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Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report

  • Authors:
    • Guangwen Zhu
    • Liting Xie
    • Xianwen Hu
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Zunyi Hospital of Traditional Chinese Medicine, Zunyi, Guizhou 563000, P.R. China, Department of Gynaecology, Zunyi Hospital of Traditional Chinese Medicine, Zunyi, Guizhou 563000, P.R. China, Department of Nuclear Medicine, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
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    Published online on: November 28, 2023
       https://doi.org/10.3892/etm.2023.12330
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Abstract

Nesidioblastosis is a rare cause of hyperinsulinemic hypoglycemia in adults and its clinical features are similar to those of insulinoma with recurrent hypoglycemic attacks. The present study reports the case of a 48‑year‑old man who visited the Affiliated Hospital of Zunyi Medical University (Zunyi, China) with a 5‑year history of recurrent hypoglycemic symptoms such as dizziness and palpitations. Abdominal magnetic resonance imaging (MRI) showed a mass of ~1.2x1.0 cm in the head of the pancreas, which was suspected to be an insulinoma. For confirmation, the patient underwent both fluorine‑18‑fluorodeoxyglucose (18F‑FDG) and gallium‑68‑labeled 1,4,7,10‑tetraazacyclododecane‑1,4,7,10‑teraacetic acid‑d‑Phel‑Tyr3‑Thr8‑OC (68Ga‑DOTATATE) positron emission tomography/computed tomography (PET/CT), which showed a moderately increased uptake of 18F‑FDG but no uptake of 68Ga‑DOTATATE in the corresponding lesion. The patient subsequently underwent surgery to remove the lesion, which was pathologically confirmed as a pancreatic nesidioblastosis. This case showed that nesidioblastosis should be considered a differential diagnosis for insulinoma and that dual nuclear tracer PET/CT imaging is helpful for differentiating between the two. If conventional imaging techniques such as ultrasound, CT and MRI cannot identify the cause of hypoglycemia in future cases, dual‑nuclide tracer PET/CT imaging should be considered.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu G, Xie L and Hu X: Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report. Exp Ther Med 27: 42, 2024.
APA
Zhu, G., Xie, L., & Hu, X. (2024). Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report. Experimental and Therapeutic Medicine, 27, 42. https://doi.org/10.3892/etm.2023.12330
MLA
Zhu, G., Xie, L., Hu, X."Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report". Experimental and Therapeutic Medicine 27.1 (2024): 42.
Chicago
Zhu, G., Xie, L., Hu, X."Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report". Experimental and Therapeutic Medicine 27, no. 1 (2024): 42. https://doi.org/10.3892/etm.2023.12330
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu G, Xie L and Hu X: Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report. Exp Ther Med 27: 42, 2024.
APA
Zhu, G., Xie, L., & Hu, X. (2024). Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report. Experimental and Therapeutic Medicine, 27, 42. https://doi.org/10.3892/etm.2023.12330
MLA
Zhu, G., Xie, L., Hu, X."Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report". Experimental and Therapeutic Medicine 27.1 (2024): 42.
Chicago
Zhu, G., Xie, L., Hu, X."Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report". Experimental and Therapeutic Medicine 27, no. 1 (2024): 42. https://doi.org/10.3892/etm.2023.12330
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