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Case Report Open Access

Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report

  • Authors:
    • Qian Wang
    • Jian Geng
    • Xiaobei Liu
    • Cheng Chen
    • Xiaoyuan Chu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, Jiangsu 210000, P.R. China, Department of Medical Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 21000, P.R. China, Department of Medical Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 21000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 67
    |
    Published online on: December 18, 2023
       https://doi.org/10.3892/etm.2023.12355
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Abstract

Sarcoidosis is an idiopathic multisystem disorder with unknown etiology. Due to clinical similarities among sarcoidosis, tuberculosis (TB) infection and malignant diseases (such as lymphoma, lung carcinoma and pituitary tumor), the diagnosis of sarcoidosis is challenging. The present report describes a case of sarcoidosis in a 48‑year‑old male with complaint of chest pain 1 month after Coronavirus disease 2019. The patient underwent whole‑body 18F‑fluorodeoxyglucose (18F‑FDG) PET‑CT imaging, which revealed multiple lymphadenopathies throughout the body without lung parenchyma involvement. Biochemical examinations such as T‑SPOT.TB test and pathological examination of right supraclavicular lymph node revealed positive T‑SPOT.TB but negative Ziehl‑Neelsen staining. However, non‑caseating epithelioid granulomas were observed in the mediastinal biopsy, indicating the diagnosis of sarcoidosis. The patient was clinically stable, and the symptom of chest pain was gradually relieved without any specific treatment. Outpatient follow‑up continued every 3 months. The present case suggested a possible link between coronavirus infection and sarcoidosis, which suggests the advantages of 18F‑FDG PET‑CT for the detection of sarcoidosis. However, T‑SPOT.TB is insufficient for differentiating between sarcoidosis and TB.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Geng J, Liu X, Chen C and Chu X: Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report. Exp Ther Med 27: 67, 2024.
APA
Wang, Q., Geng, J., Liu, X., Chen, C., & Chu, X. (2024). Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report. Experimental and Therapeutic Medicine, 27, 67. https://doi.org/10.3892/etm.2023.12355
MLA
Wang, Q., Geng, J., Liu, X., Chen, C., Chu, X."Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report". Experimental and Therapeutic Medicine 27.2 (2024): 67.
Chicago
Wang, Q., Geng, J., Liu, X., Chen, C., Chu, X."Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report". Experimental and Therapeutic Medicine 27, no. 2 (2024): 67. https://doi.org/10.3892/etm.2023.12355
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Geng J, Liu X, Chen C and Chu X: Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report. Exp Ther Med 27: 67, 2024.
APA
Wang, Q., Geng, J., Liu, X., Chen, C., & Chu, X. (2024). Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report. Experimental and Therapeutic Medicine, 27, 67. https://doi.org/10.3892/etm.2023.12355
MLA
Wang, Q., Geng, J., Liu, X., Chen, C., Chu, X."Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report". Experimental and Therapeutic Medicine 27.2 (2024): 67.
Chicago
Wang, Q., Geng, J., Liu, X., Chen, C., Chu, X."Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report". Experimental and Therapeutic Medicine 27, no. 2 (2024): 67. https://doi.org/10.3892/etm.2023.12355
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