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Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway

  • Authors:
    • Dengyong Zheng
    • Xinglin Ruan
    • Qiang Wu
    • Yuliang Qiu
    • Shiwei Ruan
  • View Affiliations / Copyright

    Affiliations: Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China, Department of Nephrology, The Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P.R. China, Department of Nephrology, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350004, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 331
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    Published online on: June 20, 2024
       https://doi.org/10.3892/etm.2024.12620
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Abstract

The present study aimed to investigate the therapeutic effects and mechanisms of Yishen Jiangzhuo decoction (YSJZD) in a mouse model of cisplatin‑induced acute kidney injury (AKI). The mice were divided into the NC, cisplatin and cisplatin + YSJZD groups. A concentration‑dependent effect of YSJZD on cisplatin‑induced AKI was observed and the optimal concentration for intervention was calculated. Changes in blood urea nitrogen and serum creatinine levels combined with hematoxylin and eosin and periodic acid‑Schiff staining and transmission electron microscopy observations indicated that YSJZD enhanced renal function, reduced pathological injury and protected renal tubular epithelial cells in cisplatin‑induced AKI mice. The results of the transcriptomic and enrichment analyses showed that the mechanisms of YSJZD may be associated with inflammation, oxidation, apoptosis and the TNF signal pathway. Immunofluorescence, oxidative stress index, terminal deoxynucleotidyl transferase dUTP nick end labeling assay and western blotting revealed that YSJZD downregulated apoptosis in the renal tissues of AKI mice and further decreased the expression levels of p‑p65, p‑p38 MAPK, TNF‑α, cleaved‑caspase‑3 and malondialdehyde, while increasing the levels of NAD‑dependent protein deacetylase sirtuin‑3, glutathione and superoxide dismutase. Overall, the results showed that YSJZD could effectively abrogate cisplatin‑induced AKI in mice through mechanisms primarily related to its anti‑inflammatory, antioxidative and antiapoptotic effects by inhibited the TNF signal pathway. YSJZD warrants further investigation as a clinical empirical prescription.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng D, Ruan X, Wu Q, Qiu Y and Ruan S: Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway. Exp Ther Med 28: 331, 2024.
APA
Zheng, D., Ruan, X., Wu, Q., Qiu, Y., & Ruan, S. (2024). Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway. Experimental and Therapeutic Medicine, 28, 331. https://doi.org/10.3892/etm.2024.12620
MLA
Zheng, D., Ruan, X., Wu, Q., Qiu, Y., Ruan, S."Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway". Experimental and Therapeutic Medicine 28.2 (2024): 331.
Chicago
Zheng, D., Ruan, X., Wu, Q., Qiu, Y., Ruan, S."Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway". Experimental and Therapeutic Medicine 28, no. 2 (2024): 331. https://doi.org/10.3892/etm.2024.12620
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng D, Ruan X, Wu Q, Qiu Y and Ruan S: Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway. Exp Ther Med 28: 331, 2024.
APA
Zheng, D., Ruan, X., Wu, Q., Qiu, Y., & Ruan, S. (2024). Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway. Experimental and Therapeutic Medicine, 28, 331. https://doi.org/10.3892/etm.2024.12620
MLA
Zheng, D., Ruan, X., Wu, Q., Qiu, Y., Ruan, S."Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway". Experimental and Therapeutic Medicine 28.2 (2024): 331.
Chicago
Zheng, D., Ruan, X., Wu, Q., Qiu, Y., Ruan, S."Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway". Experimental and Therapeutic Medicine 28, no. 2 (2024): 331. https://doi.org/10.3892/etm.2024.12620
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