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Case Report Open Access

Right eye metastasis of small‑cell lung carcinoma: A case report

  • Authors:
    • Pei Zhu
    • Mingxing Wang
    • Qingming Sun
    • Wanhui Dong
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Lu'an Hospital Affiliated To Anhui University of Chinese Medicine, Lu'an, Anhui 237006, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 318
    |
    Published online on: June 14, 2024
       https://doi.org/10.3892/etm.2024.12607
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Abstract

The incidence of eye metastasis from primary malignant tumors is low. Predominantly, these primary malignant tumors consist of breast and lung carcinoma. Ocular metastatic carcinoma is often clinically overlooked. In clinical practice, it is rare for small‑cell lung carcinoma (SCLC) to metastasize to the right eye. Early detection and treatment via the monitoring of clinical symptoms and auxiliary examinations of the eye are of great significance in preserving the patient's vision and improving their quality of life. Such treatments include radiotherapy or enucleation of the eyeball. A 54‑year‑old male patient with SCLC experienced a decline in vision and blurred vision during his systemic treatment using combined enverolumab and etoposide and cisplatin. Upon examination, including fundus photography, ocular B‑scan and magnetic resonance imaging, a right eye metastasis was suspected. Within a short period of time, the patient experienced significant pain and blindness in the right eye, which required surgical removal of the right eyeball. Postoperative pathology confirmed metastasis. After six cycles of treatment, the primary lesion in the lung reduced in size. By reporting this case of SCLC metastasis to the right eye, we aim to provide a reference for the clinical diagnosis and treatment of ocular metastatic carcinoma.
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1 

Huang J, Deng Y, Tin MS, Lok V, Ngai CH, Zhang L, Lucero-Prisno DE III, Xu W, Zheng ZJ, Elcarte E, et al: Distribution, risk factors, and temporal trends for lung cancer incidence and mortality: A global analysis. Chest. 161:1101–1111. 2022.PubMed/NCBI View Article : Google Scholar

2 

Cozzi S, Bruni A, Ruggieri MP, Borghetti P, Scotti V, Franceschini D, Fiore M, Taraborrelli M, Salvi F, Galaverni M, et al: Thoracic radiotherapy in extensive disease small cell lung cancer: Multicenter prospective observational TRENDS study. Cancers (Basel). 15(434)2023.PubMed/NCBI View Article : Google Scholar

3 

Xie Q, Chu H, Yi J, Yu H, Gu T, Guan Y, Liu X, Liang J, Li Y and Wang J: Identification of a prognostic immune-related signature for small cell lung cancer. Cancer Med. 10:9115–9128. 2021.PubMed/NCBI View Article : Google Scholar

4 

Shamim S, Vidya S, Kabir S and Ghosh B: Choroidal metastases as the initial presentation of lung cancer: A rare scenario. Niger J Clin Pract. 20:905–909. 2017.PubMed/NCBI View Article : Google Scholar

5 

Sakellakis M, Peroukides S, Iconomou G and Kalofonos H: Iris metastasis in a patient with small cell lung cancer: A case report. Iran Red Crescent Med J. 18(e21522)2016.PubMed/NCBI View Article : Google Scholar

6 

Al Zreibi C, Gibault L, Fabre E and Le Pimpec-Barthes F: Chirurgie du cancer pulmonaire à petites cellules Surgery for small-cell lung cancer. Rev Mal Respir. 38:840–847. 2021.(In French).

7 

Lally BE, Urbanic JJ, Blackstock AW, Miller AA and Perry MC: Small cell lung cancer: Have we made any progress over the last 25 years? Oncologist. 12:1096–1104. 2007.PubMed/NCBI View Article : Google Scholar

8 

Konala VM, Madhira BR, Ashraf S and Graziano S: Use of immunotherapy in extensive-stage small cell lung cancer. Oncology. 98:749–754. 2020.

9 

Melosky B, Cheema PK, Brade A, McLeod D, Liu G, Price PW, Jao K, Schellenberg DD, Juergens R, Leighl N and Chu Q: Prolonging survival: The role of immune checkpoint inhibitors in the treatment of extensive-stage small cell lung cancer. Oncologist. 25:981–992. 2020.PubMed/NCBI View Article : Google Scholar

10 

Vicini G, Nicolosi C, Pieretti G and Mazzini C: Large choroidal metastasis with exudative retinal detachment as presenting manifestation of small cell lung cancer: A case report. Respir Med Case Rep. 30(101074)2020.PubMed/NCBI View Article : Google Scholar

11 

Karunanithi S, Sharma P, Jain S, Mukherjee A and Kumar R: Iris metastasis in a patient with small cell lung cancer: Incidental detection with 18F-FDG PET/CT. Clin Nucl Med. 39:554–555. 2014.PubMed/NCBI View Article : Google Scholar

12 

Arepalli S, Kaliki S and Shields CL: Choroidal metastases: Origin, features, and therapy. Indian J Ophthalmol. 63:122–127. 2015.PubMed/NCBI View Article : Google Scholar

13 

Shome D, Honavar SG, Gupta P, Vemuganti GK and Reddy PV: Metastasis to the eye and orbit from renal cell carcinoma-a report of three cases and review of literature. Surv Ophthalmol. 52:213–223. 2007.PubMed/NCBI View Article : Google Scholar

14 

Sitaula R, Shrestha GB, Paudel N and Shrestha JK: Ocular and orbital metastases presenting as a first sign of gastric adenocarcinoma. BMJ Case Rep. 2011(bcr1020114927)2011.PubMed/NCBI View Article : Google Scholar

15 

Singh A, Malik D, Singh S and Vyas VJ: Choroidal metastasis in pancreatic adenocarcinoma. J Cancer Res Ther. 18:263–265. 2022.PubMed/NCBI View Article : Google Scholar

16 

Cohen VM: Ocular metastases. Eye (Lond). 27:137–141. 2013.PubMed/NCBI View Article : Google Scholar

17 

Cennamo G, Montorio D, Carosielli M, Romano MR and Cennamo G: Multimodal imaging in choroidal metastasis. Ophthalmic Res. 64:411–416. 2021.PubMed/NCBI View Article : Google Scholar

18 

Funazo T, Morita K, Ikegami N, Konishi C, Nakao S, Ariyasu R, Taki M, Nakagawa K, Hwang MH, Yoshimura C, et al: Successful treatment with alectinib for choroidal metastasis in anaplastic lymphoma kinase rearranged non-small cell lung cancer. Intern Med. 56:2317–2320. 2017.PubMed/NCBI View Article : Google Scholar

19 

Ahmad SM and Esmaeli B: Metastatic tumors of the orbit and ocular adnexa. Curr Opin Ophthalmol. 18:405–413. 2007.PubMed/NCBI View Article : Google Scholar

20 

Konstantinidis L and Damato B: Intraocular metastases-a review. Asia Pac J Ophthalmol (Phila). 6:208–214. 2017.PubMed/NCBI View Article : Google Scholar

21 

Das SK, Sahoo TK, Parija S, Majumdar SKD and Parida DK: Choroidal metastasis as initial presentation in adenocarcinoma of lung: A case report. J Clin Diagn Res. 11:XD04–XD06. 2017.PubMed/NCBI View Article : Google Scholar

22 

Migaou A, Ben Saad A, Joobeur S, Ben Abdeljelil N, Zina S, Cheikh Mhammed S, Rouatbi N and Fahem N: Choroidal metastasis as the initial presentation of lung adenocarcinoma: A case report. Respir Med Case Rep. 29(100992)2020.PubMed/NCBI View Article : Google Scholar

23 

Zhou Y, Sharifi A, Gupta P, Duong B, Lahiji AP, He J and Lee WH: Vision loss as presenting symptom in testicular cancer: A morbid case report. Case Rep Ophthalmol. 13:756–762. 2022.PubMed/NCBI View Article : Google Scholar

24 

Cun LP: MRI-based radiomics on prediction of lymph-vascular space invasion in cervical cancer. Chin Med Sci University, 2021.

25 

Wu L, Yan J, Bai Y, Chen F, Zou X, Xu J, Huang A, Hou L, Zhong Y, Jing Z, et al: An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression. Cell Res. 33:585–603. 2023.PubMed/NCBI View Article : Google Scholar

26 

Zhou ZY, Wang Y, Long SY, et al: Research progress on the pathogenesis of tumor-induced or infiltrative optic neuropathy and traditional Chinese medicine etiology and pathogenesis. China J Chinese Ophthalmol. 33:785–788. 2023.

27 

Yang M, Wang W, Yan JH, Li XY, Zhou MW, Huang WB and Zhang XL: Eye tumors misdiagnosed as glaucoma. Chin Med J. 128:273–276. 2015.PubMed/NCBI View Article : Google Scholar

28 

Rishi P, Dhami A and Biswas J: Biopsy techniques for intraocular tumors. Indian J Ophthalmol. 64:415–421. 2016.PubMed/NCBI View Article : Google Scholar

29 

Paul Chan RV and Young LH: Treatment options for metastatic tumors to the choroid. Semin Ophthalmol. 20:207–216. 2009.PubMed/NCBI View Article : Google Scholar

30 

Thariat J, Boudin L, Loria O, Nguyen AM, Kodjikian L and Mathis T: How to manage a patient with ocular metastases? Biomedicines. 10(3044)2022.PubMed/NCBI View Article : Google Scholar

31 

Cho KR, Lee KM, Han G, Kang SW and Lee JI: Gamma knife radiosurgery for cancer metastasized to the ocular choroid. J Korean Neurosurg Soc. 61:60–65. 2018.PubMed/NCBI View Article : Google Scholar

32 

Chik JYK, Leung CWL and Wong KH: Palliative radiation therapy for patients with orbital and ocular metastases. Ann Palliat Med. 9:4458–4466. 2020.PubMed/NCBI View Article : Google Scholar

33 

Zhao L, Long L, Liang X, et al: Clinical research progress of PD-L1 inhibitor envafolimab in the treatment of advanced malignant tumor. Journal of Modern Oncology. 32:1154–1158. 2024.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu P, Wang M, Sun Q and Dong W: Right eye metastasis of small‑cell lung carcinoma: A case report. Exp Ther Med 28: 318, 2024.
APA
Zhu, P., Wang, M., Sun, Q., & Dong, W. (2024). Right eye metastasis of small‑cell lung carcinoma: A case report. Experimental and Therapeutic Medicine, 28, 318. https://doi.org/10.3892/etm.2024.12607
MLA
Zhu, P., Wang, M., Sun, Q., Dong, W."Right eye metastasis of small‑cell lung carcinoma: A case report". Experimental and Therapeutic Medicine 28.2 (2024): 318.
Chicago
Zhu, P., Wang, M., Sun, Q., Dong, W."Right eye metastasis of small‑cell lung carcinoma: A case report". Experimental and Therapeutic Medicine 28, no. 2 (2024): 318. https://doi.org/10.3892/etm.2024.12607
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu P, Wang M, Sun Q and Dong W: Right eye metastasis of small‑cell lung carcinoma: A case report. Exp Ther Med 28: 318, 2024.
APA
Zhu, P., Wang, M., Sun, Q., & Dong, W. (2024). Right eye metastasis of small‑cell lung carcinoma: A case report. Experimental and Therapeutic Medicine, 28, 318. https://doi.org/10.3892/etm.2024.12607
MLA
Zhu, P., Wang, M., Sun, Q., Dong, W."Right eye metastasis of small‑cell lung carcinoma: A case report". Experimental and Therapeutic Medicine 28.2 (2024): 318.
Chicago
Zhu, P., Wang, M., Sun, Q., Dong, W."Right eye metastasis of small‑cell lung carcinoma: A case report". Experimental and Therapeutic Medicine 28, no. 2 (2024): 318. https://doi.org/10.3892/etm.2024.12607
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