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Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology

  • Authors:
    • Cagri Ozdemi̇r
    • Berrin Isik
    • Gulce Koca
    • Mehmet Arda Inan
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology and Reanimation, Mamak State Hospital, 06270 Ankara, Turkey, Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, 06560 Ankara, Turkey, Department of Medical Biochemistry, Faculty of Medicine, Gazi University, 06560 Ankara, Turkey, Department of Medical Pathology, Faculty of Medicine, Gazi University, 06560 Ankara, Turkey
    Copyright: © Ozdemi̇r et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 286
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    Published online on: May 16, 2024
       https://doi.org/10.3892/etm.2024.12574
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Abstract

Models of inflammation, oxidative stress, hyperoxia and hypoxia have demonstrated that magnesium sulfate (MgSO4), a commonly used drug in obstetrics, has neuroprotective potential. In the present study, the effects of MgSO4 treatment on inflammation, oxidative stress and fetal brain histopathology were evaluated in an experimental rat model following sevoflurane (Sv) exposure during the mid‑gestational period. Rats were randomly divided into groups: C (control; no injections or anesthesia), Sv (exposure to 2.5% Sv for 2 h), MgSO4 (administered 270 mg/kg MgSO4 intraperitoneally) and Sv + MgSO4 (Sv administered 30 min after MgSO4 injection). Inflammatory and oxidative stress markers were measured in the serum and neurotoxicity was investigated histopathologically in fetal brain tissue. Short‑term mid‑gestational exposure to a 1.1 minimum alveolar concentration of Sv did not significantly increase the levels of any of the measured biochemical markers, except for TNF‑α. Histopathological evaluations demonstrated no findings suggestive of pathological apoptosis, neuroinflammation or oxidative stress‑induced cell damage. MgSO4 injection prior to anesthesia caused no significant differences in biochemical or histopathological marker levels compared to the C and Sv groups. The present study indicated that short‑term exposure to Sv could potentially be considered a harmless external stimulus to the fetal brain.
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Copy and paste a formatted citation
Spandidos Publications style
Ozdemi̇r C, Isik B, Koca G and Inan MA: Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology. Exp Ther Med 28: 286, 2024.
APA
Ozdemi̇r, C., Isik, B., Koca, G., & Inan, M.A. (2024). Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology. Experimental and Therapeutic Medicine, 28, 286. https://doi.org/10.3892/etm.2024.12574
MLA
Ozdemi̇r, C., Isik, B., Koca, G., Inan, M. A."Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology". Experimental and Therapeutic Medicine 28.1 (2024): 286.
Chicago
Ozdemi̇r, C., Isik, B., Koca, G., Inan, M. A."Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology". Experimental and Therapeutic Medicine 28, no. 1 (2024): 286. https://doi.org/10.3892/etm.2024.12574
Copy and paste a formatted citation
x
Spandidos Publications style
Ozdemi̇r C, Isik B, Koca G and Inan MA: Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology. Exp Ther Med 28: 286, 2024.
APA
Ozdemi̇r, C., Isik, B., Koca, G., & Inan, M.A. (2024). Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology. Experimental and Therapeutic Medicine, 28, 286. https://doi.org/10.3892/etm.2024.12574
MLA
Ozdemi̇r, C., Isik, B., Koca, G., Inan, M. A."Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology". Experimental and Therapeutic Medicine 28.1 (2024): 286.
Chicago
Ozdemi̇r, C., Isik, B., Koca, G., Inan, M. A."Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology". Experimental and Therapeutic Medicine 28, no. 1 (2024): 286. https://doi.org/10.3892/etm.2024.12574
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