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Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis

  • Authors:
    • Chunqiang Wang
    • Tianye Huang
    • Xuebing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Anorectal Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang 311200, P.R. China, Department of Anorectal Surgery, Linyi Central Hospital, Linyi, Shandong 276401, P.R. China, Department of Anorectal Surgery, Taian Municipal Hospital, Taian, Shandong 271021, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 306
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    Published online on: May 31, 2024
       https://doi.org/10.3892/etm.2024.12595
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Abstract

The best treatment of high complex anal fistula (HCAF) is to avoid anal incontinence while improving the cure rate. On this basis, several surgical procedures for preserving the anal sphincter have been proposed. The purpose of the present study was to evaluate the efficacy and safety of transanal opening of intersphincteric space for treating HCAF. PubMed, Cochrane Library, China National Knowledge Infrastructure and the Wanfang databases were searched to collate all the articles on transanal opening of intersphincteric space for treating HCAF. A total of two researchers independently completed the whole process, from screening and inclusion to data extraction and the data was included in the RevMan 5.3 software for analysis. The main outcomes included the patients' essential characteristics, primary healing rate, management after recurrence, final healing rate, anal incontinence score before and after surgery, postoperative complication rate and types of complications. A total of six articles were included in this meta‑analysis. The results showed that the weighted final healing rate of patients following transanal opening of intersphincteric space was 89% [risk differences (RD)=0.89; 95% confidence interval (CI)=0.86‑0.92; I2=0%; P<0.00001]. The results of the anal incontinence score showed that there was no significant difference between the results before and after transanal opening of intersphincteric space surgery mean differences [(MD)=‑0.04, Cl=‑0.10‑0.02, I2=0%; P=0.21]. Only 11 patients were reported to have complications, including urinary retention and bleeding following transanal opening of intersphincteric space with a complication rate of 8% (11/138) and the weighted average complication rate was 6% (RD=0.06,95% CI=0.02‑0.10; I2=9%; P=0.003). Transanal opening of intersphincteric space has a high cure rate, a favorable anal incontinence score, fewer types of postoperative complications and a low complication rate; it can be used as a minimally invasive and sphincter‑preserving surgical method for treating HCAF and is worthy of further promotion and research in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Huang T and Wang X: Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis. Exp Ther Med 28: 306, 2024.
APA
Wang, C., Huang, T., & Wang, X. (2024). Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis. Experimental and Therapeutic Medicine, 28, 306. https://doi.org/10.3892/etm.2024.12595
MLA
Wang, C., Huang, T., Wang, X."Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis". Experimental and Therapeutic Medicine 28.2 (2024): 306.
Chicago
Wang, C., Huang, T., Wang, X."Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis". Experimental and Therapeutic Medicine 28, no. 2 (2024): 306. https://doi.org/10.3892/etm.2024.12595
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Huang T and Wang X: Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis. Exp Ther Med 28: 306, 2024.
APA
Wang, C., Huang, T., & Wang, X. (2024). Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis. Experimental and Therapeutic Medicine, 28, 306. https://doi.org/10.3892/etm.2024.12595
MLA
Wang, C., Huang, T., Wang, X."Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis". Experimental and Therapeutic Medicine 28.2 (2024): 306.
Chicago
Wang, C., Huang, T., Wang, X."Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis". Experimental and Therapeutic Medicine 28, no. 2 (2024): 306. https://doi.org/10.3892/etm.2024.12595
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