Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2024 Volume 28 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2024 Volume 28 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery

  • Authors:
    • Jingping Yao
    • Zhuoyue Gao
    • Wa Qu
    • Jingjing Li
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Daqing Oil Field General Hospital, Daqing, Heilongjiang 163000, P.R. China, Department of Anesthesia, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518000, P.R. China
    Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 343
    |
    Published online on: July 1, 2024
       https://doi.org/10.3892/etm.2024.12632
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Propofol total intravenous anesthesia (TIVA) or sevoflurane inhalation anesthesia (IA) affects post‑operative cognitive dysfunction in geriatric patients undergoing laparoscopic surgery; however, relevant real‑world clinical evidence on the matter is limited. The present study aimed to compare the effects of propofol TIVA and sevoflurane IA on post‑operative cognitive dysfunction in the aforementioned type of patients. The present prospective study enrolled 197 geriatric patients undergoing laparoscopic surgery. Patients were assigned to the propofol TIVA group (n=97) and sevoflurane IA group (n=100) according to the actual anesthesia regimens. The mini‑mental state examination (MMSE) score was assessed before surgery and on day (D)1, D3 and D7 following surgery in both groups. The MMSE score on D1 was higher in the TIVA group compared with the IA group (P=0.006). The change in the MMSE scores from before surgery to D1 (P<0.001), D3 (P=0.011) and D7 (P=0.003) was smaller in the TIVA group vs. the IA group. Multivariate linear regression analyses suggested that the anesthesia method of TIVA (vs. IA) was independently related to the increased MMSE score on D1 (b=0.803; P=0.001) and D7 (b=0.472; P=0.025). The levels of interleukin (IL)‑17A, IL‑6 and tumor necrosis factor‑α on D1, D3 and D7 exhibited a slightly decreasing trend in the TIVA group vs. the IA group, although the difference was not statistically significant (all P>0.05). Notably, the levels of IL‑17A before surgery (P=0.015), on D3 (P=0.016) and D7 (P=0.002), as well as those of IL‑6 on D1 (P=0.027), were negatively associated with the MMSE score at the corresponding time points. Overall, the present study demonstrates that propofol TIVA ameliorates post‑operative cognitive dysfunction on D1 compared with sevoflurane IA and exerts a potentially suppressive effect on inflammation in geriatric patients undergoing laparoscopic surgery.
View Figures

Figure 1

Figure 2

View References

1 

Avidan MS, Whitlock EL and Mashour GA: General anesthesia and postoperative neurocognitive outcomes. JAMA. 327:36–38. 2022.PubMed/NCBI View Article : Google Scholar

2 

Li Z, Zhu Y, Kang Y, Qin S and Chai J: Neuroinflammation as the underlying mechanism of postoperative cognitive dysfunction and therapeutic strategies. Front Cell Neurosci. 16(843069)2022.PubMed/NCBI View Article : Google Scholar

3 

Olotu C: Anesthesia for the elderly: A narrative review. Minerva Anestesiol. 87:1128–1138. 2021.PubMed/NCBI View Article : Google Scholar

4 

Gomez-Rios MA and Abad-Gurumeta A: Anesthesia in the elderly patient. Resilience in frailty time. Med Clin (Barc). 159:486–488. 2022.PubMed/NCBI View Article : Google Scholar

5 

Li Y, Chen D, Wang H, Wang Z, Song F, Li H, Ling L, Shen Z, Hu C, Peng J, et al: Intravenous versus volatile anesthetic effects on postoperative cognition in elderly patients undergoing laparoscopic abdominal surgery. Anesthesiology. 134:381–394. 2021.PubMed/NCBI View Article : Google Scholar

6 

Geng YJ, Wu QH and Zhang RQ: Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. J Clin Anesth. 38:165–171. 2017.PubMed/NCBI View Article : Google Scholar

7 

Fan Y, Liu X, Wu S and Liu Y: The risk factors for cognitive dysfunction in elderly patients after laparoscopic surgery: A retrospective analysis. Medicine (Baltimore). 100(e23977)2021.PubMed/NCBI View Article : Google Scholar

8 

Riedel B, Dubowitz J, Yeung J, Jhanji S, Kheterpal S and Avidan MS: On the horns of a dilemma: Choosing total intravenous anaesthesia or volatile anaesthesia. Br J Anaesth. 129:284–289. 2022.PubMed/NCBI View Article : Google Scholar

9 

Spruce L: Back to basics: Inhaled anesthesia. AORN J. 102:389–393. 2015.PubMed/NCBI View Article : Google Scholar

10 

Jones C and Harris J: Total intravenous anaesthesia. Br J Hosp Med (Lond). 82:1–2. 2021.PubMed/NCBI View Article : Google Scholar

11 

Zhang Y, Shan GJ, Zhang YX, Cao SJ, Zhu SN, Li HJ, Ma D and Wang DX: First Study of Perioperative Organ Protection (SPOP1) investigators. Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults. Br J Anaesth. 121:595–604. 2018.PubMed/NCBI View Article : Google Scholar

12 

Konishi Y, Evered LA, Scott DA and Silbert BS: Postoperative cognitive dysfunction after sevoflurane or propofol general anaesthesia in combination with spinal anaesthesia for hip arthroplasty. Anaesth Intensive Care. 46:596–600. 2018.PubMed/NCBI View Article : Google Scholar

13 

Rump K and Adamzik M: Epigenetic mechanisms of postoperative cognitive impairment induced by anesthesia and neuroinflammation. Cells. 11(2954)2022.PubMed/NCBI View Article : Google Scholar

14 

Liu Y, Yang W, Xue J, Chen J, Liu S, Zhang S, Zhang X, Gu X, Dong Y and Qiu P: Neuroinflammation: The central enabler of postoperative cognitive dysfunction. Biomed Pharmacother. 167(115582)2023.PubMed/NCBI View Article : Google Scholar

15 

Saklad M: Grading of patients for surgical procedures. Anesthesiology. 2:281–284. 1941.

16 

Folstein MF, Folstein SE and McHugh PR: ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 12:189–198. 1975.PubMed/NCBI View Article : Google Scholar

17 

Yu W: Anesthesia with propofol and sevoflurane on postoperative cognitive function of elderly patients undergoing general thoracic surgery. Pak J Pharm Sci. 30:1107–1110. 2017.PubMed/NCBI

18 

Vutskits L and Xie Z: Lasting impact of general anaesthesia on the brain: Mechanisms and relevance. Nat Rev Neurosci. 17:705–717. 2016.PubMed/NCBI View Article : Google Scholar

19 

Eckenhoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, Pidikiti R, Keller JM and Eckenhoff MF: Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity. Anesthesiology. 101:703–709. 2004.PubMed/NCBI View Article : Google Scholar

20 

Wang Y, Sands LP, Vaurio L, Mullen EA and Leung JM: The effects of postoperative pain and its management on postoperative cognitive dysfunction. Am J Geriatr Psychiatry. 15:50–59. 2007.PubMed/NCBI View Article : Google Scholar

21 

Deng H, Wu Y, Gao P, Kong D, Pan C, Xu S, Tang D, Jiao Y, Wen D and Yu W: Preoperative pain facilitates postoperative cognitive dysfunction via periaqueductal gray matter-dorsal raphe circuit. Neuroscience. 524:209–219. 2023.PubMed/NCBI View Article : Google Scholar

22 

Peng K, Liu HY, Wu SR, Liu H, Zhang ZC and Ji FH: Does propofol anesthesia lead to less postoperative pain compared with inhalational anesthesia?: A systematic review and meta-analysis. Anesth Analg. 123:846–858. 2016.PubMed/NCBI View Article : Google Scholar

23 

Tian Y, Guo S, Guo Y and Jian L: Anesthetic propofol attenuates apoptosis, Aβ accumulation, and inflammation induced by sevoflurane through NF-κB pathway in human neuroglioma cells. Cell Mol Neurobiol. 35:891–898. 2015.PubMed/NCBI View Article : Google Scholar

24 

Ye X, Lian Q, Eckenhoff MF, Eckenhoff RG and Pan JZ: Differential general anesthetic effects on microglial cytokine expression. PLoS One. 8(e52887)2013.PubMed/NCBI View Article : Google Scholar

25 

Kothari V, Luo Y, Tornabene T, O'Neill AM, Greene MW, Geetha T and Babu JR: High fat diet induces brain insulin resistance and cognitive impairment in mice. Biochim Biophys Acta Mol Basis Dis. 1863:499–508. 2017.PubMed/NCBI View Article : Google Scholar

26 

Pignalosa FC, Desiderio A, Mirra P, Nigro C, Perruolo G, Ulianich L, Formisano P, Beguinot F, Miele C, Napoli R and Fiory F: Diabetes and cognitive impairment: A role for glucotoxicity and dopaminergic dysfunction. Int J Mol Sci. 22(12366)2021.PubMed/NCBI View Article : Google Scholar

27 

Yang ZY and Yuan CX: IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway. BMC Anesthesiol. 18(147)2018.PubMed/NCBI View Article : Google Scholar

28 

Tian A, Ma H, Zhang R, Tan W, Wang X, Wu B, Wang J and Wan C: Interleukin17A promotes postoperative cognitive dysfunction by triggering β-amyloid accumulation via the transforming growth factor-β (TGFβ)/smad signaling pathway. PLoS One. 10(e0141596)2015.PubMed/NCBI View Article : Google Scholar

29 

Duan GY, Duan ZX, Chen H, Chen F, Chen F, Du ZY, Chen LY, Lu KZ, Zuo ZY and Li H: Cognitive function and delirium following sevoflurane or propofol anesthesia for valve replacement surgery: A multicenter randomized controlled trial. Kaohsiung J Med Sci. 39:166–174. 2023.PubMed/NCBI View Article : Google Scholar

30 

Evered LA, Chan MTV, Han R, Chu MHM, Cheng BP, Scott DA, Pryor KO, Sessler DI, Veselis R, Frampton C, et al: Anaesthetic depth and delirium after major surgery: A randomised clinical trial. Br J Anaesth. 127:704–712. 2021.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yao J, Gao Z, Qu W and Li J: Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery. Exp Ther Med 28: 343, 2024.
APA
Yao, J., Gao, Z., Qu, W., & Li, J. (2024). Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery. Experimental and Therapeutic Medicine, 28, 343. https://doi.org/10.3892/etm.2024.12632
MLA
Yao, J., Gao, Z., Qu, W., Li, J."Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery". Experimental and Therapeutic Medicine 28.3 (2024): 343.
Chicago
Yao, J., Gao, Z., Qu, W., Li, J."Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery". Experimental and Therapeutic Medicine 28, no. 3 (2024): 343. https://doi.org/10.3892/etm.2024.12632
Copy and paste a formatted citation
x
Spandidos Publications style
Yao J, Gao Z, Qu W and Li J: Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery. Exp Ther Med 28: 343, 2024.
APA
Yao, J., Gao, Z., Qu, W., & Li, J. (2024). Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery. Experimental and Therapeutic Medicine, 28, 343. https://doi.org/10.3892/etm.2024.12632
MLA
Yao, J., Gao, Z., Qu, W., Li, J."Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery". Experimental and Therapeutic Medicine 28.3 (2024): 343.
Chicago
Yao, J., Gao, Z., Qu, W., Li, J."Propofol total intravenous anesthesia vs. sevoflurane inhalation anesthesia: Effects on post‑operative cognitive dysfunction and inflammation in geriatric patients undergoing laparoscopic surgery". Experimental and Therapeutic Medicine 28, no. 3 (2024): 343. https://doi.org/10.3892/etm.2024.12632
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team