Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2024 Volume 28 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 28 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical aspects and risks of the phenol/croton oil

  • Authors:
    • Ioannis E. Liapakis
    • Georgios K. Ismailos
    • Angelos Michail
    • Georgios P. Tsakonis
    • Georgia Gloustianou
    • Ioannis Koliarakis
    • Apostolos D. Mandrekas
  • View Affiliations / Copyright

    Affiliations: Opsis Clinical Plastic and Reconstructive Surgery, 71304 Heraklion, Greece, Experimental Research Center ELPEN, ELPEN Pharmaceuticals, 19009 Pikermi, Greece, Michail Clinic for Plastic and Reconstructive Surgery, 5961 BH Maastricht, The Netherlands, Tsakonis Plastic and Reconstructive Surgery Clinic, 12134 Athens, Greece, Histopathologic Diagnosis, 11521 Athens, Greece, School of Medicine, University of Crete, 71500 Heraklion, Greece, Artion Plastic Surgery Center, 15451 Athens, Greece
  • Article Number: 422
    |
    Published online on: September 11, 2024
       https://doi.org/10.3892/etm.2024.12711
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Phenol/croton oil is a unique chemical formulation promoting deep skin resurfacing and cellular renovation. Even though it has been used for decades in plastic surgery, the clinicopathological features, as well as the risks related to phenol/croton oil clinical application have not been thoroughly studied. The aim of the present study was to assess the effectiveness of the phenol/croton oil peel, the pathological characteristics from 1 patient at least and the emerging potential risks. A total of 64 patients were treated with phenol/croton oil peel between 2014 and 2023; in total, 21 of them underwent resurfacing at their oral area (upper/lower lips), 15 underwent resurfacing at their lower eyelid wrinkles, 22 patients underwent full face resurfacing, 2 patients were treated for their acne scars and additionally 4 patients were treated for multiple body seborrheic keratosis. The wrinkles, as well as the acne scars were markedly improved in all patients, the seborrheic keratosis was eliminated, while adverse events and undesired clinical manifestations related to peel intervention were mild and reversible for all patients. The application of phenol/croton oil constitutes an immensely powerful tool for deep chemical peeling and facial skin rejuvenation; nevertheless, it should be used cautiously due to its potential complications.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Fischer TC, Perosino E, Poli F, Viera MS and Dreno B: Cosmetic dermatology european expert group. Chemical peels in aesthetic dermatology: An update 2009. J Eur Acad Dermatol Venereol. 24:281–292. 2010.PubMed/NCBI View Article : Google Scholar

2 

Rullan P: Commentary on characterization of the activity of croton tiglium oil in Hetter's very heavy phenol-croton oil chemical peels. Dermatol Surg. 47(947)2021.PubMed/NCBI View Article : Google Scholar

3 

Lemes BM, da Silva Justo A, Lin EM, Capote ACMO, Neves AKL, Machinski I, Pereira AV, Koga AY, Lipinski LC, Beltrame FL, et al: The effects of 35% trichloroacetic acid-croton oil and 35% glycolic acid-croton oil compared to 35% phenol-croton oil Hetter's very heavy formula for deep chemical peel. J Am Acad Dermatol. 87:1227–1229. 2022.PubMed/NCBI View Article : Google Scholar

4 

Baker TJ, Gordon HL, Mosienko P and Seckinger DL: Long-term histological study of skin after chemical face peeling. Plast Reconstr Surg. 53:522–525. 1974.PubMed/NCBI View Article : Google Scholar

5 

Hetter GP: An examination of the phenol-croton oil peel: Parts I-IV. Plast Reconstr Surg. 105:1227–1083. 2000.PubMed/NCBI View Article : Google Scholar

6 

Nogueira GC, Oliveira RIFM, de Queiroz MVR, de Medeiros ACTR, Oliveira LPS and de Oliveira GV: Static glabellar lines can be treated using a superlocalized phenol-croton oil peel. JAAD Int. 11:63–64. 2022.PubMed/NCBI View Article : Google Scholar

7 

Atiyeh B, Oneisi A and Ghieh FJ: Medium-depth trichloroacetic acid and deep phenol-croton oil chemical peeling for facial rejuvenation: An update. Craniofac Surg. 32:e745–e750. 2021.PubMed/NCBI View Article : Google Scholar

8 

Wambier CG and Beltrame FL: Air safety and personal protective equipment for phenol-croton oil peels. Dermatol Surg. 44:1035–1037. 2018.PubMed/NCBI View Article : Google Scholar

9 

Starkman SJ and Mangat DS: Chemical peels: Deep, medium and light. Facial Plast Surg. 35:239–247. 2019.PubMed/NCBI View Article : Google Scholar

10 

Cardoso FAMES, Moura RD, Pilar EFS, Moura ICG, Miot HA and da Costa A: Phenol-croton oil peel enhances type-1 and type-3 collagen amounts by stimulating SIRT-6 and SIRT-7. Int J Dermatol. 61:e71–e74. 2022.PubMed/NCBI View Article : Google Scholar

11 

Justo AS, Lemes BM, Nunes B, Antunes KA, Carletto B, Koga AY, Lipinski LC, Montemor Netto MR, Campagnoli EB, Beltrame FL and Wambier CG: Depth of injury of Hetter's phenol-croton oil chemical peel formula using 2 different emulsifying agents. J Am Acad Dermatol. 82:1544–1546. 2020.PubMed/NCBI View Article : Google Scholar

12 

Cardoso FAMES, Pilar EFS, Moura ICG, de Melo CB, Pompeu VMA, Moura RD, Ramos-E-Silva M and da Costa A: Neocolagenesis by phenol-croton oil peel is independent from the MMP-1/MMP-2/JunB and p53 pathways. J Cosmet Dermatol. 21:1766–1769. 2022.PubMed/NCBI View Article : Google Scholar

13 

Liapakis IE, Tzouganakis AC, Paschalis EI, Englander M, Christopoulos A, Gloustianou G and Kontoes P: Parry Romberg syndrome treatment with fat transfer and a new bleaching formula. J Cosmet Dermatol. 18:1424–1429. 2019.PubMed/NCBI View Article : Google Scholar

14 

Lee JC, Daniels MA and Roth MZ: Mesotherapy, microneedling, and chemical peels. Clin Plastic Surg. 43:583–595. 2016.PubMed/NCBI View Article : Google Scholar

15 

Justo AS, Lemes BM, Nunes B, Antunes KA, Capote ACMO, Lipinski LC, Campagnoli EB, Emiliano J, Meurer EC, Ezemma O, et al: Characterization of the activity of croton tiglium oil in Hetter's very heavy phenol-croton oil chemical peels. Dermatol Surg. 47:944–946. 2021.PubMed/NCBI View Article : Google Scholar

16 

Wambier CG, Lee KC, Soon SL, Sterling JB, Rulla PP, Landau M and Brody HJ: International Peeling Society. Advanced chemical peels: Phenol-croton oil peel. JAAD. 2:327–336. 2018.PubMed/NCBI View Article : Google Scholar

17 

Bensimon RH: Croton oil peels. Aesth Plast Surg. 28:33–45. 2008.PubMed/NCBI View Article : Google Scholar

18 

Rullan P, Landau M and Rullan J: Emulsifiers are not necessary to make formulas for deep chemical peeling: response to Wambier et al: Advanced chemical peels: Phenol-croton oil peel. J Am Acad Dermatol. 90:e197–e198. 2024.PubMed/NCBI View Article : Google Scholar

19 

Muriel-Sanchez JM, Cohena-Jimenez M and Montano-Jimenez P: Effect of phenol application time in the treatment of onychocryptosis: A randomized double-blind clinical trial. Int J Environ Res Pub Health. 18(10478)2021.PubMed/NCBI View Article : Google Scholar

20 

Sun HF, Lu HS, Sun LQ, Ping WD, Mao DS and Li D: Chemical peeling with a modified phenol formula for the treatment of facial freckles on asian skin. Aesthetic Plast Surg. 42:546–552. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liapakis IE, Ismailos GK, Michail A, Tsakonis GP, Gloustianou G, Koliarakis I and Mandrekas AD: Clinical aspects and risks of the phenol/croton oil. Exp Ther Med 28: 422, 2024.
APA
Liapakis, I.E., Ismailos, G.K., Michail, A., Tsakonis, G.P., Gloustianou, G., Koliarakis, I., & Mandrekas, A.D. (2024). Clinical aspects and risks of the phenol/croton oil. Experimental and Therapeutic Medicine, 28, 422. https://doi.org/10.3892/etm.2024.12711
MLA
Liapakis, I. E., Ismailos, G. K., Michail, A., Tsakonis, G. P., Gloustianou, G., Koliarakis, I., Mandrekas, A. D."Clinical aspects and risks of the phenol/croton oil". Experimental and Therapeutic Medicine 28.5 (2024): 422.
Chicago
Liapakis, I. E., Ismailos, G. K., Michail, A., Tsakonis, G. P., Gloustianou, G., Koliarakis, I., Mandrekas, A. D."Clinical aspects and risks of the phenol/croton oil". Experimental and Therapeutic Medicine 28, no. 5 (2024): 422. https://doi.org/10.3892/etm.2024.12711
Copy and paste a formatted citation
x
Spandidos Publications style
Liapakis IE, Ismailos GK, Michail A, Tsakonis GP, Gloustianou G, Koliarakis I and Mandrekas AD: Clinical aspects and risks of the phenol/croton oil. Exp Ther Med 28: 422, 2024.
APA
Liapakis, I.E., Ismailos, G.K., Michail, A., Tsakonis, G.P., Gloustianou, G., Koliarakis, I., & Mandrekas, A.D. (2024). Clinical aspects and risks of the phenol/croton oil. Experimental and Therapeutic Medicine, 28, 422. https://doi.org/10.3892/etm.2024.12711
MLA
Liapakis, I. E., Ismailos, G. K., Michail, A., Tsakonis, G. P., Gloustianou, G., Koliarakis, I., Mandrekas, A. D."Clinical aspects and risks of the phenol/croton oil". Experimental and Therapeutic Medicine 28.5 (2024): 422.
Chicago
Liapakis, I. E., Ismailos, G. K., Michail, A., Tsakonis, G. P., Gloustianou, G., Koliarakis, I., Mandrekas, A. D."Clinical aspects and risks of the phenol/croton oil". Experimental and Therapeutic Medicine 28, no. 5 (2024): 422. https://doi.org/10.3892/etm.2024.12711
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team