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Non‑synonymous polymorphisms in the HRC and ADRB1 genes may be associated with all‑cause death in patients with non‑ischemic heart failure

  • Authors:
    • Tanise Machado Telles
    • Bruna Miers May
    • Mauricio Pimentel
    • Bruna Letícia Da Silva Pereira
    • Michael Andrades
    • Luis Eduardo Rohde
    • Kátia Gonçalves Dos Santos
  • View Affiliations / Copyright

    Affiliations: Laboratory of Human Molecular Genetics, Lutheran University of Brazil, Canoas, Rio Grande do Sul 92425‑900, Brazil, Cardiology Division, Clinical Hospital of Porto Alegre, Porto Alegre, Rio Grande do Sul 90035‑903, Brazil, Cells, Tissues and Genes Laboratory, Clinical Hospital of Porto Alegre, Porto Alegre, Rio Grande do Sul 90035‑903, Brazil, Cardiovascular Research Laboratory, Clinical Hospital of Porto Alegre, Porto Alegre, Rio Grande do Sul 90035‑903, Brazil
    Copyright: © Telles et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 48
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    Published online on: December 4, 2023
       https://doi.org/10.3892/etm.2023.12337
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Abstract

Sudden cardiac death (SCD) is an unpredictable and common mode of death in patients with heart failure (HF). Alterations in calcium handling may lead to malignant arrhythmias, resulting in SCD, and variants in calcium signaling‑related genes have a significant association with SCD. Therefore, the aim of the present retrospective cohort study was to investigate the association of Ser96Ala [histidine‑rich calcium‑binding protein (HRC)], Ser49Gly [β1‑adrenergic receptor (ADRB1)], Arg389Gly (ADRB1) and Gly1886Ser [ryanodine receptor 2 (RYR2)] polymorphisms with serious arrhythmic events and overall mortality in patients with HF with reduced left ventricular ejection fraction of non‑ischemic etiology. In total, 136 patients with HF underwent physical examination, routine laboratory tests, non‑invasive assessment of cardiac function and an invasive electrophysiological study. The primary outcome was the occurrence of serious arrhythmic events, set as either SCD or appropriate implantable cardioverter‑­defibrillator (ICD) therapy, and the secondary outcome was all‑cause death. During a median follow‑up of 37 months, arrhythmic events occurred in 26 patients (19%) and 41 patients (30%) died. Patients carrying the Ser allele of the Ser96Ala polymorphism in HRC had worse survival than those with the Ala/Ala genotype (log‑rank P=0.043). Despite the difference in survival time, the Ala/Ala genotype was not associated with all‑cause death in the regression analysis [unadjusted hazard ratio (HR)=0.17; 95% CI, 0.02‑1.21]. Regarding the Ser49Gly and Arg389Gly polymorphisms in ADRB1, homozygosity for the major alleles at both sites (Ser49Ser and Arg389Arg) was associated with a two‑fold increased risk of all‑cause death compared with the other genotype combinations (unadjusted HR=1.98; 95% CI, 1.02‑3.82). However, this association was lost after controlling for clinical covariates. No association was observed for the Gly1886Ser polymorphism in RYR2. Overall, the present findings are concurrent with the hypothesis that the Ser96Ala (HRC), Ser49Gly (ADRB1) and Arg389Gly (ADRB1) polymorphisms may be associated with HF prognosis. In particular, the Ser96Ala polymorphism might aid in risk stratification and patient selection for ICD implantation.
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1 

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, et al: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 24:4–131. 2022.PubMed/NCBI View Article : Google Scholar

2 

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, et al: 2023 Focused update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 44:3627–3639. 2023.PubMed/NCBI View Article : Google Scholar

3 

Roger VL: Epidemiology of heart failure: A contemporary perspective. Circ Res. 128:1421–1434. 2021.PubMed/NCBI View Article : Google Scholar

4 

Mulder BA, van Veldhuisen DJ and Rienstra M: Sudden cardiac death in heart failure: More than meets the eye. Eur J Heart Fail. 23:1361–1363. 2021.PubMed/NCBI View Article : Google Scholar

5 

Elming MB, Hammer-Hansen S, Voges I, Nyktari E, Raja AA, Svendsen JH, Pehrson S, Signorovitch J, Køber L, Prasad SK, et al: Myocardial fibrosis and the effect of primary prophylactic defibrillator implantation in patients with non-ischemic systolic heart failure-DANISH-MRI. Am Heart J. 221:165–176. 2020.PubMed/NCBI View Article : Google Scholar

6 

Jilek C, Lewalter T, Pauschinger M, von Scheidt W, Frankenstein L, Pfister O, Hambrecht R, Bruder O, Brachmann J, Hartmann A, et al: Cardioverter-defibrillator does not improve short-term survival among patients with non-ischemic cardiomyopathy and reduced left ventricular ejection fraction. Clin Res Cardiol. 109:115–123. 2020.PubMed/NCBI View Article : Google Scholar

7 

Merkel ED, Schwertner WR, Behon A, Kuthi L, Veres B, Osztheimer I, Papp R, Molnár L, Zima E, Gellér L, et al: Predicting the survival benefit of cardiac resynchronization therapy with defibrillator function for non-ischemic heart failure-Role of the Goldenberg risk score. Front Cardiovasc Med. 9(1062094)2023.PubMed/NCBI View Article : Google Scholar

8 

Wasiak M, Tajstra M, Kosior D and Gąsior M: An implantable cardioverter-defibrillator for primary prevention in non-ischemic cardiomyopathy: A systematic review and meta-analysis. Cardiol J. 30:117–124. 2023.PubMed/NCBI View Article : Google Scholar

9 

Halliday BP, Cleland JGF, Goldberger JJ and Prasad SK: Personalizing risk stratification for sudden death in dilated cardiomyopathy: The past, present, and future. Circulation. 136:215–231. 2017.PubMed/NCBI View Article : Google Scholar

10 

Escobar-Lopez L, Ochoa JP, Mirelis JG, Espinosa MÁ, Navarro M, Gallego-Delgado M, Barriales-Villa R, Robles-Mezcua A, Basurte-Elorz MT, Gutiérrez García-Moreno L, et al: Association of genetic variants with outcomes in patients with nonischemic dilated cardiomyopathy. J Am Coll Cardiol. 78:1682–1699. 2021.PubMed/NCBI View Article : Google Scholar

11 

Rai V and Agrawal DK: Role of risk stratification and genetics in sudden cardiac death. Can J Physiol Pharmacol. 95:225–238. 2017.PubMed/NCBI View Article : Google Scholar

12 

Tamariz L, Balda J, Pareja D, Palacio A, Myerburg RJ, Conway D, Davis L and Goldberger JJ: Usefulness of single nucleotide polymorphisms as predictors of sudden cardiac death. Am J Cardiol. 123:1900–1905. 2019.PubMed/NCBI View Article : Google Scholar

13 

Li S, Jia Z, Zhang Z, Li Y, Yan M and Yu T: Association study of genetic variants in calcium signaling-related genes with cardiovascular diseases. Front Cell Dev Biol. 9(642141)2021.PubMed/NCBI View Article : Google Scholar

14 

Arvanitis DA, Vafiadaki E, Johnson DM, Kranias EG and Sanoudou D: The histidine-rich calcium binding protein in regulation of cardiac rhythmicity. Front Physiol. 9(1379)2018.PubMed/NCBI View Article : Google Scholar

15 

Hofmann SL, Topham M, Hsieh CL and Francke U: cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. Genomics. 9:656–669. 1991.PubMed/NCBI View Article : Google Scholar

16 

Pollak AJ, Haghighi K, Kunduri S, Arvanitis DA, Bidwell PA, Liu GS, Singh VP, Gonzalez DJ, Sanoudou D, Wiley SE, et al: Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia. Proc Natl Acad Sci USA. 114:9098–9103. 2017.PubMed/NCBI View Article : Google Scholar

17 

Han P, Cai W, Wang Y, Lam CK, Arvanitis DA, Singh VP, Chen S, Zhang H, Zhang R, Cheng H, et al: Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression. Am J Physiol Heart Circ Physiol. 301:H1588–H1595. 2011.PubMed/NCBI View Article : Google Scholar

18 

Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, et al: Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein. J Am Heart Assoc. 2(e000460)2013.PubMed/NCBI View Article : Google Scholar

19 

Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, et al: Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant. Cardiovasc Res. 113:1403–1417. 2017.PubMed/NCBI View Article : Google Scholar

20 

Arvanitis DA, Sanoudou D, Kolokathis F, Vafiadaki E, Papalouka V, Kontrogianni-Konstantopoulos A, Theodorakis GN, Paraskevaidis IA, Adamopoulos S, Dorn GW II, et al: The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy. Eur Heart J. 29:2514–2525. 2008.PubMed/NCBI View Article : Google Scholar

21 

Klappa AJ, Aleong R, Vargas-Estrada A, Morgan G and London B: Abstract 20362: The Ser96Ala variant of the histidine-rich calcium-binding protein is associated with appropriate ICD shocks in cardiomyopathy patients. Circulation. 130(A20362)2014.

22 

Galati F, Galati A and Massari S: RyR2 QQ2958 genotype and risk of malignant ventricular arrhythmias. Cardiol Res Pract. 2016(2868604)2016.PubMed/NCBI View Article : Google Scholar

23 

Mahmood A, Ahmed K and Zhang Y: β-Adrenergic receptor desensitization/down-regulation in heart failure: A friend or foe? Front Cardiovasc Med. 9(925692)2022.PubMed/NCBI View Article : Google Scholar

24 

Ahles A and Engelhardt S: Polymorphic variants of adrenoceptors: Pharmacology, physiology, and role in disease. Pharmacol Rev. 66:598–637. 2014.PubMed/NCBI View Article : Google Scholar

25 

Bencivenga L, Liccardo D, Napolitano C, Visaggi L, Rengo G and Leosco D: β-adrenergic receptor signaling and heart failure: From bench to bedside. Heart Fail Clin. 15:409–419. 2019.PubMed/NCBI View Article : Google Scholar

26 

Thomas CD and Johnson JA: Pharmacogenetic factors affecting β-blocker metabolism and response. Expert Opin Drug Metab Toxicol. 16:953–964. 2020.PubMed/NCBI View Article : Google Scholar

27 

McCrink KA and Lymperopoulos A: β1-adrenoceptor Arg389Gly polymorphism and heart disease: Marching toward clinical practice integration. Pharmacogenomics. 16:1035–1038. 2015.PubMed/NCBI View Article : Google Scholar

28 

Keefe JA, Moore OM, Ho KS and Wehrens XHT: Role of Ca2+ in healthy and pathologic cardiac function: From normal excitation-contraction coupling to mutations that cause inherited arrhythmia. Arch Toxicol. 97:73–92. 2023.PubMed/NCBI View Article : Google Scholar

29 

Benitah JP, Perrier R, Mercadier JJ, Pereira L and Gómez AM: RyR2 and calcium release in heart failure. Front Physiol. 12(734210)2021.PubMed/NCBI View Article : Google Scholar

30 

Koop A, Goldmann P, Chen SR, Thieleczek R and Varsányi M: ARVC-related mutations in divergent region 3 alter functional properties of the cardiac ryanodine receptor. Biophys J. 94:4668–4677. 2008.PubMed/NCBI View Article : Google Scholar

31 

Zhang J, Liu Z, Masumiya H, Wang R, Jiang D, Li F, Wagenknecht T and Chen SR: Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites. J Biol Chem. 278:14211–14218. 2003.PubMed/NCBI View Article : Google Scholar

32 

Francia P, Adduci C, Semprini L, Stanzione R, Serdoz A, Caprinozzi M, Santini D, Cotugno M, Palano F, Musumeci MB, et al: RyR2 common gene variant G1886S and the risk of ventricular arrhythmias in ICD patients with heart failure. J Cardiovasc Electrophysiol. 26:656–661. 2015.PubMed/NCBI View Article : Google Scholar

33 

Ran Y, Chen J, Li N, Zhang W, Feng L, Wang R, Hui R, Zhang S and Pu J: Common RyR2 variants associate with ventricular arrhythmias and sudden cardiac death in chronic heart failure. Clin Sci. 119:215–223. 2010.PubMed/NCBI View Article : Google Scholar

34 

Pimentel M, Zimerman A, Chemello D, Giaretta V, Andrades M, Silvello D, Zimerman L and Rohde LE: Predictors of serious arrhythmic events in patients with nonischemic heart failure. J Interv Card Electrophysiol. 48:131–139. 2017.PubMed/NCBI View Article : Google Scholar

35 

Kochi AN, Pimentel M, Andrades M, Zimerman T, Zimerman LI and Rohde LE: Predictors of total mortality and serious arrhythmic events in non-ischemic heart failure patients: The role of galectin-3. Arq Bras Cardiol. 117:531–541. 2021.PubMed/NCBI View Article : Google Scholar

36 

Lahiri DK and Nurnberger JI Jr: A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 19(5444)1991.PubMed/NCBI View Article : Google Scholar

37 

Griffiths A, Doebley J, Peichel C and Wassarman DA: Introduction to genetic analysis. Macmillan, New York, 12th ed., 2020.

38 

Abramson JH: WINPEPI updated: Computer programs for epidemiologists, and their teaching potential. Epidemiol Perspect Innov. 8(1)2011.PubMed/NCBI View Article : Google Scholar

39 

Biolo A, Clausell N, Santos KG, Salvaro R, Ashton-Prolla P, Borges A and Rohde LE: Impact of beta1-adrenergic receptor polymorphisms on susceptibility to heart failure, arrhythmogenesis, prognosis, and response to beta-blocker therapy. Am J Cardiol. 102:726–732. 2008.PubMed/NCBI View Article : Google Scholar

40 

Biolo A, Salvaro R, Clausell N, Silvello D, Santos KG and Rohde LE: Impact of beta-2 Thr164Ile and combined beta-adrenergic receptor polymorphisms on prognosis in a cohort of heart failure outpatients. Braz J Med Biol Res. 43:565–571. 2010.PubMed/NCBI View Article : Google Scholar

41 

Chemello D, Rohde LE, Santos KG, Silvello D, Goldraich L, Pimentel M, Rosa PR, Zimerman L and Clausell N: Genetic polymorphisms of the adrenergic system and implantable cardioverter-defibrillator therapies in patients with heart failure. Europace. 12:686–691. 2010.PubMed/NCBI View Article : Google Scholar

42 

Liu WN, Fu KL, Gao HY, Shang YY, Wang ZH, Jiang GH, Zhang Y, Zhang W and Zhong M: β1 adrenergic receptor polymorphisms and heart failure: A meta-analysis on susceptibility, response to β-blocker therapy and prognosis. PLoS One. 7(e37659)2012.PubMed/NCBI View Article : Google Scholar

43 

de Groote P, Lamblin N, Helbecque N, Mouquet F, Mc Fadden E, Hermant X, Amouyel P, Dallongeville J and Bauters C: The impact of beta-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure. Eur J Heart Fail. 7:966–973. 2005.PubMed/NCBI View Article : Google Scholar

44 

Kardia SL, Kelly RJ, Keddache MA, Aronow BJ, Grabowski GA, Hahn HS, Case KL, Wagoner LE, Dorn GW II and Liggett SB: Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival. BMC Med Genet. 9(93)2008.PubMed/NCBI View Article : Google Scholar

45 

Sehnert AJ, Daniels SE, Elashoff M, Wingrove JA, Burrow CR, Horne B, Muhlestein JB, Donahue M, Liggett SB, Anderson JL, et al: Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. J Am Coll Cardiol. 52:644–651. 2008.PubMed/NCBI View Article : Google Scholar

46 

Ogimoto A, Okayama H, Nagai T, Suzuki J, Inoue K, Nishimura K, Shigematsu Y, Tabara Y, Miki T and Higaki J: Impact of synergistic polymorphisms in adrenergic receptor-related genes and cardiovascular events in patients with dilated cardiomyopathy. Circ J. 76:2003–2008. 2012.PubMed/NCBI View Article : Google Scholar

47 

Pezzali N, Curnis A, Specchia C, Carubelli V, Covolo L, Donato F, Auricchio A, Regoli F and Metra M: Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy: Preliminary results. Europace. 15:1475–1481. 2013.PubMed/NCBI View Article : Google Scholar

48 

Zanolla L, Guarise P, Tomasi L, Vassanelli C, Cicorella N, Zanini R, Guarrera S, Fiorito G and Matullo G: Association between beta1-adrenergic receptor polymorphism and risk of ICD shock in heart failure patients. Pacing Clin Electrophysiol. 39:557–564. 2016.PubMed/NCBI View Article : Google Scholar

49 

Pereira SB, Velloso MW, Chermont S, Quintão MM, Nunes Abdhala R, Giro C, Oliveira E, Alves T, Camacho V, De Fátima Maia Contarato L, Pena FM, et al: β-adrenergic receptor polymorphisms in susceptibility, response to treatment and prognosis in heart failure: Implication of ethnicity. Mol Med Rep. 7:259–265. 2013.PubMed/NCBI View Article : Google Scholar

50 

Parikh KS, Fiuzat M, Davis G, Neely M, Blain-Nelson P, Whellan DJ, Abraham WT, Adams KF Jr, Felker GM, Liggett SB, et al: Dose response of β-blockers in adrenergic receptor polymorphism genotypes. Circ Genom Precis Med. 11(e002210)2018.PubMed/NCBI View Article : Google Scholar

51 

Cresci S, Kelly RJ, Cappola TP, Diwan A, Dries D, Kardia SL and Dorn GW II: Clinical and genetic modifiers of long-term survival in heart failure. J Am Coll Cardiol. 54:432–444. 2009.PubMed/NCBI View Article : Google Scholar

52 

Petersen M, Andersen JT, Hjelvang BR, Broedbaek K, Afzal S, Nyegaard M, Børglum AD, Stender S, Køber L, Torp-Pedersen C, et al: Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients. Br J Clin Pharmacol. 71:556–565. 2011.PubMed/NCBI View Article : Google Scholar

53 

Guerra LA, Lteif C, Arwood MJ, McDonough CW, Dumeny L, Desai AA, Cavallari LH and Duarte JD: Genetic polymorphisms in ADRB2 and ADRB1 are associated with differential survival in heart failure patients taking β-blockers. Pharmacogenomics J. 22:62–68. 2022.PubMed/NCBI View Article : Google Scholar

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Telles TM, May BM, Pimentel M, Pereira BL, Andrades M, Rohde LE and Dos Santos KG: Non‑synonymous polymorphisms in the <em>HRC</em> and <em>ADRB1</em> genes may be associated with all‑cause death in patients with non‑ischemic heart failure. Exp Ther Med 27: 48, 2024.
APA
Telles, T.M., May, B.M., Pimentel, M., Pereira, B.L., Andrades, M., Rohde, L.E., & Dos Santos, K.G. (2024). Non‑synonymous polymorphisms in the <em>HRC</em> and <em>ADRB1</em> genes may be associated with all‑cause death in patients with non‑ischemic heart failure. Experimental and Therapeutic Medicine, 27, 48. https://doi.org/10.3892/etm.2023.12337
MLA
Telles, T. M., May, B. M., Pimentel, M., Pereira, B. L., Andrades, M., Rohde, L. E., Dos Santos, K. G."Non‑synonymous polymorphisms in the <em>HRC</em> and <em>ADRB1</em> genes may be associated with all‑cause death in patients with non‑ischemic heart failure". Experimental and Therapeutic Medicine 27.1 (2024): 48.
Chicago
Telles, T. M., May, B. M., Pimentel, M., Pereira, B. L., Andrades, M., Rohde, L. E., Dos Santos, K. G."Non‑synonymous polymorphisms in the <em>HRC</em> and <em>ADRB1</em> genes may be associated with all‑cause death in patients with non‑ischemic heart failure". Experimental and Therapeutic Medicine 27, no. 1 (2024): 48. https://doi.org/10.3892/etm.2023.12337
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Spandidos Publications style
Telles TM, May BM, Pimentel M, Pereira BL, Andrades M, Rohde LE and Dos Santos KG: Non‑synonymous polymorphisms in the <em>HRC</em> and <em>ADRB1</em> genes may be associated with all‑cause death in patients with non‑ischemic heart failure. Exp Ther Med 27: 48, 2024.
APA
Telles, T.M., May, B.M., Pimentel, M., Pereira, B.L., Andrades, M., Rohde, L.E., & Dos Santos, K.G. (2024). Non‑synonymous polymorphisms in the <em>HRC</em> and <em>ADRB1</em> genes may be associated with all‑cause death in patients with non‑ischemic heart failure. Experimental and Therapeutic Medicine, 27, 48. https://doi.org/10.3892/etm.2023.12337
MLA
Telles, T. M., May, B. M., Pimentel, M., Pereira, B. L., Andrades, M., Rohde, L. E., Dos Santos, K. G."Non‑synonymous polymorphisms in the <em>HRC</em> and <em>ADRB1</em> genes may be associated with all‑cause death in patients with non‑ischemic heart failure". Experimental and Therapeutic Medicine 27.1 (2024): 48.
Chicago
Telles, T. M., May, B. M., Pimentel, M., Pereira, B. L., Andrades, M., Rohde, L. E., Dos Santos, K. G."Non‑synonymous polymorphisms in the <em>HRC</em> and <em>ADRB1</em> genes may be associated with all‑cause death in patients with non‑ischemic heart failure". Experimental and Therapeutic Medicine 27, no. 1 (2024): 48. https://doi.org/10.3892/etm.2023.12337
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