Clinical characteristics and prognostic analysis of patients with HIV and glioma: A case series and literature review

Ding,Xinghuan; Ding,Xinghuan; Liang,Tingyu; Liang,Tingyu; Liang,Bo; Liang,Bo; Zhou,Xingang; Zhou,Xingang; Chen,Jiamin; Chen,Jiamin; Gao,Haili; Gao,Haili; Wang,Fang; Wang,Fang; Zheng,Xinmei; Zheng,Xinmei; Feng,Enshan; Feng,Enshan

doi:10.3892/etm.2024.12380

Clinical characteristics and prognostic analysis of patients with HIV and glioma: A case series and literature review

Authors:
- Xinghuan Ding
- Tingyu Liang
- Bo Liang
- Xingang Zhou
- Jiamin Chen
- Haili Gao
- Fang Wang
- Xinmei Zheng
- Enshan Feng
View Affiliations

Affiliations: Department of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China, Department of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China, National Center for Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China, National Center for Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China
Published online on: January 8, 2024 https://doi.org/10.3892/etm.2024.12380
Article Number: 90
Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Cerebral glial tumors have become increasingly common in human immunodeficiency virus (HIV)‑positive patients. The present study aimed to report a series of such cases, explore their clinical and pathological characteristics and subject all the reported cases to a survival analysis. The characteristics, management and prognosis of 10 HIV‑positive patients with brain gliomas enrolled in a single hospital were investigated in detail. Immunohistochemical assessment of CD31, CD68 and CD163 was performed in the 10 HIV‑positive patients with glioma and 18 HIV‑negative patients with glioma. The relevant literature was also reviewed using relevant search terms. The potential predictive factors were screened by univariate and multivariate logistic regression analyses, and a nomogram was established based on the potential predictive factors. A total of 50 patients, including the 10 primary cases, were included in the survival analysis. The median survival time was 9 months. The gliomas of HIV‑negative patients had a lower cell count of CD163⁺ cells than those of HIV‑positive patients. High CD4⁺ T‑cell count and the use of highly active antiretroviral therapy (HAART) tended to increase the median survival duration, although not significantly according to the log‑rank analysis. In the univariate analysis, only surgery, radiotherapy (RT) and World Health Organization (WHO) tumor grade had significant associations with overall survival. In the multivariate analysis, only RT and WHO grade were independent predictors. In conclusion, gliomas may occur more frequently in HIV‑positive populations than is currently recognized. The survival duration of most HIV‑positive patients with glioma is determined by the tumor rather than HIV status. Adjuvant radiotherapy and the WHO grade of the glioma are predicted to be independent prognostic factors. Surgical resection followed by RT plus regular HAART is recommended for patients with glioma who are HIV‑positive.

View Figures

View References

1	Chamberlain MC: Gliomas in patients with acquired immune deficiency syndrome. Cancer. 74:1912–1914. 1994.PubMed/NCBI View Article : Google Scholar
2	Engels EA, Pfeiffer RM, Goedert JJ, Virgo P, McNeel TS, Scoppa SM and Biggar RJ: HIV/AIDS Cancer Match Study. Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS. 20:1645–1654. 2006.PubMed/NCBI View Article : Google Scholar
3	Moulignier A, Mikol J, Pialoux G, Eliaszewicz M, Thurel C and Thiebaut JB: Cerebral glial tumors and human immunodeficiency virus-1 infection. More than a coincidental association. Cancer. 74:686–692. 1994.PubMed/NCBI View Article : Google Scholar
4	Tacconi L, Stapleton S, Signorelli F and Thomas DG: Acquired immune deficiency syndrome (AIDS) and cerebral astrocytoma. Clin Neurol Neurosurg. 98:149–151. 1996.PubMed/NCBI View Article : Google Scholar
5	Blumenthal DT, Raizer JJ, Rosenblum MK, Bilsky MH, Hariharan S and Abrey LE: Primary intracranial neoplasms in patients with HIV. Neurology. 52:1648–1651. 1999.PubMed/NCBI View Article : Google Scholar
6	Mendez Valdez MJ, Lu VM, Kim E, Rivas SR, Govindarajan V, Ivan M, Komotar R, Nath A, Heiss JD and Shah AH: Glioblastoma multiforme in patients with human immunodeficiency virus: An integrated review and analysis. J Neurooncol. 159:571–579. 2022.PubMed/NCBI View Article : Google Scholar
7	Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, et al: Clinical practice guidelines for the management of adult diffuse gliomas. Cancer Lett. 499:60–72. 2021.PubMed/NCBI View Article : Google Scholar
8	Gasnault J, Roux FX and Vedrenne C: Cerebral astrocytoma in association with HIV infection. J Neurol Neurosurg Psychiatry. 51:422–424. 1988.PubMed/NCBI View Article : Google Scholar
9	Carrana EJ, Rossitch E, Moore MR and Funkenstein HH: Anaplastic astrocytoma in association with human immunodeficiency virus type 1 infection. Am J Emerg Med. 8:565–567. 1990.PubMed/NCBI View Article : Google Scholar
10	Ho KL, Gottlieb C and Zarbo RJ: Cytomegalovirus infection of cerebral astrocytoma in an AIDS patient. Clin Neuropathol. 10:127–133. 1991.PubMed/NCBI
11	Kasantikul V, Kaoroptham S and Hanvanich M: Acquired immunodeficiency syndrome associated with cerebral astrocytoma. Clin Neuropathol. 11:25–27. 1992.PubMed/NCBI
12	Chappell ET, Guthrie BL and Orenstein J: The role of stereotactic biopsy in the management of HIV-related focal brain lesions. Neurosurgery. 30:825–829. 1992.PubMed/NCBI View Article : Google Scholar
13	Gervasoni C, Ridolfo AL, Rocca A, Vago L and d'Arminio Monforte A: Cerebral astrocytoma in HIV-infected patients. AIDS. 9:403–404. 1995.PubMed/NCBI
14	Neal JW, Llewelyn MB, Morrison HL, Jasani B and Borysiewicz LK: A malignant astrocytoma in a patient with AIDS: A possible association between astrocytomas and HIV infection. J Infect. 33:159–162. 1996.PubMed/NCBI View Article : Google Scholar
15	d'Arminio Monforte A, Cinque P, Vago L, Rocca A, Castagna A, Gervasoni C, Terreni MR, Novati R, Gori A, Lazzarin A and Moroni M: A comparison of brain biopsy and CSF-PCR in the diagnosis of CNS lesions in AIDS patients. J Neurol. 244:35–39. 1997.PubMed/NCBI View Article : Google Scholar
16	Vannemreddy PS, Fowler M, Polin RS, Todd JR and Nanda A: Glioblastoma multiforme in a case of acquired immunodeficiency syndrome: Investigation a possible oncogenic influence of human immunodeficiency virus on glial cells. Case report and review of the literature. J Neurosurg. 92:161–164. 2000.PubMed/NCBI View Article : Google Scholar
17	Wolff R, Zimmermann M, Marquardt G, Lanfermann H, Nafe R and Seifert V: Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. Acta Neurochir (Wien). 144:941–944; discussion 944-5. 2002.PubMed/NCBI View Article : Google Scholar
18	Corti ME, Yampolsky C, Metta H, Valerga M, Sevlever G and Capizzano A: Oligodendroglioma in a patient with AIDS: Case report and review of the literature. Rev Inst Med Trop Sao Paulo. 46:195–197. 2004.PubMed/NCBI View Article : Google Scholar
19	Hall JR and Short SC: Management of glioblastoma multiforme in HIV patients: A case series and review of published studies. Clin Oncol (R Coll Radiol). 21:591–597. 2009.PubMed/NCBI View Article : Google Scholar
20	Chaudhry NS, Ahmad FU, Blieden C and Benveniste RJ: Brainstem anaplastic glioma in patients with AIDS: A case report and review of the literature. BMJ Case Rep. 2013(bcr2012008384)2013.PubMed/NCBI View Article : Google Scholar
21	Brassesco MS, Darrigo LG Jr, Valera ET, Oliveira RS, Yamamoto YA, de Castro Barros MV and Tone LG: Giant-cell glioblastoma of childhood associated with HIV-1 and JC virus coinfection. Childs Nerv Syst. 29:1387–1390. 2013.PubMed/NCBI View Article : Google Scholar
22	Oliveira VC, Gomes T, Ferreira LC, Damian MM, Silva VM, Araújo JR, Safe IP and Ramasawmy R: Glioblastoma multiforme in an HIV-Infected patient: An unexpected diagnosis. J Int Assoc Provid AIDS Care. 13:411–413. 2014.PubMed/NCBI View Article : Google Scholar
23	Wang T, Gao T, Niu X, Xing X, Yang Y, Liu Y and Mao Q: Clinical characteristics and prognostic analysis of glioma in human immunodeficiency virus-infected patients. World Neurosurg. 114:e218–e223. 2018.PubMed/NCBI View Article : Google Scholar
24	Jokonya L, Musara A, Esene IN, Kabulo KDM, Kabeya CM and Kalangu KKN: Prevalence of human immunodeficiency virus infection in brain glioma patients: Is the virus protective from gliomas? Surg Neurol Int. 9(103)2018.PubMed/NCBI View Article : Google Scholar
25	Simpson DM and Tagliati M: Neurologic manifestations of HIV infection. Ann Intern Med. 121:769–785. 1994.PubMed/NCBI View Article : Google Scholar
26	GBD 2017 HIV collaborators: Global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2017, and forecasts to. 2030, for 195 countries and territories: A systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. Lancet. HIV 6: e831-e859, 2019.
27	Ostrom QT, Cote DJ, Ascha M, Kruchko C and Barnholtz-Sloan JS: Adult glioma incidence and survival by race or ethnicity in the United States From 2000 to 2014. JAMA Oncol. 4:1254–1262. 2018.PubMed/NCBI View Article : Google Scholar
28	Liu S, Zhang C, Maimela NR, Yang L, Zhang Z, Ping Y, Huang L and Zhang Y: Molecular and clinical characterization of CD163 expression via large-scale analysis in glioma. Oncoimmunology. 8(1601478)2019.PubMed/NCBI View Article : Google Scholar
29	Xu L, Liu Z, Wang H, Lu J, Xu J, Meng Y, Huang K and Liu B: SESN2 could be a potential marker for diagnosis and prognosis in glioma. Genes (Basel). 14(701)2023.PubMed/NCBI View Article : Google Scholar
30	Zhang M, Cheng Y, Xue Z, Sun Q and Zhang J: A novel pyroptosis-related gene signature predicts the prognosis of glioma through immune infiltration. BMC Cancer. 21(1311)2021.PubMed/NCBI View Article : Google Scholar
31	Hajjar M, Lacoste D, Brossard G, Morlat P, Dupon M, Salmi LR and Dabis F: Non-acquired immune deficiency syndrome-defining malignancies in a hospital-based cohort of human immunodeficiency virus-infected patients: Bordeaux, France, 1985-1991. Groupe d'Epidémiologie Clinique du SIDA en Aquitaine. J Natl Cancer Inst. 84:1593–1595. 1992.PubMed/NCBI View Article : Google Scholar
32	Rabkin CS and Blattner WA: HIV infection and cancers other than non-Hodgkin lymphoma and Kaposi's sarcoma. Cancer Surv. 10:151–160. 1991.PubMed/NCBI
33	Pore N, Gupta AK, Cerniglia GJ and Maity A: HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells. Neoplasia. 8:889–895. 2006.PubMed/NCBI View Article : Google Scholar