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Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report

  • Authors:
    • Takeshi Horaguchi
    • Yoshihiro Tanaka
    • Yuta Sato
    • Kazuo Yamamoto
    • Masahiro Fukada
    • Itaru Yasufuku
    • Ryuichi Asai
    • Jesse Yu Tajima
    • Shigeru Kiyama
    • Nobuhisa Matsuhashi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery and Pediatric Surgery, Gifu University Graduate School of Medicine, Gifu, Gifu 501-1193, Japan
    Copyright: © Horaguchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 396
    |
    Published online on: August 8, 2024
       https://doi.org/10.3892/etm.2024.12685
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Abstract

Owing to advances in cancer treatment and the diversification of treatment methods, cancer-associated thrombosis is increasing. Cancer can cause blood clots by activating the blood clotting system, increasing clotting factors through inflammation, reducing blood flow due to immobilization and damaging blood vessels through treatments such as chemotherapy. In clinical practice, superior mesenteric vein (SMV) thrombosis is occasionally observed in patients with cancer; however, certain cases of asymptomatic thrombosis can be serious. In the present case, a 71-year-old woman underwent laparoscopic high anterior resection for colorectal cancer. The patient received capecitabine as postoperative adjuvant chemotherapy for 6 months. Contrast-enhanced CT after the completion of chemotherapy revealed a sizable thrombus in the SMV. The thrombus occupied the SMV lumen without evident intestinal ischemia. D-dimer levels were elevated. Since the patient remained asymptomatic, edoxaban (30 mg/day) was administered in an outpatient setting. Six months later, contrast-enhanced CT confirmed thrombus resolution. No hemorrhagic events were observed during edoxaban treatment. In conclusion, cancer and chemotherapy are risk factors for thrombosis, indicating that regular D-dimer measurements may be necessary during cancer treatment. In addition, edoxaban may be an effective therapeutic tool for SMV thrombosis during chemotherapy for cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Horaguchi T, Tanaka Y, Sato Y, Yamamoto K, Fukada M, Yasufuku I, Asai R, Tajima JY, Kiyama S, Matsuhashi N, Matsuhashi N, et al: Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report. Exp Ther Med 28: 396, 2024.
APA
Horaguchi, T., Tanaka, Y., Sato, Y., Yamamoto, K., Fukada, M., Yasufuku, I. ... Matsuhashi, N. (2024). Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report. Experimental and Therapeutic Medicine, 28, 396. https://doi.org/10.3892/etm.2024.12685
MLA
Horaguchi, T., Tanaka, Y., Sato, Y., Yamamoto, K., Fukada, M., Yasufuku, I., Asai, R., Tajima, J. Y., Kiyama, S., Matsuhashi, N."Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report". Experimental and Therapeutic Medicine 28.4 (2024): 396.
Chicago
Horaguchi, T., Tanaka, Y., Sato, Y., Yamamoto, K., Fukada, M., Yasufuku, I., Asai, R., Tajima, J. Y., Kiyama, S., Matsuhashi, N."Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report". Experimental and Therapeutic Medicine 28, no. 4 (2024): 396. https://doi.org/10.3892/etm.2024.12685
Copy and paste a formatted citation
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Spandidos Publications style
Horaguchi T, Tanaka Y, Sato Y, Yamamoto K, Fukada M, Yasufuku I, Asai R, Tajima JY, Kiyama S, Matsuhashi N, Matsuhashi N, et al: Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report. Exp Ther Med 28: 396, 2024.
APA
Horaguchi, T., Tanaka, Y., Sato, Y., Yamamoto, K., Fukada, M., Yasufuku, I. ... Matsuhashi, N. (2024). Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report. Experimental and Therapeutic Medicine, 28, 396. https://doi.org/10.3892/etm.2024.12685
MLA
Horaguchi, T., Tanaka, Y., Sato, Y., Yamamoto, K., Fukada, M., Yasufuku, I., Asai, R., Tajima, J. Y., Kiyama, S., Matsuhashi, N."Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report". Experimental and Therapeutic Medicine 28.4 (2024): 396.
Chicago
Horaguchi, T., Tanaka, Y., Sato, Y., Yamamoto, K., Fukada, M., Yasufuku, I., Asai, R., Tajima, J. Y., Kiyama, S., Matsuhashi, N."Successful direct oral anticoagulant management of asymptomatic superior mesenteric vein thrombosis after adjuvant chemotherapy for colorectal cancer patient: A case report". Experimental and Therapeutic Medicine 28, no. 4 (2024): 396. https://doi.org/10.3892/etm.2024.12685
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