Open Access

Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review)

  • Authors:
    • Shaohua Ju
    • Youli Tan
    • Qiang Wang
    • Ling Zhou
    • Kun Wang
    • Chenghong Wen
    • Mingjian Wang
  • View Affiliations

  • Published online on: April 12, 2024     https://doi.org/10.3892/etm.2024.12536
  • Article Number: 248
  • Copyright: © Ju et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin. The aim of the present study was to systematically review relevant literature on the antioxidant and anti‑inflammatory effects of esculetin and esculin. Esculetin and esculin can promote the expression of various endogenous antioxidant proteins, such as superoxide dismutase, glutathione peroxidase and glutathione reductase. This is associated with the activation of the nuclear factor erythroid‑derived factor 2‑related factor 2 signaling pathway. The anti‑inflammatory effects of esculetin and esculin are associated with the inhibition of the nuclear factor κ‑B and mitogen‑activated protein kinase inflammatory signaling pathways. In various inflammatory models, esculetin and esculin can reduce the expression levels of various proinflammatory factors such as tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6, thereby inhibiting the development of inflammation. In summary, esculetin and esculin may be promising candidates for the treatment of numerous diseases associated with inflammation and oxidative stress, such as ulcerative colitis, acute lung and kidney injury, lung cancer, acute kidney injury.
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June-2024
Volume 27 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Ju S, Tan Y, Wang Q, Zhou L, Wang K, Wen C and Wang M: Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review). Exp Ther Med 27: 248, 2024
APA
Ju, S., Tan, Y., Wang, Q., Zhou, L., Wang, K., Wen, C., & Wang, M. (2024). Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review). Experimental and Therapeutic Medicine, 27, 248. https://doi.org/10.3892/etm.2024.12536
MLA
Ju, S., Tan, Y., Wang, Q., Zhou, L., Wang, K., Wen, C., Wang, M."Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review)". Experimental and Therapeutic Medicine 27.6 (2024): 248.
Chicago
Ju, S., Tan, Y., Wang, Q., Zhou, L., Wang, K., Wen, C., Wang, M."Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review)". Experimental and Therapeutic Medicine 27, no. 6 (2024): 248. https://doi.org/10.3892/etm.2024.12536