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Role of the circular RNA regulatory network in the pathogenesis of biliary atresia

  • Authors:
    • Dong Liu
    • Yinghui Dong
    • Jiahui Gao
    • Zhouguang Wu
    • Lihui Zhang
    • Bin Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong 518000, P.R. China, Department of Ultrasound, Shenzhen People's Hospital, Shenzhen, Guangdong 518000, P.R. China, Department of Traditional Chinese Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 95
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    Published online on: January 9, 2024
       https://doi.org/10.3892/etm.2024.12383
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Abstract

Circular RNAs (circRNAs) serve an essential role in the occurrence and development of cholangiocarcinoma, but the expression and function of circRNA in biliary atresia (BA) is not clear. In the present study, circRNA expression profiles were investigated in the liver tissues of patients with BA as well as in the choledochal cyst (CC) tissues of control patients using RNA sequencing. A total of 78 differentially expressed circRNAs (DECs) were identified between the BA and CC tissues. The expression levels of eight circRNAs (hsa_circ_0006137, hsa_circ_0079422, hsa_circ_0007375, hsa_circ_0005597, hsa_circ_0006961, hsa_circ_0081171, hsa_circ_0084665 and hsa_circ_0075828) in the liver tissues of the BA group and control group were measured using reverse transcription‑quantitative polymerase chain reaction. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis demonstrated that the identified DECs are involved in a variety of biological processes, including apoptosis and metabolism. In addition, based on the GO and KEGG pathway enrichment analyses, it was revealed that target genes that can be affected by circRNAs regulatory network were enriched in the TGF‑β signaling pathway, EGFR tyrosine kinase inhibitor resistance pathway and transcription factor regulation pathway as well as other pathways that may be associated with the pathogenesis of BA. The present study revealed that circRNAs are potentially implicated in the pathogenesis of BA and could help to find promising targets and biomarkers for BA.
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1 

Kawano Y, Yoshimaru K, Uchida Y, Kajihara K, Toriigahara Y, Shirai T, Takahashi Y and Matsuura T: Biliary atresia in a preterm and extremely low birth weight infant: A case report and literature review. Surg Case Rep. 6(321)2020.PubMed/NCBI View Article : Google Scholar

2 

Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E and Sokol RJ: Biliary atresia: Clinical and research challenges for the twenty-first century. Hepatology. 68:1163–1173. 2018.PubMed/NCBI View Article : Google Scholar

3 

Hsiao CH, Chang MH, Chen HL, Lee HC, Wu TC, Lin CC, Yang YJ, Chen AC, Tiao MM, Lau BH, et al: Universal screening for biliary atresia using an infant stool color card in Taiwan. Hepatology. 47:1233–1240. 2008.PubMed/NCBI View Article : Google Scholar

4 

Hartley JL, Davenport M and Kelly DA: Biliary atresia. Lancet. 374:1704–1713. 2009.PubMed/NCBI View Article : Google Scholar

5 

Davenport M, Tizzard SA, Underhill J, Mieli-Vergani G, Portmann B and Hadzić N: The biliary atresia splenic malformation syndrome: A 28-year single-center retrospective study. J Pediatr. 149:393–400. 2006.PubMed/NCBI View Article : Google Scholar

6 

Hartley JL, O'Callaghan C, Rossetti S, Consugar M, Ward CJ, Kelly DA and Harris PC: Investigation of primary cilia in the pathogenesis of biliary atresia. J Pediatr Gastroenterol Nutr. 52:485–488. 2011.PubMed/NCBI View Article : Google Scholar

7 

Fabris L, Cadamuro M, Guido M, Spirli C, Fiorotto R, Colledan M, Torre G, Alberti D, Sonzogni A, Okolicsanyi L and Strazzabosco M: Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for notch signaling. Am J Pathol. 171:641–653. 2007.PubMed/NCBI View Article : Google Scholar

8 

Muraji T: Biliary atresia: New lessons learned from the past. J Pediatr Gastroenterol Nutr. 53:586–587. 2011.PubMed/NCBI View Article : Google Scholar

9 

Edom PT, Meurer L, da Silveira TR, Matte U and dos Santos JL: Immunolocalization of VEGF A and its receptors, VEGFR1 and VEGFR2, in the liver from patients with biliary atresia. Appl Immunohistochem Mol Morphol. 19:360–368. 2011.PubMed/NCBI View Article : Google Scholar

10 

Bolha L, Ravnik-Glavač M and Glavač D: Circular RNAs: Biogenesis, function, and a role as possible cancer biomarkers. Int J Genomics. 2017(6218353)2017.PubMed/NCBI View Article : Google Scholar

11 

Zeng X, Lin W, Guo M and Zou Q: A comprehensive overview and evaluation of circular RNA detection tools. PLoS Comput Biol. 13(e1005420)2017.PubMed/NCBI View Article : Google Scholar

12 

Verduci L, Strano S, Yarden Y and Blandino G: The circRNA-microRNA code: Emerging implications for cancer diagnosis and treatment. Mol Oncol. 13:669–680. 2019.PubMed/NCBI View Article : Google Scholar

13 

Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ and Kjems J: miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J. 30:4414–4422. 2011.PubMed/NCBI View Article : Google Scholar

14 

Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL and Gorospe M: Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol. 14:361–369. 2017.PubMed/NCBI View Article : Google Scholar

15 

Miao Q, Zhong Z, Jiang Z, Lin Y, Ni B, Yang W and Tang J: RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus. Lupus. 28:520–528. 2019.PubMed/NCBI View Article : Google Scholar

16 

Li LJ, Zhu ZW, Zhao W, Tao SS, Li BZ, Xu SZ, Wang JB, Zhang MY, Wu J, Leng RX, et al: Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus. Immunology. 155:137–149. 2018.PubMed/NCBI View Article : Google Scholar

17 

Wang L, Shen C, Wang Y, Zou T, Zhu H, Lu X, Li L, Yang B, Chen J, Chen S, et al: Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease. Atherosclerosis. 286:88–96. 2019.PubMed/NCBI View Article : Google Scholar

18 

Lei M, Zheng G, Ning Q, Zheng J and Dong D: Translation and functional roles of circular RNAs in human cancer. Mol Cancer. 19(30)2020.PubMed/NCBI View Article : Google Scholar

19 

Floris G, Zhang L, Follesa P and Sun T: Regulatory role of circular RNAs and neurological disorders. Mol Neurobiol. 54:5156–5165. 2017.PubMed/NCBI View Article : Google Scholar

20 

Zhang X, Lu N, Wang L, Wang Y, Li M, Zhou Y, Yan H, Cui M, Zhang M and Zhang L: Circular RNAs and esophageal cancer. Cancer Cell Int. 20(362)2020.PubMed/NCBI View Article : Google Scholar

21 

Chen X, Zhu S, Li HD, Wang JN, Sun LJ, Xu JJ, Hui YR, Li XF, Li LY, Zhao YX, et al: N6-methyladenosine-modified circIRF2, identified by YTHDF2, suppresses liver fibrosis via facilitating FOXO3 nuclear translocation. Int J Biol Macromol. 248(125811)2023.PubMed/NCBI View Article : Google Scholar

22 

Wang Q, Long Z, Zhu F, Li H, Xiang Z, Liang H, Wu Y, Dai X and Zhu Z: Integrated analysis of lncRNA/circRNA-miRNA-mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis. BMC Genomics. 24(417)2023.PubMed/NCBI View Article : Google Scholar

23 

Bolger AM, Lohse M and Usadel B: Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics. 30:2114–2120. 2014.PubMed/NCBI View Article : Google Scholar

24 

Kozomara A and Griffiths-Jones S: miRBase: Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42 (Database Issue):D68–D73. 2014.PubMed/NCBI View Article : Google Scholar

25 

Friedländer MR, Mackowiak SD, Li N, Chen W and Rajewsky N: miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res. 40:37–52. 2012.PubMed/NCBI View Article : Google Scholar

26 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010.PubMed/NCBI View Article : Google Scholar

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

28 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42 (Database Issue):D92–D97. 2014.PubMed/NCBI View Article : Google Scholar

29 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47 (D1):D607–D613. 2019.PubMed/NCBI View Article : Google Scholar

30 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003.PubMed/NCBI View Article : Google Scholar

31 

Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC and Müller M: pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 12(77)2011.PubMed/NCBI View Article : Google Scholar

32 

Xu X, Song B, Zhang Q, Qi W and Xu Y: Hsa_circ_0022383 promote non-small cell lung cancer tumorigenesis through regulating the miR-495-3p/KPNA2 axis. Cancer Cell Int. 23(282)2023.PubMed/NCBI View Article : Google Scholar

33 

Zhang C and He W: Circ_0020014 mediates CTSB expression and participates in IL-1β-prompted chondrocyte injury via interacting with miR-24-3p. J Orthop Surg Res. 18(877)2023.PubMed/NCBI View Article : Google Scholar

34 

Karreth FA, Reschke M, Ruocco A, Ng C, Chapuy B, Léopold V, Sjoberg M, Keane TM, Verma A, Ala U, et al: The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo. Cell. 161:319–332. 2015.PubMed/NCBI View Article : Google Scholar

35 

Lakshminarayanan B and Davenport M: Biliary atresia: A comprehensive review. J Autoimmun. 73:1–9. 2016.PubMed/NCBI View Article : Google Scholar

36 

Girard M and Panasyuk G: Genetics in biliary atresia. Curr Opin Gastroenterol. 35:73–81. 2019.PubMed/NCBI View Article : Google Scholar

37 

Debray D, Corvol H and Housset C: Modifier genes in cystic fibrosis-related liver disease. Curr Opin Gastroenterol. 35:88–92. 2019.PubMed/NCBI View Article : Google Scholar

38 

Costa FF: Non-coding RNAs, epigenetics and complexity. Gene. 410:9–17. 2008.PubMed/NCBI View Article : Google Scholar

39 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 146:353–358. 2011.PubMed/NCBI View Article : Google Scholar

40 

Calvopina DA, Coleman MA, Lewindon PJ and Ramm GA: Function and regulation of microRNAs and their potential as biomarkers in paediatric liver disease. Int J Mol Sci. 17(1795)2016.PubMed/NCBI View Article : Google Scholar

41 

Vicens Q and Westhof E: Biogenesis of circular RNAs. Cell. 159:13–14. 2014.PubMed/NCBI View Article : Google Scholar

42 

Li H, Zheng X, Gao J, Leung KS, Wong MH, Yang S, Liu Y, Dong M, Bai H, Ye X and Cheng L: Whole transcriptome analysis reveals non-coding RNA's competing endogenous gene pairs as novel form of motifs in serous ovarian cancer. Comput Biol Med. 148(105881)2022.PubMed/NCBI View Article : Google Scholar

43 

Wu S, Wu Y, Deng S, Lei X and Yang X: Emerging roles of noncoding RNAs in human cancers. Discov Oncol. 14(128)2023.PubMed/NCBI View Article : Google Scholar

44 

Ramljak S, Schmitz M, Repond C, Zerr I and Pellerin L: Altered mRNA and protein expression of monocarboxylate transporter MCT1 in the cerebral cortex and cerebellum of prion protein knockout mice. Int J Mol Sci. 22(1566)2021.PubMed/NCBI View Article : Google Scholar

45 

Acalovschi M: Gallstones in patients with liver cirrhosis: Incidence, etiology, clinical and therapeutical aspects. World J Gastroenterol. 20:7277–7285. 2014.PubMed/NCBI View Article : Google Scholar

46 

Konyn P, Alshuwaykh O, Dennis BB, Cholankeril G, Ahmed A and Kim D: Gallstone disease and its association with nonalcoholic fatty liver disease, all-cause and cause-specific mortality. Clin Gastroenterol Hepatol. 21:940–948.e2. 2023.PubMed/NCBI View Article : Google Scholar

47 

Li M, Xiao Y, Liu M, Ning Q, Xiang Z, Zheng X, Tang S and Mo Z: MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell. BMC Cancer. 22(876)2022.PubMed/NCBI View Article : Google Scholar

48 

Xing X, Guo S, Zhang G, Liu Y, Bi S, Wang X and Lu Q: miR-26a-5p protects against myocardial ischemia/reperfusion injury by regulating the PTEN/PI3K/AKT signaling pathway. Braz J Med Biol Res. 53(e9106)2020.PubMed/NCBI View Article : Google Scholar

49 

Ye Y, Li Z, Feng Q, Chen Z, Wu Z, Wang J, Ye X, Zhang D, Liu L, Gao W, et al: Downregulation of microRNA-145 may contribute to liver fibrosis in biliary atresia by targeting ADD3. PLoS One. 12(e0180896)2017.PubMed/NCBI View Article : Google Scholar

50 

Zhang C, Zhou H, Yuan K, Xie R and Chen C: Overexpression of hsa_circ_0136666 predicts poor prognosis and initiates osteosarcoma tumorigenesis through miR-593-3p/ZEB2 pathway. Aging (Albany NY). 12:10488–10496. 2020.PubMed/NCBI View Article : Google Scholar

51 

Abd El-Aziz A, El-Desouky MA, Shafei A, Elnakib M and Abdelmoniem AM: Influence of pentoxifylline on gene expression of PAG1/miR-1206/SNHG14 in ischemic heart disease. Biochem Biophys Rep. 25(100911)2021.PubMed/NCBI View Article : Google Scholar

52 

Zhang Y, Wang D, Zhu T, Yu J, Wu X, Lin W, Zhu M, Dai Y and Zhu J: CircPUM1 promotes hepatocellular carcinoma progression through the miR-1208/MAP3K2 axis. J Cell Mol Med. 25:600–612. 2021.PubMed/NCBI View Article : Google Scholar

53 

Roskoski R Jr: Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers. Pharmacol Res. 139:395–411. 2019.PubMed/NCBI View Article : Google Scholar

54 

Tzavlaki K and Moustakas A: TGF-β signaling. Biomolecules. 10(487)2020.PubMed/NCBI View Article : Google Scholar

55 

Chung-Davidson YW, Ren J, Yeh CY, Bussy U, Huerta B, Davidson PJ, Whyard S and Li W: TGF-β signaling plays a pivotal role during developmental biliary atresia in sea lamprey (petromyzon marinus). Hepatol Commun. 4:219–234. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liu D, Dong Y, Gao J, Wu Z, Zhang L and Wang B: Role of the circular RNA regulatory network in the pathogenesis of biliary atresia. Exp Ther Med 27: 95, 2024.
APA
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., & Wang, B. (2024). Role of the circular RNA regulatory network in the pathogenesis of biliary atresia. Experimental and Therapeutic Medicine, 27, 95. https://doi.org/10.3892/etm.2024.12383
MLA
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., Wang, B."Role of the circular RNA regulatory network in the pathogenesis of biliary atresia". Experimental and Therapeutic Medicine 27.3 (2024): 95.
Chicago
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., Wang, B."Role of the circular RNA regulatory network in the pathogenesis of biliary atresia". Experimental and Therapeutic Medicine 27, no. 3 (2024): 95. https://doi.org/10.3892/etm.2024.12383
Copy and paste a formatted citation
x
Spandidos Publications style
Liu D, Dong Y, Gao J, Wu Z, Zhang L and Wang B: Role of the circular RNA regulatory network in the pathogenesis of biliary atresia. Exp Ther Med 27: 95, 2024.
APA
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., & Wang, B. (2024). Role of the circular RNA regulatory network in the pathogenesis of biliary atresia. Experimental and Therapeutic Medicine, 27, 95. https://doi.org/10.3892/etm.2024.12383
MLA
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., Wang, B."Role of the circular RNA regulatory network in the pathogenesis of biliary atresia". Experimental and Therapeutic Medicine 27.3 (2024): 95.
Chicago
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., Wang, B."Role of the circular RNA regulatory network in the pathogenesis of biliary atresia". Experimental and Therapeutic Medicine 27, no. 3 (2024): 95. https://doi.org/10.3892/etm.2024.12383
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