Risk factors for post‑retrograde cholangiopancreatography pancreatitis in patients with common bile duct stones: A meta‑analysis

Zhou,Bo; Zhao,Liyuan; Xing,Xinfeng; Wang,Hai; Kuwantai,Asihati; Chen,Kai

doi:10.3892/etm.2023.12320

Risk factors for post‑retrograde cholangiopancreatography pancreatitis in patients with common bile duct stones: A meta‑analysis

Authors:
- Bo Zhou
- Liyuan Zhao
- Xinfeng Xing
- Hai Wang
- Asihati Kuwantai
- Kai Chen
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Affiliations: Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830011, P.R. China, Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830054, P.R. China
Published online on: November 24, 2023 https://doi.org/10.3892/etm.2023.12320
Article Number: 32
Copyright : © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Endoscopic retrograde cholangiopancreatography (ERCP) has become a common treatment method for common bile duct stones. However, ERCP is also associated with a high risk of post‑endoscopic retrograde cholangiopancreatography pancreatitis (PEP). Identification of risk factors is essential for reducing the incidence of PEP. The present study aimed to summarize the risk factors for PEP by performing a meta‑analysis. Therefore, studies published between 2000 and 2022 were screened in PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang Digital Periodicals and the Weipu Database, with no language restrictions. Newcastle‑Ottawa Scale was used to assess the quality of the included studies. Stata 17.0 software was utilized for the meta‑analysis of 14 possible risk factors. Overall, 15 high‑quality studies were included into the present meta‑analysis. The results showed that female [odds ratio (OR), 1.42; 95% CI, 1.23‑1.64), age <60 years (OR, 1.53; 95% CI, 1.06‑2.21), difficult intubation (OR, 4.87; 95% CI, 2.73‑8.68), ≥3 cannulation attempts (OR, 9.64; 95% CI, 4.16‑22.35), cannulation time ≥10 min (OR, 2.37; 95% CI, 1.67‑3.35), history of pancreatitis (OR, 2.95; 95% CI, 1.06‑5.51), pancreatic duct visualization (OR, 3.63; 95% CI, 2.47‑5.34) and sphincter of Oddi dysfunction (OR, 5.72; 95% CI, 1.80‑18.24) are potential risk factors for PEP (P<0.05). In conclusion, the present meta‑analysis suggests that PEP can be affected by several risk factors, particularly the technique‑related factors such as the frequency and time of cannulation. Therefore, effective precautions should be taken as early as possible to reduce the incidence of PEP.

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