Open Access

Role of the circular RNA regulatory network in the pathogenesis of biliary atresia

  • Authors:
    • Dong Liu
    • Yinghui Dong
    • Jiahui Gao
    • Zhouguang Wu
    • Lihui Zhang
    • Bin Wang
  • View Affiliations

  • Published online on: January 9, 2024     https://doi.org/10.3892/etm.2024.12383
  • Article Number: 95
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) serve an essential role in the occurrence and development of cholangiocarcinoma, but the expression and function of circRNA in biliary atresia (BA) is not clear. In the present study, circRNA expression profiles were investigated in the liver tissues of patients with BA as well as in the choledochal cyst (CC) tissues of control patients using RNA sequencing. A total of 78 differentially expressed circRNAs (DECs) were identified between the BA and CC tissues. The expression levels of eight circRNAs (hsa_circ_0006137, hsa_circ_0079422, hsa_circ_0007375, hsa_circ_0005597, hsa_circ_0006961, hsa_circ_0081171, hsa_circ_0084665 and hsa_circ_0075828) in the liver tissues of the BA group and control group were measured using reverse transcription‑quantitative polymerase chain reaction. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis demonstrated that the identified DECs are involved in a variety of biological processes, including apoptosis and metabolism. In addition, based on the GO and KEGG pathway enrichment analyses, it was revealed that target genes that can be affected by circRNAs regulatory network were enriched in the TGF‑β signaling pathway, EGFR tyrosine kinase inhibitor resistance pathway and transcription factor regulation pathway as well as other pathways that may be associated with the pathogenesis of BA. The present study revealed that circRNAs are potentially implicated in the pathogenesis of BA and could help to find promising targets and biomarkers for BA.
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March-2024
Volume 27 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Liu D, Dong Y, Gao J, Wu Z, Zhang L and Wang B: Role of the circular RNA regulatory network in the pathogenesis of biliary atresia. Exp Ther Med 27: 95, 2024
APA
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., & Wang, B. (2024). Role of the circular RNA regulatory network in the pathogenesis of biliary atresia. Experimental and Therapeutic Medicine, 27, 95. https://doi.org/10.3892/etm.2024.12383
MLA
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., Wang, B."Role of the circular RNA regulatory network in the pathogenesis of biliary atresia". Experimental and Therapeutic Medicine 27.3 (2024): 95.
Chicago
Liu, D., Dong, Y., Gao, J., Wu, Z., Zhang, L., Wang, B."Role of the circular RNA regulatory network in the pathogenesis of biliary atresia". Experimental and Therapeutic Medicine 27, no. 3 (2024): 95. https://doi.org/10.3892/etm.2024.12383