Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2024 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2024 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis

  • Authors:
    • Ran Fan
    • Jun Zhou
    • Yan Xu
    • Ling Gao
    • Zhe Yu
    • Yinshan Zang
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology and Immunology, The Suqian Clinical College of Xuzhou Medical University, Suqian, Jiangsu 223800, P.R. China
    Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 76
    |
    Published online on: December 27, 2023
       https://doi.org/10.3892/etm.2023.12364
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

14‑3‑3η can regulate the cell cycle, immunity, inflammation and the secretion of matrix metalloproteinases, while it may also be involved in the development of rheumatoid arthritis (RA) and promote bone injury. Therefore, the present meta‑analysis focused on the dysregulated serum levels of 14‑3‑3η and its association with osteoporosis in patients with RA. Studies comparing the serum levels of 14‑3‑3η between patients with RA and healthy controls (HCs) or patients with RA with different bone mineral densities were retrieved from the EMBASE, Web of Science, PubMed and Cochrane databases. A total of 14 studies comprising 2,164 patients with RA and 1,136 HCs were included and analysed. Pooled analyses showed that the serum levels of 14‑3‑3η were enhanced in patients with RA compared with HCs [standardized mean difference (SMD): 1.34; 95% confidence interval (CI): 1.01‑1.66; P<0.001]. In addition, the serum levels of 14‑3‑3η were also significantly higher in patients with RA with osteoporosis and osteopenia compared with those with normal bone mass (SMD: 1.96; 95% CI: 0.01‑3.92; P=0.049 and SMD: 0.80; 95% CI: 0.09‑1.52; P=0.028, respectively). Begg's and Egger's tests demonstrated that the publication bias for each evaluated indicator was low (all P>0.05). However, sensitivity analyses revealed that the findings were not very robust, which may be due to the omission of several individual studies. Overall, the present meta‑analysis suggested that the serum levels of 14‑3‑3η were elevated and were associated with a higher risk of osteoporosis in patients with RA, thus supporting its potency as a circulating biomarker in the management of RA.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Finckh A, Gilbert B, Hodkinson B, Bae SC, Thomas R, Deane KD, Alpizar-Rodriguez D and Lauper K: Global epidemiology of rheumatoid arthritis. Nat Rev Rheumatol. 18:591–602. 2022.PubMed/NCBI View Article : Google Scholar

2 

van der Woude D and van der Helm-van Mil AHM: Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis. Best Pract Res Clin Rheumatol. 32:174–187. 2018.PubMed/NCBI View Article : Google Scholar

3 

Yu KH, Chen HH, Cheng TT, Jan YJ, Weng MY, Lin YJ, Chen HA, Cheng JT, Huang KY, Li KJ, et al: Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid arthritis. Medicine (Baltimore). 101(e28501)2022.PubMed/NCBI View Article : Google Scholar

4 

Mitrović J, Hrkač S, Tečer J, Golob M, Ljilja Posavec A, Kolar Mitrović H and Grgurević L: Pathogenesis of extraarticular manifestations in rheumatoid arthritis-a comprehensive review. Biomedicines. 11(1262)2023.PubMed/NCBI View Article : Google Scholar

5 

Moshayedi S, Tasorian B and Almasi-Hashiani A: The prevalence of osteoporosis in rheumatoid arthritis patient: A systematic review and meta-analysis. Sci Rep. 12(15844)2022.PubMed/NCBI View Article : Google Scholar

6 

Raterman HG, Bultink IE and Lems WF: Osteoporosis in patients with rheumatoid arthritis: An update in epidemiology, pathogenesis, and fracture prevention. Expert Opin Pharmacother. 21:1725–1737. 2020.PubMed/NCBI View Article : Google Scholar

7 

Baker R, Narla R, Baker JF and Wysham KD: Risk factors for osteoporosis and fractures in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 36(101773)2022.PubMed/NCBI View Article : Google Scholar

8 

Yu XH, Yang YQ, Cao RR, Cai MK, Zhang L, Deng FY and Lei SF: Rheumatoid arthritis and osteoporosis: Shared genetic effect, pleiotropy and causality. Hum Mol Genet. 30:1932–1940. 2021.PubMed/NCBI View Article : Google Scholar

9 

Wysham KD, Baker JF and Shoback DM: Osteoporosis and fractures in rheumatoid arthritis. Curr Opin Rheumatol. 33:270–276. 2021.PubMed/NCBI View Article : Google Scholar

10 

Johnson C, Crowther S, Stafford MJ, Campbell DG, Toth R and MacKintosh C: Bioinformatic and experimental survey of 14-3-3-binding sites. Biochem J. 427:69–78. 2010.PubMed/NCBI View Article : Google Scholar

11 

Gardino AK, Smerdon SJ and Yaffe MB: Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: A comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Semin Cancer Biol. 16:173–182. 2006.PubMed/NCBI View Article : Google Scholar

12 

Zhang Y, Liang Y, Feng L and Cui L: Diagnostic performance of 14-3-3η and anti-carbamylated protein antibodies in rheumatoid arthritis in Han population of Northern China. Clin Chim Acta. 502:102–110. 2020.PubMed/NCBI View Article : Google Scholar

13 

Adel Y and Sadeq Y: 14-3-3η protein is associated with disease activity and osteoporosis in patients with rheumatoid arthritis. Reumatologia. 60:384–391. 2022.PubMed/NCBI View Article : Google Scholar

14 

Huang J, Zeng T, Zhang X, Tian Y, Wu Y, Yu J, Pei Z, Liu Y, Hu T and Tan L: Clinical diagnostic significance of 14-3-3η protein, high-mobility group box-1, anti-cyclic citrullinated peptide antibodies, anti-mutated citrullinated vimentin antibodies and rheumatoid factor in rheumatoid arthritis. Br J Biomed Sci. 77:19–23. 2020.PubMed/NCBI View Article : Google Scholar

15 

Hussin DAAH, Shaat RM, Metwally SS and Awad M: The significance of serum 14-3-3η level in rheumatoid arthritis patients. Clin Rheumatol. 40:2193–2202. 2021.PubMed/NCBI View Article : Google Scholar

16 

Shovman O, Gilburd B, Watad A, Amital H, Langevitz P, Bragazzi NL, Adawi M, Perez D, Bornstein G, Grossman C, et al: The diagnostic value of 14-3-3η protein levels in patients with rheumatoid arthritis. Best Pract Res Clin Rheumatol. 32:610–617. 2018.PubMed/NCBI View Article : Google Scholar

17 

Maksymowych WP, Naides SJ, Bykerk V, Siminovitch KA, van Schaardenburg D, Boers M, Landewé R, van der Heijde D, Tak PP, Genovese MC, et al: Serum 14-3-3η is a novel marker that complements current serological measurements to enhance detection of patients with rheumatoid arthritis. J Rheumatol. 41:2104–2113. 2014.PubMed/NCBI View Article : Google Scholar

18 

Zeng T, Tan L, Wu Y and Yu J: 14-3-3η protein in rheumatoid arthritis: Promising diagnostic marker and independent risk factor for osteoporosis. Lab Med. 51:529–539. 2020.PubMed/NCBI View Article : Google Scholar

19 

Sun Y, Hong L and Gao C: The association among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis. Pak J Med Sci. 36:872–876. 2020.PubMed/NCBI View Article : Google Scholar

20 

Gong X, Xu SQ, Wu Y, Ma CC, Qi S, Liu W and Xu JH: Elevated serum 14-3-3η protein may be helpful for diagnosis of early rheumatoid arthritis associated with secondary osteoporosis in Chinese population. Clin Rheumatol. 36:2581–2587. 2017.PubMed/NCBI View Article : Google Scholar

21 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ. 339(b2700)2009.PubMed/NCBI View Article : Google Scholar

22 

Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M and Tugwell P: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses, 2000.

23 

Luo D, Wan X, Liu J and Tong T: Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res. 27:1785–1805. 2018.PubMed/NCBI View Article : Google Scholar

24 

Wan X, Wang W, Liu J and Tong T: Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 14(135)2014.PubMed/NCBI View Article : Google Scholar

25 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ and Welch VA: Cochrane handbook for systematic reviews of interventions (version 6.0). Cochrane Handbook for Systematic Reviews of Interventions, London, 2019.

26 

Maksymowych WP, Boire G, van Schaardenburg D, Wichuk S, Turk S, Boers M, Siminovitch KA, Bykerk V, Keystone E, Tak PP, et al: 14-3-3η autoantibodies: Diagnostic use in early rheumatoid arthritis. J Rheumatol. 42:1587–1594. 2015.PubMed/NCBI View Article : Google Scholar

27 

Mohamed AH, Abdellatif S and El-Noshokaty EH: Serum level of 14-3-3η (Eta) protein as a diagnostic marker for rheumatoid arthritis and potential correlation with disease activity. MOJ Orthop Rheumatol. 7(280)2018.

28 

El-Sherif WT, Nigm DA, Abd-Elsamea MH and Kassem AM: Evaluation of serum protein 14-3-3η (Eta) as a novel biomarker for rheumatoid arthritis. Egypt J Immunol. 26:163–175. 2019.PubMed/NCBI

29 

Guan SZ, Yang YQ, Bai X, Wang Y, Feng KQ, Zhang HJ, Dong M, Yang HW and Li HQ: Serum 14-3-3η could improve the diagnostic rate of rheumatoid arthritis and correlates to disease activity. Ann Clin Lab Sci. 49:57–62. 2019.PubMed/NCBI

30 

Qu CH, Hou Y, Bi YF, Han QR, Jiao CH and Zou QF: Diagnostic values of serum IL-10 and IL-17 in rheumatoid arthritis and their correlation with serum 14-3-3η protein. Eur Rev Med Pharmacol Sci. 23:1899–1906. 2019.PubMed/NCBI View Article : Google Scholar

31 

Salman E, Çetiner S, Boral B, Kibar F, Erken E, Ersözlü ED, Badak SÖ, Bilici Salman R, Sertdemir Y, Çetin Duran A and Yaman A: Importance of 14-3-3eta, anti-CarP, and anti-Sa in the diagnosis of seronegative rheumatoid arthritis. Turk J Med Sci. 49:1498–1502. 2019.PubMed/NCBI View Article : Google Scholar

32 

Zeng T and Tan L: 14-3-3η protein: A promising biomarker for rheumatoid arthritis. Biomark Med. 12:917–925. 2018.PubMed/NCBI View Article : Google Scholar

33 

Kilani RT, Maksymowych WP, Aitken A, Boire G, St-Pierre Y, Li Y and Ghahary A: Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation. J Rheumatol. 34:1650–1657. 2007.PubMed/NCBI

34 

Kadiri M, Charbonneau M, Lalanne C, Harper K, Balg F, Marotta A and Dubois CM: 14-3-3η promotes invadosome formation via the FOXO3-snail axis in rheumatoid arthritis fibroblast-like synoviocytes. Int J Mol Sci. 23(123)2021.PubMed/NCBI View Article : Google Scholar

35 

Tu J, Chen X, Dai M, Pan A, Liu C, Zhou Y, Xia X and Sun L: Serum levels of 14-3-3η are associated with increased disease risk, activity and duration of rheumatoid arthritis in Chinese patients. Exp Ther Med. 20:754–761. 2020.PubMed/NCBI View Article : Google Scholar

36 

Munier CC, Ottmann C and Perry MWD: 14-3-3 Modulation of the inflammatory response. Pharmacol Res. 163(105236)2021.PubMed/NCBI View Article : Google Scholar

37 

Kim H, Lee K, Kim JM, Kim MY, Kim JR, Lee HW, Chung YW, Shin HI, Kim T, Park ES, et al: Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nat Commun. 12(2258)2021.PubMed/NCBI View Article : Google Scholar

38 

Hammam N, Salah S, Kholef EF, Moussa EM and Marotta A: 14-3-3η Protein in serum and synovial fluid correlates with radiographic damage and progression in a longitudinal evaluation of patients with established rheumatoid arthritis. Mod Rheumatol. 30:664–670. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fan R, Zhou J, Xu Y, Gao L, Yu Z and Zang Y: Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis. Exp Ther Med 27: 76, 2024.
APA
Fan, R., Zhou, J., Xu, Y., Gao, L., Yu, Z., & Zang, Y. (2024). Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis. Experimental and Therapeutic Medicine, 27, 76. https://doi.org/10.3892/etm.2023.12364
MLA
Fan, R., Zhou, J., Xu, Y., Gao, L., Yu, Z., Zang, Y."Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis". Experimental and Therapeutic Medicine 27.2 (2024): 76.
Chicago
Fan, R., Zhou, J., Xu, Y., Gao, L., Yu, Z., Zang, Y."Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis". Experimental and Therapeutic Medicine 27, no. 2 (2024): 76. https://doi.org/10.3892/etm.2023.12364
Copy and paste a formatted citation
x
Spandidos Publications style
Fan R, Zhou J, Xu Y, Gao L, Yu Z and Zang Y: Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis. Exp Ther Med 27: 76, 2024.
APA
Fan, R., Zhou, J., Xu, Y., Gao, L., Yu, Z., & Zang, Y. (2024). Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis. Experimental and Therapeutic Medicine, 27, 76. https://doi.org/10.3892/etm.2023.12364
MLA
Fan, R., Zhou, J., Xu, Y., Gao, L., Yu, Z., Zang, Y."Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis". Experimental and Therapeutic Medicine 27.2 (2024): 76.
Chicago
Fan, R., Zhou, J., Xu, Y., Gao, L., Yu, Z., Zang, Y."Serum 14‑3‑3η levels are increased and associated with a higher risk of osteoporosis in patients with rheumatoid arthritis: A meta‑analysis". Experimental and Therapeutic Medicine 27, no. 2 (2024): 76. https://doi.org/10.3892/etm.2023.12364
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team