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Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity

  • Authors:
    • Ke Chen
    • Yehong Liu
    • Baida Xu
    • Ting Ye
    • Liang Chen
    • Gangyong Wu
    • Gangjun Zong
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 60
    |
    Published online on: December 12, 2023
       https://doi.org/10.3892/etm.2023.12348
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Abstract

Coronary atherosclerosis is a chronic systemic inflammatory disease. Laboratory parameters such as the neutrophil‑to‑lymphocyte ratio (NLR), platelet‑to‑lymphocyte ratio (PLR) and systemic immune inflammation index (SII) have been used to assess inflammation degree and coronary artery disease (CAD) severity. The lymphocyte‑to‑C‑reactive protein ratio (LCR) is a new SII. However, its relationship with CAD development and severity is unclear. A total of 1,107 patients (479 in control group, 628 in CAD group) underwent coronary angiography. The routine and biochemical indices of the venous blood of patients were assessed before coronary angiography. LCR, SII, NLR and PLR were calculated and statistical analyses were performed. Propensity score matching (PSM) and a logistic regression model were used to analyze the relationship between LCR and CAD. After the PSM, 384 pairs of patients with or without CAD were successfully matched. After the median binary classification of all indicators, uni‑ and multivariate logistic regression analyses showed that platelet count was an independent risk factor and LCR was an independent protective factor. Using the same method, in the coronary heart disease severity group, 212 pairs were successfully matched and NLR and PLR were independent risk factors, while LCR was an independent protective factor. In conclusion, LCR is an independent protective factor against CAD development and severity.
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Copy and paste a formatted citation
Spandidos Publications style
Chen K, Liu Y, Xu B, Ye T, Chen L, Wu G and Zong G: Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity. Exp Ther Med 27: 60, 2024.
APA
Chen, K., Liu, Y., Xu, B., Ye, T., Chen, L., Wu, G., & Zong, G. (2024). Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity. Experimental and Therapeutic Medicine, 27, 60. https://doi.org/10.3892/etm.2023.12348
MLA
Chen, K., Liu, Y., Xu, B., Ye, T., Chen, L., Wu, G., Zong, G."Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity". Experimental and Therapeutic Medicine 27.2 (2024): 60.
Chicago
Chen, K., Liu, Y., Xu, B., Ye, T., Chen, L., Wu, G., Zong, G."Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity". Experimental and Therapeutic Medicine 27, no. 2 (2024): 60. https://doi.org/10.3892/etm.2023.12348
Copy and paste a formatted citation
x
Spandidos Publications style
Chen K, Liu Y, Xu B, Ye T, Chen L, Wu G and Zong G: Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity. Exp Ther Med 27: 60, 2024.
APA
Chen, K., Liu, Y., Xu, B., Ye, T., Chen, L., Wu, G., & Zong, G. (2024). Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity. Experimental and Therapeutic Medicine, 27, 60. https://doi.org/10.3892/etm.2023.12348
MLA
Chen, K., Liu, Y., Xu, B., Ye, T., Chen, L., Wu, G., Zong, G."Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity". Experimental and Therapeutic Medicine 27.2 (2024): 60.
Chicago
Chen, K., Liu, Y., Xu, B., Ye, T., Chen, L., Wu, G., Zong, G."Relationship between the lymphocyte to C‑reactive protein ratio and coronary artery disease severity". Experimental and Therapeutic Medicine 27, no. 2 (2024): 60. https://doi.org/10.3892/etm.2023.12348
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