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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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February-2024 Volume 27 Issue 2

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Case Report

Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report

  • Authors:
    • Takeshi Kawakami
    • Yuika Sasatani
    • Sachie Hasegawa
    • Gen Ohara
    • Shinichiro Okauchi
    • Manato Taguchi
    • Eiji Ojima
    • Hiroaki Satoh
    • Nobuyuki Hizawa
  • View Affiliations / Copyright

    Affiliations: Division of Respiratory Medicine, University of Tsukuba Hospital, University of Tsukuba, Tsukuba, Ibaraki 305‑8576, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba‑Mito Kyodo General Hospital, Mito, Ibaraki 310‑0015, Japan, Division of Cardiology, Mito Medical Center, University of Tsukuba‑Mito Kyodo General Hospital, Mito, Ibaraki 310‑0015, Japan
  • Article Number: 81
    |
    Published online on: January 4, 2024
       https://doi.org/10.3892/etm.2024.12370
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Abstract

Systemic emboli are not uncommon in patients with advanced non‑small cell lung cancer. The present study describes a rare case of long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli. Briefly, a 56‑year‑old man was diagnosed with metastatic lung adenocarcinoma and was treated with pembrolizumab, which was discontinued due to the appearance of a pulmonary immune‑related adverse event. During the clinical course, the patient developed pseudo‑progression of a brain tumor, repeated thromboembolism in multiple organs and a small vegetation attached to the aortic valve. These lesions were controlled with apixaban after heparin therapy for >3 years. Lung cancer was subsequently treated with pemetrexed and bevacizumab; however, this treatment was terminated due to a complete response and the patient's request to discontinue treatment. More than 3 years have passed since the diagnosis of lung adenocarcinoma, and the patient has been followed up at the hospital without signs of cancer recurrence. Although unusual, the patient's course may provide useful suggestions for the treatment of other patients with a similar evolution.
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Copy and paste a formatted citation
Spandidos Publications style
Kawakami T, Sasatani Y, Hasegawa S, Ohara G, Okauchi S, Taguchi M, Ojima E, Satoh H and Hizawa N: Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report. Exp Ther Med 27: 81, 2024.
APA
Kawakami, T., Sasatani, Y., Hasegawa, S., Ohara, G., Okauchi, S., Taguchi, M. ... Hizawa, N. (2024). Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report. Experimental and Therapeutic Medicine, 27, 81. https://doi.org/10.3892/etm.2024.12370
MLA
Kawakami, T., Sasatani, Y., Hasegawa, S., Ohara, G., Okauchi, S., Taguchi, M., Ojima, E., Satoh, H., Hizawa, N."Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report". Experimental and Therapeutic Medicine 27.2 (2024): 81.
Chicago
Kawakami, T., Sasatani, Y., Hasegawa, S., Ohara, G., Okauchi, S., Taguchi, M., Ojima, E., Satoh, H., Hizawa, N."Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report". Experimental and Therapeutic Medicine 27, no. 2 (2024): 81. https://doi.org/10.3892/etm.2024.12370
Copy and paste a formatted citation
x
Spandidos Publications style
Kawakami T, Sasatani Y, Hasegawa S, Ohara G, Okauchi S, Taguchi M, Ojima E, Satoh H and Hizawa N: Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report. Exp Ther Med 27: 81, 2024.
APA
Kawakami, T., Sasatani, Y., Hasegawa, S., Ohara, G., Okauchi, S., Taguchi, M. ... Hizawa, N. (2024). Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report. Experimental and Therapeutic Medicine, 27, 81. https://doi.org/10.3892/etm.2024.12370
MLA
Kawakami, T., Sasatani, Y., Hasegawa, S., Ohara, G., Okauchi, S., Taguchi, M., Ojima, E., Satoh, H., Hizawa, N."Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report". Experimental and Therapeutic Medicine 27.2 (2024): 81.
Chicago
Kawakami, T., Sasatani, Y., Hasegawa, S., Ohara, G., Okauchi, S., Taguchi, M., Ojima, E., Satoh, H., Hizawa, N."Long‑term control in a patient with lung adenocarcinoma, nonbacterial thrombotic endocarditis and multiple systemic emboli: A case report". Experimental and Therapeutic Medicine 27, no. 2 (2024): 81. https://doi.org/10.3892/etm.2024.12370
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