Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2024 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2024 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1

  • Authors:
    • Fei He
    • Chunmian Chen
    • Yangyang Wang
    • Shuen Wang
    • Shuangyan Lyu
    • Junqiang Jiao
    • Guoyong Huang
    • Jiangshun Yang
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation Medicine, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325006, P.R. China, Key Laboratory of Neuropsychiatric Endocrinology, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 325006, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 71
    |
    Published online on: December 19, 2023
       https://doi.org/10.3892/etm.2023.12358
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Safranal is an active ingredient of saffron (Crocus sativus L.). Its neuroprotective role in ischemic stroke (IS) through reducing oxidative stress damage has been widely reported. However, the neurorestorative mechanisms of safranal are still in the preliminary stage of exploration. the present study is aimed to discuss the effects of safranal on the recovery of neural function after IS. A middle cerebral artery occlusion/reperfusion (MCAO/R) rat model and an oxygen‑glucose deprivation/reoxygenation (OGD/R) model in rat brain microvascular endothelial cells (RBMEC) were established to explore the effects of safranal on IS in vivo and in vitro. It was found that safranal dramatically reduced infarct size and Nissl's body loss in rats subjected to MCAO/R. Safranal also promoted neuron survival, stimulated neurogenesis, induced angiogenesis and increased SIRT1 expression in vivo and in vitro. Silencing of SIRT1 reversed the above effects of safranal on OGD/R‑induced RBMEC. The present study indicated that safranal was a promising compound to exert neurorestorative effect in IS via upregulating SIRT1 expression. These results offer insight into developing new mechanisms in the recovery of neural function after safranal treatment of IS.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Chen Z, Jiang B, Ru X, Sun H, Sun D, Liu X, Li Y, Li D, Guo X and Wang W: Mortality of stroke and its subtypes in China: Results from a nationwide population-based survey. Neuroepidemiology. 48:95–102. 2017.PubMed/NCBI View Article : Google Scholar

2 

Žitňanová I, Šiarnik P, Kollár B, Chomová M, Pazderová P, Andrezálová L, Ježovičová M, Koňariková K, Laubertová L, Krivošíková Z, et al: Oxidative stress markers and their dynamic changes in patients after acute ischemic stroke. Oxid Med Cell Longev. 2016(9761697)2016.PubMed/NCBI View Article : Google Scholar

3 

Katan M and Luft A: Global burden of stroke. Semin Neurol. 38:208–211. 2018.PubMed/NCBI View Article : Google Scholar

4 

Donkor ES: Stroke in the 21st century: A snapshot of the burden, epidemiology, and quality of life. Stroke Res Treat. 2018(3238165)2018.PubMed/NCBI View Article : Google Scholar

5 

Boehme AK, Esenwa C and Elkind MS: Stroke Risk factors, genetics, and prevention. Circ Res. 120:472–495. 2017.PubMed/NCBI View Article : Google Scholar

6 

Ma H, Campbell BCV, Parsons MW, Churilov L, Levi CR, Hsu C, Kleinig TJ, Wijeratne T, Curtze S, Dewey HM, et al: Thrombolysis guided by perfusion imaging up to 9 h after onset of stroke. N Engl J Med. 380:1795–1803. 2019.PubMed/NCBI View Article : Google Scholar

7 

Campbell BCV, Ma H, Ringleb PA, Parsons MW, Churilov L, Bendszus M, Levi CR, Hsu C, Kleinig TJ, Fatar M, et al: Extending thrombolysis to 4·5-9 h and wake-up stroke using perfusion imaging: A systematic review and meta-analysis of individual patient data. Lancet. 394:139–147. 2019.PubMed/NCBI View Article : Google Scholar

8 

Li Y, Zhang X, Cui L, Chen R, Zhang Y, Zhang C, Zhu X, He T, Shen Z, Dong L, et al: Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice. J Neurochem. 143:87–99. 2017.PubMed/NCBI View Article : Google Scholar

9 

Oshikawa M, Okada K, Kaneko N, Sawamoto K and Ajioka I: Affinity-immobilization of VEGF on laminin porous sponge enhances angiogenesis in the ischemic brain. Adv Healthc Mater. 6:2017.PubMed/NCBI View Article : Google Scholar

10 

Javadi B, Sahebkar A and Emami SA: A survey on saffron in major islamic traditional medicine books. Iran J Basic Med Sci. 16:1–11. 2013.PubMed/NCBI

11 

Khazdair MR, Boskabady MH, Hosseini M, Rezaee R and M Tsatsakis A: The effects of Crocus sativus (saffron) and its constituents on nervous system: A review. Avicenna J Phytomed. 5:376–391. 2015.PubMed/NCBI

12 

Nasrallah N: Ingredients used in foods and medicinal preparations: Herbs, spices, aromatics, minerals, food colors, and seasoning sauces. Treasure Trove of Benefits and Variety at the Table: A Fourteenth-Century Egyptian Cookbook. Brill, pp529-575, 2017.

13 

Asalgoo S, Tat M, Sahraei H and Pirzad Jahromi G: The psychoactive agent crocin can regulate hypothalamic-pituitary-adrenal axis activity. Front Neurosci. 11(668)2017.PubMed/NCBI View Article : Google Scholar

14 

Mokhtari Hashtjini M, Pirzad Jahromi G, Meftahi GH, Esmaeili D and Javidnazar D: Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats. Avicenna J Phytomed. 8:358–369. 2018.PubMed/NCBI

15 

Saleem S, Ahmad M, Ahmad AS, Yousuf S, Ansari MA, Khan MB, Ishrat T and Islam F: Effect of saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats. J Med Food. 9:246–253. 2006.PubMed/NCBI View Article : Google Scholar

16 

Vakili A, Einali MR and Bandegi AR: Protective effect of crocin against cerebral ischemia in a dose-dependent manner in a rat model of ischemic stroke. J Stroke Cerebrovasc Dis. 23:106–113. 2014.PubMed/NCBI View Article : Google Scholar

17 

Tarantilis PA, Tsoupras G and Polissiou M: Determination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatography-UV-visible photodiode-array detection-mass spectrometry. J Chromatogr A. 699:107–118. 1995.PubMed/NCBI View Article : Google Scholar

18 

Hosseinzadeh H and Younesi HM: Antinociceptive and anti-inflammatory effects of Crocus sativus L stigma and petal extracts in mice. BMC Pharmacol. 2(7)2002.PubMed/NCBI View Article : Google Scholar

19 

Farahmand SK, Samini F, Samini M and Samarghandian S: Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver. Biogerontology. 14:63–71. 2013.PubMed/NCBI View Article : Google Scholar

20 

Samarghandian S, Borji A, Delkhosh MB and Samini F: Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. J Pharm Pharm Sci. 16:352–362. 2013.PubMed/NCBI View Article : Google Scholar

21 

Malaekeh-Nikouei B, Mousavi SH, Shahsavand S, Mehri S, Nassirli H and Moallem SA: Assessment of cytotoxic properties of safranal and nanoliposomal safranal in various cancer cell lines. Phytother Res. 27:1868–1873. 2013.PubMed/NCBI View Article : Google Scholar

22 

Imenshahidi M, Hosseinzadeh H and Javadpour Y: Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res. 24:990–994. 2010.PubMed/NCBI View Article : Google Scholar

23 

Baluchnejadmojarad T, Mohamadi-Zarch SM and Roghani M: Safranal, an active ingredient of saffron, attenuates cognitive deficits in amyloid β-induced rat model of Alzheimer's disease: Underlying mechanisms. Metab Brain Dis. 34:1747–1759. 2019.PubMed/NCBI View Article : Google Scholar

24 

Bo-Qiang L, Si-Tong Z, Zu-Yuan L, Wan-Yun N, Bin C, Yuan L, Xuyun L, Liangen M, You-Chao C, Xin-Zhen Y, et al: Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice. Pharmazie. 73:207–212. 2018.PubMed/NCBI View Article : Google Scholar

25 

Zhang C, Ma J, Fan L, Zou Y, Dang X, Wang K and Song J: Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating. Tissue Cell. 47:291–300. 2015.PubMed/NCBI View Article : Google Scholar

26 

Pan PK, Qiao LY and Wen XN: Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway. Cell Mol Biol (Noisy-le-grand). 62:11–17. 2016.PubMed/NCBI

27 

Sadeghnia HR, Shaterzadeh H, Forouzanfar F and Hosseinzadeh H: Neuroprotective effect of safranal, an active ingredient of Crocus sativus, in a rat model of transient cerebral ischemia. Folia Neuropathol. 55:206–213. 2017.PubMed/NCBI View Article : Google Scholar

28 

Hosseinzadeh H and Sadeghnia HR: Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J Pharm Pharm Sci. 8:394–399. 2005.PubMed/NCBI

29 

Forouzanfar F, Asadpour E, Hosseinzadeh H, Boroushaki MT, Adab A, Dastpeiman SH and Sadeghnia HR: Safranal protects against ischemia-induced PC12 cell injury through inhibiting oxidative stress and apoptosis. Naunyn Schmiedebergs Arch Pharmacol. 394:707–716. 2021.PubMed/NCBI View Article : Google Scholar

30 

Meng X, Wang M, Wang X, Sun G, Ye J, Xu H and Sun X: Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways. Free Radic Res. 48:823–838. 2014.PubMed/NCBI View Article : Google Scholar

31 

Belayev L, Alonso OF, Busto R, Zhao W and Ginsberg MD: Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke. 27:1616–1623. 1996.PubMed/NCBI View Article : Google Scholar

32 

Alinejad B, Ghorbani A and Sadeghnia HR: Effects of combinations of curcumin, linalool, rutin, safranal, and thymoquinone on glucose/serum deprivation-induced cell death. Avicenna J Phytomed. 3:321–328. 2013.PubMed/NCBI

33 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

34 

Patel AR, Ritzel R, McCullough LD and Liu F: Microglia and ischemic stroke: A double-edged sword. Int J Physiol Pathophysiol Pharmacol. 5:73–90. 2013.PubMed/NCBI

35 

Zhu J, Dou S, Jiang Y, Chen J, Wang C and Cheng B: Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy. Brain Res. 1715:203–212. 2019.PubMed/NCBI View Article : Google Scholar

36 

Herskovits AZ and Guarente L: SIRT1 in neurodevelopment and brain senescence. Neuron. 81:471–483. 2014.PubMed/NCBI View Article : Google Scholar

37 

Edelbrock AN, Àlvarez Z, Simkin D, Fyrner T, Chin SM, Sato K, Kiskinis E and Stupp SI: Supramolecular nanostructure activates TrkB receptor signaling of neuronal cells by mimicking brain-derived neurotrophic factor. Nano Lett. 18:6237–6247. 2018.PubMed/NCBI View Article : Google Scholar

38 

Dimyan MA and Cohen LG: Neuroplasticity in the context of motor rehabilitation after stroke. Nat Rev Neurol. 7:76–85. 2011.PubMed/NCBI View Article : Google Scholar

39 

Liu Y, Li C, Wang J, Fang Y, Sun H, Tao X, Zhou XF and Liao H: Nafamostat mesilate improves neurological outcome and axonal regeneration after stroke in rats. Mol Neurobiol. 54:4217–4231. 2017.PubMed/NCBI View Article : Google Scholar

40 

Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Cheng S, Delling FN, et al: Heart disease and stroke statistics-2021 update: A report from the american heart association. Circulation. 143:e254–e743. 2021.PubMed/NCBI View Article : Google Scholar

41 

Liu W, Wang X, O'Connor M, Wang G and Han F: Brain-derived neurotrophic factor and its potential therapeutic role in stroke comorbidities. Neural Plast. 2020(1969482)2020.PubMed/NCBI View Article : Google Scholar

42 

Fonarow GC, Smith EE, Saver JL, Reeves MJ, Bhatt DL, Grau-Sepulveda MV, Olson DM, Hernandez AF, Peterson ED and Schwamm LH: Timeliness of tissue-type plasminogen activator therapy in acute ischemic stroke: Patient characteristics, hospital factors, and outcomes associated with door-to-needle times within 60 min. Circulation. 123:750–758. 2011.PubMed/NCBI View Article : Google Scholar

43 

Yang S, Jin H, Zhu Y, Wan Y, Opoku EN, Zhu L and Hu B: Diverse functions and mechanisms of pericytes in ischemic stroke. Curr Neuropharmacol. 15:892–905. 2017.PubMed/NCBI View Article : Google Scholar

44 

Zhu T, Wang L, Xie W, Meng X, Feng Y, Sun G and Sun X: Notoginsenoside R1 improves cerebral ischemia/reperfusion injury by promoting neurogenesis via the BDNF/Akt/CREB pathway. Front Pharmacol. 12(615998)2021.PubMed/NCBI View Article : Google Scholar

45 

Herpich F and Rincon F: Management of acute ischemic stroke. Crit Care Med. 48:1654–1663. 2020.PubMed/NCBI View Article : Google Scholar

46 

Xu S, Yang J, Wan H, Yu L and He Y: Combination of radix astragali and safflower promotes angiogenesis in rats with ischemic stroke via silencing PTGS2. Int J Mol Sci. 24(2126)2023.PubMed/NCBI View Article : Google Scholar

47 

Wen HC, Huo YN, Chou CM and Lee WS: PMA inhibits endothelial cell migration through activating the PKC-δ/Syk/NF-κB-mediated up-regulation of Thy-1. Sci Rep. 8(16247)2018.PubMed/NCBI View Article : Google Scholar

48 

Yao Y: Basement membrane and stroke. J Cereb Blood Flow Metab. 39:3–19. 2019.PubMed/NCBI View Article : Google Scholar

49 

Save SS, Rachineni K, Hosur RV and Choudhary S: Natural compound safranal driven inhibition and dis-aggregation of α-synuclein fibrils. Int J Biol Macromol. 141:585–595. 2019.PubMed/NCBI View Article : Google Scholar

50 

Vogt N: Sensing neurotransmitters. Nat Methods. 16(17)2019.PubMed/NCBI View Article : Google Scholar

51 

Ramer MS, Priestley JV and McMahon SB: Functional regeneration of sensory axons into the adult spinal cord. Nature. 403:312–316. 2000.PubMed/NCBI View Article : Google Scholar

52 

Wang T, Zhang J, Li P, Ding Y, Tang J, Chen G and Zhang JH: NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats. J Neuroinflammation. 17(158)2020.PubMed/NCBI View Article : Google Scholar

53 

Michan S and Sinclair D: Sirtuins in mammals: Insights into their biological function. Biochem J. 404:1–13. 2007.PubMed/NCBI View Article : Google Scholar

54 

Zakhary SM, Ayubcha D, Dileo JN, Jose R, Leheste JR, Horowitz JM and Torres G: Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems. Anat Rec (Hoboken). 293:1024–1032. 2010.PubMed/NCBI View Article : Google Scholar

55 

Fu B, Zhang J, Zhang X, Zhang C, Li Y, Zhang Y, He T, Li P, Zhu X, Zhao Y, et al: Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia. Neuroscience. 281:251–257. 2014.PubMed/NCBI View Article : Google Scholar

56 

Lv H, Wang L, Shen J, Hao S, Ming A, Wang X, Su F and Zhang Z: Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats. Brain Res Bull. 115:30–36. 2015.PubMed/NCBI View Article : Google Scholar

57 

Wan D, Zhou Y, Wang K, Hou Y, Hou R and Ye X: Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats. Brain Res Bull. 121:255–262. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He F, Chen C, Wang Y, Wang S, Lyu S, Jiao J, Huang G and Yang J: Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1. Exp Ther Med 27: 71, 2024.
APA
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J. ... Yang, J. (2024). Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1. Experimental and Therapeutic Medicine, 27, 71. https://doi.org/10.3892/etm.2023.12358
MLA
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J., Huang, G., Yang, J."Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1". Experimental and Therapeutic Medicine 27.2 (2024): 71.
Chicago
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J., Huang, G., Yang, J."Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1". Experimental and Therapeutic Medicine 27, no. 2 (2024): 71. https://doi.org/10.3892/etm.2023.12358
Copy and paste a formatted citation
x
Spandidos Publications style
He F, Chen C, Wang Y, Wang S, Lyu S, Jiao J, Huang G and Yang J: Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1. Exp Ther Med 27: 71, 2024.
APA
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J. ... Yang, J. (2024). Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1. Experimental and Therapeutic Medicine, 27, 71. https://doi.org/10.3892/etm.2023.12358
MLA
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J., Huang, G., Yang, J."Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1". Experimental and Therapeutic Medicine 27.2 (2024): 71.
Chicago
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J., Huang, G., Yang, J."Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1". Experimental and Therapeutic Medicine 27, no. 2 (2024): 71. https://doi.org/10.3892/etm.2023.12358
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team