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Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease

  • Authors:
    • Tiantian Cen
    • Minxuan Huang
    • Mingcai Li
    • Jie Jin
    • Qunli Ding
    • Dan Lv
    • Lin Fei
    • Shanshan Wang
    • Hongying Ma
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China, Department of Respiratory and Critical Care Medicine, Cixi, Zhejiang 315300, P.R. China
    Copyright: © Cen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 312
    |
    Published online on: June 5, 2024
       https://doi.org/10.3892/etm.2024.12601
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Abstract

Interleukin (IL)‑41 is a novel immunomodulatory cytokine involved in the pathogenesis of several inflammatory and metabolic illnesses. However, it remains unclear how IL‑41 contributes to the pathogenesis of chronic obstructive pulmonary disease (COPD). Therefore, the aim of the present study was to explore the correlation between the expression level of IL‑41 and acute exacerbation of COPD (AECOPD). In total, 107 patients with COPD and 56 healthy controls were recruited from the First Affiliated Hospital of Ningbo University (Ningbo, China). Serum IL‑41, IL‑6, and matrix metalloproteinase‑2 (MMP‑2) levels were evaluated using enzyme‑linked immunosorbent assay. Serum amyloid A (SAA) and C‑reactive protein (CRP) levels were assessed in the hospital laboratory. The levels of IL‑41 were higher in the AECOPD group than in the stable COPD (SCOPD) and control groups (P<0.0001). IL‑6, SAA and CRP levels, the percentage of neutrophils, as well as neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios were higher in the AECOPD group than those in the SCOPD and control groups. The smoking index was positively correlated with serum IL‑41, CRP and SAA levels. The expression level of IL‑41 was correlated with the number of acute exacerbations, severity of the exacerbations, and COPD assessment test scores in the AECOPD group. Examination of the receiver operating characteristic (ROC) curves showed that IL‑41, especially when combined with other inflammatory factors, had a specific diagnostic value for AECOPD. According to the ROC curve analysis, the area under the curve (AUC) for IL‑41 was 0.742 (P=0.051), and the AUC for IL‑41 combined with other inflammatory factors was 0.925 (P=0.030). Increased serum IL‑41 levels were associated with AECOPD and may play a role in the monitoring and evaluation of COPD.
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Copy and paste a formatted citation
Spandidos Publications style
Cen T, Huang M, Li M, Jin J, Ding Q, Lv D, Fei L, Wang S and Ma H: Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease. Exp Ther Med 28: 312, 2024.
APA
Cen, T., Huang, M., Li, M., Jin, J., Ding, Q., Lv, D. ... Ma, H. (2024). Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease. Experimental and Therapeutic Medicine, 28, 312. https://doi.org/10.3892/etm.2024.12601
MLA
Cen, T., Huang, M., Li, M., Jin, J., Ding, Q., Lv, D., Fei, L., Wang, S., Ma, H."Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 28.2 (2024): 312.
Chicago
Cen, T., Huang, M., Li, M., Jin, J., Ding, Q., Lv, D., Fei, L., Wang, S., Ma, H."Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 28, no. 2 (2024): 312. https://doi.org/10.3892/etm.2024.12601
Copy and paste a formatted citation
x
Spandidos Publications style
Cen T, Huang M, Li M, Jin J, Ding Q, Lv D, Fei L, Wang S and Ma H: Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease. Exp Ther Med 28: 312, 2024.
APA
Cen, T., Huang, M., Li, M., Jin, J., Ding, Q., Lv, D. ... Ma, H. (2024). Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease. Experimental and Therapeutic Medicine, 28, 312. https://doi.org/10.3892/etm.2024.12601
MLA
Cen, T., Huang, M., Li, M., Jin, J., Ding, Q., Lv, D., Fei, L., Wang, S., Ma, H."Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 28.2 (2024): 312.
Chicago
Cen, T., Huang, M., Li, M., Jin, J., Ding, Q., Lv, D., Fei, L., Wang, S., Ma, H."Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 28, no. 2 (2024): 312. https://doi.org/10.3892/etm.2024.12601
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