Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2024 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2024 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report

  • Authors:
    • Julia Parras‑Hernández
    • Álvaro Tofé‑Povedano
    • Javier Herce‑López
    • David Matute‑García
    • Elena Martínez‑Carapeto
    • Guadalupe Cuadrado‑Caballero
    • Ángel Rollón‑Mayordomo
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Reina Sofía University Hospital, 14004 Córdoba, Spain, Department of Oral and Maxillofacial Surgery, Puerta del Mar University Hospital, 11009 Cádiz, Spain, Department of Oral and Maxillofacial Surgery, Virgen Macarena University Hospital, 41009 Sevilla, Spain, Vidadent Comprehensive Dental Center, 41600 Arahal, Spain
    Copyright: © Parras‑Hernández et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 438
    |
    Published online on: September 25, 2024
       https://doi.org/10.3892/etm.2024.12727
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Severe atrophy of the maxilla occasionally renders it impossible to place standard endosseous implants to replace absent teeth. For such cases, personalized subperiosteal implants (PSI) are presented as a treatment alternative. Due to novel design and manufacturing technologies, PSIs are fitted closely to the bone structure of the patient, after defining the anchorage areas where the bone is of higher quality and allowing a passive dental prosthesis to be attached to restore function and aesthetics to the patient. The present case report documents a patient with severe bone defects as a sequela of rhino‑orbit‑cerebral mucormycosis. After a failed microvascular fibula flap reconstruction, the patient was treated with a removable implant‑supported prosthesis attached to a PSI, which provided occlusion with the mandible of the patient and closed the oronasal‑antral communication defect. At 18 months after treatment, the patient felt well, with no biological complications and the prosthesis was well adjusted and with good function. Consequently, we consider that in some cases such as this, a customized solution of this type can avoid complex reconstruction treatments.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Paltauf A: Mycosis mucorina. Archiv F Pathol Anat. 102:543–564. 1885.

2 

O'Neill BM, Alessi AS, George EB and Piro J: Disseminated rhinocerebral mucormycosis: A case report and review of the literature. J Oral Maxillofac Surg. 64:326–333. 2006.PubMed/NCBI View Article : Google Scholar

3 

Arnáiz-García ME, Alonso-Peña D, González-Vela Mdel C, García-Palomo JD, Sanz-Giménez-Rico JR and Arnáiz-García AM: Cutaneous mucormycosis: Report of five cases and review of the literature. J Plast Reconstr Aesthet Surg. 62:e434–e441. 2009.PubMed/NCBI View Article : Google Scholar

4 

Rangel-Guerra RA, Martínez HR, Sáenz C, Bosques-Padilla F and Estrada-Bellmann I: Rhinocerebral and systemic mucormycosis. Clinical experience with 36 cases. J Neurol Sci. 143:19–30. 1996.PubMed/NCBI View Article : Google Scholar

5 

Oh WS and Roumanas E: Dental implant-assisted prosthetic rehabilitation of a patient with a bilateral maxillectomy defect secondary to mucormycosis. J Prosthet Dent. 96:88–95. 2006.PubMed/NCBI View Article : Google Scholar

6 

Lenox ND and Kim DD: Maxillary reconstruction. Oral Maxillofac Surg Clin North Am. 25:215–222. 2013.PubMed/NCBI View Article : Google Scholar

7 

Moreno MA, Skoracki RJ, Hanna EY and Hanasono MM: Microvascular free flap reconstruction versus palatal obturation for maxillectomy defects. Head Neck. 32:860–868. 2010.PubMed/NCBI View Article : Google Scholar

8 

Colombo M, Mangano C, Mijiritsky E, Krebs M, Hauschild U and Fortin T: Clinical applications and effectiveness of guided implant surgery: A critical review based on randomized controlled trials. BMC Oral Health. 17(150)2017.PubMed/NCBI View Article : Google Scholar

9 

Joda T, Zarone F and Ferrari M: The complete digital workflow in fixed prosthodontics: A systematic review. BMC Oral Health. 17(124)2017.PubMed/NCBI View Article : Google Scholar

10 

Dahl C: If the opportunity for implantation in the jaw of metal skeletons as the base or retention for fixed or removable dentures. Odontol Tidskr. 51:440–449. 1943.

11 

Mommaerts MY: Evolutionary steps in the design and biofunctionalization of the additively manufactured sub-periosteal jaw implant ‘AMSJI’ for the maxilla. Int J Oral Maxillofac Surg. 48:108–114. 2019.PubMed/NCBI View Article : Google Scholar

12 

Tofé-Povedano Á, Hernández JP, López JH, García DM, González-Moguena VA and Rollón-Mayordomo Á: Design modifications in subperiosteal implants to avoid complications. Presentation of a case series study and literature review. Rev Esp Cir Oral Maxilofac. 45:57–63. 2023.

13 

Kondaka S, Singh VD, Vadlamudi C and Bathala LR: Prosthetic rehabilitation of untailored defects using patient-specific implants. Dent Res J (Isfahan). 19(83)2022.PubMed/NCBI

14 

Cordeiro PG and Chen CM: A 15-year review of midface reconstruction after total and subtotal maxillectomy: Part II. Technical modifications to maximize aesthetic and functional outcomes. Plast Reconstr Surg. 129:139–147. 2012.PubMed/NCBI View Article : Google Scholar

15 

Andi KA, Holmes SB and Hutchison IL: Infraorbital orbitotomy: Modification of the Weber-Ferguson approach. Br J Oral Maxillofac Surg. 48:44–45. 2010.PubMed/NCBI View Article : Google Scholar

16 

Adjari A, Zolfagharypoor A, Firouzifar M and Akbarpour M: Rhinocerebral mucormycosis in immunocompetent patients: A case report and review of literature. Infection. 52:673–684. 2024.PubMed/NCBI View Article : Google Scholar

17 

Ferguson BJ: Mucormycosis of the nose and paranasal sinuses. Otolaryngol Clin North Am. 33:349–365. 2000.PubMed/NCBI View Article : Google Scholar

18 

Deek AJ, Boukovalas S, Rathfoot CJ and Gotcher JE: Rhinocerebral Mucormycosis as a Sequelae of COVID-19 Treatment: A case report & literature review. J Oral Maxillofac Surg. 80:333–340. 2022.PubMed/NCBI View Article : Google Scholar

19 

Maassarani D, Bassil GF, Nehme M, Nassar A, Ghanime G and Sleiman Z: Rhinocerebral Mucormycosis: An emerging threat in the Era of COVID-19. Cureus. 14(e28057)2022.PubMed/NCBI View Article : Google Scholar

20 

Al-Tawfiq JA, Alhumaid S, Alshukairi AN, Temsah MH, Barry M, Al Mutair A, Rabaan AA, Al-Omari A, Tirupathi R, AlQahtani M, et al: COVID-19 and mucormycosis superinfection: The perfect storm. Infection. 49:833–853. 2021.PubMed/NCBI View Article : Google Scholar

21 

Robb GL, Marunick MT, Martin JW and Zlotolow IM: Midface reconstruction: Surgical reconstruction versus prosthesis. Head Neck. 23:48–58. 2001.PubMed/NCBI

22 

Cao Y, Yu C, Liu W, Miao C, Han B, Yang J, Li L and Li C: Obturators versus flaps after maxillary oncological ablation: A systematic review and best evidence synthesis. Oral Oncol. 82:152–161. 2018.PubMed/NCBI View Article : Google Scholar

23 

Buurman DJM, Speksnijder CM, de Groot RJ, Kessler P and Rieger JM: Mastication in maxillectomy patients: A comparison between reconstructed maxillae and implant supported obturators: A cross-sectional study. J Oral Rehabil. 47:1171–1177. 2020.PubMed/NCBI View Article : Google Scholar

24 

Rieger JM, Tang JA, Wolfaardt J, Harris J and Seikaly H: Comparison of speech and aesthetic outcomes in patients with maxillary reconstruction versus maxillary obturators after maxillectomy. J Otolaryngol Head Neck Surg. 40:40–47. 2011.PubMed/NCBI

25 

Keyf F: Obturator prostheses for hemimaxillectomy patients. J Oral Rehabil. 28:821–829. 2001.PubMed/NCBI View Article : Google Scholar

26 

Rathee M, Divakar S, Jain P, Alam M and Singh S: Post maxillectomy rehabilitation and amelioration of quality of life of post-COVID rhinocerebral mucormycosis patients using obturator: A case series. J Family Med Prim Care. 11:7476–7482. 2022.PubMed/NCBI View Article : Google Scholar

27 

Hazra R, Srivastava A and Kumar D: Obturators: A proposed classification and its associated techniques. J Indian Prosthodont Soc. 23:192–197. 2023.PubMed/NCBI View Article : Google Scholar

28 

Jiao T, Zhu C, Dong X and Gu X: Rehabilitation of maxillectomy defects with obturator prostheses fabricated using computer-aided design and rapid prototyping: A pilot study. Int J Prosthodont. 27:480–486. 2014.PubMed/NCBI View Article : Google Scholar

29 

Herce-López J, Pingarrón MDC, Tofé-Povedano Á, García-Arana L, Espino-Segura-Illa M, Sieira-Gil R, Rodado-Alonso C, Sánchez-Torres A and Figueiredo R: Customized subperiosteal implants for the rehabilitation of atrophic jaws: A consensus report and literature review. Biomimetics (Basel). 9(61)2024.PubMed/NCBI View Article : Google Scholar

30 

Cerea M and Dolcini GA: Custom-Made direct metal laser sintering titanium subperiosteal implants: A retrospective clinical study on 70 patients. Biomed Res Int. 2018(5420391)2018.PubMed/NCBI View Article : Google Scholar

31 

Mommaerts MY: Additively manufactured sub-periosteal jaw implants. Int J Oral Maxillofac Surg. 46:938–940. 2017.PubMed/NCBI View Article : Google Scholar

32 

Gellrich NC, Zimmerer RM, Spalthoff S, Jehn P, Pott PC, Rana M and Rahlf B: A customised digitally engineered solution for fixed dental rehabilitation in severe bone deficiency: A new innovative line extension in implant dentistry. J Craniomaxillofac Surg. 45:1632–1638. 2017.PubMed/NCBI View Article : Google Scholar

33 

Cebrián Carretero JL, Del Castillo Pardo de Vera JL, Montesdeoca García N, Garrido Martínez P, Pampín Martínez MM, Aragón Niño I, Navarro Cuéllar I and Navarro Cuéllar C: Virtual surgical planning and customized subperiosteal titanium maxillary implant (CSTMI) for three dimensional reconstruction and dental implants of maxillary defects after oncological resection: Case series. J Clin Med. 11(4594)2022.PubMed/NCBI View Article : Google Scholar

34 

O'Connell DA and Futran ND: Reconstruction of the midface and maxilla. Curr Opin Otolaryngol Head Neck Surg. 18:304–310. 2010.PubMed/NCBI View Article : Google Scholar

35 

Korn P, Gellrich NC, Jehn P, Spalthoff S and Rahlf B: A new strategy for patient-specific implant-borne dental rehabilitation in patients with extended maxillary defects. Front Oncol. 11(718872)2021.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Parras‑Hernández J, Tofé‑Povedano Á, Herce‑López J, Matute‑García D, Martínez‑Carapeto E, Cuadrado‑Caballero G and Rollón‑Mayordomo Á: Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report. Exp Ther Med 28: 438, 2024.
APA
Parras‑Hernández, J., Tofé‑Povedano, Á., Herce‑López, J., Matute‑García, D., Martínez‑Carapeto, E., Cuadrado‑Caballero, G., & Rollón‑Mayordomo, Á. (2024). Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report. Experimental and Therapeutic Medicine, 28, 438. https://doi.org/10.3892/etm.2024.12727
MLA
Parras‑Hernández, J., Tofé‑Povedano, Á., Herce‑López, J., Matute‑García, D., Martínez‑Carapeto, E., Cuadrado‑Caballero, G., Rollón‑Mayordomo, Á."Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report". Experimental and Therapeutic Medicine 28.6 (2024): 438.
Chicago
Parras‑Hernández, J., Tofé‑Povedano, Á., Herce‑López, J., Matute‑García, D., Martínez‑Carapeto, E., Cuadrado‑Caballero, G., Rollón‑Mayordomo, Á."Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report". Experimental and Therapeutic Medicine 28, no. 6 (2024): 438. https://doi.org/10.3892/etm.2024.12727
Copy and paste a formatted citation
x
Spandidos Publications style
Parras‑Hernández J, Tofé‑Povedano Á, Herce‑López J, Matute‑García D, Martínez‑Carapeto E, Cuadrado‑Caballero G and Rollón‑Mayordomo Á: Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report. Exp Ther Med 28: 438, 2024.
APA
Parras‑Hernández, J., Tofé‑Povedano, Á., Herce‑López, J., Matute‑García, D., Martínez‑Carapeto, E., Cuadrado‑Caballero, G., & Rollón‑Mayordomo, Á. (2024). Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report. Experimental and Therapeutic Medicine, 28, 438. https://doi.org/10.3892/etm.2024.12727
MLA
Parras‑Hernández, J., Tofé‑Povedano, Á., Herce‑López, J., Matute‑García, D., Martínez‑Carapeto, E., Cuadrado‑Caballero, G., Rollón‑Mayordomo, Á."Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report". Experimental and Therapeutic Medicine 28.6 (2024): 438.
Chicago
Parras‑Hernández, J., Tofé‑Povedano, Á., Herce‑López, J., Matute‑García, D., Martínez‑Carapeto, E., Cuadrado‑Caballero, G., Rollón‑Mayordomo, Á."Personalized subperiosteal implant‑supported obturator for the rehabilitation of rhino‑orbit‑cerebral mucormycosis sequela: A case report". Experimental and Therapeutic Medicine 28, no. 6 (2024): 438. https://doi.org/10.3892/etm.2024.12727
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team