplaneta Americana L. extract against ethanol-induced gastric ulcer in mice by suppressing apoptosis-related pathways. Front Pharmacol. 12(798421)2021.PubMed/NCBI View Article : Google Scholar

23 

Barron SJ, Del Vecchio MT and Aronoff SC: Intravenous immunoglobulin in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis: A meta-analysis with meta-regression of observational studies. Int J Dermatol. 54:108–115. 2015.PubMed/NCBI View Article : Google Scholar

24 

Huang YC, Chien YN, Chen YT, Li YC and Chen TJ: Intravenous immunoglobulin for the treatment of toxic epidermal necrolysis: A systematic review and meta-analysis. G Ital Dermatol Venereol. 151:515–524. 2016.PubMed/NCBI

25 

Yang Y, Xu J, Li F and Zhu X: Combination therapy of intravenous immunoglobulin and corticosteroid in the treatment of toxic epidermal necrolysis and Stevens-Johnson syndrome: A retrospective comparative study in China. Int J Dermatol. 48:1122–1128. 2009.PubMed/NCBI View Article : Google Scholar

26 

Al Rajaibi R, Al Rumhi T and Al Abri AM: Carbamazepine-Induced stevens-johnson syndrome/toxic epidermal necrolysis overlap treated successfully with oral cyclosporin: Case report and literature review. Sultan Qaboos Univ Med J. 21:491–494. 2021.PubMed/NCBI View Article : Google Scholar

27 

Han F, Zhang J, Guo Q, Feng Y, Gao Y, Guo L, Hou Y, An J, Wang X, Yan B, et al: Successful treatment of toxic epidermal necrolysis using plasmapheresis: A prospective observational study. J Crit Care. 42:65–68. 2017.PubMed/NCBI View Article : Google Scholar

28 

Clark WF and Huang SS: Introduction to therapeutic plasma exchange. Transfus Apher Sci. 58:228–229. 2019.PubMed/NCBI View Article : Google Scholar

29 

Thakor AS, Burke A, Handfield-Jones S, Sinha A, Palmer M and Burns A: Toxic epidermal necrolysis and neutropaenia: Complications of omeprazole. Australas J Dermatol. 50:207–210. 2009.PubMed/NCBI View Article : Google Scholar

30 

Lin CY, Wang CW, Hui CR, Chang YC, Yang CH, Cheng CY, Chen WW, Ke WM and Chung WH: Delayed-type hypersensitivity reactions induced by proton pump inhibitors: A clinical and in vitro T-cell reactivity study. Allergy. 73:221–229. 2018.PubMed/NCBI View Article : Google Scholar

31 

Trayes KP, Love G and Studdiford JS: Erythema multiforme: Recognition and management. Am Fam Physician. 100:82–88. 2019.PubMed/NCBI

32 

Soares A and Sokumbi O: Recent updates in the treatment of erythema multiforme. Medicina (Kaunas). 57(921)2012.PubMed/NCBI View Article : Google Scholar

33 

Rykiel K, Melchor J, Motie I, Mulles K and Farhangi V: Recurrent erythema multiforme major following COVID-19 infection. Cureus. 15(e42646)2023.PubMed/NCBI View Article : Google Scholar

34 

Lu X, Hu R, Peng L, Liu M and Sun Z: Efficacy and safety of adalimumab biosimilars: Current critical clinical data in rheumatoid arthritis. Front Immunol. 12(638444)2021.PubMed/NCBI View Article : Google Scholar

35 

Yamamoto T: An update on adalimumab for pyoderma gangrenosum. Drugs Today (Barc). 57:535–542. 2021.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hao L, Cai W, Zeng Z, Geng X, Li Q, Chen H, Zhang Y and Ding J: Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report. Exp Ther Med 27: 20, 2024.
APA
Hao, L., Cai, W., Zeng, Z., Geng, X., Li, Q., Chen, H. ... Ding, J. (2024). Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report. Experimental and Therapeutic Medicine, 27, 20. https://doi.org/10.3892/etm.2023.12309
MLA
Hao, L., Cai, W., Zeng, Z., Geng, X., Li, Q., Chen, H., Zhang, Y., Ding, J."Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report". Experimental and Therapeutic Medicine 27.1 (2024): 20.
Chicago
Hao, L., Cai, W., Zeng, Z., Geng, X., Li, Q., Chen, H., Zhang, Y., Ding, J."Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report". Experimental and Therapeutic Medicine 27, no. 1 (2024): 20. https://doi.org/10.3892/etm.2023.12309
Copy and paste a formatted citation
x
Spandidos Publications style
Hao L, Cai W, Zeng Z, Geng X, Li Q, Chen H, Zhang Y and Ding J: Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report. Exp Ther Med 27: 20, 2024.
APA
Hao, L., Cai, W., Zeng, Z., Geng, X., Li, Q., Chen, H. ... Ding, J. (2024). Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report. Experimental and Therapeutic Medicine, 27, 20. https://doi.org/10.3892/etm.2023.12309
MLA
Hao, L., Cai, W., Zeng, Z., Geng, X., Li, Q., Chen, H., Zhang, Y., Ding, J."Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report". Experimental and Therapeutic Medicine 27.1 (2024): 20.
Chicago
Hao, L., Cai, W., Zeng, Z., Geng, X., Li, Q., Chen, H., Zhang, Y., Ding, J."Toxic epidermal necrolysis after injection of sclerosing agent and medical adhesive into oesophageal variceal ligation in a patient with a malignant liver tumour: A case report". Experimental and Therapeutic Medicine 27, no. 1 (2024): 20. https://doi.org/10.3892/etm.2023.12309
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team