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Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases

  • Authors:
    • Sheng Chen
    • Nan Zhao
    • Xiangrong Li
    • Dedong Cao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, P.R. China, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 418
    |
    Published online on: September 6, 2024
       https://doi.org/10.3892/etm.2024.12707
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Abstract

Primary liver cancer is a major public health issue in China, with high incidence and mortality rates. Notably, progress has been made in improving the surgical methods and hepatic arterial infusion chemotherapy (HAIC) regimens of liver cancer and the combination of HAIC with immunotherapy is expected to further increase the surgical conversion rate or objective response rate. However, patients with liver cancer often have underlying cirrhosis, which may lead to complications, such as esophageal varices and high‑pressure gastric diseases. The present study describes three cases of giant gastric ulcers that occurred during the process of HAIC or combined immunotherapy. Notably, the causal relationship between HAIC and immunotherapy is unclear. In patients with tumors receiving immunotherapy, gastrointestinal adverse reactions are common, and some may develop serious complications, such as gastrointestinal perforation. The present study provides a detailed analysis of this issue and emphasizes the need for further clarification of its mechanisms and effective treatment methods.
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Copy and paste a formatted citation
Spandidos Publications style
Chen S, Zhao N, Li X and Cao D: Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases. Exp Ther Med 28: 418, 2024.
APA
Chen, S., Zhao, N., Li, X., & Cao, D. (2024). Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases. Experimental and Therapeutic Medicine, 28, 418. https://doi.org/10.3892/etm.2024.12707
MLA
Chen, S., Zhao, N., Li, X., Cao, D."Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases". Experimental and Therapeutic Medicine 28.5 (2024): 418.
Chicago
Chen, S., Zhao, N., Li, X., Cao, D."Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases". Experimental and Therapeutic Medicine 28, no. 5 (2024): 418. https://doi.org/10.3892/etm.2024.12707
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Zhao N, Li X and Cao D: Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases. Exp Ther Med 28: 418, 2024.
APA
Chen, S., Zhao, N., Li, X., & Cao, D. (2024). Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases. Experimental and Therapeutic Medicine, 28, 418. https://doi.org/10.3892/etm.2024.12707
MLA
Chen, S., Zhao, N., Li, X., Cao, D."Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases". Experimental and Therapeutic Medicine 28.5 (2024): 418.
Chicago
Chen, S., Zhao, N., Li, X., Cao, D."Analysis of complications of giant gastric ulcers induced by hepatic arterial infusion chemotherapy or combined immunotherapy: A report of three cases". Experimental and Therapeutic Medicine 28, no. 5 (2024): 418. https://doi.org/10.3892/etm.2024.12707
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