Open Access

BMP and activin receptor membrane bound inhibitor: BAMBI has multiple roles in gene expression and diseases (Review)

  • Authors:
    • Xiaochang Chen
    • Jue Li
    • Aoqi Xiang
    • Hua Guan
    • Peihong Su
    • Lusha Zhang
    • Dian Zhang
    • Qi Yu
  • View Affiliations

  • Published online on: November 22, 2023     https://doi.org/10.3892/etm.2023.12316
  • Article Number: 28
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

BMP and activin membrane‑bound inhibitor (BAMBI) is a transmembrane glycoprotein, known as a pseudo‑receptor for TGFβ, as, while its extracellular domain is similar to that of type I TGFβ receptors, its intracellular structure is shorter and lacks a serine/threonine phosphokinase signaling motif. BAMBI can regulate numerous biological phenomena, including glucose and lipid metabolism, inflammatory responses, and cell proliferation and differentiation. Furthermore, abnormal expression of BAMBI at the mRNA and protein levels contributes to various human pathologies, including obesity and cancer. In the present review, the structure of BAMBI is briefly introduced and its associated signaling pathways and physiological functions are described. Understanding of BAMBI structure and function may contribute to knowledge regarding the occurrence of diseases, including obesity and diabetes, among others. The present review provides a theoretical foundation for the development of BAMBI as a potential biomarker or therapeutic target.
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January-2024
Volume 27 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Li J, Xiang A, Guan H, Su P, Zhang L, Zhang D and Yu Q: BMP and activin receptor membrane bound inhibitor: BAMBI has multiple roles in gene expression and diseases (Review). Exp Ther Med 27: 28, 2024
APA
Chen, X., Li, J., Xiang, A., Guan, H., Su, P., Zhang, L. ... Yu, Q. (2024). BMP and activin receptor membrane bound inhibitor: BAMBI has multiple roles in gene expression and diseases (Review). Experimental and Therapeutic Medicine, 27, 28. https://doi.org/10.3892/etm.2023.12316
MLA
Chen, X., Li, J., Xiang, A., Guan, H., Su, P., Zhang, L., Zhang, D., Yu, Q."BMP and activin receptor membrane bound inhibitor: BAMBI has multiple roles in gene expression and diseases (Review)". Experimental and Therapeutic Medicine 27.1 (2024): 28.
Chicago
Chen, X., Li, J., Xiang, A., Guan, H., Su, P., Zhang, L., Zhang, D., Yu, Q."BMP and activin receptor membrane bound inhibitor: BAMBI has multiple roles in gene expression and diseases (Review)". Experimental and Therapeutic Medicine 27, no. 1 (2024): 28. https://doi.org/10.3892/etm.2023.12316