Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2024 Volume 27 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2024 Volume 27 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population

  • Authors:
    • Li Zhou
    • Jun Shan
    • Dao-Ming Zu
    • Shu-Hao Deng
    • Yuan Zhang
    • Xiu-Rong Shi
    • Yi-Cheng Zhu
    • Quan Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201200, P.R. China, Department of Ultrasound, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201200, P.R. China, Department of Paediatrics, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201200, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 259
    |
    Published online on: April 23, 2024
       https://doi.org/10.3892/etm.2024.12547
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present retrospective study was designed to explore the value of conventional ultrasound (US) and Virtual Touch Tissue Imaging and Quantification (VTIQ) in the assessment of mesenteric lymphadenitis (ML) in a paediatric population. A total of 103 patients with ML and 60 healthy paediatric patients were examined. VTIQ was performed to assess mesenteric lymph node (MLN) stiffness via shear‑wave velocity (SWV). Univariate and multivariate logistic regression analyses were conducted to reveal independent variables for the identification of ML. The diagnostic performance of US, and US combined with VTIQ, were compared. All the quantitative VTIQ parameters (including the SWVMean, SWVMax and SWVMin) were significantly greater for MLNs in the control group than for MLNs in the ML group (all P<0.001). The SWV values in the control group were nearly 2‑fold greater than that in the ML group. According to the multivariate logistic regression analysis, the longest diameter [odds ratio (OR)=6.042; P=0.046] was revealed to be the strongest independent predictor for ML, followed by the CRP level (OR=2.310; P<0.001) and the SWVMean (OR=0.106; P<0.001). According to the receiver operating characteristic analysis, the area under the curve (AUC) for US combined with VTIQ was 0.890 (95% CI: 0.831‑0.949) with a greater sensitivity of 91.26% and a greater specificity of 86.67% than that for US alone (AUC: 0.798; 95% CI: 0.724‑0.872; sensitivity: 79.61%; specificity: 80.00%). A significant negative correlation between increased VTIQ parameters and ML was observed. Utilizing VTIQ to assess MLN stiffness offers a non‑invasive, convenient, reliable and reproducible approach for identifying mesenteric lymphadenopathy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Devine M and Coffey JC: Mesenteric Adenopathy and Adenitis. Prog Inflammation Res. 90:127–148. 2023.

2 

Simanovsky N and Hiller N: Importance of sonographic detection of enlarged abdominal lymph nodes in children. J Ultrasound Med. 26:581–584. 2007.PubMed/NCBI View Article : Google Scholar

3 

Toorenvliet B, Vellekoop A, Bakker R, Wiersma F, Mertens B, Merkus J, Breslau P and Hamming J: Clinical differentiation between acute appendicitis and acute mesenteric lymphadenitis in children. Eur J Pediatr Surg. 21:120–123. 2011.PubMed/NCBI View Article : Google Scholar

4 

Ozdamar MY and Karavas E: Acute mesenteric lymphadenitis in children: Findings related to differential diagnosis and hospitalization. Arch Med Sci. 16:313–320. 2018.PubMed/NCBI View Article : Google Scholar

5 

Evans A, Whelehan P, Thomson K, McLean D, Brauer K, Purdie C, Baker L, Jordan L, Rauchhaus P and Thompson A: Invasive breast cancer: Relationship between shear-wave elastographic findings and histologic prognostic factors. Radiology. 263:673–677. 2012.PubMed/NCBI View Article : Google Scholar

6 

Wong VW, Vergniol J, Wong GL, Foucher J, Chan HL, Le Bail B, Choi PC, Kowo M, Chan AW, Merrouche W, et al: Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology. 51:454–462. 2010.PubMed/NCBI View Article : Google Scholar

7 

Sun CY, Lei KR, Liu BJ, Bo XW, Li XL, He YP, Wang D, Ren WW, Zhao CK and Xu HX: Virtual touch tissue imaging and quantification (VTIQ) in the evaluation of thyroid nodules: The associated factors leading to misdiagnosis. Sci Rep. 7(41958)2017.PubMed/NCBI View Article : Google Scholar

8 

Glišić TM, Perišić MD, Dimitrijevic S and Jurišić V: Doppler assessment of splanchnic arterial flow in patients with liver cirrhosis: Correlation with ammonia plasma levels and MELD score. J Clin Ultrasound. 42:264–269. 2014.PubMed/NCBI View Article : Google Scholar

9 

Zhou H, Zhou XL, Xu HX, Li DD, Liu BJ, Zhang YF, Xu JM, Bo XW, Li XL, Guo LH and Qu S: Virtual touch tissue imaging and quantification in the evaluation of thyroid nodules. J Ultrasound Med. 36:251–260. 2017.PubMed/NCBI View Article : Google Scholar

10 

Kong WT, Zhou WJ, Wang Y, Zhuang XM and Wu M: The value of virtual touch tissue imaging quantification in the differential diagnosis between benign and malignant breast lesions. J Med Ultrason (2001). 46:459–466. 2019.PubMed/NCBI View Article : Google Scholar

11 

Ruger H, Psychogios G, Jering M and Zenk J: Multimodal ultrasound including virtual touch imaging quantification for differentiating cervical lymph nodes. Ultrasound Med Biol. 46:2677–2682. 2020.PubMed/NCBI View Article : Google Scholar

12 

Bayramoglu Z, Caliskan E, Karakas Z, Karaman S, Tugcu D, Somer A, Acar M, Akıcı F and Adaletli I: Diagnostic performances of superb microvascular imaging, shear wave elastography and shape index in pediatric lymph nodes categorization: A comparative study. Br J Radiol. 91(20180129)2018.PubMed/NCBI View Article : Google Scholar

13 

Jurisic V, Terzic T, Colic S and Jurisic M: The concentration of TNF-alpha correlate with number of inflammatory cells and degree of vascularization in radicular cysts. Oral Dis. 14:600–605. 2008.PubMed/NCBI View Article : Google Scholar

14 

Dzopalić T, Božić-Nedeljković B and Jurišić V: Function of innate lymphoid cells in the immune-related disorders. Hum Cell. 32:231–239. 2019.PubMed/NCBI View Article : Google Scholar

15 

Handorf AM, Zhou Y, Halanski MA and Li WJ: Tissue stiffness dictates development, homeostasis, and disease progression. Organogenesis. 11:1–15. 2015.PubMed/NCBI View Article : Google Scholar

16 

Desmots F, Fakhry N, Mancini J, Reyre A, Vidal V, Jacquier A, Santini L, Moulin G and Varoquaux A: Shear wave elastography in head and neck lymph node assessment: Image quality and diagnostic impact compared with B-Mode and doppler ultrasonography. Ultrasound Med Biol. 42:387–398. 2016.PubMed/NCBI View Article : Google Scholar

17 

Yang JR, Song Y, Jia YL and Ruan LT: Application of multimodal ultrasonography for differentiating benign and malignant cervical lymphadenopathy. Jpn J Radiol. 39:938–945. 2021.PubMed/NCBI View Article : Google Scholar

18 

Dudea SM, Botar-Jid C, Dumitriu D, Vasilescu D, Manole S and Lenghel ML: Differentiating benign from malignant superficial lymph nodes with sonoelastography. Med Ultrason. 15:132–139. 2013.PubMed/NCBI View Article : Google Scholar

19 

Grossman M and Shiramizu B: Evaluation of lymphadenopathy in children. Curr Opin Pediatr. 6:68–76. 1994.PubMed/NCBI View Article : Google Scholar

20 

Lau WY, Fan ST, Yiu TF, Chu KW and Wong SH: Negative findings at appendectomy. Am J Surg. 148:375–378. 1984.PubMed/NCBI View Article : Google Scholar

21 

Gross I, Siedner-Weintraub Y, Stibbe S, Rekhtman D, Weiss D, Simanovsky N, Arbell D and Hashavya S: Characteristics of mesenteric lymphadenitis in comparison with those of acute appendicitis in children. Eur J Pediatr. 176:199–205. 2017.PubMed/NCBI View Article : Google Scholar

22 

Schulte B, Beyer D, Kaiser C, Horsch S and Wiater A: Ultrasonography in suspected acute appendicitis in childhood-report of 1285 cases. Eur J Ultrasound. 8:177–182. 1998.PubMed/NCBI View Article : Google Scholar

23 

Sivit CJ, Newman KD and Chandra RS: Visualization of enlarged mesenteric lymph nodes at US examination. Clinical significance. Pediatr Radiol. 23:471–475. 1993.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou L, Shan J, Zu D, Deng S, Zhang Y, Shi X, Zhu Y and Jiang Q: Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population. Exp Ther Med 27: 259, 2024.
APA
Zhou, L., Shan, J., Zu, D., Deng, S., Zhang, Y., Shi, X. ... Jiang, Q. (2024). Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population. Experimental and Therapeutic Medicine, 27, 259. https://doi.org/10.3892/etm.2024.12547
MLA
Zhou, L., Shan, J., Zu, D., Deng, S., Zhang, Y., Shi, X., Zhu, Y., Jiang, Q."Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population". Experimental and Therapeutic Medicine 27.6 (2024): 259.
Chicago
Zhou, L., Shan, J., Zu, D., Deng, S., Zhang, Y., Shi, X., Zhu, Y., Jiang, Q."Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population". Experimental and Therapeutic Medicine 27, no. 6 (2024): 259. https://doi.org/10.3892/etm.2024.12547
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou L, Shan J, Zu D, Deng S, Zhang Y, Shi X, Zhu Y and Jiang Q: Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population. Exp Ther Med 27: 259, 2024.
APA
Zhou, L., Shan, J., Zu, D., Deng, S., Zhang, Y., Shi, X. ... Jiang, Q. (2024). Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population. Experimental and Therapeutic Medicine, 27, 259. https://doi.org/10.3892/etm.2024.12547
MLA
Zhou, L., Shan, J., Zu, D., Deng, S., Zhang, Y., Shi, X., Zhu, Y., Jiang, Q."Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population". Experimental and Therapeutic Medicine 27.6 (2024): 259.
Chicago
Zhou, L., Shan, J., Zu, D., Deng, S., Zhang, Y., Shi, X., Zhu, Y., Jiang, Q."Value of conventional ultrasound and shear‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population". Experimental and Therapeutic Medicine 27, no. 6 (2024): 259. https://doi.org/10.3892/etm.2024.12547
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team