Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2024 Volume 28 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2024 Volume 28 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Anti‑inflammatory effects of methanol extract from Peperomia dindygulensis Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells

  • Authors:
    • Won-Hong Min
    • Chae-Yeon Ko
    • Hyemin Kim
    • Hyuk-Kwon Kwon
    • Hyun-Jae Jang
    • Tran The Bach
    • Le Ngoc Han
    • Jeong-Hyung Lee
    • Hyo-Jin Kim
    • Cheol Hwangbo
  • View Affiliations / Copyright

    Affiliations: Division of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju‑si, Gyeongsang 52828, Republic of Korea, Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheonju‑si, Chungcheongbuk‑do 28116, Republic of Korea, Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Cau Giay, Hanoi 01211, Vietnam, Department of Biochemistry (BK21 Four), College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon 24414, Republic of Korea
    Copyright: © Min et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 317
    |
    Published online on: June 14, 2024
       https://doi.org/10.3892/etm.2024.12606
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Inflammation serves as a multifaceted defense mechanism activated by pathogens, cellular damage and irritants, aiming to eliminate primary causes of injury and promote tissue repair. Peperomia dindygulensis Miq. (P. dindygulensis), prevalent in Vietnam and southern China, has a history of traditional use for treating cough, fever and asthma. Previous studies on its phytochemicals have shown their potential as anti‑inflammatory agents, yet underlying mechanisms remain to be elucidated. The present study investigated the regulatory effects of P. dindygulensis on the anti‑inflammatory pathways. The methanol extracts of P. dindygulensis (PDME) were found to inhibit nitric oxide (NO) production and induce heme oxygenase‑1 (HO‑1) expression in murine macrophages. While MAPKs inhibitors, such as SP600125, SB203580 and U0126 did not regulate HO‑1 expression, the treatment of cycloheximide, a translation inhibitor, reduced HO‑1. Furthermore, PDME inhibited lipopolysaccharide (LPS)‑induced inducible nitric oxide synthase (iNOS), cyclooxygenase‑2 (COX‑2) and TNF‑α expression at both the mRNA and protein levels. The activity of NOS and the expression of TNF‑α, iNOS and COX‑2 decreased in LPS‑stimulated Raw 264.7 cells treated with PDME and this effect was regulated by inhibition of HO‑1 activity. These findings suggested that PDME functions as an HO‑1 inducer and serves as an effective natural anti‑inflammatory agent in LPS‑induced inflammation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Meram C and Wu J: Anti-inflammatory effects of egg yolk livetins (α, β, and γ-livetin) fraction and its enzymatic hydrolysates in lipopolysaccharide-induced RAW 264.7 macrophages. Food Res Int. 100:449–459. 2017.PubMed/NCBI View Article : Google Scholar

2 

Dewanjee S, Dua TK and Sahu R: Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: A wild edible plant. Food Chem Toxicol. 59:514–520. 2013.PubMed/NCBI View Article : Google Scholar

3 

Cooke JP: Inflammation and its role in regeneration and repair. Circ Res. 124:1166–1168. 2019.PubMed/NCBI View Article : Google Scholar

4 

McGlade EA, Miyamoto A and Winuthayanon W: Progesterone and inflammatory response in the oviduct during physiological and pathological conditions. Cells. 11(1075)2022.PubMed/NCBI View Article : Google Scholar

5 

Chen L, Zhou Y and Dong JX: Chemical constituents of Peperomia dindygulensis. Zhong Cao Yao. 38:491–493. 2007.(In Chinese).

6 

Fujiwara N and Kobayashi K: Macrophages in inflammation. Curr Drug Targets Inflamm Allergy. 4:281–286. 2005.PubMed/NCBI View Article : Google Scholar

7 

Tenhunen R, Marver HS and Schmid R: The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA. 61:748–755. 1968.PubMed/NCBI View Article : Google Scholar

8 

Campbell NK, Fitzgerald HK and Dunne A: Regulation of inflammation by the antioxidant haem oxygenase 1. Nat Rev Immunol. 21:411–425. 2021.PubMed/NCBI View Article : Google Scholar

9 

Funes SC, Rios M, Fernández-Fierro A, Covián C, Bueno SM, Riedel CA, Mackern-Oberti JP and Kalergis AM: Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases. Front Immunol. 11(1467)2020.PubMed/NCBI View Article : Google Scholar

10 

Cruse I and Maines M: Evidence suggesting that the two forms of heme oxygenase are products of different genes. J Biol Chem. 263:3348–3353. 1988.PubMed/NCBI

11 

Trakshel GM, Kutty RK and Maines MD: Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. J Biol Chem. 261:11131–11137. 1986.PubMed/NCBI

12 

Ryter SW, Alam J and Choi AM: Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications. Physiol Rev. 86:583–650. 2006.PubMed/NCBI View Article : Google Scholar

13 

Choi AM and Alam J: Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol. 15:9–19. 1996.PubMed/NCBI View Article : Google Scholar

14 

Alam J, Igarashi K, Immenschuh S, Shibahara S and Tyrrell RM: Regulation of heme oxygenase-1 gene transcription: Recent advances and highlights from the international conference (Uppsala, 2003) on Heme Oxygenase. Antioxid Redox Signal. 6:924–933. 2004.PubMed/NCBI View Article : Google Scholar

15 

Lee TS, Tsai HL and Chau LY: Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. J Biol Chem. 278:19325–19330. 2003.PubMed/NCBI View Article : Google Scholar

16 

Wiesel P, Foster LC, Pellacani A, Layne MD, Hsieh CM, Huggins GS, Strauss P, Yet SF and Perrella MA: Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators. J Biol Chem. 275:24840–24846. 2000.PubMed/NCBI View Article : Google Scholar

17 

Morse D, Pischke SE, Zhou Z, Davis RJ, Flavell RA, Loop T, Otterbein SL, Otterbein LE and Choi AM: Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem. 278:36993–36998. 2003.PubMed/NCBI View Article : Google Scholar

18 

Lee TS and Chau LY: Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med. 8:240–246. 2002.PubMed/NCBI View Article : Google Scholar

19 

Lee JA, Lee MY, Shin IS, Seo CS, Ha H and Shin HK: Anti-inflammatory effects of Amomum compactum on RAW 264.7 cells via induction of heme oxygenase-1. Arch Pharm Res. 35:739–746. 2012.PubMed/NCBI View Article : Google Scholar

20 

Suh GY, Jin Y, Yi AK, Wang XM and Choi AM: CCAAT/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2. Am J Respir Cell Mol Biol. 35:220–226. 2006.PubMed/NCBI View Article : Google Scholar

21 

Oh GS, Pae HO, Lee BS, Kim BN, Kim JM, Kim HR, Jeon SB, Jeon WK, Chae HJ and Chung HT: Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Free Radic Biol Med. 41:106–119. 2006.PubMed/NCBI View Article : Google Scholar

22 

Li Volti G, Sorrenti V, Murabito P, Galvano F, Veroux M, Gullo A, Acquaviva R, Stacchiotti A, Bonomini F, Vanella L and Di Giacomo C: Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemia-reperfusion injury. Transplant Proc. 39:2986–2991. 2007.PubMed/NCBI View Article : Google Scholar

23 

Datta PK, Koukouritaki SB, Hopp KA and Lianos EA: Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis. J Am Soc Nephrol. 10:2540–2550. 1999.PubMed/NCBI View Article : Google Scholar

24 

Lee DS, Kim BN, Lim S, Lee J, Kim J, Jeong JG and Kim S: Effective suppression of nitric oxide production by HX106N through transcriptional control of heme oxygenase-1. Exp Biol Med. 240:1136–1146. 2015.PubMed/NCBI View Article : Google Scholar

25 

Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, Liu Z, Guo Z, Chen X, He P, et al: Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling. Aging (Albany NY). 10:1722–1744. 2018.PubMed/NCBI View Article : Google Scholar

26 

Duan Z, Wang Y and Huang X: The Peperomia dindygulensis: a review of phytochemistry and pharmacology perspectives. Asian J Tradit Med. 14:193–201. 2019.

27 

Wu JL, Li N, Hasegawa T, Sakai J, Mitsui T, Ogura H, Kataoka T, Oka S, Kiuchi M, Tomida A, et al: Bioactive secolignans from Peperomia dindygulensis. J Nat Prod. 69:790–794. 2006.PubMed/NCBI View Article : Google Scholar

28 

Lin MG, Yu DH, Wang QW, Lu Q, Zhu WJ, Bai F, Li GX, Wang XW, Yang YF, Qin XM, et al: Secolignans with antiangiogenic activities from Peperomia dindygulensis. Chem Biodivers. 8:862–871. 2011.PubMed/NCBI View Article : Google Scholar

29 

Wang QW, Yu DH, Lin MG, Zhao M, Zhu WJ, Lu Q, Li GX, Wang C, Yang YF, Qin XM, et al: Antiangiogenic polyketides from Peperomia dindygulensis Miq. Molecules. 17:4474–4483. 2012.PubMed/NCBI View Article : Google Scholar

30 

Park S, Han HT, Oh SS, Kim DH, Jeong JW, Lee KW, Kim M, Lim JS, Cho YY, Hwangbo C, et al: NDRG2 sensitizes myeloid leukemia to arsenic trioxide via GSK3β-NDRG2-PP2A complex formation. Cells. 8(495)2019.PubMed/NCBI View Article : Google Scholar

31 

Choi SC, Kim KD, Kim JT, Oh SS, Yoon SY, Song EY, Lee HG, Choe YK, Choi I, Lim JS and Kim JW: NDRG2 is one of novel intrinsic factors for regulation of IL-10 production in human myeloid cell. Biochem Biophys Res Commun. 396:684–690. 2010.PubMed/NCBI View Article : Google Scholar

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

33 

Dulak J, Loboda A and Jozkowicz A: Effect of heme oxygenase-1 on vascular function and disease. Curr Opin Lipidol. 19:505–512. 2008.PubMed/NCBI View Article : Google Scholar

34 

Sun RF, Zhu CC, Yang Y and Yu NJ: Novel secolignans from peperomia dindygulensis and their inhibitory activities on JAK-STAT signaling pathways. Fitoterapia. 122:80–84. 2017.PubMed/NCBI View Article : Google Scholar

35 

Yan J, Li M, Wang XD, Lu ZY and Ni XL: Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE(-/-)) mice through reducing inflammation via the suppression of NLRP3 signaling pathway. Biomed Pharmacother. 105:862–869. 2018.PubMed/NCBI View Article : Google Scholar

36 

Beutler B and Rietschel ET: Innate immune sensing and its roots: The story of endotoxin. Nat Rev Immunol. 3:169–176. 2003.PubMed/NCBI View Article : Google Scholar

37 

Medzhitov R and Janeway C Jr: Innate immune recognition: Mechanisms and pathways. Immunol Rev. 173:89–97. 2000.PubMed/NCBI View Article : Google Scholar

38 

Liu S, Yang T, Ming TW, Gaun TKW, Zhou T, Wang S and Ye B: Isosteroid alkaloids with different chemical structures from Fritillariae cirrhosae bulbus alleviate LPS-induced inflammatory response in RAW 264.7 cells by MAPK signaling pathway. Int Immunopharmacol. 78(106047)2020.PubMed/NCBI View Article : Google Scholar

39 

Hu TY, Ju JM, Mo LH, Ma L, Hu WH, You RR, Chen XQ, Chen YY, Liu ZQ, Qiu SQ, et al: Anti-inflammation action of xanthones from Swertia chirayita by regulating COX-2/NF-κB/MAPKs/Akt signaling pathways in RAW 264.7 macrophage cells. Phytomedicine. 55:214–221. 2019.PubMed/NCBI View Article : Google Scholar

40 

Kim Y, Sung J, Sung M, Choi Y, Jeong HS and Lee J: Involvement of heme oxygenase-1 in the anti-inflammatory activity of Chrysanthemum boreale Makino extracts on the expression of inducible nitric oxide synthase in RAW264.7 macrophages. J Ethnopharmacol. 131:550–554. 2010.PubMed/NCBI View Article : Google Scholar

41 

Medina MV, Sapochnik D, Sola MG and Coso O: Regulation of the expression of heme oxygenase-1: Signal transduction, gene promoter activation, and beyond. Antioxid Redox Signal. 32:1033–1044. 2020.PubMed/NCBI View Article : Google Scholar

42 

Yang Q and Wang W: The nuclear translocation of heme oxygenase-1 in human diseases. Front Cell Dev Biol. 10(890186)2022.PubMed/NCBI View Article : Google Scholar

43 

Kietzmann T, Samoylenko A and Immenschuh S: Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J Biol Chem. 278:17927–17936. 2003.PubMed/NCBI View Article : Google Scholar

44 

Ohlmann A, Giffhorn-Katz S, Becker I, Katz N and Immenschuh S: Regulation of heme oxygenase-1 gene expression by anoxia and reoxygenation in primary rat hepatocyte cultures. Exp Biol Med (Maywood). 228:584–589. 2003.PubMed/NCBI View Article : Google Scholar

45 

Shan Y, Pepe J, Lu TH, Elbirt KK, Lambrecht RW and Bonkovsky HL: Induction of the heme oxygenase-1 gene by metalloporphyrins. Arch Biochem Biophys. 380:219–227. 2000.PubMed/NCBI View Article : Google Scholar

46 

Li X, Huang R, Liu K, Li M, Luo H, Cui L, Huang L and Luo L: Fucoxanthin attenuates LPS-induced acute lung injury via inhibition of the TLR4/MyD88 signaling axis. Aging (Albany NY). 13:2655–2667. 2020.PubMed/NCBI View Article : Google Scholar

47 

Lipinski P, Starzynski RR, Drapier JC, Bouton C, Bartlomiejczyk T, Sochanowicz B, Smuda E, Gajkowska A and Kruszewski M: Induction of iron regulatory protein 1 RNA-binding activity by nitric oxide is associated with a concomitant increase in the labile iron pool: Implications for DNA damage. Biochem Biophys Res Commun. 327:349–355. 2005.PubMed/NCBI View Article : Google Scholar

48 

Bouton C and Demple B: Nitric oxide-inducible expression of heme oxygenase-1 in human cells. Translation-independent stabilization of the mRNA and evidence for direct action of nitric oxide. J Biol Chem. 275:32688–32693. 2000.PubMed/NCBI View Article : Google Scholar

49 

Kramer M, Sponholz C, Slaba M, Wissuwa B, Claus RA, Menzel U, Huse K, Platzer M and Bauer M: Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. PLoS One. 8(e77224)2013.PubMed/NCBI View Article : Google Scholar

50 

Lin PH, Chiang MT and Chau LY: Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway. Biochim Biophys Acta. 1783:1826–1834. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Min W, Ko C, Kim H, Kwon H, Jang H, Bach TT, Han LN, Lee J, Kim H, Hwangbo C, Hwangbo C, et al: Anti‑inflammatory effects of methanol extract from <em>Peperomia dindygulensis</em> Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells. Exp Ther Med 28: 317, 2024.
APA
Min, W., Ko, C., Kim, H., Kwon, H., Jang, H., Bach, T.T. ... Hwangbo, C. (2024). Anti‑inflammatory effects of methanol extract from <em>Peperomia dindygulensis</em> Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells. Experimental and Therapeutic Medicine, 28, 317. https://doi.org/10.3892/etm.2024.12606
MLA
Min, W., Ko, C., Kim, H., Kwon, H., Jang, H., Bach, T. T., Han, L. N., Lee, J., Kim, H., Hwangbo, C."Anti‑inflammatory effects of methanol extract from <em>Peperomia dindygulensis</em> Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells". Experimental and Therapeutic Medicine 28.2 (2024): 317.
Chicago
Min, W., Ko, C., Kim, H., Kwon, H., Jang, H., Bach, T. T., Han, L. N., Lee, J., Kim, H., Hwangbo, C."Anti‑inflammatory effects of methanol extract from <em>Peperomia dindygulensis</em> Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells". Experimental and Therapeutic Medicine 28, no. 2 (2024): 317. https://doi.org/10.3892/etm.2024.12606
Copy and paste a formatted citation
x
Spandidos Publications style
Min W, Ko C, Kim H, Kwon H, Jang H, Bach TT, Han LN, Lee J, Kim H, Hwangbo C, Hwangbo C, et al: Anti‑inflammatory effects of methanol extract from <em>Peperomia dindygulensis</em> Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells. Exp Ther Med 28: 317, 2024.
APA
Min, W., Ko, C., Kim, H., Kwon, H., Jang, H., Bach, T.T. ... Hwangbo, C. (2024). Anti‑inflammatory effects of methanol extract from <em>Peperomia dindygulensis</em> Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells. Experimental and Therapeutic Medicine, 28, 317. https://doi.org/10.3892/etm.2024.12606
MLA
Min, W., Ko, C., Kim, H., Kwon, H., Jang, H., Bach, T. T., Han, L. N., Lee, J., Kim, H., Hwangbo, C."Anti‑inflammatory effects of methanol extract from <em>Peperomia dindygulensis</em> Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells". Experimental and Therapeutic Medicine 28.2 (2024): 317.
Chicago
Min, W., Ko, C., Kim, H., Kwon, H., Jang, H., Bach, T. T., Han, L. N., Lee, J., Kim, H., Hwangbo, C."Anti‑inflammatory effects of methanol extract from <em>Peperomia dindygulensis</em> Miq. mediated by HO‑1 in LPS‑induced RAW 264.7 cells". Experimental and Therapeutic Medicine 28, no. 2 (2024): 317. https://doi.org/10.3892/etm.2024.12606
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team