Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2024 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2024 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway

  • Authors:
    • Jiaming Lei
    • Jianbao Yang
    • Shijiao Cheng
    • Feifei Lu
    • Zihan Wu
    • Ziyi Wang
    • Ziqi Wang
    • Chenyu Sun
    • Li Lin
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, School of Public Health, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Department of Ultrasound, Xianning Traditional Chinese Medicine Hospital, Xianning, Hubei 437100, P.R. China, Department of Medicine, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Key Laboratory of Environmental Related Diseases and One Health, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China
    Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 447
    |
    Published online on: October 3, 2024
       https://doi.org/10.3892/etm.2024.12737
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glioblastoma (GBM) is one of the most malignant forms of intracranial tumors, with high mortality rates and invariably poor prognosis, due to the limited clinical treatment strategies available. As a natural compound, peimine's favorable pharmacological activities have been widely revealed. However, potential inhibitory effects of peimine on GBM have not been explored. In the present study, both in vitro and in vivo experiments were performed to elucidate the effects of peimine on GBM and to further delineate the underlying molecular mechanism of action. Different doses (0, 25 and 50 µM) of peimine were added to U87 cells, before MTT, colony formation, wound healing, Transwell migration and invasion, reactive oxygen species and mitochondrial transmembrane potential assays were used to measure proliferation, migration, invasion and apoptosis. Furthermore, western blotting was used to examine the possible effects of peimine on the expression of proteins associated with apoptosis and the PI3K/AKT signaling pathway. Subsequently, a GBM mouse xenograft model was used to assess the effects of peimine in vivo. The findings showed that peimine inhibited GBM proliferation, migration and invasion in a dose‑dependent manner, whilst also inducing apoptosis. Peimine also reduced tumor growth in vivo. Mechanistically, peimine downregulated the expression of Bcl‑2 and Caspase 3, whilst upregulating the protein expression levels of p53, Bax and Cleaved‑Caspase 3 in a dose‑dependent manner. In addition, PI3K and AKT phosphorylation levels were found to be decreased by peimine in a dose‑dependent manner. In conclusion, these findings suggest that peimine may limit GBM growth by regulating the PI3K/AKT signaling pathway both in vitro and in vivo. These findings may have promising clinical implications.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Tamimi AF and Juweid M: Epidemiology and outcome of glioblastoma. In: Glioblastoma. De Vleeschouwer S (ed). Codon Publications, Brisbane, AU, 2017.

2 

Batash R, Asna N, Schaffer P, Francis N and Schaffer M: Glioblastoma multiforme, diagnosis and treatment; recent literature review. Curr Med Chem. 24:3002–3009. 2017.PubMed/NCBI View Article : Google Scholar

3 

Omuro A and DeAngelis LM: Glioblastoma and other malignant gliomas: A clinical review. JAMA. 310:1842–1850. 2013.PubMed/NCBI View Article : Google Scholar

4 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023.PubMed/NCBI View Article : Google Scholar

5 

Dréan A, Goldwirt L, Verreault M, Canney M, Schmitt C, Guehennec J, Delattre JY, Carpentier A and Idbaih A: Blood-brain barrier, cytotoxic chemotherapies and glioblastoma. Expert Rev Neurother. 16:1285–1300. 2016.PubMed/NCBI View Article : Google Scholar

6 

Schaff LR and Mellinghoff IK: Glioblastoma and other primary brain malignancies in adults: A review. JAMA. 329:574–587. 2023.PubMed/NCBI View Article : Google Scholar

7 

Fang XH, Zou MY, Chen FQ, Ni H, Nie SP and Yin JY: An overview on interactions between natural product-derived β-glucan and small-molecule compounds. Carbohydr Polym. 261(117850)2021.PubMed/NCBI View Article : Google Scholar

8 

McKinnon C, Nandhabalan M, Murray SA and Plaha P: Glioblastoma: Clinical presentation, diagnosis, and management. BMJ. 374(n1560)2021.PubMed/NCBI View Article : Google Scholar

9 

An YL, Wei WL and Guo DA: Application of analytical technologies in the discrimination and authentication of herbs from Fritillaria: A review. Crit Rev Anal Chem. 54:1775–1796. 2024.PubMed/NCBI View Article : Google Scholar

10 

Yi PF, Wu YC, Dong HB, Guo Y, Wei Q, Zhang C, Song Z, Qin QQ, Lv S, Wu SC and Fu BD: Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 35:567–572. 2013.PubMed/NCBI View Article : Google Scholar

11 

Xu J, Zhao W, Pan L, Zhang A, Chen Q, Xu K, Lu H and Chen Y: Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia. 111:1–6. 2016.PubMed/NCBI View Article : Google Scholar

12 

Zhang L, Cui M and Chen S: Identification of the molecular mechanisms of peimine in the treatment of cough using computational target fishing. Molecules. 25(1105)2020.PubMed/NCBI View Article : Google Scholar

13 

Zhang T, Liu GY, Cao JL, Li YN, Xue H, Wu HT and Jin CH: Peimine-induced apoptosis and inhibition of migration by regulating reactive oxygen species-mediated MAPK/STAT3/NF-κB and Wnt/β-catenin signaling pathways in gastric cancer MKN-45 cells. Drug Dev Res. 83:1683–1696. 2022.PubMed/NCBI View Article : Google Scholar

14 

Sun J, Li J, Kong X and Guo Q: Peimine inhibits MCF-7 breast cancer cell growth by modulating inflammasome activation: Critical roles of MAPK and NF-κB signaling. Anticancer Agents Med Chem. 23:317–327. 2023.PubMed/NCBI View Article : Google Scholar

15 

Tan H, Zhang G, Yang X, Jing T, Shen D and Wang X: Peimine inhibits the growth and motility of prostate cancer cells and induces apoptosis by disruption of intracellular calcium homeostasis through Ca2+/CaMKII/JNK pathway. J Cell Biochem. 121:81–92. 2020.PubMed/NCBI View Article : Google Scholar

16 

Chen J, Yu Y, Li H, Hu Q, Chen X, He Y, Xue C, Ren F, Ren Z, Li J, et al: Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer. Mol Cancer. 18(33)2019.PubMed/NCBI View Article : Google Scholar

17 

Chen K, Lv ZT, Zhou CH, Liang S, Huang W, Wang ZG, Zhu WT, Wang YT, Jing XZ, Lin H, et al: Peimine suppresses interleukin-1β-induced inflammation via MAPK downregulation in chondrocytes. Int J Mol Med. 43:2241–2251. 2019.PubMed/NCBI View Article : Google Scholar

18 

Tanaka S, Louis DN, Curry WT, Batchelor TT and Dietrich J: Diagnostic and therapeutic avenues for glioblastoma: No longer a dead end? Nat Rev Clin Oncol. 10:14–26. 2013.PubMed/NCBI View Article : Google Scholar

19 

Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, Reifenberger G and Weller M: Molecular targeted therapy of glioblastoma. Cancer Treat Rev. 80(101896)2019.PubMed/NCBI View Article : Google Scholar

20 

Zhao W, Zheng XD, Tang PY, Li HM, Liu X, Zhong JJ and Tang YJ: Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi-active components combination. Med Res Rev. 43:1778–1808. 2023.PubMed/NCBI View Article : Google Scholar

21 

Sevastre AS, Costachi A, Tataranu LG, Brandusa C, Artene SA, Stovicek O, Alexandru O, Danoiu S, Sfredel V and Dricu A: Glioblastoma pharmacotherapy: A multifaceted perspective of conventional and emerging treatments (review). Exp Ther Med. 22(1408)2021.PubMed/NCBI View Article : Google Scholar

22 

Wang W, Yuan X, Mu J, Zou Y, Xu L, Chen J, Zhu X, Li B, Zeng Z, Wu X, et al: Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-catenin and Akt/NF-κB signaling pathways. Phytomedicine. 118(154933)2023.PubMed/NCBI View Article : Google Scholar

23 

Shen J, Zhang T, Cheng Z, Zhu N, Wang H, Lin L, Wang Z, Yi H and Hu M: Lycorine inhibits glioblastoma multiforme growth through EGFR suppression. J Exp Clin Cancer Res. 37(157)2018.PubMed/NCBI View Article : Google Scholar

24 

Luo H, Vong CT, Chen H, Gao Y, Lyu P, Qiu L, Zhao M, Liu Q, Cheng Z, Zou J, et al: Naturally occurring anti-cancer compounds: Shining from Chinese herbal medicine. Chin Med. 14(48)2019.PubMed/NCBI View Article : Google Scholar

25 

Zhao L, Zhang H, Li N, Chen J, Xu H, Wang Y and Liang Q: Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula. J Ethnopharmacol. 309(116306)2023.PubMed/NCBI View Article : Google Scholar

26 

Hussain A, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA and Sharma C: Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells. Cancer Biother Radiopharm. 26:519–527. 2011.PubMed/NCBI View Article : Google Scholar

27 

Liu Y, Yang S, Wang K, Lu J, Bao X, Wang R, Qiu Y, Wang T and Yu H: Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products. Cell Prolif. 53(e12894)2020.PubMed/NCBI View Article : Google Scholar

28 

Wang X, Li J, Chen R, Li T and Chen M: Active ingredients from Chinese medicine for combination cancer therapy. Int J Biol Sci. 19:3499–3525. 2023.PubMed/NCBI View Article : Google Scholar

29 

Zhang P, Jiang Y, Ye X, Zhang C and Tang Y: PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model. Exp Ther Med. 25(223)2023.PubMed/NCBI View Article : Google Scholar

30 

Wong RS: Apoptosis in cancer: From pathogenesis to treatment. J Exp Clin Cancer Res. 30(87)2011.PubMed/NCBI View Article : Google Scholar

31 

Wu Y, Chang J, Ge J, Xu K, Zhou Q, Zhang X, Zhu N and Hu M: Isobavachalcone's alleviation of pyroptosis contributes to enhanced apoptosis in glioblastoma: Possible involvement of NLRP3. Mol Neurobiol. 59:6934–6955. 2022.PubMed/NCBI View Article : Google Scholar

32 

Bertheloot D, Latz E and Franklin BS: Necroptosis, pyroptosis and apoptosis: An intricate game of cell death. Cell Mol Immunol. 18:1106–1121. 2021.PubMed/NCBI View Article : Google Scholar

33 

Ketelut-Carneiro N and Fitzgerald KA: Apoptosis, pyroptosis, and necroptosis-oh my! The many ways a cell can die. J Mol Biol. 434(167378)2022.PubMed/NCBI View Article : Google Scholar

34 

Attwaters M: Persisting through apoptosis. Nat Rev Mol Cell Biol. 23(697)2022.PubMed/NCBI View Article : Google Scholar

35 

Newton K, Strasser A, Kayagaki N and Dixit VM: Cell death. Cell. 187:235–256. 2024.PubMed/NCBI View Article : Google Scholar

36 

Zhang L, Liu Z, Dong Y and Kong L: E2F2 drives glioma progression via PI3K/AKT in a PFKFB4-dependent manner. Life Sci. 276(119412)2021.PubMed/NCBI View Article : Google Scholar

37 

Chautard E, Ouédraogo ZG, Biau J and Verrelle P: Role of Akt in human malignant glioma: From oncogenesis to tumor aggressiveness. J Neurooncol. 117:205–215. 2014.PubMed/NCBI View Article : Google Scholar

38 

Zhang X, Li Z, Wei C, Luo L, Li S, Zhou J, Liang H, Li Y and Han L: PLK4 initiates crosstalk between cell cycle, cell proliferation and macrophages infiltration in gliomas. Front Oncol. 12(1055371)2022.PubMed/NCBI View Article : Google Scholar

39 

Liu F, Chen G, Zhou LN, Wang Y, Zhang ZQ, Qin X and Cao C: YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation. Protein Cell. 14:223–229. 2023.PubMed/NCBI View Article : Google Scholar

40 

Ren J, Zheng S, Zhang L, Liu J, Cao H, Wu S, Xu Y and Sun J: MAPK4 predicts poor prognosis and facilitates the proliferation and migration of glioma through the AKT/mTOR pathway. Cancer Med. 12:11624–11640. 2023.PubMed/NCBI View Article : Google Scholar

41 

Tang YQ, Li ZW, Feng YF, Yang HQ, Hou CL, Geng C, Yang PR, Zhao HM and Wang J: MK2206 attenuates atherosclerosis by inhibiting lipid accumulation, cell migration, proliferation, and inflammation. Acta Pharmacol Sin. 43:897–907. 2022.PubMed/NCBI View Article : Google Scholar

42 

Xiang RF, Wang Y, Zhang N, Xu WB, Cao Y, Tong J, Li JM, Wu YL and Yan H: MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway. Cell Death Dis. 8(e2776)2017.PubMed/NCBI View Article : Google Scholar

43 

Cui X, Zhao J, Li G, Yang C, Yang S, Zhan Q, Zhou J, Wang Y, Xiao M, Hong B, et al: Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma. Cancer Commun (Lond). 43:1326–1353. 2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lei J, Yang J, Cheng S, Lu F, Wu Z, Wang Z, Wang Z, Sun C and Lin L: Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway. Exp Ther Med 28: 447, 2024.
APA
Lei, J., Yang, J., Cheng, S., Lu, F., Wu, Z., Wang, Z. ... Lin, L. (2024). Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 28, 447. https://doi.org/10.3892/etm.2024.12737
MLA
Lei, J., Yang, J., Cheng, S., Lu, F., Wu, Z., Wang, Z., Wang, Z., Sun, C., Lin, L."Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 28.6 (2024): 447.
Chicago
Lei, J., Yang, J., Cheng, S., Lu, F., Wu, Z., Wang, Z., Wang, Z., Sun, C., Lin, L."Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 28, no. 6 (2024): 447. https://doi.org/10.3892/etm.2024.12737
Copy and paste a formatted citation
x
Spandidos Publications style
Lei J, Yang J, Cheng S, Lu F, Wu Z, Wang Z, Wang Z, Sun C and Lin L: Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway. Exp Ther Med 28: 447, 2024.
APA
Lei, J., Yang, J., Cheng, S., Lu, F., Wu, Z., Wang, Z. ... Lin, L. (2024). Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 28, 447. https://doi.org/10.3892/etm.2024.12737
MLA
Lei, J., Yang, J., Cheng, S., Lu, F., Wu, Z., Wang, Z., Wang, Z., Sun, C., Lin, L."Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 28.6 (2024): 447.
Chicago
Lei, J., Yang, J., Cheng, S., Lu, F., Wu, Z., Wang, Z., Wang, Z., Sun, C., Lin, L."Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 28, no. 6 (2024): 447. https://doi.org/10.3892/etm.2024.12737
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team