Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2024 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2024 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome

  • Authors:
    • Guohong Zheng
    • Jiansheng Zheng
    • Xiangrong Hu
    • Tang Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The First Hospital of Putian, Putian, Fujian 351199, P.R. China, Key Laboratory of Translational Tumor Medicine in Fujian Province, School of Basic Medical Science, Putian University, Putian, Fujian 351100, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 69
    |
    Published online on: December 19, 2023
       https://doi.org/10.3892/etm.2023.12357
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Incomplete pulmonary function and insufficient production of pulmonary surfactant in premature infants may affect alveolar relaxation, inducing neonatal respiratory distress syndrome (NRDS). The present study was a retrospective comparison of lipid metabolism indexes and clinic information between NRDS and non‑NRDS infants. Data on general information, pregnancy, clinical symptoms, family history as well as plasma biochemical and lipid metabolic indexes were retrospectively collected and statistically analyzed from 79 patients with NRDS and 44 non‑NRDS infants. Infants in the NRDS group showed lower body weight (2,055 vs. 3,225 g) and gestation age (33.39 vs. 38.53 weeks) than those in the non‑NRDS group (P<0.05). Baseline information was corrected by the inverse probability of treatment weighting (IPTW) analysis. The weighted adjusted median age was the same in both groups and there was no significant difference between two groups in birth weight. The IPTW analysis revealed that the levels of plasma triglyceride (TG), total cholesterol, low‑density lipoprotein, free triiodothyronine, free thyroxine, glucose, calcium (Ca2+) and phosphorus in the NRDS infants were significantly lower compared with those in the non‑NRDS infants. Additionally, NRDS infants had significantly higher incidence rates of pneumonia, sepsis, brain injury infection, preterm birth, patent foramen ovale, patent ductus arteriosus and premature rupture of membranes compared with the non‑NRDS infants (P<0.05). Multivariate logistic analysis showed that TG and Ca2+ were risk factors associated with NRDS (P<0.05). Infants with NRDS have significantly lower levels of plasma lipid indexes. The results of the present study provide data to guide the clinical management of NRDS.
View Figures
View References

1 

Thompson BT, Chambers RC and Liu KD: Acute respiratory distress syndrome. N Engl J Med. 377:562–572. 2017.PubMed/NCBI View Article : Google Scholar

2 

Khemani RG, Smith LS, Zimmerman JJ and Erickson S: Pediatric Acute Lung Injury Consensus Conference Group. Pediatric acute respiratory distress syndrome: Definition, incidence, and epidemiology: Proceedings from the pediatric acute lung injury consensus conference. Pediatr Crit Care Med. 16 (5 Suppl 1):S23–S40. 2015.PubMed/NCBI View Article : Google Scholar

3 

Tochie JN, Choukem SP, Langmia RN, Barla E and Koki-Ndombo P: Neonatal respiratory distress in a reference neonatal unit in Cameroon: An analysis of prevalence, predictors, etiologies and outcomes. Pan Afr Med J. 24(152)2016.PubMed/NCBI View Article : Google Scholar

4 

Schouten LR, Veltkamp F, Bos AP, van Woensel JB, Serpa Neto A, Schultz MJ and Wösten-van Asperen RM: Incidence and mortality of acute respiratory distress syndrome in children: A systematic review and meta-analysis. Crit Care Med. 44:819–829. 2016.PubMed/NCBI View Article : Google Scholar

5 

Liu J, Cao HY, Wang HW and Kong XY: The role of lung ultrasound in diagnosis of respiratory distress syndrome in newborn infants. Iran J Pediatr. 24:147–154. 2014.PubMed/NCBI

6 

Wang J, Liu X, Zhu T and Yan C: Analysis of neonatal respiratory distress syndrome among different gestational segments. Int J Clin Exp Med. 8:16273–16279. 2015.PubMed/NCBI

7 

Wang T: Physiology, 9th edition. People's Medical Publishing House, 2018.

8 

Lane DM, McConathy WJ, McCaffree MA and Hall M: Cord serum lipid and apolipoprotein levels in preterm infants with the neonatal respiratory distress syndrome. J Matern Fetal Neonatal Med. 11:118–125. 2002.PubMed/NCBI View Article : Google Scholar

9 

Hassan HGEMA, Nagi MAMA, Salama AMM, Dawoud MOAEA, Elgendy GG and Abdelrahman AS: Sonographic prediction of fetal main pulmonary artery (MPA) Doppler indices of lung maturity and neonatal respiratory distress syndrome (RDS) development. J Ultrasound. 26:525–533. 2023.PubMed/NCBI View Article : Google Scholar

10 

Whitsett JA and Weaver TE: Alveolar development and disease. Am J Respir Cell Mol Biol. 53:1–7. 2015.PubMed/NCBI View Article : Google Scholar

11 

Hass MA and Longmore WJ: Surfactant cholesterol metabolism of the isolated perfused rat lung. Biochim Biophys Acta. 573:166–174. 1979.PubMed/NCBI View Article : Google Scholar

12 

Voyno-Yasenetskaya TA, Dobbs LG, Erickson SK and Hamilton RL: Low density lipoprotein- and high density lipoprotein-mediated signal transduction and exocytosis in alveolar type II cells. Proc Natl Acad Sci USA. 90:4256–4260. 1993.PubMed/NCBI View Article : Google Scholar

13 

Ryan AJ, Medh JD, McCoy DM, Salome RG and Mallampalli RK: Maternal loading with very low-density lipoproteins stimulates fetal surfactant synthesis. Am J Physiol Lung Cell Mol Physiol. 283:L310–L318. 2002.PubMed/NCBI View Article : Google Scholar

14 

Shao XM: Practice of neonatology, 5th edition. People's Medical Publishing House, 2019.

15 

Wang WP: Pediatrics, 9th edition. People's Medical Publishing House, 2018.

16 

Kelishadi R, Barekatain B and Fatahi A: Comparison of serum triglyceride and cholesterol levels in premature neonates with or without respiratory distress syndrome (RDS). Int J Pediatr. 2021(8893754)2021.PubMed/NCBI View Article : Google Scholar

17 

Kim JW, Kim YH, Moon JH, Jung HA and Noh EJ: The efficacy of third-generation cephalosporin plus metronidazole versus third-generation cephalosporin plus clarithromycin in neonatal outcomes and oxidative stress markers in women with preterm premature rupture of membranes. Clin Exp Obstet Gynecol. 47:194–198. 2020.

18 

Moya F: Preterm nutrition and the lung. World Rev Nutr Diet. 110:239–252. 2014.PubMed/NCBI View Article : Google Scholar

19 

Joss-Moore LA, Wang Y, Baack ML, Yao J, Norris AW, Yu X, Callaway CW, McKnight RA, Albertine KH and Lane RH: IUGR decreases PPARgamma and SETD8 expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation. Early Hum Dev. 86:785–791. 2010.PubMed/NCBI View Article : Google Scholar

20 

Blanco PG, Freedman SD, Lopez MC, Ollero M, Comen E, Laposata M and Alvarez JG: Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm fetuses. Am J Obstet Gynecol. 190:1369–1374. 2004.PubMed/NCBI View Article : Google Scholar

21 

Hopiavuori BR, Anderson RE and Agbaga MP: ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function. Prog Retin Eye Res. 69:137–158. 2019.PubMed/NCBI View Article : Google Scholar

22 

Jobe AH: Pulmonary surfactant therapy. N Engl J Med. 328:861–868. 1993.PubMed/NCBI View Article : Google Scholar

23 

King RJ: The surfactant system of the lung. Fed Proc. 33:2238–2247. 1974.PubMed/NCBI

24 

Wang H, Zhang W, Wang J, Li HL and Wen CL: Relationship between early serum lipid profiles and respiratory distress syndrome in preterm infants. Zhongguo Dang Dai Er Ke Za Zhi. 15:614–618. 2013.PubMed/NCBI(In Chinese).

25 

Gunes T, Koklu E and Ozturk MA: Maternal and cord serum lipid profiles of preterm infants with respiratory distress syndrome. J Perinatol. 27:415–421. 2007.PubMed/NCBI View Article : Google Scholar

26 

Dhanireddy R, Smith YF, Hamosh M, Mullon DK, Scanlon JW and Hamosh P: Respiratory distress syndrome in the newborn: Relationship to serum prolactin, thyroxine, and sex. Biol Neonate. 43:9–15. 1983.PubMed/NCBI View Article : Google Scholar

27 

Hadeed AJ, Asay LD, Klein AH and Fisher DA: Significance of transient postnatal hypothyroxinemia in premature infants with and without respiratory distress syndrome. Pediatrics. 68:494–498. 1981.PubMed/NCBI

28 

Keret R, Mathiash S, Brown M, Pertzelan A, Levy I and Laron Z: Correlation between plasma growth hormone and insulin and blood glucose concentrations in premature infants. Horm Res. 7:313–318. 1976.PubMed/NCBI View Article : Google Scholar

29 

Nguyen P, Leray V, Diez M, Serisier S, Le Bloc'h J, Siliart B and Dumon H: Liver lipid metabolism. J Anim Physiol Anim Nutr (Berl). 92:272–283. 2008.PubMed/NCBI View Article : Google Scholar

30 

Brem AS: Electrolyte disorders associated with respiratory distress syndrome and bronchopulmonary dysplasia. Clin Perinatol. 19:223–232. 1992.PubMed/NCBI

31 

Kalok A, Aziz NHA, Malik DA, Shah SA, Nasuruddin DN, Omar MH, Ismail Nam and Shafiee MN: Maternal serum vitamin D and spontaneous preterm birth. Clin Exp Obstet Gynecol. 47:16–20. 2020.

32 

Dautel SE, Kyle JE, Clair G, Sontag RL, Weitz KK, Shukla AK, Nguyen SN, Kim YM, Zink EM and Luders T: , et al: Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung. Sci Rep. 7(40555)2017.PubMed/NCBI View Article : Google Scholar

33 

Jamal M, Masood A, Belcastro R, Lopez L, Li J, Belik J, Jankov RP and Keith Tanswell A: Lipid hydroperoxide formation regulates postnatal rat lung cell apoptosis and alveologenesis. Free Radic Biol Med. 55:83–92. 2013.PubMed/NCBI View Article : Google Scholar

34 

Viscardi RM: Role of fatty acids in lung development. J Nutr. 125 (6 Suppl):1645S–1651S. 1995.PubMed/NCBI View Article : Google Scholar

35 

McGladdery SH and Frohlich JJ: Lipoprotein lipase and apoE polymorphisms: Relationship to hypertriglyceridemia during pregnancy. J Lipid Res. 42:1905–1912. 2001.PubMed/NCBI

36 

Thadhani R, Stampfer MJ, Hunter DJ, Manson JE, Solomon CG and Curhan GC: High body mass index and hypercholesterolemia: Risk of hypertensive disorders of pregnancy. Obstet Gynecol. 94:543–550. 1999.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng G, Zheng J, Hu X and Zhu T: Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome. Exp Ther Med 27: 69, 2024.
APA
Zheng, G., Zheng, J., Hu, X., & Zhu, T. (2024). Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome. Experimental and Therapeutic Medicine, 27, 69. https://doi.org/10.3892/etm.2023.12357
MLA
Zheng, G., Zheng, J., Hu, X., Zhu, T."Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome". Experimental and Therapeutic Medicine 27.2 (2024): 69.
Chicago
Zheng, G., Zheng, J., Hu, X., Zhu, T."Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome". Experimental and Therapeutic Medicine 27, no. 2 (2024): 69. https://doi.org/10.3892/etm.2023.12357
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng G, Zheng J, Hu X and Zhu T: Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome. Exp Ther Med 27: 69, 2024.
APA
Zheng, G., Zheng, J., Hu, X., & Zhu, T. (2024). Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome. Experimental and Therapeutic Medicine, 27, 69. https://doi.org/10.3892/etm.2023.12357
MLA
Zheng, G., Zheng, J., Hu, X., Zhu, T."Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome". Experimental and Therapeutic Medicine 27.2 (2024): 69.
Chicago
Zheng, G., Zheng, J., Hu, X., Zhu, T."Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome". Experimental and Therapeutic Medicine 27, no. 2 (2024): 69. https://doi.org/10.3892/etm.2023.12357
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team