Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2024 Volume 27 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2024 Volume 27 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction

  • Authors:
    • Ling Chen
    • Meiting Wu
    • Yu Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 114
    |
    Published online on: January 26, 2024
       https://doi.org/10.3892/etm.2024.12402
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Preeclampsia (PE) is a pregnancy-specific syndrome with complex pathogenesis. The present study aimed to explore the role of heat shock protein B8 (HSPB8) and c-Myc in trophoblast cell dysfunction using a hypoxia/reoxygenation (H/R)-treated HTR8/SVneo cell model. HSPB8 expression in tissues of patients with PE was analyzed using the Gene Expression Omnibus database. Following detection of HSPB8 expression in H/R-stimulated HTR8/SVneo cells, HSPB8 was overexpressed by transfection of the gene with a HSPB8-specific plasmid. Cell Counting Kit-8, wound healing and Transwell assays were used to evaluate the proliferation, migration and invasion of HTR8/SVneo cells exposed to H/R conditions. Reactive oxygen species (ROS) were determined by 2,7-dichlorodihydrofluorescein diacetate staining. 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbo-cyanine iodide (JC-1) staining was applied to assess mitochondrial membrane potential. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were detected using the corresponding commercial kits. In addition, the induction of apoptosis was assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. Moreover, the Biogrid database predicted that HSPB8 was bound to c-Myc, and a co-immunoprecipitation (Co-IP) assay was used to verify this interaction. Subsequently, c-Myc expression was silenced to conduct rescue experiments in HTR8/SVneo cells exposed to H/R conditions and upregulated HSPB8 expression. Notably, reduced HSPB8 expression was noted in PE tissues and H/R-stimulated HTR8/SVneo cells. HSPB8 enforced expression promoted the proliferation, migration and invasion of HTR8/SVneo cells. Moreover, H/R caused an increase in ROS and MDA levels as well as in TUNEL staining and a decrease in aggregated JC-1 fluorescence and SOD activity levels, which were restored following HSPB8 overexpression. Co-IP confirmed the interaction between HSPB8 and c-Myc. Moreover, knockdown of c-Myc expression compromised the effects of HSPB8 upregulation on trophoblast cell dysfunction following induction of H/R. Collectively, the data indicated that HSPB8 could improve mitochondrial oxidative stress by binding to c-Myc to alleviate trophoblast cell dysfunction. The findings may provide new insights into the pathogenesis of PE and highlight the role of HSPB8/c-Myc in the prevention and treatment of PE in the future.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Chang KJ, Seow KM and Chen KH: Preeclampsia: Recent advances in predicting, preventing, and managing the maternal and fetal life-threatening condition. Int J Environ Res Public Health. 20(2994)2023.PubMed/NCBI View Article : Google Scholar

2 

Kingwell K: RNA interference: Pre-empting preeclampsia. Nat Rev Drug Discov. 18(18)2018.PubMed/NCBI View Article : Google Scholar

3 

Serra B, Mendoza M, Scazzocchio E, Meler E, Nolla M, Sabrià E, Rodríguez I and Carreras E: A new model for screening for early-onset preeclampsia. Am J Obstet Gynecol. 222:608.e1–608.e18. 2020.PubMed/NCBI View Article : Google Scholar

4 

Phipps EA, Thadhani R, Benzing T and Karumanchi SA: Pre-eclampsia: Pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 15:275–289. 2019.PubMed/NCBI View Article : Google Scholar

5 

Abbas Y, Turco MY, Burton GJ and Moffett A: Investigation of human trophoblast invasion in vitro. Hum Reprod Update. 26:501–513. 2020.PubMed/NCBI View Article : Google Scholar

6 

Sato Y: Endovascular trophoblast and spiral artery remodeling. Mol Cell Endocrinol. 503(110699)2020.PubMed/NCBI View Article : Google Scholar

7 

Kingdom JC, Audette MC, Hobson SR, Windrim RC and Morgen E: A placenta clinic approach to the diagnosis and management of fetal growth restriction. Am J Obstet Gynecol. 218 (2S):S803–S817. 2018.PubMed/NCBI View Article : Google Scholar

8 

Collins SL, Birks JS, Stevenson GN, Papageorghiou AT, Noble JA and Impey L: Measurement of spiral artery jets: General principles and differences observed in small-for-gestational-age pregnancies. Ultrasound Obstet Gynecol. 40:171–178. 2012.PubMed/NCBI View Article : Google Scholar

9 

Myatt L and Roberts JM: Preeclampsia: Syndrome or disease? Curr Hypertens Rep. 17(83)2015.PubMed/NCBI View Article : Google Scholar

10 

Pennington KA, Schlitt JM, Jackson DL, Schulz LC and Schust DJ: Preeclampsia: Multiple approaches for a multifactorial disease. Dis Model Mech. 5:9–18. 2012.PubMed/NCBI View Article : Google Scholar

11 

Reister F, Heyl W, Kaufmann P and Rath W: Trophoblast invasion in pre-eclampsia. Zentralbl Gynakol. 121:587–590. 1999.PubMed/NCBI(In German).

12 

Rana S, Lemoine E, Granger JP and Karumanchi SA: Preeclampsia: Pathophysiology, challenges, and perspectives. Circ Res. 124:1094–1112. 2019.PubMed/NCBI View Article : Google Scholar

13 

Zsengellér ZK, Rajakumar A, Hunter JT, Salahuddin S, Rana S, Stillman IE and Ananth Karumanchi S: Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1. Pregnancy Hypertens. 6:313–319. 2016.PubMed/NCBI View Article : Google Scholar

14 

Chiarello DI, Abad C, Rojas D, Toledo F, Vázquez CM, Mate A, Sobrevia L and Marín R: Oxidative stress: Normal pregnancy versus preeclampsia. Biochim Biophys Acta Mol Basis Dis. 1866(165354)2020.PubMed/NCBI View Article : Google Scholar

15 

Dai H and Lu X: MGST1 alleviates the oxidative stress of trophoblast cells induced by hypoxia/reoxygenation and promotes cell proliferation, migration, and invasion by activating the PI3K/AKT/mTOR pathway. Open Med (Wars). 17:2062–2071. 2022.PubMed/NCBI View Article : Google Scholar

16 

Haram K, Mortensen JH, Myking O, Magann EF and Morrison JC: The role of oxidative stress, adhesion molecules and antioxidants in preeclampsia. Curr Hypertens Rev. 15:105–112. 2019.PubMed/NCBI View Article : Google Scholar

17 

Xu Z, Jin X, Cai W, Zhou M, Shao P, Yang Z, Fu R, Cao J, Liu Y, Yu F, et al: Proteomics analysis reveals abnormal electron transport and excessive oxidative stress cause mitochondrial dysfunction in placental tissues of early-onset preeclampsia. Proteomics Clin Appl. 12(e1700165)2018.PubMed/NCBI View Article : Google Scholar

18 

Yu L, Liang Q, Zhang W, Liao M, Wen M, Zhan B, Bao H and Cheng X: HSP22 suppresses diabetes-induced endothelial injury by inhibiting mitochondrial reactive oxygen species formation. Redox Biol. 21(101095)2019.PubMed/NCBI View Article : Google Scholar

19 

Li X, Sun C, Chen J, Ma JF and Pan YH: ERK-CREB pathway is involved in HSPB8-mediated glioma cell growth and metastatic properties. Exp Mol Pathol. (104653)2021.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print).

20 

Boczek EE, Fürsch J, Niedermeier ML, Jawerth L, Jahnel M, Ruer-Gruß M, Kammer KM, Heid P, Mediani L, Wang J, et al: HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain. Elife. 10(e69377)2021.PubMed/NCBI View Article : Google Scholar

21 

Matsushima-Nishiwaki R, Toyoda H, Takamatsu R, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Yoshimi N, Kumada T and Kozawa O: Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathway. Biochim Biophys Acta Mol Basis Dis. 1863:1629–1639. 2017.PubMed/NCBI View Article : Google Scholar

22 

Piccolella M, Crippa V, Cristofani R, Rusmini P, Galbiati M, Cicardi ME, Meroni M, Ferri N, Morelli FF, Carra S, et al: The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells. Oncotarget. 8:10400–10415. 2017.PubMed/NCBI View Article : Google Scholar

23 

Shu B, Zhou Y, Liang Q, He C and Li F: HSPB8 promoted intrahepatic cholangiocarcinoma progression by enhancing epithelial-mesenchymal transition and autophagy. Exp Mol Pathol. 123(104691)2021.PubMed/NCBI View Article : Google Scholar

24 

Li F, Yang B, Li T, Gong X, Zhou F and Hu Z: HSPB8 over-expression prevents disruption of blood-brain barrier by promoting autophagic flux after cerebral ischemia/reperfusion injury. J Neurochem. 148:97–113. 2019.PubMed/NCBI View Article : Google Scholar

25 

Azar C, Valentine MC, Trausch-Azar J, Rois L, Mahjoub M, Nelson DM and Schwartz AL: RNA-Seq identifies genes whose proteins are upregulated during syncytia development in murine C2C12 myoblasts and human BeWo trophoblasts. Physiol Rep. 9(e14671)2021.PubMed/NCBI View Article : Google Scholar

26 

Dhanasekaran R, Deutzmann A, Mahauad-Fernandez WD, Hansen AS, Gouw AM and Felsher DW: The MYC oncogene-the grand orchestrator of cancer growth and immune evasion. Nat Rev Clin Oncol. 19:23–36. 2022.PubMed/NCBI View Article : Google Scholar

27 

Sun M, Chen H, Liu J, Tong C and Meng T: MicroRNA-34a inhibits human trophoblast cell invasion by targeting MYC. BMC Cell Biol. 16(21)2015.PubMed/NCBI View Article : Google Scholar

28 

Hu X, Ao J, Li X, Zhang H, Wu J and Cheng W: Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia. Clin Epigenetics. 10(48)2018.PubMed/NCBI View Article : Google Scholar

29 

Hu X, Li X, Tian GG, Zhang H, Cheng W and Wu J: Expression profiling dataset of competing endogenous RNA in pre-eclampsia. Data Brief. 27(104795)2019.PubMed/NCBI View Article : Google Scholar

30 

Medina-Bastidas D, Guzmán-Huerta M, Borboa-Olivares H, Ruiz-Cruz C, Parra-Hernández S, Flores-Pliego A, Salido-Guadarrama I, Camargo-Marín L, Arambula-Meraz E and Estrada-Gutierrez G: Placental microarray profiling reveals common mRNA and lncRNA expression patterns in preeclampsia and intrauterine growth restriction. Int J Mol Sci. 21(3597)2020.PubMed/NCBI View Article : Google Scholar

31 

Yang Z, Bai B, Luo X, Xiao X, Liu X, Ding Y, Zhang H, Gao L, Li J and Qi H: Downregulated Krüppel-like factor 8 is involved in decreased trophoblast invasion under hypoxia-reoxygenation conditions. Reprod Sci. 21:72–81. 2014.PubMed/NCBI View Article : Google Scholar

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

33 

Thompson LP, Pence L, Pinkas G, Song H and Telugu BP: Placental hypoxia during early pregnancy causes maternal hypertension and placental insufficiency in the hypoxic guinea pig model. Biol Reprod. 95(128)2016.PubMed/NCBI View Article : Google Scholar

34 

Masturzo B, Di Martino D, Prefumo F, Cavoretto P, Germano C, Gennarelli G, Roletti E, Bottazzoli E, Fusè F, Ferrazzi E, et al: Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age. Arch Gynecol Obstet. 300:861–867. 2019.PubMed/NCBI View Article : Google Scholar

35 

Fox R, Kitt J, Leeson P, Aye CYL and Lewandowski AJ: Preeclampsia: Risk factors, diagnosis, management, and the cardiovascular impact on the offspring. J Clin Med. 8(1625)2019.PubMed/NCBI View Article : Google Scholar

36 

Merviel P, Carbillon L, Challier JC, Rabreau M, Beaufils M and Uzan S: Pathophysiology of preeclampsia: Links with implantation disorders. Eur J Obstet Gynecol Reprod Biol. 115:134–147. 2004.PubMed/NCBI View Article : Google Scholar

37 

Huppertz B: The critical role of abnormal trophoblast development in the etiology of preeclampsia. Curr Pharm Biotechnol. 19:771–780. 2018.PubMed/NCBI View Article : Google Scholar

38 

Hemberger M: Health during pregnancy and beyond: Fetal trophoblast cells as chief co-ordinators of intrauterine growth and reproductive success. Ann Med. 44:325–337. 2012.PubMed/NCBI View Article : Google Scholar

39 

Sánchez-Aranguren LC, Prada CE, Riaño-Medina CE and Lopez M: Endothelial dysfunction and preeclampsia: role of oxidative stress. Front Physiol. 5(372)2014.PubMed/NCBI View Article : Google Scholar

40 

Murata M, Fukushima K, Takao T, Seki H, Takeda S and Wake N: Oxidative stress produced by xanthine oxidase induces apoptosis in human extravillous trophoblast cells. J Reprod Dev. 59:7–13. 2013.PubMed/NCBI View Article : Google Scholar

41 

Staff AC: The two-stage placental model of preeclampsia: An update. J Reprod Immunol. 134-135:1–10. 2019.PubMed/NCBI View Article : Google Scholar

42 

Yang HY: MiR-133b regulates oxidative stress injury of trophoblasts in preeclampsia by mediating the JAK2/STAT3 signaling pathway. J Mol Histol. 52:1177–1188. 2021.PubMed/NCBI View Article : Google Scholar

43 

Xu X, Ye X, Zhu M, Zhang Q, Li X and Yan J: FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway. BMC Pregnancy Childbirth. 23(131)2023.PubMed/NCBI View Article : Google Scholar

44 

Zhang K, Yin W, Ma L, Liu Z and Li Q: HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway. Biochem Cell Biol. 101:1–11. 2023.PubMed/NCBI View Article : Google Scholar

45 

Shen J, Li M and Min L: HSPB8 promotes cancer cell growth by activating the ERK-CREB pathway and is indicative of a poor prognosis in gastric cancer patients. Oncol Rep. 39:2978–2986. 2018.PubMed/NCBI View Article : Google Scholar

46 

Yu LL, Wang Y, Xiao ZK and Chen SS: Heat shock protein B8 promotes proliferation and migration in lung adenocarcinoma A549 cells by maintaining mitochondrial function. Mol Cell Biochem. 476:187–197. 2021.PubMed/NCBI View Article : Google Scholar

47 

Cheng J, Ji M, Jing H and Lin H: DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy. J Biochem Mol Toxicol. 37(e23310)2023.PubMed/NCBI View Article : Google Scholar

48 

Li F, Tan J, Zhou F, Hu Z and Yang B: Heat shock protein B8 (HSPB8) reduces oxygen-glucose deprivation/reperfusion injury via the induction of mitophagy. Cell Physiol Biochem. 48:1492–1504. 2018.PubMed/NCBI View Article : Google Scholar

49 

Duffy MJ, O'Grady S, Tang M and Crown J: MYC as a target for cancer treatment. Cancer Treat Rev. 94(102154)2021.PubMed/NCBI View Article : Google Scholar

50 

Fatma H, Maurya SK and Siddique HR: Epigenetic modifications of c-MYC: Role in cancer cell reprogramming, progression and chemoresistance. Semin Cancer Biol. 83:166–176. 2022.PubMed/NCBI View Article : Google Scholar

51 

Dai M, Song J, Wang L, Zhou K and Shu L: HOXC13 promotes cervical cancer proliferation, invasion and Warburg effect through β-catenin/c-Myc signaling pathway. J Bioenerg Biomembr. 53:597–608. 2021.PubMed/NCBI View Article : Google Scholar

52 

Shan N, Ni LY, Zhu YS, Shen Y, Gao ZJ and Cai ZZ: Girdin influences pancreatic cancer progression by regulating c-MYC expression. Neoplasma. 69:193–202. 2022.PubMed/NCBI View Article : Google Scholar

53 

Ali A, Ali A, Devi HS, Daddam JR, Sarwar R and Badrealam FK: The HDAC2/YY1/c-Myc signaling axis regulates lung cancer cell migration and proliferation. Environ Toxicol. 38:1989–2001. 2023.PubMed/NCBI View Article : Google Scholar

54 

Wu Z, Cheng S, Wang S, Li W and Liu J: C-MYC ameliorates ventricular remodeling of myocardial infarction rats via binding to the promoter of microRNA-29a-3p to facilitate TET2 expression. Int J Cardiol. 357:105–112. 2022.PubMed/NCBI View Article : Google Scholar

55 

Prieto J, García-Cañaveras JC, León M, Sendra R, Ponsoda X, Izpisúa Belmonte JC, Lahoz A and Torres J: c-MYC triggers lipid remodelling during early somatic cell reprogramming to pluripotency. Stem Cell Rev Rep. 17:2245–2261. 2021.PubMed/NCBI View Article : Google Scholar

56 

Kfoury A, Armaro M, Collodet C, Sordet-Dessimoz J, Giner MP, Christen S, Moco S, Leleu M, de Leval L, Koch U, et al: AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress. EMBO J. 37(e97673)2018.PubMed/NCBI View Article : Google Scholar

57 

Pu HH, Duan J, Wang Y, Fan DX, Li DJ and Jin LP: Thymic stromal lymphopoietin promotes the proliferation of human trophoblasts via phosphorylated STAT3-mediated c-Myc upregulation. Placenta. 33:387–391. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen L, Wu M and Zhou Y: HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction. Exp Ther Med 27: 114, 2024.
APA
Chen, L., Wu, M., & Zhou, Y. (2024). HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction. Experimental and Therapeutic Medicine, 27, 114. https://doi.org/10.3892/etm.2024.12402
MLA
Chen, L., Wu, M., Zhou, Y."HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction". Experimental and Therapeutic Medicine 27.3 (2024): 114.
Chicago
Chen, L., Wu, M., Zhou, Y."HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction". Experimental and Therapeutic Medicine 27, no. 3 (2024): 114. https://doi.org/10.3892/etm.2024.12402
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Wu M and Zhou Y: HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction. Exp Ther Med 27: 114, 2024.
APA
Chen, L., Wu, M., & Zhou, Y. (2024). HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction. Experimental and Therapeutic Medicine, 27, 114. https://doi.org/10.3892/etm.2024.12402
MLA
Chen, L., Wu, M., Zhou, Y."HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction". Experimental and Therapeutic Medicine 27.3 (2024): 114.
Chicago
Chen, L., Wu, M., Zhou, Y."HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction". Experimental and Therapeutic Medicine 27, no. 3 (2024): 114. https://doi.org/10.3892/etm.2024.12402
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team