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Review Open Access

Role of angiomotin family members in human diseases (Review)

  • Authors:
    • Haoyun Wang
    • Meng Ye
    • Xiaofeng Jin
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    Affiliations: Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 258
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    Published online on: April 23, 2024
       https://doi.org/10.3892/etm.2024.12546
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Abstract

Angiomotin (Amot) family members, including Amot, Amot‑like protein 1 (Amotl1) and Amot‑like protein 2 (Amotl2), have been found to interact with angiostatins. In addition, Amot family members are involved in various physiological and pathological functions such as embryonic development, angiogenesis and tumorigenesis. Some studies have also demonstrated its regulation in signaling pathways such as the Hippo signaling pathway, AMPK signaling pathway and mTOR signaling pathways. Amot family members play an important role in neural stem cell differentiation, dendritic formation and synaptic maturation. In addition, an increasing number of studies have focused on their function in promoting and/or suppressing cancer, but the underlying mechanisms remain to be elucidated. The present review integrated relevant studies on upstream regulation and downstream signals of Amot family members, as well as the latest progress in physiological and pathological functions and clinical applications, hoping to offer important ideas for further research.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Ye M and Jin X: Role of angiomotin family members in human diseases (Review). Exp Ther Med 27: 258, 2024.
APA
Wang, H., Ye, M., & Jin, X. (2024). Role of angiomotin family members in human diseases (Review). Experimental and Therapeutic Medicine, 27, 258. https://doi.org/10.3892/etm.2024.12546
MLA
Wang, H., Ye, M., Jin, X."Role of angiomotin family members in human diseases (Review)". Experimental and Therapeutic Medicine 27.6 (2024): 258.
Chicago
Wang, H., Ye, M., Jin, X."Role of angiomotin family members in human diseases (Review)". Experimental and Therapeutic Medicine 27, no. 6 (2024): 258. https://doi.org/10.3892/etm.2024.12546
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Ye M and Jin X: Role of angiomotin family members in human diseases (Review). Exp Ther Med 27: 258, 2024.
APA
Wang, H., Ye, M., & Jin, X. (2024). Role of angiomotin family members in human diseases (Review). Experimental and Therapeutic Medicine, 27, 258. https://doi.org/10.3892/etm.2024.12546
MLA
Wang, H., Ye, M., Jin, X."Role of angiomotin family members in human diseases (Review)". Experimental and Therapeutic Medicine 27.6 (2024): 258.
Chicago
Wang, H., Ye, M., Jin, X."Role of angiomotin family members in human diseases (Review)". Experimental and Therapeutic Medicine 27, no. 6 (2024): 258. https://doi.org/10.3892/etm.2024.12546
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