Open Access

KLF9‑regulated FBXO31 inhibits the progression of endometrial cancer and enhances the sensitivity of endometrial cancer cells to cisplatin

  • Authors:
    • Mudan Yang
    • Changmin Niu
  • View Affiliations

  • Published online on: December 5, 2023     https://doi.org/10.3892/etm.2023.12342
  • Article Number: 54
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Endometrial cancer (EC) is one of the most common malignancies with an increasing annual incidence. F‑box only protein 31 (FBXO31) plays a significant regulatory role in several types of cancer. The transcription factor Krüppel‑like factor 9 (KLF9) of FBXO31 is reduced in EC as a tumor suppressor. However, their particular regulatory role and mechanism in EC have not been previously reported. Therefore, the UALCAN database was used to predict the expression levels of FBXO31 in EC. In addition, the regulatory effect of FBXO31 on EC cell proliferation, invasion, migration, apoptosis and cisplatin (DDP) sensitivity was investigated at the cellular level. The association between KLF9 and FBXO31 was predicted using the JASPAR database and verified by chromatin immunoprecipitation and luciferase reporter assays. Finally, the regulatory effects of KLF9 and FBXO31 overexpression or silencing were also explored. The results demonstrated that FBXO31 was poorly expressed in EC. Additionally, FBXO31 overexpression inhibited the malignant progression of EC cells and enhanced their sensitivity to DDP. Furthermore, KLF9 promoted FBXO31 transcription. Overall, the present study suggested that the KLF9‑mediated regulation of FBXO31 could inhibit the progression of EC and enhance the sensitivity of EC cells to DDP.
View Figures
View References

Related Articles

Journal Cover

February-2024
Volume 27 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang M and Yang M: KLF9‑regulated FBXO31 inhibits the progression of endometrial cancer and enhances the sensitivity of endometrial cancer cells to cisplatin. Exp Ther Med 27: 54, 2024
APA
Yang, M., & Yang, M. (2024). KLF9‑regulated FBXO31 inhibits the progression of endometrial cancer and enhances the sensitivity of endometrial cancer cells to cisplatin. Experimental and Therapeutic Medicine, 27, 54. https://doi.org/10.3892/etm.2023.12342
MLA
Yang, M., Niu, C."KLF9‑regulated FBXO31 inhibits the progression of endometrial cancer and enhances the sensitivity of endometrial cancer cells to cisplatin". Experimental and Therapeutic Medicine 27.2 (2024): 54.
Chicago
Yang, M., Niu, C."KLF9‑regulated FBXO31 inhibits the progression of endometrial cancer and enhances the sensitivity of endometrial cancer cells to cisplatin". Experimental and Therapeutic Medicine 27, no. 2 (2024): 54. https://doi.org/10.3892/etm.2023.12342