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CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis

  • Authors:
    • Qinghu Yan
    • Wenlong Zhao
    • Haili Kong
    • Jingyu Chi
    • Zhengjun Dai
    • Dexin Yu
    • Jia Cui
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong 250013, P.R. China, Huiying Medical Technology (Beijing) Co., Ltd., Beijing 100192, P.R. China, Department of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 112
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    Published online on: January 24, 2024
       https://doi.org/10.3892/etm.2024.12400
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Abstract

Global incidence rate of non‑tuberculous mycobacteria (NTM) pulmonary disease has been increasing rapidly. In some countries and regions, its incidence rate is higher than that of tuberculosis. It is easily confused with tuberculosis. The topic of this study is to identify two diseases using CT radioomics. The aim in the present study was to investigate the value of CT‑based radiomics to analyze consolidation features in differentiation of non‑tuberculous mycobacteria (NTM) from pulmonary tuberculosis (TB). A total of 156 patients (75 with NTM pulmonary disease and 81 with TB) exhibiting consolidation characteristics in Shandong Public Health Clinical Center were retrospectively analyzed. Subsequently, 305 regions of interest of CT consolidation were outlined. Using a random number generated via a computer, 70 and 30% of consolidations were allocated to the training and the validation cohort, respectively. By means of variance threshold, when investigating the effective radiomics features, SelectKBest and the least absolute shrinkage and selection operator regression method were employed for feature selection and combined to calculate the radiomics score. K‑nearest neighbor (KNN), support vector machine (SVM) and logistic regression (LR) were used to analyze effective radiomics features. A total of 18 patients with NTM pulmonary disease and 18 with TB possessing consolidation characteristics in Jinan Infectious Disease Hospital were collected for external validation of the model. A total of three methods was used in the selection of 52 optimal features. For KNN, the area under the curve (AUC; sensitivity, specificity) for the training and validation cohorts were 0.98 (0.93, 0.94) and 0.90 (0.88, 083), respectively; for SVM, AUC was 0.99 (0.96, 0.96) and 0.92 (0.86, 0.85) and for LR, AUC was 0.99 (0.97, 0.97) and 0.89 (0.88, 0.85). In the external validation cohort, AUC values of models were all >0.84 and LR classifier exhibited the most significant precision, recall and F1 score (0.87, 0.94 and 0.88, respectively). LR classifier possessed the best performance in differentiating diseases. Therefore, CT‑based radiomics analysis of consolidation features may distinguish NTM pulmonary disease from TB.
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Copy and paste a formatted citation
Spandidos Publications style
Yan Q, Zhao W, Kong H, Chi J, Dai Z, Yu D and Cui J: CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis. Exp Ther Med 27: 112, 2024.
APA
Yan, Q., Zhao, W., Kong, H., Chi, J., Dai, Z., Yu, D., & Cui, J. (2024). CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis. Experimental and Therapeutic Medicine, 27, 112. https://doi.org/10.3892/etm.2024.12400
MLA
Yan, Q., Zhao, W., Kong, H., Chi, J., Dai, Z., Yu, D., Cui, J."CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis". Experimental and Therapeutic Medicine 27.3 (2024): 112.
Chicago
Yan, Q., Zhao, W., Kong, H., Chi, J., Dai, Z., Yu, D., Cui, J."CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis". Experimental and Therapeutic Medicine 27, no. 3 (2024): 112. https://doi.org/10.3892/etm.2024.12400
Copy and paste a formatted citation
x
Spandidos Publications style
Yan Q, Zhao W, Kong H, Chi J, Dai Z, Yu D and Cui J: CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis. Exp Ther Med 27: 112, 2024.
APA
Yan, Q., Zhao, W., Kong, H., Chi, J., Dai, Z., Yu, D., & Cui, J. (2024). CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis. Experimental and Therapeutic Medicine, 27, 112. https://doi.org/10.3892/etm.2024.12400
MLA
Yan, Q., Zhao, W., Kong, H., Chi, J., Dai, Z., Yu, D., Cui, J."CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis". Experimental and Therapeutic Medicine 27.3 (2024): 112.
Chicago
Yan, Q., Zhao, W., Kong, H., Chi, J., Dai, Z., Yu, D., Cui, J."CT‑based radiomics analysis of consolidation characteristics in differentiating pulmonary disease of non‑tuberculous mycobacterium from pulmonary tuberculosis". Experimental and Therapeutic Medicine 27, no. 3 (2024): 112. https://doi.org/10.3892/etm.2024.12400
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