Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2024 Volume 27 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2024 Volume 27 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A novel animal model of abdominal aortic aneurysm by mechanical injury

  • Authors:
    • Soo-Hong Kim
    • Je-Hyung Park
    • Dong Hyun Kim
    • Jin-Ho Mun
    • Jae Hun Chung
    • Sang Su Lee
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, School of Medicine, Pusan National University, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam 50612, Republic of Korea, Department of Surgery, Bongseng Memorial Hospital, Busan 48775, Republic of Korea, Department of Surgery, Division of Endovascular and Vascular Surgery, School of Medicine, Pusan National University Yangsan Hospital, Pusan National University, Yangsan, Gyeongsangnam 50612, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 103
    |
    Published online on: January 16, 2024
       https://doi.org/10.3892/etm.2024.12391
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study established a novel and reproducible animal model to study abdominal aortic aneurysms. In total, 22 adult Lewis rats underwent a procedure to produce mechanical injuries at the infrarenal aorta which was opened temporarily. The aortas were injured 6 times and repaired. Those rats were divided into 2 groups and the aortic aneurysm tissue was harvested after 42 (6‑week group) or 63 (9‑week group) days and evaluated for the progression of aortic aneurysms. In the 6‑week group, changes in the aneurysm were observed in 6/10 (60%) rats and the mean maximum diameter of the aorta demonstrated a 119% increase in size from the baseline measurement. In the 9‑week group, changes in the aneurysm were observed in 8/11 (88%) rats and the mean maximum diameter of aorta demonstrated a 133% increase in size. Additional findings from the aortic aneurysm tissue were found microscopically, including the destruction of the tunica media and the elastic fiber. The present study demonstrated that this novel animal model for the development of abdominal aortic aneurysms (AAAs) produced by mechanical injury may have high reproducibility and similar gross and microscopic morphology to humans. This model could be helpful to investigate the treatment of AAAs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Rughani G, Robertson L and Clarke M: Medical treatment for small abdominal aortic aneurysms. Cochrane Database Syst Rev. (CD009536)2012.PubMed/NCBI View Article : Google Scholar

2 

Patelis N, Moris D, Schizas D, Damaskos C, Perrea D, Bakoyiannis C, Liakakos T and Georgopoulos S: Animal models in the research of abdominal aortic aneurysms development. Physiol Res. 66:899–915. 2017.PubMed/NCBI View Article : Google Scholar

3 

Yoshimura K, Morikage N, Nishino-Fujimoto S, Furutani A, Shirasawa B and Hamano K: Current status and perspectives on pharmacologic therapy for abdominal aortic aneurysm. Curr Drug Targets. 19:1265–1275. 2018.PubMed/NCBI View Article : Google Scholar

4 

Wang Y, Krishna S and Golledge J: The calcium chloride-induced rodent model of abdominal aortic aneurysm. Atherosclerosis. 226:29–39. 2013.PubMed/NCBI View Article : Google Scholar

5 

Fashandi AZ, Hawkins RB, Salmon MD, Spinosa MD, Montgomery WG, Cullen JM, Lu G, Su G, Ailawadi G and Upchurch GR Jr: A novel reproducible model of aortic aneurysm rupture. Surgery. 163:397–403. 2018.PubMed/NCBI View Article : Google Scholar

6 

Mouton R, Pollock J, Soar J, Mitchell DC and Rogers CA: Remote ischaemic preconditioning versus sham procedure for abdominal aortic aneurysm repair: An external feasibility randomized controlled trial. Trials. 16(377)2015.PubMed/NCBI View Article : Google Scholar

7 

Allaire E, Muscatelli-Groux B, Mandet C, Guinault AM, Bruneval P, Desgranges P, Clowes A, Méllière D and Becquemin JP: Paracrine effect of vascular smooth muscle cells in the prevention of aortic aneurysm formation. J Vasc Surg. 36:1018–1026. 2002.PubMed/NCBI View Article : Google Scholar

8 

Halpern VJ, Nackman GB, Gandhi RH, Irizarry E, Scholes JV, Ramey WG and Tilson MD: The elastase infusion model of experimental aortic aneurysms: Synchrony of induction of endogenous proteinases with matrix destruction and inflammatory cell response. J Vasc Surg. 20:51–60. 1994.PubMed/NCBI View Article : Google Scholar

9 

Marinov GR, Marois Y, Pâris E, Roby P, Formichi M, Douville Y and Guidoin R: Can the infusion of elastase in the abdominal aorta of the Yucatán miniature swine consistently produce experimental aneurysms? J Invest Surg. 10:129–150. 1997.PubMed/NCBI View Article : Google Scholar

10 

Zhu JX, Tang QQ, Zhou C, Shi XC, Yi SY and Yang Y: Establishment of a new abdominal aortic aneurysm model in rats by a retroperitoneal approach. Front Cardiovasc Med. 9(808732)2022.PubMed/NCBI View Article : Google Scholar

11 

Li MW, Mian MO, Barhoumi T, Rehman A, Mann K, Paradis P and Schiffrin EL: Endothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol. 33:2306–2315. 2013.PubMed/NCBI View Article : Google Scholar

12 

Lin PY, Wu YT, Lin GC, Shih YH, Sampilvanjil A, Chen LR, Yang YJ, Wu HL and Jiang MJ: Coarctation-induced degenerative abdominal aortic aneurysm in a porcine model. J Vasc Surg. 57:806–815.e1. 2013.PubMed/NCBI View Article : Google Scholar

13 

Czerski A, Bujok J, Gnus J, Hauzer W, Ratajczak K, Nowak M, Janeczek M, Zawadzki W, Witkiewicz W and Rusiecka A: Experimental methods of abdominal aortic aneurysm creation in swine as a large animal model. J Physiol Pharmacol. 64:185–192. 2013.PubMed/NCBI

14 

Quintana RA and Taylor WR: Cellular mechanisms of aortic aneurysm formation. Circ Res. 124:607–618. 2019.PubMed/NCBI View Article : Google Scholar

15 

Takagi H and Umemoto T: ALICE (All-Literature Investigation of Cardiovascular Evidence) Group. Association of hypertension with abdominal aortic aneurysm expansion. Ann Vasc Surg. 39:74–89. 2017.PubMed/NCBI View Article : Google Scholar

16 

Gao J, Cao H, Hu G, Wu Y, Xu Y, Cui H, Lu HS and Zheng L: The mechanism and therapy of aortic aneurysms. Signal Transduct Target Ther. 8(55)2023.PubMed/NCBI View Article : Google Scholar

17 

Bi Y, Zhong H, Xu K, Zhang Z, Qi X, Xia Y and Ren L: Development of a novel rabbit model of abdominal aortic aneurysm via a combination of periaortic calcium chloride and elastase incubation. PLoS One. 8(e68476)2013.PubMed/NCBI View Article : Google Scholar

18 

Ghoshal S and Loftin CD: Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice. PLoS One. 7(e44369)2012.PubMed/NCBI View Article : Google Scholar

19 

Riber SS, Ali M, Bergseth SH, Stubbe J, Stenger M, Behr-Rasmussen C and Lindholt JS: Induction of autoimmune abdominal aortic aneurysm in pigs-A novel large animal model. Ann Med Surg (Lond). 20:26–31. 2017.PubMed/NCBI View Article : Google Scholar

20 

Maynar M, Qian Z, Hernandez J, Sun F, DeMiguel C, Crisostomo V, Usón J, Pineda LF, Espinoza CG and Castañeda WR: An animal model of abdominal aortic aneurysm created with peritoneal patch: Technique and initial results. Cardiovasc Intervent Radiol. 26:168–176. 2003.PubMed/NCBI View Article : Google Scholar

21 

Verbrugghe P, Verhoeven J, Clijsters M, Vervoort D, Coudyzer W, Verbeken E, Meuris B and Herijgers P: Creation of abdominal aortic aneurysms in sheep by extrapolation of rodent models: Is it feasible? Ann Vasc Surg. 52:225–236. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim S, Park J, Kim DH, Mun J, Chung JH and Lee SS: A novel animal model of abdominal aortic aneurysm by mechanical injury. Exp Ther Med 27: 103, 2024.
APA
Kim, S., Park, J., Kim, D.H., Mun, J., Chung, J.H., & Lee, S.S. (2024). A novel animal model of abdominal aortic aneurysm by mechanical injury. Experimental and Therapeutic Medicine, 27, 103. https://doi.org/10.3892/etm.2024.12391
MLA
Kim, S., Park, J., Kim, D. H., Mun, J., Chung, J. H., Lee, S. S."A novel animal model of abdominal aortic aneurysm by mechanical injury". Experimental and Therapeutic Medicine 27.3 (2024): 103.
Chicago
Kim, S., Park, J., Kim, D. H., Mun, J., Chung, J. H., Lee, S. S."A novel animal model of abdominal aortic aneurysm by mechanical injury". Experimental and Therapeutic Medicine 27, no. 3 (2024): 103. https://doi.org/10.3892/etm.2024.12391
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Park J, Kim DH, Mun J, Chung JH and Lee SS: A novel animal model of abdominal aortic aneurysm by mechanical injury. Exp Ther Med 27: 103, 2024.
APA
Kim, S., Park, J., Kim, D.H., Mun, J., Chung, J.H., & Lee, S.S. (2024). A novel animal model of abdominal aortic aneurysm by mechanical injury. Experimental and Therapeutic Medicine, 27, 103. https://doi.org/10.3892/etm.2024.12391
MLA
Kim, S., Park, J., Kim, D. H., Mun, J., Chung, J. H., Lee, S. S."A novel animal model of abdominal aortic aneurysm by mechanical injury". Experimental and Therapeutic Medicine 27.3 (2024): 103.
Chicago
Kim, S., Park, J., Kim, D. H., Mun, J., Chung, J. H., Lee, S. S."A novel animal model of abdominal aortic aneurysm by mechanical injury". Experimental and Therapeutic Medicine 27, no. 3 (2024): 103. https://doi.org/10.3892/etm.2024.12391
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team