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Case Report Open Access

Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report

  • Authors:
    • Yachun Yu
    • Guohua He
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Affiliated Changsha Central Hospital, University of South China, Changsha, Hunan 410000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 260
    |
    Published online on: April 23, 2024
       https://doi.org/10.3892/etm.2024.12548
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Abstract

Central nervous system (CNS) tuberculosis mainly manifests as tuberculous meningitis and intracranial tuberculosis; intramedullary tuberculosis is uncommon. Scrub typhus is an acute naturally occurring infectious disease caused by Orientia tsutsugamushi. CNS tuberculoma following typhus is rare. The present study described a 60-year-old man with high fever, muscle soreness, yellowish skin and sclera and hepatosplenomegaly. At first, the patient was diagnosed with scrub typhus, after treatment with doxycycline he recovered completely. However, half a month after discharge, the patient experienced headache, night sweats and anorexia. Tuberculosis-specific enzyme-linked immunospot assay showed positive Mycobacterium tuberculosis antibody in cerebrospinal fluid (CSF). Metagenomic next-generation sequencing detected the presence of Mycobacterium tuberculosis in CSF. Magnetic resonance imaging of the brain and spinal cord showed multiple rings enhancing lesions in the cerebral hemispheres, cerebellum, brainstem and spinal cords. After the diagnosis of CNS tuberculoma, the patient was started on conventional anti-tuberculosis therapy resulting in a good prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Yu Y and He G: Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report. Exp Ther Med 27: 260, 2024.
APA
Yu, Y., & He, G. (2024). Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report. Experimental and Therapeutic Medicine, 27, 260. https://doi.org/10.3892/etm.2024.12548
MLA
Yu, Y., He, G."Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report". Experimental and Therapeutic Medicine 27.6 (2024): 260.
Chicago
Yu, Y., He, G."Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report". Experimental and Therapeutic Medicine 27, no. 6 (2024): 260. https://doi.org/10.3892/etm.2024.12548
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y and He G: Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report. Exp Ther Med 27: 260, 2024.
APA
Yu, Y., & He, G. (2024). Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report. Experimental and Therapeutic Medicine, 27, 260. https://doi.org/10.3892/etm.2024.12548
MLA
Yu, Y., He, G."Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report". Experimental and Therapeutic Medicine 27.6 (2024): 260.
Chicago
Yu, Y., He, G."Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report". Experimental and Therapeutic Medicine 27, no. 6 (2024): 260. https://doi.org/10.3892/etm.2024.12548
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