Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2024 Volume 28 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2024 Volume 28 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis

  • Authors:
    • Yun-Lu Wang
    • Xi-Yong Li
    • Lun Liu
    • Song-Feng Li
    • Peng-Fei Han
    • Xiao-Dong Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Second People's Hospital of Changzhi City, Changzhi, Shanxi 046000, P.R. China, Graduate School, Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China, Department of Orthopedics, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 279
    |
    Published online on: May 13, 2024
       https://doi.org/10.3892/etm.2024.12567
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

To investigate the association of gene polymorphisms of TNF‑α‑308G/A rs1800629 with the susceptibility and severity of rheumatoid arthritis (RA), literature from PubMed, EMBASE, Web of Science and CNKI databases was searched. Two authors screened the literature independently, extracted data and evaluated the risk of bias of the included studies. According to the inclusion and exclusion criteria, five genetic models were established: The allelic model (A vs. G), dominant model (GA + AA vs. GG), recessive model (AA vs. GG + GA), co‑dominant model (AA vs. GG) and super‑dominant model (GG + AA vs. GA). Stata 17.0 software was used for the meta‑analysis. A total of 34 eligible studies with 12,611 subjects were included, including 6,030 cases in the RA group and 6,581 controls. Meta‑analysis calculations revealed that the genetic polymorphisms of TNF‑α‑308G/A rs1800629 were not significantly associated with susceptibility to RA, with an odds ratio and 95% confidence interval (CI) for each genetic model [A vs. G: 0.937 (0.762‑1.152); GA + AA vs. GG: 0.918 (0.733‑1.148); AA vs. GG + GA: 1.131 (0.709‑1.802); AA vs. GG: 1.097 (0.664‑1.813); and GG + AA vs. GA: 1.108 (0.894‑1.373)]. For the association between TNF‑α‑308G/A rs1800629 gene polymorphisms and the severity of RA, the results of subgroup analysis calculations showed that TNF‑α‑308G/A rs1800629 gene polymorphisms were associated with the severity of RA in European populations, with the gene model and 95% CI [GA + AA vs. GG: 0.503 (0.297‑0.853); and GG + AA vs. GA: 2.268 (1.434‑3.590)]. When assessing the confidence in the positive results of the present study through the false‑positive report probability, the positive results were observed to be reliable. No significant association was observed between genetic polymorphisms in TNF‑α‑308G/A rs1800629 and susceptibility to RA. However, a significant association exists with the severity of RA in European populations.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, Kavanaugh A, McInnes IB, Solomon DH, Strand V and Yamamoto K: Rheumatoid arthritis. Nat Rev Dis Primers. 4(18001)2018.PubMed/NCBI View Article : Google Scholar

2 

Rosa-Gonçalves D, Bernardes M and Costa L: Quality of life and functional capacity in patients with rheumatoid arthritis-cross-sectional study. Reumatol Clin (Engl Ed). 14:360–366. 2018.PubMed/NCBI View Article : Google Scholar

3 

Giannini D, Antonucci M, Petrelli F, Bilia S, Alunno A and Puxeddu I: One year in review 2020: Pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol. 38:387–397. 2020.PubMed/NCBI View Article : Google Scholar

4 

Jahid M, Rehan-Ul-Haq Jha PK, Chawla D, Avasthi RS and Ahmed RS: Tumor necrosis factor-α-308 polymorphism in North Indian rheumatoid arthritis patients and association with mRNA and serum TNF-α. Clin Rheumatol. 36:2209–2216. 2017.PubMed/NCBI View Article : Google Scholar

5 

Boechat AL, Boechat Nde O, Ogusku MM, Alencar MR, Abensur Tda C, Cardoso Neto J, Amorim Lde S, de Oliveira LM, Sadahiro A and Dos-Santos MC: The influence of a TNF gene polymorphism on the severity of rheumatoid arthritis in the Brazilian Amazon. Cytokine. 61:406–412. 2013.PubMed/NCBI View Article : Google Scholar

6 

Sun R, Huang Y, Zhang H and Liu R: MMP-2, TNF-α and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis. Mol Biol Rep. 40:6303–6308. 2013.PubMed/NCBI View Article : Google Scholar

7 

Cadena-Sandoval D, Alemán-Ávila I, Barbosa-Cobos RE, Becerril-Mendoza LT, Fragoso JM and Ramírez-Bello J: Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population. Mol Biol Rep. 45:227–232. 2018.PubMed/NCBI View Article : Google Scholar

8 

Zheng G, Zhang W, Xu J, Yuan A, Li Q and Gastwirth JL: Genetic risks and genetic model specification. J Theor Biol. 403:68–74. 2016.PubMed/NCBI View Article : Google Scholar

9 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010.PubMed/NCBI View Article : Google Scholar

10 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al: The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. J Clin Epidemiol. 134:178–189. 2021.PubMed/NCBI View Article : Google Scholar

11 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997.PubMed/NCBI View Article : Google Scholar

12 

Al-Rayes H, Al-Swailem R, Albelawi M, Arfin M, Al-Asmari A and Tariq M: TNF-α and TNF-β gene polymorphism in Saudi rheumatoid arthritis patients. Clin Med Insights Arthritis Musculoskelet Disord. 4:55–63. 2011.PubMed/NCBI View Article : Google Scholar

13 

Aranda F, Perés Wingeyer SD, Schneeberger E, Valerio M, Saint Martin E, Dal Pra F, Correa Mde L, Citera G, Martínez L, Mannucci P, et al: The-308 G/A polymorphism in the tumor necrosis factor-α gene is not associated with development and progression of rheumatoid arthritis in Argentinean patients. Int J Rheum Dis. 19:476–481. 2016.PubMed/NCBI View Article : Google Scholar

14 

Ates O, Hatemi G, Hamuryudan V and Topal-Sarikaya A: Tumor necrosis factor-alpha and interleukin-10 gene promoter polymorphisms in Turkish rheumatoid arthritis patients. Clin Rheumatol. 27:1243–1248. 2008.PubMed/NCBI View Article : Google Scholar

15 

Brinkman BM, Huizinga TW, Kurban SS, van der Velde EA, Schreuder GM, Hazes JM, Breedveld FC and Verweij CL: Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: Association with susceptibility to, or severity of, disease? Br J Rheumatol. 36:516–521. 1997.PubMed/NCBI View Article : Google Scholar

16 

Rodríguez-Carreón AA, Zúñiga J, Hernández-Pacheco G, Rodríguez-Pérez JM, Pérez-Hernández N, Montes de Oca JV, Cardiel MH, Granados J and Vargas-Alarcón G: Tumor necrosis factor-alpha-308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans. J Autoimmun. 24:63–68. 2005.PubMed/NCBI View Article : Google Scholar

17 

Chen R, Fang M, Cai Q, Duan S, Lv K, Cheng N, Ren D, Shen J, He D, He L and Sun S: Tumor necrosis factor alpha-308 polymorphism is associated with rheumatoid arthritis in Han population of Eastern China. Rheumatol Int. 28:121–126. 2007.PubMed/NCBI View Article : Google Scholar

18 

Correa PA, Gomez LM, Cadena J and Anaya JM: Autoimmunity and tuberculosis. Opposite association with TNF polymorphism. J Rheumatol. 32:219–224. 2005.PubMed/NCBI

19 

Cuenca J, Cuchacovich M, Pérez C, Ferreira L, Aguirre A, Schiattino I, Soto L, Cruzat A, Salazar-Onfray F and Aguillón JC: The-308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis. Rheumatology (Oxford). 42:308–313. 2003.PubMed/NCBI View Article : Google Scholar

20 

Danis VA, Millington M, Hyland V, Lawford R, Huang Q and Grennan D: Increased frequency of the uncommon allele of a tumour necrosis factor alpha gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus. Dis Markers. 12:127–133. 1995.PubMed/NCBI View Article : Google Scholar

21 

Das S, Baruah C, Saikia AK, Tiwari D and Bose S: Genetic and expression changes in TNF-α as a risk factor for rheumatoid arthritis pathogenesis in northeast India. J Genet. 98(3)2019.PubMed/NCBI

22 

Emonts M, Hazes MJMW, Houwing-Duistermaat JJ, van der Gaast-de Jongh CE, de Vogel L, Han HKH, Wouters JMGW, Laman JD and Dolhain RJEM: Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: A case control study. BMC Med Genet. 12(36)2011.PubMed/NCBI View Article : Google Scholar

23 

Fugger L, Morling N, Ryder LP, Georgsen J, Jakobsen BK, Svejgaard A, Andersen V, Oxholm P, Karup Pedersen F, Friis J, et al: NcoI restriction fragment length polymorphism (RFLP) of the tumor necrosis factor (TNF alpha) region in four autoimmune diseases. Tissue Antigens. 34:17–22. 1989.PubMed/NCBI View Article : Google Scholar

24 

Guo X, You C, Wang L, Ma K, Zhou Y, Shi X, Li F and Gao L: Correlation analysis of gene polymorphisms of TNF-α and its receptors with rheumatoid arthritis susceptibility and related serological markers. Acad J Second Mil Med Univ. 32:155–159. 2012.

25 

Hussein YM, Mohamed RH, Pasha HF, El-Shahawy EE and Alzahrani SS: Association of tumor necrosis factor alpha and its receptor polymorphisms with rheumatoid arthritis in female patients. Cell Immunol. 271:192–196. 2011.PubMed/NCBI View Article : Google Scholar

26 

Li F, Gao J, Sokolove J, Xu J, Zheng J, Zhu K and Pan Z: Polymorphisms in the TNF-α, TNFR1 gene and risk of rheumatoid arthritis in Chinese Han population. Int J Immunogenet. 41:499–502. 2014.PubMed/NCBI View Article : Google Scholar

27 

Li F, Xie X, Chen J, Gao J and Lu F: Association of TNF-α gene polymorphisms with the risk of rheumatoid arthritis in Han Chinese population from Hunan. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 40:945–954. 2015.PubMed/NCBI View Article : Google Scholar

28 

Lv HZ, Lin T, Zhu XY, Zhang JT and Lu J: Association of TNF-α single nucleotide polymorphisms in human rheumatoid arthritis of Han nationality in northern China. Cell Mol Immunol. 27:906–908. 2011.

29 

Manolova I, Ivanova M, Stoilov R, Rashkov R and Stanilova S: Association of single nucleotide polymorphism at position-308 of the tumor necrosis factor-alpha gene with ankylosing spondylitis and rheumatoid arthritis. Biotechnol Biotechnol Equip. 28:1108–1114. 2014.PubMed/NCBI View Article : Google Scholar

30 

Nemec P, Pavkova-Goldbergova M, Stouracova M, Vasku A, Soucek M and Gatterova J: Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population. Clin Rheumatol. 27:59–65. 2008.PubMed/NCBI View Article : Google Scholar

31 

Pawlik A, Florczak M, Ostanek L, Brzosko M, Brzosko I and Szklarz BG: TNF-alpha-308 promoter polymorphism in patients with rheumatoid arthritis. Scand J Rheumatol. 34:22–26. 2005.PubMed/NCBI

32 

Domínguez-Pérez RA, Loyola-Rodriguez JP, Abud-Mendoza C, Alpuche-Solis AG, Ayala-Herrera JL and Martínez-Martínez RE: Association of cytokines polymorphisms with chronic peridontitis and rheumatoid arthritis in a Mexican population. Acta Odontol Scand. 75:243–248. 2017.PubMed/NCBI View Article : Google Scholar

33 

Rezaieyazdi Z, Afshari JT, Sandooghi M and Mohajer F: Tumour necrosis factor a-308 promoter polymorphism in patients with rheumatoid arthritis. Rheumatol Int. 28:189–191. 2007.PubMed/NCBI View Article : Google Scholar

34 

Shafia S, Sofi FA, Dilafroze Rasool R, Rasool R, Javeed S and Shah ZA: The association between TNFα gene polymorphisms and susceptibility to rheumatoid arthritis in an ethnic Kashmiri population: Relationship with disease activity and severity markers. Int J Rheum Dis. 19:362–369. 2016.PubMed/NCBI View Article : Google Scholar

35 

Trajkov D, Mishevska-Perchinkova S, Karadzova-Stojanoska A, Petlichkovski A, Strezova A and Spiroski M: Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians. Clin Rheumatol. 28:1291–1300. 2009.PubMed/NCBI View Article : Google Scholar

36 

Vinasco J, Beraún Y, Nieto A, Fraile A, Mataran L, Pareja E and Martín J: Polymorphism at the TNF loci in rheumatoid arthritis. Tissue Antigens. 49:74–78. 1997.PubMed/NCBI View Article : Google Scholar

37 

Wang P, He YL, Zeng YQ, Wang LM and Hu LH: Association between TNF-α gene polymorphisms and rheumatoid arthritis. J Clin Hematol. 28:97–99. 2015.

38 

Wang Z, Kong L, Zhang H, Sun F, Guo Z, Zhang R and Dou Y: Tumor necrosis factor alpha-308G/A gene polymorphisms combined with neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio predicts the efficacy and safety of Anti-TNF-α therapy in patients with ankylosing spondylitis, rheumatoid arthritis, and psoriasis arthritis. Front Pharmacol. 12(811719)2022.PubMed/NCBI View Article : Google Scholar

39 

Yen JH, Chen CJ, Tsai WC, Lin CH, Ou TT, Wu CC and Liu HW: Tumor necrosis factor promoter polymorphisms in patients with rheumatoid arthritis in Taiwan. J Rheumatol. 28:1788–1792. 2001.PubMed/NCBI

40 

You CG, Li XJ, Li YM, Wang LP, Li FF, Guo XL and Gao LN: Association analysis of single nucleotide polymorphisms of proinflammatory cytokine and their receptors genes with rheumatoid arthritis in northwest Chinese Han population. Cytokine. 61:133–138. 2013.PubMed/NCBI View Article : Google Scholar

41 

Zaghlol HM, Abdelshafy S, Mohamed RA and Abdelaleem EA: Tumour necrosis factor gene polymorphisms in Egyptian patients with rheumatoid arthritis and their relation to disease activity and severity. Cent Eur J Immunol. 44:277–284. 2019.PubMed/NCBI View Article : Google Scholar

42 

Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L and Rothman N: Assessing the probability that a positive report is false: An approach for molecular epidemiology studies. J Natl Cancer Inst. 96:434–442. 2004.PubMed/NCBI View Article : Google Scholar

43 

Buch MH, Eyre S and McGonagle D: Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis. Nat Rev Rheumatol. 17:17–33. 2021.PubMed/NCBI View Article : Google Scholar

44 

Klein K and Gay S: Epigenetics in rheumatoid arthritis. Curr Opin Rheumatol. 27:76–82. 2015.PubMed/NCBI View Article : Google Scholar

45 

Zelová H and Hošek J: TNF-α signalling and inflammation: Interactions between old acquaintances. Inflamm Res. 62:641–651. 2013.PubMed/NCBI View Article : Google Scholar

46 

Idriss HT and Naismith JH: TNF alpha and the TNF receptor superfamily: Structure-function relationship(s). Microsc Res Tech. 50:184–195. 2000.PubMed/NCBI View Article : Google Scholar

47 

Balkwill F: TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev. 25:409–416. 2006.PubMed/NCBI View Article : Google Scholar

48 

Song GG, Bae SC, Kim JH and Lee YH: Association between TNF-α promoter-308 A/G polymorphism and rheumatoid arthritis: A meta-analysis. Rheumatol Int. 34:465–471. 2014.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Li X, Liu L, Li S, Han P and Li X: Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis. Exp Ther Med 28: 279, 2024.
APA
Wang, Y., Li, X., Liu, L., Li, S., Han, P., & Li, X. (2024). Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 28, 279. https://doi.org/10.3892/etm.2024.12567
MLA
Wang, Y., Li, X., Liu, L., Li, S., Han, P., Li, X."Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 28.1 (2024): 279.
Chicago
Wang, Y., Li, X., Liu, L., Li, S., Han, P., Li, X."Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 28, no. 1 (2024): 279. https://doi.org/10.3892/etm.2024.12567
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Li X, Liu L, Li S, Han P and Li X: Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis. Exp Ther Med 28: 279, 2024.
APA
Wang, Y., Li, X., Liu, L., Li, S., Han, P., & Li, X. (2024). Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 28, 279. https://doi.org/10.3892/etm.2024.12567
MLA
Wang, Y., Li, X., Liu, L., Li, S., Han, P., Li, X."Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 28.1 (2024): 279.
Chicago
Wang, Y., Li, X., Liu, L., Li, S., Han, P., Li, X."Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 28, no. 1 (2024): 279. https://doi.org/10.3892/etm.2024.12567
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team