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Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review)

  • Authors:
    • Yiqi Wu
    • Xiao Wang
    • Yan Zeng
    • Xiuheng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 439
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    Published online on: September 25, 2024
       https://doi.org/10.3892/etm.2024.12728
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Abstract

Prostate cancer poses a serious threat to the well‑being of men worldwide, with the leading cause of mortality being primarily through metastasis. Prostate cancer metastasis is dependent on cell communication, which is an essential component of this process; yet its exact mechanism remains obscure. Nonetheless, cell‑to‑cell communication plays a critical part in prostate cancer metastasis. Exosomes play an indispensable role in the development of metastatic growth by promoting intercellular communication. They are pivotal regulatory agents for both prostate cancer cells as well as their microenvironment. The present study investigated the makeup and function of exosomes in the tumor microenvironment, highlighting their significance to prostate cancer metastasis.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

2 

Zhang Y, Chen B, Xu N, Xu P, Lin W, Liu C and Huang P: Exosomes promote the transition of androgen-dependent prostate cancer cells into androgen-independent manner through up-regulating the heme oxygenase-1. Int J Nanomedicine. 16:315–327. 2021.PubMed/NCBI View Article : Google Scholar

3 

Rebello RJ, Oing C, Knudsen KE, Loeb S, Johnson DC, Reiter RE, Gillessen S, Van der Kwast T and Bristow RG: Prostate cancer. Nat Rev Dis Primers. 7(9)2021.PubMed/NCBI View Article : Google Scholar

4 

Sandhu S, Moore CM, Chiong E, Beltran H, Bristow RG and Williams SG: Prostate cancer. Lancet. 398:1075–1090. 2021.PubMed/NCBI View Article : Google Scholar

5 

Pegtel DM and Gould SJ: Exosomes. Annu Rev Biochem. 88:487–514. 2019.PubMed/NCBI View Article : Google Scholar

6 

Beit-Yannai E, Tabak S and Stamer WD: Physical exosome:Exosome interactions. J Cell Mol Med. 22:2001–2006. 2018.PubMed/NCBI View Article : Google Scholar

7 

Terrasini N and Lionetti V: Exosomes in critical illness. Crit Care Med. 45:1054–1060. 2017.PubMed/NCBI View Article : Google Scholar

8 

Soung YH, Ford S, Zhang V and Chung J: Exosomes in cancer diagnostics. Cancers (Basel). 9(8)2017.PubMed/NCBI View Article : Google Scholar

9 

No authors listed. Exosomes. Nat Biotechnol. 38(1150)2020.PubMed/NCBI View Article : Google Scholar

10 

Yang L: Tumor microenvironment and metabolism. Int J Mol Sci. 18(2729)2017.PubMed/NCBI View Article : Google Scholar

11 

Anderson NM and Simon MC: The tumor microenvironment. Curr Biol. 30:R921–R925. 2020.PubMed/NCBI View Article : Google Scholar

12 

Jiang X, Wang J, Deng X, Xiong F, Zhang S, Gong Z, Li X, Cao K, Deng H, He Y, et al: The role of microenvironment in tumor angiogenesis. J Exp Clin Cancer Res. 39(204)2020.PubMed/NCBI View Article : Google Scholar

13 

Hu C, Chen M, Jiang R, Guo Y, Wu M and Zhang X: Exosome-related tumor microenvironment. J Cancer. 9:3084–3092. 2018.PubMed/NCBI View Article : Google Scholar

14 

Lau AN and Vander Heiden MG: Metabolism in the tumor microenvironment. Annu Rev Cancer Biol. 4:17–40. 2020.

15 

Ugel S, Canè S, De Sanctis F and Bronte V: Monocytes in the tumor microenvironment. Annu Rev Pathol. 16:93–122. 2021.PubMed/NCBI View Article : Google Scholar

16 

Pan BT and Johnstone RM: Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor. Cell. 33:967–978. 1983.PubMed/NCBI View Article : Google Scholar

17 

Wróblewska JP, Lach MS, Kulcenty K, Galus Ł, Suchorska WM, Rösel D, Brábek J and Marszałek A: The analysis of inflammation-related proteins in a cargo of exosomes derived from the serum of uveal melanoma patients reveals potential biomarkers of disease progression. Cancers (Basel). 13(3334)2021.PubMed/NCBI View Article : Google Scholar

18 

Javed A, Kong N, Mathesh M, Duan W and Yang W: Nanoarchitectonics-based electrochemical aptasensors for highly efficient exosome detection. Sci Technol Adv Mater. 25(2345041)2024.PubMed/NCBI View Article : Google Scholar

19 

Kakarla R, Hur J, Kim YJ, Kim J and Chwae YJ: Apoptotic cell-derived exosomes: Messages from dying cells. Exp Mol Med. 52:1–6. 2020.PubMed/NCBI View Article : Google Scholar

20 

Kiral FR, Kohrs FE, Jin EJ and Hiesinger PR: Rab GTPases and membrane trafficking in neurodegeneration. Curr Biol. 28:R471–R486. 2018.PubMed/NCBI View Article : Google Scholar

21 

Shikanai M, Yuzaki M and Kawauchi T: Rab family small GTPases-mediated regulation of intracellular logistics in neural development. Histol Histopathol. 33:765–771. 2018.PubMed/NCBI View Article : Google Scholar

22 

Vitale I, Manic G, Coussens LM, Kroemer G and Galluzzi L: Macrophages and metabolism in the tumor microenvironment. Cell Metab. 30:36–50. 2019.PubMed/NCBI View Article : Google Scholar

23 

Baroni S, Romero-Cordoba S, Plantamura I, Dugo M, D'Ippolito E, Cataldo A, Cosentino G, Angeloni V, Rossini A, Daidone MG and Iorio MV: Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts. Cell Death Dis. 7(e2312)2016.PubMed/NCBI View Article : Google Scholar

24 

Zhu Y, Dou H, Liu Y, Yu P, Li F, Wang Y and Xiao M: Breast cancer exosome-derived miR-425-5p Induces cancer-associated fibroblast-like properties in human mammary fibroblasts by TGF β 1/ROS signaling pathway. Oxid Med Cell Longev. 2022(5266627)2022.PubMed/NCBI View Article : Google Scholar

25 

Yan Z, Sheng Z, Zheng Y, Feng R, Xiao Q, Shi L, Li H, Yin C, Luo H, Hao C, et al: Cancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7. Cell Death Dis. 12(1120)2021.PubMed/NCBI View Article : Google Scholar

26 

Kang J and Guo Y: Human umbilical cord mesenchymal stem cells derived exosomes promote neurological function recovery in a rat spinal cord injury model. Neurochem Res. 47:1532–1540. 2022.PubMed/NCBI View Article : Google Scholar

27 

Wang G, Yuan J, Cai X, Xu Z, Wang J, Ocansey DKW, Yan Y, Qian H, Zhang X, Xu W and Mao F: HucMSC-exosomes carrying miR-326 inhibit neddylation to relieve inflammatory bowel disease in mice. Clin Transl Med. 10(e113)2020.PubMed/NCBI View Article : Google Scholar

28 

Zhang Z, Chen L, Chen X, Qin Y, Tian C, Dai X, Meng R, Zhong Y, Liang W, Shen C, et al: Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-EXO) regulate autophagy through AMPK-ULK1 signaling pathway to ameliorate diabetic cardiomyopathy. Biochem Biophys Res Commun. 632:195–203. 2022.PubMed/NCBI View Article : Google Scholar

29 

Wang X, Cui Z, Zeng B, Qiong Z and Long Z: Human mesenchymal stem cell derived exosomes inhibit the survival of human melanoma cells through modulating miR-138-5p/SOX4 pathway. Cancer Biomark. 34:533–543. 2022.PubMed/NCBI View Article : Google Scholar

30 

Pan Y, Wang X, Li Y, Yan P and Zhang H: Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST. Cancer Gene Ther. 29:1130–1139. 2022.PubMed/NCBI View Article : Google Scholar

31 

Zhang Y, Huo M, Li W, Zhang H, Liu Q, Jiang J, Fu Y and Huang C: Exosomes in tumor-stroma crosstalk: Shaping the immune microenvironment in colorectal cancer. FASEB J. 38(e23548)2024.PubMed/NCBI View Article : Google Scholar

32 

Chen XJ, Guo CH, Wang ZC, Yang Y, Pan YH, Liang JY, Sun MG, Fan LS, Liang L and Wang W: Hypoxia-induced ZEB1 promotes cervical cancer immune evasion by strengthening the CD47-SIRPα axis. Cell Commun Signal. 22(15)2024.PubMed/NCBI View Article : Google Scholar

33 

Giovannelli P, Di Donato M, Galasso G, Monaco A, Licitra F, Perillo B, Migliaccio A and Castoria G: Communication between cells: Exosomes as a delivery system in prostate cancer. Cell Commun Signal. 19(110)2021.PubMed/NCBI View Article : Google Scholar

34 

Parolini I, Federici C, Raggi C, Lugini L, Palleschi S, De Milito A, Coscia C, Iessi E, Logozzi M, Molinari A, et al: Microenvironmental pH is a key factor for exosome traffic in tumor cells. J Biol Chem. 284:34211–3422. 2009.PubMed/NCBI View Article : Google Scholar

35 

Wang X, Sun C, Huang X, Li J, Fu Z, Li W and Yin Y: The advancing roles of exosomes in breast cancer. Front Cell Dev Biol. 9(731062)2021.PubMed/NCBI View Article : Google Scholar

36 

Ban JJ, Lee M, Im W and Kim M: Low pH increases the yield of exosome isolation. Biochem Biophys Res Commun. 461:76–79. 2015.PubMed/NCBI View Article : Google Scholar

37 

Saber SH, Ali HEA, Gaballa R, Gaballah M, Ali HI, Zerfaoui M and Abd Elmageed ZY: Exosomes are the driving force in preparing the soil for the metastatic seeds: Lessons from the prostate cancer. Cells. 9(564)2020.PubMed/NCBI View Article : Google Scholar

38 

Li Z, He P, Luo G, Shi X, Yuan G, Zhang B, Seidl C, Gewies A, Wang Y, Zou Y, et al: Increased tumoral microenvironmental pH improves cytotoxic effect of pharmacologic ascorbic acid in castration-resistant prostate cancer cells. Front Pharmacol. 11(570939)2020.PubMed/NCBI View Article : Google Scholar

39 

Xi L, Peng M, Liu S, Liu Y, Wan X, Hou Y, Qin Y, Yang L, Chen S, Zeng H, et al: Hypoxia-stimulated ATM activation regulates autophagy-associated exosome release from cancer-associated fibroblasts to promote cancer cell invasion. J Extracell Vesicles. 10(e12146)2021.PubMed/NCBI View Article : Google Scholar

40 

Luo C, Xin H, Zhou Z, Hu Z, Sun R, Yao N, Sun Q, Borjigin U, Wu X, Fan J, et al: Tumor-derived exosomes induce immunosuppressive macrophages to foster intrahepatic cholangiocarcinoma progression. Hepatology. 76:982–999. 2022.PubMed/NCBI View Article : Google Scholar

41 

Shen Y, Guo D, Weng L, Wang S, Ma Z, Yang Y, Wang P, Wang J and Cai Z: Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway. OncoImmunology. 6(e1362527)2017.PubMed/NCBI View Article : Google Scholar

42 

Deicher A, Andersson R, Tingstedt B, Lindell G, Bauden M and Ansari D: Targeting dendritic cells in pancreatic ductal adenocarcinoma. Cancer Cell Int. 18(85)2018.PubMed/NCBI View Article : Google Scholar

43 

Panigrahi GK, Praharaj PP, Peak TC, Long J, Singh R, Rhim JS, Abd Elmageed ZY and Deep G: Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells. Sci Rep. 8(3853)2018.PubMed/NCBI View Article : Google Scholar

44 

Llorente A, Skotland T, Sylvänne T, Kauhanen D, Róg T, Orłowski A, Vattulainen I, Ekroos K and Sandvig K: Molecular lipidomics of exosomes released by PC-3 prostate cancer cells. Biochim Biophys Acta. 1831:1302–1309. 2013.PubMed/NCBI View Article : Google Scholar

45 

Bertokova A, Svecova N, Kozics K, Gabelova A, Vikartovska A, Jane E, Hires M, Bertok T and Tkac J: Exosomes from prostate cancer cell lines: Isolation optimisation and characterisation. Biomed Pharmacother. 151(113093)2022.PubMed/NCBI View Article : Google Scholar

46 

Spetzler D, Pawlowski TL, Tinder T, Kimbrough J, Deng T, Kim J, Moran B, Conrad A, Esmay P and Kuslich C: The molecular evolution of prostate cancer cell line exosomes with passage number. J Clin Oncol. 28 (15 Suppl)(e21071)2010.

47 

Müller JS, Burns DT, Griffin H, Wells GR, Zendah RA, Munro B, Schneider C and Horvath R: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. Life Sci Alliance. 3(e202000678)2020.PubMed/NCBI View Article : Google Scholar

48 

Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, et al: Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway. J Hematol Oncol. 12(144)2019.PubMed/NCBI View Article : Google Scholar

49 

Adekoya TO and Richardson RM: Cytokines and chemokines as mediators of prostate cancer metastasis. Int J Mol Sci. 21(4449)2020.PubMed/NCBI View Article : Google Scholar

50 

Dann J, Castronovo FP, McKusick KA, Griffin PP, Strauss HW and Prout GR Jr: Total bone uptake in management of metastatic carcinoma of the prostate. J Urol. 137:444–448. 1987.PubMed/NCBI View Article : Google Scholar

51 

Chau CH and Figg WD: Molecular and phenotypic heterogeneity of metastatic prostate cancer. Cancer Biol Ther. 4:166–167. 2005.PubMed/NCBI View Article : Google Scholar

52 

Bilen MA, Pan T, Lee YC, Lin SC, Yu G, Pan J, Hawke D, Pan BF, Vykoukal J, Gray K, et al: Proteomics profiling of exosomes from primary mouse osteoblasts under proliferation versus mineralization conditions and characterization of their uptake into prostate cancer cells. J Proteome Res. 16:2709–2728. 2017.PubMed/NCBI View Article : Google Scholar

53 

Renzulli JF II, Del Tatto M, Dooner G, Aliotta J, Goldstein L, Dooner M, Colvin G, Chatterjee D and Quesenberry P: Microvesicle induction of prostate specific gene expression in normal human bone marrow cells. J Urol. 184:2165–2171. 2010.PubMed/NCBI View Article : Google Scholar

54 

Duan Y, Tan Z, Yang M, Li J, Liu C, Wang C, Zhang F, Jin Y, Wang Y and Zhu L: PC-3-derived exosomes inhibit osteoclast differentiation by downregulating miR-214 and blocking NF-κB signaling pathway. Biomed Res Int. 2019(8650846)2019.PubMed/NCBI View Article : Google Scholar

55 

Karlsson T, Lundholm M, Widmark A and Persson E: Tumor cell-derived exosomes from the prostate cancer cell line TRAMP-C1 impair osteoclast formation and differentiation. PLoS One. 11(e0166284)2016.PubMed/NCBI View Article : Google Scholar

56 

Lee J, Kwon MH, Kim JA and Rhee WJ: Detection of exosome miRNAs using molecular beacons for diagnosing prostate cancer. Artif Cells Nanomed Biotechnol. 46 (Suppl 3):S52–S63. 2018.PubMed/NCBI View Article : Google Scholar

57 

Che Y, Shi X, Shi Y, Jiang X, Ai Q, Shi Y, Gong F and Jiang W: Exosomes derived from miR-143-Overexpressing MSCs inhibit cell migration and invasion in human prostate cancer by downregulating TFF3. Mol Ther Nucleic Acids. 18:232–244. 2019.PubMed/NCBI View Article : Google Scholar

58 

Li T, Sun X and Chen L: Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker. J Cell Biochem. 121:2118–2126. 2019.PubMed/NCBI View Article : Google Scholar

59 

Petanidis S, Domvri K, Porpodis K, Anestakis D, Freitag L, Hohenforst-Schmidt W, Tsavlis D and Zarogoulidis K: Inhibition of kras-derived exosomes downregulates immunosuppressive BACH2/GATA-3 expression via RIP-3 dependent necroptosis and miR-146/miR-210 modulation. Biomed Pharmacother. 122(109461)2020.PubMed/NCBI View Article : Google Scholar

60 

Ayala-Mar S, Donoso-Quezada J and González-Valdez J: Clinical implications of exosomal PD-L1 in cancer immunotherapy. J Immunol Res. 2021(8839978)2021.PubMed/NCBI View Article : Google Scholar

61 

Wang J, Zeng H, Zhang H and Han Y: The role of exosomal PD-L1 in tumor immunotherapy. Transl Oncol. 14(101047)2021.PubMed/NCBI View Article : Google Scholar

62 

Bai W, Tang X, Xiao T, Qiao Y, Tian X, Zhu B, Chen J, Chen C, Li Y, Lin X, et al: Enhancing antitumor efficacy of oncolytic virus M1 via albendazole-sustained CD8+ T cell activation. Mol Ther Oncol. 32(200813)2024.PubMed/NCBI View Article : Google Scholar

63 

Liu J, Wu S, Zheng X, Zheng P, Fu Y, Wu C, Lu B, Ju J and Jiang J: Immune suppressed tumor microenvironment by exosomes derived from gastric cancer cells via modulating immune functions. Sci Rep. 10(14749)2020.PubMed/NCBI View Article : Google Scholar

64 

Yang J, Chen J, Liang H and Yu Y: Nasopharyngeal cancer cell-derived exosomal PD-L1 inhibits CD8+ T-cell activity and promotes immune escape. Cancer Sci. 113:3044–3054. 2022.PubMed/NCBI View Article : Google Scholar

65 

Kim DH, Kim H, Choi YJ, Kim SY, Lee JE, Sung KJ, Sung YH, Pack CG, Jung MK, Han B, et al: Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer. Exp Mol Med. 51:1–13. 2019.PubMed/NCBI View Article : Google Scholar

66 

Schmittgen TD: Exosomal miRNA cargo as mediator of immune escape mechanisms in neuroblastoma. Cancer Res. 79:1293–1294. 2019.PubMed/NCBI View Article : Google Scholar

67 

Yao X, Tu Y, Xu Y, Guo Y, Yao F and Zhang X: Endoplasmic reticulum stress-induced exosomal miR-27a-3p promotes immune escape in breast cancer via regulating PD-L1 expression in macrophages. J Cell Mol Med. 24:9560–9573. 2020.PubMed/NCBI View Article : Google Scholar

68 

Palicelli A, Bonacini M, Croci S, Bisagni A, Zanetti E, De Biase D, Sanguedolce F, Ragazzi M, Zanelli M, Chaux A, et al: What do we have to know about PD-L1 expression in prostate cancer? A systematic literature review. Part 7: PD-L1 expression in liquid biopsy. J Pers Med. 11(1312)2021.PubMed/NCBI View Article : Google Scholar

69 

Xu W, Lu M, Xie S, Zhou D, Zhu M and Liang C: Endoplasmic reticulum stress promotes prostate cancer cells to release exosome and up-regulate PD-L1 expression via PI3K/Akt signaling pathway in macrophages. J Cancer. 14:1062–1074. 2023.PubMed/NCBI View Article : Google Scholar

70 

Li D, Zhou X, Xu W, Chen Y, Mu C, Zhao X, Yang T, Wang G, Wei L and Ma B: Prostate cancer cells synergistically defend against CD8+ T cells by secreting exosomal PD-L1. Cancer Med. 12:16405–16415. 2023.PubMed/NCBI View Article : Google Scholar

71 

Hosseini R, Asef-Kabiri L, Yousefi H, Sarvnaz H, Salehi M, Akbari ME and Eskandari N: The roles of tumor-derived exosomes in altered differentiation, maturation and function of dendritic cells. Mol Cancer. 20(83)2021.PubMed/NCBI View Article : Google Scholar

72 

Felmeden DC, Blann AD and Lip GYH: Angiogenesis: Basic pathophysiology and implications for disease. Eur Heart J. 24:586–603. 2003.PubMed/NCBI View Article : Google Scholar

73 

Kargozar S, Baino F, Hamzehlou S, Hamblin MR and Mozafari M: Nanotechnology for angiogenesis: Opportunities and challenges. Chem Soc Rev. 49:5008–5057. 2020.PubMed/NCBI View Article : Google Scholar

74 

Jin Y, Xing J, Xu K, Liu D and Zhuo Y: Exosomes in the tumor microenvironment: Promoting cancer progression. Front Immunol. 13(1025218)2022.PubMed/NCBI View Article : Google Scholar

75 

Yu L, Gui S, Liu Y, Qiu X, Zhang G, Zhang X, Pan J, Fan J, Qi S and Qiu B: Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2. Aging (Albany NY). 11:5300–5318. 2019.PubMed/NCBI View Article : Google Scholar

76 

Zhang C, Ji Q, Yang Y, Li Q and Wang Z: Exosome: Function and role in cancer metastasis and drug resistance. Technol Cancer Res Treat. 17(1533033818763450)2018.PubMed/NCBI View Article : Google Scholar

77 

Khan S, Jutzy JMS, Valenzuela MMA, Turay D, Aspe JR, Ashok A, Mirshahidi S, Mercola D, Lilly MB and Wall NR: Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer. PLoS One. 7(e46737)2012.PubMed/NCBI View Article : Google Scholar

78 

Bagnato G, Leopizzi M, Urciuoli E and Peruzzi B: Nuclear functions of the tyrosine kinase Src. Int J Mol Sci. 21(2675)2020.PubMed/NCBI View Article : Google Scholar

79 

Rivera-Torres J and San José E: Src tyrosine kinase inhibitors: New perspectives on their immune, antiviral, and senotherapeutic potential. Front Pharmacol. 10(1011)2019.PubMed/NCBI View Article : Google Scholar

80 

DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL and Languino RL: c-Src, insulin-like growth factor I receptor, G-protein-coupled receptor kinases and focal adhesion kinase are enriched into prostate cancer cell exosomes. J Cell Biochem. 118:66–73. 2016.PubMed/NCBI View Article : Google Scholar

81 

Larssen P, Wik L, Czarnewski P, Eldh M, Löf L, Ronquist KG, Dubois L, Freyhult E, Gallant CJ, Oelrich J, et al: Tracing cellular origin of human exosomes using multiplex proximity extension assays. Mol Cell Proteomics. 16:502–511. 2017.PubMed/NCBI View Article : Google Scholar

82 

Alcayaga-Miranda F, González PL, Lopez-Verrilli A, Varas-Godoy M, Aguila-Díaz C, Contreras L and Khoury M: Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species. Oncotarget. 7:44462–44477. 2016.PubMed/NCBI View Article : Google Scholar

83 

Maisto R, Oltra M, Vidal-Gil L, Martínez-Gil N, Sancho-Pellúz J, Filippo CD, Rossi S, D Amico M, Barcia JM and Romero FJ: ARPE-19-derived VEGF-containing exosomes promote neovascularization in HUVEC: The role of the melanocortin receptor 5. Cell Cycle. 18:413–424. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Wang X, Zeng Y and Liu X: Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review). Exp Ther Med 28: 439, 2024.
APA
Wu, Y., Wang, X., Zeng, Y., & Liu, X. (2024). Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review). Experimental and Therapeutic Medicine, 28, 439. https://doi.org/10.3892/etm.2024.12728
MLA
Wu, Y., Wang, X., Zeng, Y., Liu, X."Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review)". Experimental and Therapeutic Medicine 28.6 (2024): 439.
Chicago
Wu, Y., Wang, X., Zeng, Y., Liu, X."Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review)". Experimental and Therapeutic Medicine 28, no. 6 (2024): 439. https://doi.org/10.3892/etm.2024.12728
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Wang X, Zeng Y and Liu X: Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review). Exp Ther Med 28: 439, 2024.
APA
Wu, Y., Wang, X., Zeng, Y., & Liu, X. (2024). Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review). Experimental and Therapeutic Medicine, 28, 439. https://doi.org/10.3892/etm.2024.12728
MLA
Wu, Y., Wang, X., Zeng, Y., Liu, X."Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review)". Experimental and Therapeutic Medicine 28.6 (2024): 439.
Chicago
Wu, Y., Wang, X., Zeng, Y., Liu, X."Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review)". Experimental and Therapeutic Medicine 28, no. 6 (2024): 439. https://doi.org/10.3892/etm.2024.12728
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