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Article

Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration

  • Authors:
    • Pu Lv
    • Linwei Zhang
    • Xin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, Department of Neurology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China
  • Article Number: 61
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    Published online on: December 13, 2023
       https://doi.org/10.3892/etm.2023.12349
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Abstract

Early neurological deterioration (END) is an unfavorable outcome of acute ischemic stroke and is associated with poor prognosis. Blood pressure variability has been suggested to be involved in the development of END. Therefore, the present study investigated the association between blood pressure variability and the development of END. In the present prospective observational study, 286 patients who developed acute ischemic stroke and then hospitalized within 24 h of stroke onset were recruited. Blood pressure parameters (systolic blood pressure, diastolic blood pressure and pulse pressure) were monitored using a 24 h ambulatory sphygmomanometer within 72 h of ischemic onset. Clinical characteristics were also recorded. Multivariate logistic regression analysis was used to analyze the possible relationship between blood pressure parameters and END after adjustment for confounders. Of the 286 patients in the present study, 64 (22.3%) developed END. Pulse pressure variables, including the mean of 24‑h pulse pressure (24‑h PPMEAN) and the mean of daytime pulse pressure (Day PPMEAN), were found to be higher in the END group compared with those in the non‑END group (P<0.05). Multivariate logistic regression analysis revealed that the blood pressure parameters 24‑h PPMEAN [odds ratio (OR), 1.08; 95% CI, 1.01‑1.16; P=0.02) and Day PPMEAN (OR, 1.20; 95% CI, 1.011‑1.45; P=0.04) were significantly associated with END. These findings suggest that the pulse pressure level fluctuations during the acute stage of ischemic stroke can serve important roles in the development of END, which worsens outcomes after stroke.
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Copy and paste a formatted citation
Spandidos Publications style
Lv P, Zhang L and Chen X: Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration. Exp Ther Med 27: 61, 2024.
APA
Lv, P., Zhang, L., & Chen, X. (2024). Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration. Experimental and Therapeutic Medicine, 27, 61. https://doi.org/10.3892/etm.2023.12349
MLA
Lv, P., Zhang, L., Chen, X."Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration". Experimental and Therapeutic Medicine 27.2 (2024): 61.
Chicago
Lv, P., Zhang, L., Chen, X."Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration". Experimental and Therapeutic Medicine 27, no. 2 (2024): 61. https://doi.org/10.3892/etm.2023.12349
Copy and paste a formatted citation
x
Spandidos Publications style
Lv P, Zhang L and Chen X: Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration. Exp Ther Med 27: 61, 2024.
APA
Lv, P., Zhang, L., & Chen, X. (2024). Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration. Experimental and Therapeutic Medicine, 27, 61. https://doi.org/10.3892/etm.2023.12349
MLA
Lv, P., Zhang, L., Chen, X."Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration". Experimental and Therapeutic Medicine 27.2 (2024): 61.
Chicago
Lv, P., Zhang, L., Chen, X."Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration". Experimental and Therapeutic Medicine 27, no. 2 (2024): 61. https://doi.org/10.3892/etm.2023.12349
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