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Early depressive manifestations in patients with dementia caused by Alzheimer's disease

  • Authors:
    • Fabiola Sârbu
    • Mihaela Lungu
    • Violeta Diana Oprea
    • Aurelia Romila
  • View Affiliations / Copyright

    Affiliations: Elisabeta Doamna Psychiatric Hospital of Galati, 800179 Galați, Romania, Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 800216 Galati, Romania
    Copyright: © Sârbu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 56
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    Published online on: December 8, 2023
       https://doi.org/10.3892/etm.2023.12344
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Abstract

Previous studies on the complex interplay between depression and dementia in patients with Alzheimer's disease revealed that early‑life depression is a risk factor for dementia. Both depression and dementia appear to share common etiopathological mechanisms. In the present study, a comprehensive retrospective analysis was performed on a study group of patients with dementia suffering from previously diagnosed depression. The aim was to assess potentially relevant clinical and imaging parameters that can be used to characterize depression as a risk factor for dementia in later life. Statistically significant data correlating cognitive scores with the moment of depression onset and the length of time period to the diagnosis of dementia were identified. Furthermore, at the moment of depression diagnosis, structural cerebral alterations tended to appear more frequently in women compared with men. However, this sex‑associated difference is not maintained after the moment of dementia diagnosis. Results from the present study contributed additional data to the evidence supporting a relationship between a history of depression and the occurrence of Alzheimer's disease, discussing relevant clinical and imaging parameters featured in patients with dementia and their inter‑relations.
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1 

Brzezińska A, Bourke J, Rivera-Hernández R, Tsolaki M, Woźniak J and Kaźmierski J: Depression in dementia or dementia in depression? Systematic review of studies and hypotheses. Curr Alzheimer Res. 17:16–28. 2020.PubMed/NCBI View Article : Google Scholar

2 

Byers A and Yaffe K: Depression and risk of developing dementia. Nat Rev Neurol. 7:323–331. 2011.PubMed/NCBI View Article : Google Scholar

3 

WHO data-updated March 2023. Available from: https://www.who.int/health-topics/dementia#tab=tab_2. Accessed on 28 April 2023.

4 

GBD 2016 Dementia Collaborators. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: A systematic analysis for the global burden of disease study 2016. Lancet Neurol. 18:88–106. 2019.PubMed/NCBI View Article : Google Scholar

5 

Javaid SF, Giebel C, Khan MA and Hashim MJ: Epidemiology of Alzheimer's disease and other dementias: Rising global burden and forecasted trends [version 1; peer review: 1 Approved with reservations]. F1000Res. 10(425)2021.

6 

Sousa RM, Ferri CP, Acosta D, Albanese E, Guerra M, Huang Y, Jacob KS, Jotheeswaran AT, Rodriguez JJ, Pichardo GR, et al: Contribution of chronic diseases to disability in elderly people in countries with low and middle incomes: A 10/66 dementia research group population-based survey. Lancet. 374:1821–1830. 2009.PubMed/NCBI View Article : Google Scholar

7 

Barnes DE and Yaffe K: The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 10:819–828. 2011.PubMed/NCBI View Article : Google Scholar

8 

Enache D, Winblad B and Aarsland D: Depression in dementia: Epidemiology, mechanisms, and treatment. Curr Opin Psychiatry. 24:461–472. 2011.PubMed/NCBI View Article : Google Scholar

9 

Diniz BS, Butters MA, Albert SM, Dew MA and Reynolds CF III: Late-life depression and risk of vascular dementia and Alzheimer's disease: Systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry. 202:329–335. 2013.PubMed/NCBI View Article : Google Scholar

10 

Aizenstein HJ, Baskys A, Boldrini M, Butters MA, Diniz BS, Jaiswal MK, Jellinger KA, Kruglov LS, Meshandin IA, Mijajlovic MD, et al: Vascular depression consensus report-a critical update. BMC Med. 14(161)2016.PubMed/NCBI View Article : Google Scholar

11 

Taylor WD, Aizenstein HJ and Alexopoulos GS: The vascular depression hypothesis: Mechanisms linking vascular disease with depression. Mol Psychiatry. 18:963–974. 2013.PubMed/NCBI View Article : Google Scholar

12 

Riddle M, Potter GG, McQuoid DR, Steffens DC, Beyer JL and Taylor WD: Longitudinal cognitive outcomes of clinical phenotypes of late-life depression. Am J Geriatr Psychiatry. 25:1123–1134. 2017.PubMed/NCBI View Article : Google Scholar

13 

Muliyala KP and Varghese M: The complex relationship between depression and dementia. Ann Indian Acad Neurol. 13 (Suppl 2):S69–S73. 2010.PubMed/NCBI View Article : Google Scholar

14 

Leonard BE: Inflammation, depression and dementia: Are they connected? Neurochem Res. 32:1749–1756. 2007.PubMed/NCBI View Article : Google Scholar

15 

Ly M and Andreescu C: Advances and barriers for clinical neuroimaging in late-life mood and anxiety disorders. Curr Psychiatry Rep. 20(7)2018.PubMed/NCBI View Article : Google Scholar

16 

Palsetia D, Rao GP, Tiwari SC, Lodha P and De Sousa A: The clock drawing test versus mini-mental status examination as a screening tool for dementia: A clinical comparison. Indian J Psychol Med. 40:1–10. 2018.PubMed/NCBI View Article : Google Scholar

17 

Kørner A, Lauritzen L, Abelskov K, Gulmann N, Marie Brodersen A, Wedervang-Jensen T and Marie Kjeldgaard K: The geriatric depression scale and the cornell scale for depression in dementia. A validity study. Nord J Psychiatry. 60:360–364. 2006.PubMed/NCBI View Article : Google Scholar

18 

Ismail Z, Rajji TK and Shulman KI: Brief cognitive screening instruments: An update. Int J Geriatr Psychiatry. 25:111–120. 2010.PubMed/NCBI View Article : Google Scholar

19 

WMA Declaration of Helsinki-Ethical Principles for Medical Research Involving Human Subjects-7th revision, 2013. Available from: https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/ Accessed on 28.04.2023.

20 

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, et al: Dementia prevention, intervention, and care: 2020 Report of the lancet commission. Lancet. 396:413–446. 2020.PubMed/NCBI View Article : Google Scholar

21 

Rastad S, Barjaste N, Lanjanian H, Moeini A, Kiani F and Masoudi-Nejad A: Parallel molecular alteration between Alzheimer's disease and major depressive disorder in the human brain dorsolateral prefrontal cortex: An insight from gene expression and methylation profile analyses. Genes Genet Syst. 97:311–324. 2023.PubMed/NCBI View Article : Google Scholar

22 

Błaszczyk JW: Pathogenesis of dementia. Int J Mol Sci. 24(543)2022.PubMed/NCBI View Article : Google Scholar

23 

Du F, Yu Q, Swerdlow RH and Waites CL: Glucocorticoid-driven mitochondrial damage stimulates Tau pathology. Brain. 146:4378–4394. 2023.PubMed/NCBI View Article : Google Scholar

24 

Phillips C: Brain-derived neurotrophic factor, depression, and physical activity: Making the neuroplastic connection. Neural Plast. 2017(7260130)2017.PubMed/NCBI View Article : Google Scholar

25 

Rapp MA, Schnaider-Beeri M, Wysocki M, Guerrero-Berroa E, Grossman HT, Heinz A and Haroutunian V: Cognitive decline in patients with dementia as a function of depression. Am J Geriatr Psychiatry. 19:357–363. 2011.PubMed/NCBI View Article : Google Scholar

26 

Almeida OP, Hankey GJ, Yeap BB, Golledge J and Flicker L: Depression as a modifiable factor to decrease the risk of dementia. Transl Psychiatry. 7(e1117)2017.PubMed/NCBI View Article : Google Scholar

27 

Zhang Y, Geng R, Liu M, Deng S, Ding J, Zhong H and Tu Q: Shared peripheral blood biomarkers for Alzheimer's disease, major depressive disorder, and type 2 diabetes and cognitive risk factor analysis. Heliyon. 9(e14653)2023.PubMed/NCBI View Article : Google Scholar

28 

Réus GZ, Titus SE, Abelaira HM, Freitas SM, Tuon T, Quevedo J and Budni J: Neurochemical correlation between major depressive disorder and neurodegenerative diseases. Life Sci. 158:121–129. 2016.PubMed/NCBI View Article : Google Scholar

29 

Fanelli G, Franke B, De Witte W, Ruisch IH, Haavik J, van Gils V, Jansen WJ, Vos SJB, Lind L, Buitelaar JK, et al: Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders. Transl Psychiatry. 12(59)2022.PubMed/NCBI View Article : Google Scholar

30 

Harerimana NV, Liu Y, Gerasimov ES, Duong D, Beach TG, Reiman EM, Schneider JA, Boyle P, Lori A, Bennett DA, et al: Genetic evidence supporting a causal role of depression in Alzheimer's disease. Biol Psychiatry. 92:25–33. 2022.PubMed/NCBI View Article : Google Scholar

31 

Ni H, Xu M, Zhan GL, Fan Y, Zhou H, Jiang HY, Lu WH, Tan L, Zhang DF, Yao YG and Zhang C: The GWAS risk genes for depression may be actively involved in Alzheimer's disease. J Alzheimers Dis. 64:1149–1161. 2018.PubMed/NCBI View Article : Google Scholar

32 

Ghasemi M, Phillips C, Fahimi A, McNerney MW and Salehi A: Mechanisms of action and clinical efficacy of NMDA receptor modulators in mood disorders. Neurosci Biobehav Rev. 80:555–572. 2017.PubMed/NCBI View Article : Google Scholar

33 

Yatawara C, Lim L, Chander R, Zhou J and Kandiah N: Depressive symptoms influence global cognitive impairment indirectly by reducing memory and executive function in patients with mild cognitive impairment. J Neurol Neurosurg Psychiatry. 87:1375–1383. 2016.PubMed/NCBI View Article : Google Scholar

34 

Holmquist S, Nordström A and Nordström P: The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016. PLoS Med. 17(e1003016)2020.PubMed/NCBI View Article : Google Scholar

35 

Gurgu M, Zamfirescu A, Stroie AM and Aurel R: Cognitive impairment prevalence and correlations with subjective memory impairment: Findings from Brasov, Romania. J Nutr Health Aging. 16(862)2012.

36 

Kane RL, Butler M, Fink HA, Brasure M, Davila H, Desai P, Jutkowitz E, McCreedy E, Nelson VA, McCarten JR, et al: Interventions to prevent age-related cognitive decline, mild cognitive impairment, and clinical Alzheimer's-type dementia. Comparative Effectiveness Review No. 188. (Prepared by the Minnesota Evidence-based Practice Center under Contract No. 290-2015-00008-I.) AHRQ Publication No. 17-EHC008-EF. Rockville, MD: Agency for Healthcare Research and Quality; March 2017. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

37 

Amidfar M, Garcez ML and Kim YK: The shared molecular mechanisms underlying aging of the brain, major depressive disorder, and Alzheimer's disease: The role of circadian rhythm disturbances. Prog Neuropsychopharmacol Biol Psychiatry. 123(110721)2023.PubMed/NCBI View Article : Google Scholar

38 

Morgan SL, Naderi P, Koler K, Pita-Juarez Y, Prokopenko D, Vlachos IS, Tanzi RE, Bertram L and Hide WA: Most pathways can be related to the pathogenesis of Alzheimer's disease. Front Aging Neurosci. 14(846902)2022.PubMed/NCBI View Article : Google Scholar

39 

Bou Khalil R, Khoury E and Koussa S: Linking multiple pathogenic pathways in Alzheimer's disease. World J Psychiatr. 6:208–214. 2016.PubMed/NCBI View Article : Google Scholar

40 

Du Y, Yan F, Zhao L, Fang Y, Qiu Q, Wei W, Wang J, Tang Y, Lin X and Li X: Depression symptoms moderate the relationship between gray matter volumes and cognitive function in patients with mild cognitive impairment. J Psychiatr Res. 151:516–522. 2022.PubMed/NCBI View Article : Google Scholar

41 

Botto R, Callai N, Cermelli A, Causarano L and Rainero I: Anxiety and depression in Alzheimer's disease: A systematic review of pathogenetic mechanisms and relation to cognitive decline. Neurol Sci. 43:4107–4124. 2022.PubMed/NCBI View Article : Google Scholar

42 

Bature F, Guinn BA, Pang D and Pappas Y: Signs and symptoms preceding the diagnosis of Alzheimer's disease: A systematic scoping review of literature from 1937 to 2016. BMJ Open. 7(e015746)2017.PubMed/NCBI View Article : Google Scholar

43 

Ismail Z, Gatchel J, Bateman DR, Barcelos-Ferreira R, Cantillon M, Jaeger J, Donovan NJ and Mortby ME: Affective and emotional dysregulation as pre-dementia risk markers: Exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria. Int Psychogeriatr. 30:185–196. 2018.PubMed/NCBI View Article : Google Scholar

44 

Morozova A, Zorkina Y, Abramova O, Pavlova O, Pavlov K, Soloveva K, Volkova M, Alekseeva P, Andryshchenko A, Kostyuk G, et al: Neurobiological highlights of cognitive impairment in psychiatric disorders. Int J Mol Sci. 23(1217)2022.PubMed/NCBI View Article : Google Scholar

45 

Oprea VD, Marinescu M, Rișcă Popazu C, Sârbu F, Onose G and Romila A: Cardiovascular comorbidities in relation to the functional status and vitamin D levels in elderly patients with dementia. Diagnostics (Basel). 12(2994)2022.PubMed/NCBI View Article : Google Scholar

46 

Wang JH, Wu YJ, Tee BL and Lo RY: Medical comorbidity in Alzheimer's disease: A nested case-control study. J Alzheimers Dis. 63:773–781. 2018.PubMed/NCBI View Article : Google Scholar

47 

Weber CJ, Carrillo MC, Jagust W, Jack CR Jr, Shaw LM, Trojanowski JQ, Saykin AJ, Beckett LA, Sur C, Rao NP, et al: The worldwide Alzheimer's disease neuroimaging initiative: ADNI-3 updates and global perspectives. Alzheimer's Dement. 7(e12226)2021.PubMed/NCBI View Article : Google Scholar

48 

Li H, Tan CC, Tan L and Xu W: Predictors of cognitive deterioration in subjective cognitive decline: Evidence from longitudinal studies and implications for SCD-plus criteria. J Neurol Neurosurg Psychiatry. 94:844–854. 2023.PubMed/NCBI View Article : Google Scholar

49 

Sinclair LI and Ballard CG: Alzheimer's Disease Neuroimaging Initiative. Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer's disease. Int J Geriatr Psychiatry. 38(e5858)2023.PubMed/NCBI View Article : Google Scholar

50 

Walia N, Eratne D, Loi SM, Farrand S, Li QX, Malpas CB, Varghese S, Walterfang M, Evans AH, Parker S, et al: Cerebrospinal fluid neurofilament light and cerebral atrophy in younger-onset dementia and primary psychiatric disorders. Intern Med J. 53:1564–1569. 2023.PubMed/NCBI View Article : Google Scholar

51 

Dintica CS, Habes M, Erus G, Simone T, Schreiner P and Yaffe K: Long-term depressive symptoms and midlife brain age. J Affect Disord. 320:436–441. 2023.PubMed/NCBI View Article : Google Scholar

52 

Gerritsen L, Sigurdsson S, Jonsson PV, Gudnason V, Launer LJ and Geerlings MI: Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study. Neurobiol Aging. 111:14–23. 2022.PubMed/NCBI View Article : Google Scholar

53 

Siafarikas N, Alnæs D, Monereo-Sanchez J, Lund MJ, Selbaek G, Stylianou-Korsnes M, Persson K, Barca ML, Almdahl IS, Fladby T, et al: Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment and Alzheimer's disease with dementia. Int Psychogeriatr. 33:1217–1228. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Sârbu F, Lungu M, Oprea VD and Romila A: Early depressive manifestations in patients with dementia caused by Alzheimer's disease. Exp Ther Med 27: 56, 2024.
APA
Sârbu, F., Lungu, M., Oprea, V.D., & Romila, A. (2024). Early depressive manifestations in patients with dementia caused by Alzheimer's disease. Experimental and Therapeutic Medicine, 27, 56. https://doi.org/10.3892/etm.2023.12344
MLA
Sârbu, F., Lungu, M., Oprea, V. D., Romila, A."Early depressive manifestations in patients with dementia caused by Alzheimer's disease". Experimental and Therapeutic Medicine 27.2 (2024): 56.
Chicago
Sârbu, F., Lungu, M., Oprea, V. D., Romila, A."Early depressive manifestations in patients with dementia caused by Alzheimer's disease". Experimental and Therapeutic Medicine 27, no. 2 (2024): 56. https://doi.org/10.3892/etm.2023.12344
Copy and paste a formatted citation
x
Spandidos Publications style
Sârbu F, Lungu M, Oprea VD and Romila A: Early depressive manifestations in patients with dementia caused by Alzheimer's disease. Exp Ther Med 27: 56, 2024.
APA
Sârbu, F., Lungu, M., Oprea, V.D., & Romila, A. (2024). Early depressive manifestations in patients with dementia caused by Alzheimer's disease. Experimental and Therapeutic Medicine, 27, 56. https://doi.org/10.3892/etm.2023.12344
MLA
Sârbu, F., Lungu, M., Oprea, V. D., Romila, A."Early depressive manifestations in patients with dementia caused by Alzheimer's disease". Experimental and Therapeutic Medicine 27.2 (2024): 56.
Chicago
Sârbu, F., Lungu, M., Oprea, V. D., Romila, A."Early depressive manifestations in patients with dementia caused by Alzheimer's disease". Experimental and Therapeutic Medicine 27, no. 2 (2024): 56. https://doi.org/10.3892/etm.2023.12344
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