Open Access

Early depressive manifestations in patients with dementia caused by Alzheimer's disease

  • Authors:
    • Fabiola Sârbu
    • Mihaela Lungu
    • Violeta Diana Oprea
    • Aurelia Romila
  • View Affiliations

  • Published online on: December 8, 2023     https://doi.org/10.3892/etm.2023.12344
  • Article Number: 56
  • Copyright: © Sârbu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies on the complex interplay between depression and dementia in patients with Alzheimer's disease revealed that early‑life depression is a risk factor for dementia. Both depression and dementia appear to share common etiopathological mechanisms. In the present study, a comprehensive retrospective analysis was performed on a study group of patients with dementia suffering from previously diagnosed depression. The aim was to assess potentially relevant clinical and imaging parameters that can be used to characterize depression as a risk factor for dementia in later life. Statistically significant data correlating cognitive scores with the moment of depression onset and the length of time period to the diagnosis of dementia were identified. Furthermore, at the moment of depression diagnosis, structural cerebral alterations tended to appear more frequently in women compared with men. However, this sex‑associated difference is not maintained after the moment of dementia diagnosis. Results from the present study contributed additional data to the evidence supporting a relationship between a history of depression and the occurrence of Alzheimer's disease, discussing relevant clinical and imaging parameters featured in patients with dementia and their inter‑relations.
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February-2024
Volume 27 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Sârbu F, Lungu M, Oprea VD and Romila A: Early depressive manifestations in patients with dementia caused by Alzheimer's disease. Exp Ther Med 27: 56, 2024
APA
Sârbu, F., Lungu, M., Oprea, V.D., & Romila, A. (2024). Early depressive manifestations in patients with dementia caused by Alzheimer's disease. Experimental and Therapeutic Medicine, 27, 56. https://doi.org/10.3892/etm.2023.12344
MLA
Sârbu, F., Lungu, M., Oprea, V. D., Romila, A."Early depressive manifestations in patients with dementia caused by Alzheimer's disease". Experimental and Therapeutic Medicine 27.2 (2024): 56.
Chicago
Sârbu, F., Lungu, M., Oprea, V. D., Romila, A."Early depressive manifestations in patients with dementia caused by Alzheimer's disease". Experimental and Therapeutic Medicine 27, no. 2 (2024): 56. https://doi.org/10.3892/etm.2023.12344